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Physiologic changes of
pregnancy
. DINA AKEEL
AIMS
 TO GAIN AN UNDERSTANDING OF THE
PHYSIOLOGICAL CHANGES THAT
OCCUR DURING PREGNANCY
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Organ systems
 Cardiovascular system
 Pulmonary system
 Genital tract
 Urinary system
 Endocrine system
 Gastrointestinal Tract
 Skin
CHANGES ARE DUE TO
 ALTERATIONS IN
 HORMONAL PRODUCTION
 CIRCULATION
 METABOLISM
HORMONES
OESTROGEN
 Produced in corpus luteum
 Produced by placenta after 12 weeks
 Responsible for growth particularly of
uterus and breasts
progesterone
 Produced in corpus luteum and then the
placenta
 Relaxes smooth muscle
 Inhibits uterine contractions until uterus is
prepared for labour
 Regulates storage of body fat
Maternal changes - anatomical
and physiological
 Cardiovascular changes
 increase in SV
 increase in cardiac output
 increase in HR at given work load
 increase in blood volume (mostly during
latter half of pregnancy)
 Uterus may compress large blood vessels
reducing venous return
Circulatory
System
Supine hypotension related to
Venal cava syndrome
This leads to dizziness,
air hunger, nausea
Total body water
 Increases 6-8 L
 Increases by 40 %
 Normal body water
 2/3 intracellular
 1/3 extracellular
 ¾ interstitial
 ¼ intravasular
 2/3 increase is extravascular
Respiratory system
 Mechanical
 diaphragm
 Consumption
 Increase in needed oxygen
 Stimulation
 Progesterone stimulation
Respiratory Changes
Respiratory Changes

 Respiratory capacity
Respiratory capacity
increases
increases

 Shortness of breath
Shortness of breath

 Pulmonary reserve
Pulmonary reserve
decreases
decreases

 Increased risk of
Increased risk of
muscle soreness
muscle soreness

 Tendency to
Tendency to
hyperventilate
hyperventilate
RESULT
RESULT adjust the intensity level and duration of exercise
adjust the intensity level and duration of exercise
Physiologic changes -
 RESPIRATORY SYSTEM
increase respiratory rate
increased oxygen consumption
common are nasal stuffiness,
nosebleeds due to Increased
vascular swelling to nose
Respiratory
 Consumption
 O2 consumption Increases 15-20 %
 50 % of this increase is required by the uterus
 Despite increase in oxygen requirements, with the
increase in Cardiac Output and increase in
alveolar ventilation oxygen consumption exceeds
the requirements.
 .
Physiologic changes -
 GASTROINTESTINAL
 Digestive system slow due to
progesterone
 Nausea and vomiting
 Ptyalism: increase salivation
 Heartburn
 Hemorrhoids
 Prolonged gallbladder emptying time
may lead to gall stones
 Bile salt buildup may lead to itching.
Gastrointestinal Tract
 Displacement of the stomach and intestines
 Appendix can be displaced to reach the right
flank
 Gastric emptying and intestinal transit times
are delayed secondary to hormonal and
mechanical factors
 Vascular swelling of the gums
 Hemorrhoids due to elevated pressure in
veins
Digestive Changes
Digestive Changes

 Digestive system slows
Digestive system slows

 Intestines are pushed up
Intestines are pushed up
and to the sides
and to the sides

 Smooth muscle of the
Smooth muscle of the
stomach relaxes and can
stomach relaxes and can
cause heartburn
cause heartburn

 Constipation and hemorrhoids are
Constipation and hemorrhoids are
common during pregnancy
common during pregnancy

 Morning sickness
Morning sickness
Physiologic changes -
 METABOLISM
BMR increases by 20-25 % during
pregnancy
Recommended weight gain – 25-35
lb
Overweight – 15-25 lb
Underweight – 25-35 lb
Need for increased iron, calcium,
Genital Tract
 Increased vascularity and hyperemia
 Vagina
 Perineum
 Vulva
 Increased secretions
 Characteristic violet color of the vagina
 Chadwick’s sign
 Increased length to the vaginal wall
 Hypertrophy of the papillae of the vaginal
mucosa
Changes in the cervix
 Length remains the same
 Increase in width
 Softening after third month due to
oestrogen
 Increased vascularity
 Increased cervical mucosa
 Increased glandular function
uterus grows to 30x23x20 at term
weight increases to 900gms
hypertrophy.. Oestrogen causes cells to
increase until 20 weeks gestation
Hyperplasia:- number of cells increase
under the influence of oestrogen
.
Relative Uterus Size During
Pregnancy
Figure 28.15
PLASMA VOLUME
Increases from 10th week of pregnancy
variable related to parity, fetal weight and
number
Reaches maximum level approx 50%
above non-pregnant levels at 32-34 weeks
then maintained
 50% rise in plasma volume
 20% rise in red cell mass
 Heamodilution: Physiological anaemia
 Most apparent at 32-34 weeks
RENAL SYSTEM
 DILATION OF THE RENAL VESSELS
 DUE THE EFFECTS OF
PROGESTERONE
 INCREASED RENAL BLOOD FLOW
 GFR INCREASES BY 60% IN EARLY
PREGNANCY
Urinary Changes
 Kidneys grow and filter more
blood as the blood volume
increases
 Become more susceptible to
bladder and kidney infections
 Bladder becomes compressed
causing frequent urination and
incontinence
Wajed Hatamleh RN, MSN, PhD.
Physiologic changes -
URINARY TRACT
Increased glomerular filtration
rate
Frequency
Infection : Smooth muscle of
bladder relaxes/stasis
WATER, WATER, WATER
 Provide a ready source of water
 Encourage frequent water breaks
Hydration is a major concern
during maternal exercise.
Skin changes
 Chloasma or melasma gravidarum
 Striae
 Linea nigra
Skin Changes
 Stretch marks
 Dark pigmented line on there abdomen
which is called Linea Nigra
 Pigment changes on their face and neck
 Small blood vessels in the face, neck
and upper chest
 MOST OF THESE RESOLVE AFTER
PREGNANCY
Melasma
Melasma
Melasma
 Also known as the mask of pregnancy
 More common in dark skin people
 More pronounced in the summer
 Fades a few months after delivery
 Repeated pregnancy can intensify
 Can occur in normal non-pregnant
women with harmless hormonal
imbalances or women on OCPs or depo
Striae
Striae
 Reddish slightly depressed
 Breasts, thighs, and abdomen
 In future pregnancies they appear as
glistening, silver lines
Linea nigra

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2_2019_07_14!12_49_58_PM.ppt

  • 2. AIMS  TO GAIN AN UNDERSTANDING OF THE PHYSIOLOGICAL CHANGES THAT OCCUR DURING PREGNANCY
  • 4. Organ systems  Cardiovascular system  Pulmonary system  Genital tract  Urinary system  Endocrine system  Gastrointestinal Tract  Skin
  • 5. CHANGES ARE DUE TO  ALTERATIONS IN  HORMONAL PRODUCTION  CIRCULATION  METABOLISM
  • 6. HORMONES OESTROGEN  Produced in corpus luteum  Produced by placenta after 12 weeks  Responsible for growth particularly of uterus and breasts
  • 7. progesterone  Produced in corpus luteum and then the placenta  Relaxes smooth muscle  Inhibits uterine contractions until uterus is prepared for labour  Regulates storage of body fat
  • 8. Maternal changes - anatomical and physiological  Cardiovascular changes  increase in SV  increase in cardiac output  increase in HR at given work load  increase in blood volume (mostly during latter half of pregnancy)  Uterus may compress large blood vessels reducing venous return
  • 10. Supine hypotension related to Venal cava syndrome This leads to dizziness, air hunger, nausea
  • 11. Total body water  Increases 6-8 L  Increases by 40 %  Normal body water  2/3 intracellular  1/3 extracellular  ¾ interstitial  ¼ intravasular  2/3 increase is extravascular
  • 12. Respiratory system  Mechanical  diaphragm  Consumption  Increase in needed oxygen  Stimulation  Progesterone stimulation
  • 13. Respiratory Changes Respiratory Changes   Respiratory capacity Respiratory capacity increases increases   Shortness of breath Shortness of breath   Pulmonary reserve Pulmonary reserve decreases decreases   Increased risk of Increased risk of muscle soreness muscle soreness   Tendency to Tendency to hyperventilate hyperventilate RESULT RESULT adjust the intensity level and duration of exercise adjust the intensity level and duration of exercise
  • 14. Physiologic changes -  RESPIRATORY SYSTEM increase respiratory rate increased oxygen consumption common are nasal stuffiness, nosebleeds due to Increased vascular swelling to nose
  • 15. Respiratory  Consumption  O2 consumption Increases 15-20 %  50 % of this increase is required by the uterus  Despite increase in oxygen requirements, with the increase in Cardiac Output and increase in alveolar ventilation oxygen consumption exceeds the requirements.  .
  • 16. Physiologic changes -  GASTROINTESTINAL  Digestive system slow due to progesterone  Nausea and vomiting  Ptyalism: increase salivation  Heartburn  Hemorrhoids  Prolonged gallbladder emptying time may lead to gall stones  Bile salt buildup may lead to itching.
  • 17. Gastrointestinal Tract  Displacement of the stomach and intestines  Appendix can be displaced to reach the right flank  Gastric emptying and intestinal transit times are delayed secondary to hormonal and mechanical factors  Vascular swelling of the gums  Hemorrhoids due to elevated pressure in veins
  • 18. Digestive Changes Digestive Changes   Digestive system slows Digestive system slows   Intestines are pushed up Intestines are pushed up and to the sides and to the sides   Smooth muscle of the Smooth muscle of the stomach relaxes and can stomach relaxes and can cause heartburn cause heartburn   Constipation and hemorrhoids are Constipation and hemorrhoids are common during pregnancy common during pregnancy   Morning sickness Morning sickness
  • 19. Physiologic changes -  METABOLISM BMR increases by 20-25 % during pregnancy Recommended weight gain – 25-35 lb Overweight – 15-25 lb Underweight – 25-35 lb Need for increased iron, calcium,
  • 20. Genital Tract  Increased vascularity and hyperemia  Vagina  Perineum  Vulva  Increased secretions  Characteristic violet color of the vagina  Chadwick’s sign  Increased length to the vaginal wall  Hypertrophy of the papillae of the vaginal mucosa
  • 21. Changes in the cervix  Length remains the same  Increase in width  Softening after third month due to oestrogen  Increased vascularity  Increased cervical mucosa  Increased glandular function
  • 22. uterus grows to 30x23x20 at term weight increases to 900gms hypertrophy.. Oestrogen causes cells to increase until 20 weeks gestation Hyperplasia:- number of cells increase under the influence of oestrogen .
  • 23. Relative Uterus Size During Pregnancy Figure 28.15
  • 24. PLASMA VOLUME Increases from 10th week of pregnancy variable related to parity, fetal weight and number Reaches maximum level approx 50% above non-pregnant levels at 32-34 weeks then maintained
  • 25.  50% rise in plasma volume  20% rise in red cell mass  Heamodilution: Physiological anaemia  Most apparent at 32-34 weeks
  • 26. RENAL SYSTEM  DILATION OF THE RENAL VESSELS  DUE THE EFFECTS OF PROGESTERONE  INCREASED RENAL BLOOD FLOW  GFR INCREASES BY 60% IN EARLY PREGNANCY
  • 27. Urinary Changes  Kidneys grow and filter more blood as the blood volume increases  Become more susceptible to bladder and kidney infections  Bladder becomes compressed causing frequent urination and incontinence
  • 28. Wajed Hatamleh RN, MSN, PhD. Physiologic changes - URINARY TRACT Increased glomerular filtration rate Frequency Infection : Smooth muscle of bladder relaxes/stasis
  • 29. WATER, WATER, WATER  Provide a ready source of water  Encourage frequent water breaks Hydration is a major concern during maternal exercise.
  • 30. Skin changes  Chloasma or melasma gravidarum  Striae  Linea nigra
  • 31. Skin Changes  Stretch marks  Dark pigmented line on there abdomen which is called Linea Nigra  Pigment changes on their face and neck  Small blood vessels in the face, neck and upper chest  MOST OF THESE RESOLVE AFTER PREGNANCY
  • 34. Melasma  Also known as the mask of pregnancy  More common in dark skin people  More pronounced in the summer  Fades a few months after delivery  Repeated pregnancy can intensify  Can occur in normal non-pregnant women with harmless hormonal imbalances or women on OCPs or depo
  • 36. Striae  Reddish slightly depressed  Breasts, thighs, and abdomen  In future pregnancies they appear as glistening, silver lines