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How to Learn II
Office EE 318
Email: melloch@purdue.edu
Phone: 49-43528
Michael R. Melloch
Professor of Electrical and Computer Engineering
Purdue University
Move three dimes to form a triangle
pointing downward
My Solution
Solution
Thiss equation contains three errrors.
Thiss equation contains three errrors.
Error 1: spelling of Thiss
Error 2: Spelling of errrors
Error 3: There are only two errors, so statement
is an error
Connect the dots with four continuous straight lines
Connect the dots with four continuous straight lines
Form four equilateral triangles
from six equal-length pencils
• Sleep
• Mindset
• Grit
• Exercise
• Meditation
• Nutrition
Human Brain
• 2% of the body weight
• Uses 20% of the body’s glucose & oxygen
1/3 for cell health maintenance
2/3 for neuron activity
• Cut off energy supply and the brain stops
functioning in 10 seconds
Sleep
Factors Determining When You Sleep
• Suprachiasmatic Nucleus (Circadian Rhythm)
• Adenosine build up
• Effects of lack of sleep on functioning when
awake
• Learning lost from lack of adequate sleep
Effects of Lack of Sleep
• Memory in-box shut down (hippocampus)
• Lack of concentration (microsleeps)
• Immune system is impaired
• Emotional problems (Amygdala)
• Metabolic contaminants build up
• Increase in cortisol
• Increase risk of type 2 diabetes, cardiovascular
disease, stroke, depression, and anxiety.
Glymphatic System
Jeffrey J. Iliff, et al., “A Paravascular Pathway Facilitates CSF Flow Through the Brain
Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β,” Science
Translational Medicine Aug 15, 2012, vol. 4, issue 147.
Microsleep
• Brief period your mind is blind to the outside word
• Most of the time you have no awareness
Microsleep
• Response to hitting a button when a light
flashed for 10 minutes.
• Eight-hour sleep group maintained stable,
near-perfect performance for two weeks
• The no-sleep group saw a continuous increase
in missed responses indicating microsleeps.
• Ten days of six-hour sleep missed responses
equivalent to 24 hours of no sleep
Julian Lim and David Dinges, “Sleep Deprivation and Vigilant Attention,” Annals of
the Hew York Academy of Sciences, 1129, pp 305-322 (2008).
Brain Activity
Sleep Spindle
8-13 Hz
4-7 Hz
< 4 Hz
11-16 Hz
Brain Processes Information During Sleep
During deep NREM Sleep information transfers
from short- to long-term memory
Sensory input
hippocampus
Wake asleep
Sleep spindles
hippocampus hippocampus
Neocortex Neocortex
During REM sleep brain works to find hidden
relations among memories and to solve
problems we were working on while awake.
Rats learning a Maze
• Implants that monitor brain activity
• Could tell where in the maze the rats were
from the brain activity
• Maze brain activity occurred while rats were
sleeping
James J. Knierim, “The Matrix in Your Head,” Scientific American Mind, June/ July 2007
Scullin, M., McDaniel, M., Howard, D., & Kudelka, C. (2011, June). Sleep and
testing promote conceptual learning of classroom materials. Presented at the
25th Anniversary Meeting of the Associated Professional Sleep Societies LLC,
Minneapolis, MN.
• 102 UG who had never taken an econ course
• Split into two groups
• Group 1 watched a virtual lecture in the
morning and 12 hours later took an exam
(wake)
• Group 2 watched a virtual lecture in the
evening and 12 hours later, after a night’s
sleep took an exam (sleep)
Novel Problems
Problems Similar
to lecture
Another Sleep Example
• Subjects taught to solve a mathematical
problem using a long tedious method.
• Came back 12 hours later to solve more of
these problems.
• Group 1 stayed awake and group 2 slept
• There was a quick simpler method for solving
the problem.
• 23% of group 1 discovered the simpler quick
method
• 59% of group 2 discovered the simpler quick
method
Ulrich Wagner, Steffen Gais, Hide Haider, Rolf Verleger, & Jan Born, “Sleep
Inspires Insight, Nature volume 427, 352-355, Jan 22, 2004.
Participants learned a novel, artificial
grammar to a 90% proficiency
• Group 1 slept naturally consuming no alcohol
• Group 2 consumed 2-3 shots of vodka the first
night, but no other alcohol during the week
• Group 3 consumed 2-3 shots of vodka on the
third night, but no other alcohol during the
week.
A week later they were tested on the grammar
• Group 1 slept naturally consuming no alcohol
Maintained 90% efficiency and showed an
enhancement of abstraction
• Group 2 consumed 2-3 shots of vodka the first
night, but no other alcohol during the week
50% efficiency
• Group 3 consumed 2-3 shots of vodka on the
third night, but no other alcohol during the week.
60% efficiency
People who study in the morning—whether it’s words or pattern
recognition games, straight retention or comprehension of deeper
structure—do about 30 percent better on an evening test if
they’ve had an hour-long nap than if they haven’t.
Mednick, Nakayama, and Stickgold, “Sleep-dependent learning: a nap is as
good as a night,” Nature Neuroscience, 2003
Dreaming
• 100 participants studied a virtual maze
• Half took a 90-minute nap, half an equivalent
period of wake
All were prompted three times
to report everything that was going
through their minds
Erin J. Wamsley et al., “Dreaming of a Learning Task is Associated with Enhanced
Sleep-Dependent Memory Consolidation, Curr Biol 20, no. 9, 850-855 (2010)
Mindsets
Calvin and Hobbes, 1995
Calvin Susie
Mindset: The New Psychology of Success by Carol Dweck
For effective learning, differences in native ability are dwarfed by habits and methods.
Fixed (entity) mindset—effort is a bad thing, means you are not smart or talented
Growth (incremental) mindset—effort is what makes you smart or talented
Fixed
mindset
Growth
mindset
Mindsets
• Effort means you don’t have the skill or talent
• Concerned with proving
• Failure means you are not smart
• Self-handicapping to prevent a poor performance from reflecting on their
ability (staying up all night partying before a test)
Fixed Mindset
Growth Mindset
• Although people differ in initial talent and aptitude, everyone can grow
through application and experience
• Concerned with improving
• Failure means you are learning
• True potential is unknown, it takes time to flower
Do you believe your intelligence is fixed
or something you could develop?
You can increase your intelligence
Flynn effect: scores on IQ tests have gone up 15
points over the last 50 years
Flynn, James R. “The Mean IQ of Americans: Massive Gains 1932 to 1978,”
Psychological Bulletin (1984) 95: 29–51.
Brain is remarkably plastic
• Brain can grow at any age
• Neurons are born in the hippocampus every day
(neurogenesis)
• Dendrites grow and sprout
• Newly born synapses (synaptogenesis)
• Newly formed blood vessels (angiogenesis)
Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance
by Majid Fotuhi, M.D., Ph.D.
.
J. Altman & G. Das, "Postnatal Neurogenesis in the Guinea-pig,” Nature, 214, 1098–1101 (10 June 1967)
Joseph Altman discovered adult neurogenesis, the
creation of new neurons in an adult mammalian brain
P. Eriksson, E. Perfilieva, T. Bjork-Eriksson, A-M. Alborn, C. Mordborg, D. Peterson, and F. Gage,
“Neurogenesis in the Adult Human Hippocampus,” Nature Medicine 4, no. 11 (1998) 1313-1317.
G. Kempermann, H.G. Kuhn, and F. Gage, “More Hippocampal Neurons in Adult Mice Living in
an Enriched Environment,” Nature 386, no. 6624 (1997), 493-95.
Brain is remarkably plastic
• Measured IQ of adolescents at the start and end
of a four-year period
• Performed MRI brain scans at the start and the
end of the four-year period
• Those who improved their math IQ strengthened
the areas of the brain related to math, the same
was true with English
Ramsden S, Richardson FM, Josse G, et al. Verbal and nonverbal intelligence changes
in the teenage brain. Nature. 2011;479(7371):113-116.
1952 Nobel Prize for NMR
Edward Mills Purcell (1912–1997)
1952 Nobel Prize for NMR
Edward Mills Purcell (1912–1997)
Purdue BSEE
London Taxi Drivers
• Must know an area of 6-mile radius
• No grid like other cities, 25,000 streets
• Must know most efficient route between any
two points
• Thames river
• Must know location of every landmark
• Those who pass the test on “the Knowledge”
typically study for 4 years
Over the four years of studying “the
Knowledge,” MRI studies showed an
increase in volume of the posterior
hippocampi of those who successfully
passed the London Taxi drivers test
Maguire, E. A.; Gadian, D. G.; Johnsrude, I. S.; Good, C. D.; Ashburner, J.; Frackowiak,
R. S. J.; Frith, C. D., “Navigation-related structural change in the hippocampi of taxi
Drivers,” Proceedings of the National Academy of Sciences. 97 (8): 4398–4403 (2000).
Katherine Woodlett and Eleanor Maguire, “Acquiring "the Knowledge" of London’s
Layout Drives Structural Brain Changes,” Current Biology 21, 2109-2114 (2011).
In blind and deaf people the brain
rewires to use areas normally dedicated
to processing sights or sounds
The Brain's Way of Healing: Remarkable Discoveries and
Recoveries from the Frontiers of Neuroplasticity by Norman Doidge
Premed Chemistry
Determine the mindset by asking questions like, “Do you believe
your intelligence is fixed or something you could develop?”
• Fixed mindset did poorly
reread text and notes, tried to memorize
• Growth mindset earned better grades
looked for themes and underlying principles
studying to learn, not to ace an exam
Grant, H. & Dweck, C. S. (2003) “Clarifying achievement goals and their impact,”
Journal of Personality and Social Psychology, 85, 541–553
Effect of type of Praise
• Diverse group of 5th graders given 10 moderately
difficult problems from a non-verbal IQ test
• One group was praised for their intelligence, one
group for their effort, and one group received
non-specific praise
• They all completed a second test of very difficult
problems
• They all completed a third test that was similar in
difficulty to the first test
Mueller, C. M., & Dweck, C. S. (1998). “Intelligence praise can undermine motivation and
Performance,” Journal of Personality and Social Psychology, 75, 33–52.
One more striking result
Mindset intervention
• Entering 7th graders divided into two groups
• Control group had six sessions on study skills
• Intervention group had six sessions some on
study skills and some on growth mindsets—
the brain grows new connections and gets
smarter when working on challenging tasks
• Earned a C- in high school English
• SAT verbal score of 475 out of 800
• Needed 5 years to graduate high school
• Reads 2 to 3 times slower than average person
• Difficulty learning to spell
John Irving
• Has written 17 novels
• The World According to Garp won the
National Book Award
• He won an Academy Award for his screenplay
to his novel The Cider House Rules.
Self-Control and Grit
Procrastinators report higher stress, worse health, and lower grades
Tice, D. M., & Baumeister, R. F. (1997). Longitudinal study of procrastination,
performance, stress, and health: The costs and benefits of dawdling. Psychological
Science, 8(6), 454-458.
“Never put off till tomorrow, what you can
do the day after tomorrow,” Mark Twain.
Marshmallow test
Mischel, W., & Ebbesen, E. B.(1970). Attention in delay of gratification.
Journal of Personality and Social Psychology, 16, 329–337
Mischel, W., Shoda, Y., & Rodriguez, M. I. (1989) Delay of gratification in children.
Science, 244(4907), 933–938
When these students were seniors in high school,
it was found there was a direct correlation between
their SAT scores and their ability to wait as preschoolers
Caveats
stability of the home environment could play a role,
the participants came from Stanford’s on-campus nursery school
and many of the kids were children of Stanford students or professors,
Multitasking
• 263 students told to study something important for 15
minutes
• Researchers noted what they were doing once a
minute
• On-task behavior began to decline at the 2-minute
mark
• Spent 65% of the 15 minutes studying
Larry D. Rosen, L. Mark Carrier, and Nancy A. Cheever, “Facebook and texting
made me do it: Media-induced task-switching while studying,” Computers in
Human Behavior, Vol. 29, pages 948-958, May 2013.
texting and using Facebook—in class and while doing
homework—were negatively correlated with college
students’ GPAs
Reynol Junco, “Too much face and not enough books: The relationship between multiple
Indices of Facebook use and academic performance,” Computers in Human Behavior,
Vol 28, pages 187-198, 2012.
The new Marshmallow test of self-discipline,
the ability to resist a blinking inbox or a buzzing phone
Grit
Duckworth, Angela & Peterson, Christopher & D Matthews, Michael & R Kelly, Dennis. (2007),
“Grit: Perseverance and Passion for Long-Term Goals,” Journal of personality and social
psychology. 92. 1087-101. 10.1037/0022-3514.92.6.1087.
passion and perseverance for long-term goals
https://www.ted.com/talks/angela_lee_duckworth_grit_the_power_
of_passion_and_perseverance#t-178164
Self-control is the ability to resist hourly temptations,
momentary pleasures that are immediately regretted.
Grit is the ability to pursue something challenging
for months, years, and sometimes decades.
Hereditary Genius: an Inquiry Into Its Laws and Consequences by Francis Galton 1869
Grit Math
Talent X Effort = Skill
Skill X Effort = Achievement
Violin Students at the Berlin University
of the Arts
Anders Ericsson, K & Krampe, Ralf & Tesch-Roemer, Clemens. (1993). “The Role of Deliberate
Practice in the Acquisition of Expert Performance,” Psychological Review. 100. 363-406.
People with a growth mindset are grittier and more
optimistic than fixed mindset people
Growth
mindset
Optimistic
Self-talk
Perseverance
over adversity
Grit and self-discipline can be acquired
• Culture can instill it, being around gritty people
• Thinking of yourself as gritty can lead to being
gritty
• Engage in an extracurricular activity and stick
with it for two years (Steve Faloon was a serious
runner)
• Make a list of tasks for tomorrow (commitment)
• Meditate
• Routines
• Pomodoro technique
Eisenberger, R., “Learned industriousness,” Psychological Review, 99, 248-267 (1992)
Six Steps of Original Pomodoro Technique
1. Decide on the task to be done.
2. Set a timer (traditionally to 25 minutes).
3. Work on the task.
4. End work when the timer rings and put a checkmark
on a piece of paper.
5. If you have fewer than four checkmarks, take a short
break (3–5 minutes), then go to step 2.
6. After four pomodoros, take a longer break
(15–30 minutes), reset your checkmark count to zero,
then go to step 1.
Exercise
Exercise
• Improves Circulation (angiogenesis)
• Spurs the production of neurotransmitters
• Facilitates synaptic plasticity
• Boosts levels of BDNF (brain-derived
neurotrophic factor)
Hippocampus constantly creates new neurons,
BDNF helps them grow.
Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance
by Majid Fotuhi, M.D., Ph.D.
Neurogenesis in Adult Mouse Hippocampus
control running
Henriette van Praag, Gerd Kempermann, and Fred H. Gage, “Running Increases
Cell Proliferation and Neurogenesis in the Adult Mouse Dentate Gyrus,” Nature
Neuroscience, Vol 2, no, 3 March 1999.
• Sedentary students were recruited at the
University of Dublin
• For five weeks engaged in strenuous exercise
on a stationary bike
• MRIs were taken before and after the five
weeks looking at the hippocampus
Éadaoin W. Griffin, Sinéad Mulally, Carole Foley, Stuart A. Warmington, Shane M. O’Mara,
and Áine M. Kelly, “Aerobic Exercise Improves Hippocampal Function and Increases
BDNF in the Serum of Young Adult Males,” Physiology and Behavior 104, no. 5 (2011): 934–41.
Before After
• 59 cognitively health people between ages of 60-
79 years
• Split into two groups
• One group did aerobic exercises and the other
stretching and toning exercises for 6 months
• Brain MRI scans taken before and after
• Those who did aerobic exercises had more gray
and white matter in the frontal and temporal
lobes
S. J. Colcombe, K. I. Erickson, P. E. Scalf, J. S. Kim, R. Prakash, E. McAuley, S. Elavsky,
D. X. Marquez, L. Hu, and A. F. Kramer, “Aerobic Exercise Training Increases Brain Volume
in Aging Humans,” Journals of Gerontology, Series A: Biological Sciences and Medicine
Sciences 61, no. 11 (2006): 1166–70.
Meditation
Mindfulness Meditation
• Strength training for you brain
• Many types
Some Benefits
• Stress relief
• Heightened awareness
• Enhanced concentration
• Ignore the mental chatter that distracts you
Mindful Cycle
Paying attention to
the present moment
Becoming distracted
Noticing your
mind has wondered
Deciding to
refocus attention
Attention Network
Salience Network
Default Mode Network
Wendy Hasenkamp and Lawrence W. Barasou, “Effects of meditation experience on
Functional connectivity of distributed brain networks,” Frontiers Human Neuroscience,
March 2012
Changes the Brain at the Physical Level
Harvard Studies — 16 healthy adults who never meditated
Weekly classes on meditation
Averaged three hours per week meditating for 8 weeks
MRI scans before and after
increase in gray matter around hippocampus
decrease in gray matter around amygdala
Britta K. Hölzel, James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti,
Tim Gard, and Sara W. Lazar, “Mindfulness Practice Leads to Increases in Regional
Brain Gray Matter Density,” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.
Changes the Brain at the Physical Level
UCLA Studies
thickens the brain and strengthens the connections
between brain cells
Slows age-related loss of gray matter
larger amounts of gyrification (“folding” of the cortex,
which may allow the brain to process information faster)
Eileen Luders, Arthur W. Toga, Natasha Lepore, and Christian Gaser, “The Underlying
Anatomical Correlates of Long-Term Meditation: Larger Hippocampal and Frontal
Volumes of Gray Matter,” NeuroImage 45, no. 3 (2009): 672–78.
Study conducted by the University of Pennsylvania Medical
Center found that experienced meditators had significantly
higher blood flow to the prefrontal cortex, parietal cortex,
and other areas of the brain that support attention,
regulation of emotion, and autonomic function.
Fotuhi, Majid. Boost Your Brain: The New Art and Science Behind Enhanced
Brain Performance (Kindle Locations 1865-1868). HarperCollins. Kindle Edition.
B. Newberg, N. Wintering, M. R. Waldman, D. Amen, D. S. Khalsa, and A. Alavi,
“Cerebral Blood Flow Differences Between Long-Term Meditators and
Non-Meditators,” Conscious and Cognition 19, no. 4 (2010): 899–905.
Nutrition
Brain
• 75% water
• 60% of the rest is fat
Regulatory Roles
Low Omega-6 to Omega-3 ratio
• Wild caught cold water fish
• Grass-fed beef
• Pasture raised eggs
Omega 3 PUFAs found in these foods are EPA and DHA
DHA and exercise promote the formation of BDNF
High in Omega 6
• Safflower oils
• sunflower oils
• Canola oils
• corn oils
• grapeseed (often hidden in salad dressings)
• Rapeseed oils
• Peanut oils
• Vegetable oils
• soybean oils
Avoid foods fried in any of these oils
Monounsaturated Fatty Acids
• Extra Virgin Olive Oil*
• Avocados
• Avocado oil
• Macadamia nuts
• Wild Salmon
• Grass-fed beef
Used in the myelin sheath around nerve cells
*Aleiz Sala-Vila, et al., “Mediterranean Diet and Age-Related Cognitive Decline:
A Randomized Clinical Trial,” JAMA Internal Medicine, 175, no 7, 1094-1103(2015).
Refined Sugars
• Became available early 1800s
• 1900 Americans consumed 26 lbs per year
• Today Americans consume 160 lbs per year
• Table sugar (50% glucose/50% fructose)
• HFCS (45% sugar/55% fructose)
• Insulin and glucagon balance the glucose in
your blood stream
Robert H. Lustig, Laura A. Schmidt, and Claire D. Brindis, “The toxic truth about sugar,”
Nature, vol. 482, pages 27-29 (2012).
Some Foods that cause inflammation
• Sugar and High-Fructose Corn Syrup
• Artificial Trans Fats
• Vegetable and Seed Oils
• Refined Carbohydrates
• Excessive Alcohol
• Processed Foods
Glycation
• Attachment of sugar to a protein or lipid
• Fructose is 10 times more active glycation
• Glycated molecules eventually become
Advanced Glycation End Products (AGEs)
AGEs are gerontotoxins
diabetes, atherosclerosis, chronic kidney disease, and Alzheimer’s
Brian Healthy Foods
• DHA omega-3 fatty acids (wild-fish, grass-fed beef)
• Extra virgin olive oil
• Avocados
• Almonds
• Berries (Blue, black, straw, & rasp)
• Red grapes
• Dark leafy greens
• Cruciferous Vegetables (Broccoli, Brussel sprouts,
cabbage)
• Pastured raised eggs
• Green tea
• Dark Chocolate (>85% cacao)
Some Key Points
• Spaced, instead of blocked
• Interleave topics, subjects
• Study in different settings
• Preparation and incubation
• Deliberate practice
—study to understand, not just to memorize
a procedure or equation
—testing, recall
• Explain out loud
Some Key Points continued
• All senses including touch, take handwritten
notes
• Develop a growth mindset, grit, self-control
• Develop a habit of study and reduce your habit of
procrastination—Routines, Mindfulness
• Make a list of tasks for the next day
• Sleep
• Exercise
• Healthy Diet
Make It Stick by Peter Brown, Henry L. Roediger, and Mark A. McDaniel
Why We Sleep: Unlocking the Power of Sleep and Dreams, Matthew Walker
How We Learn: The Surprising Truth About When, Where,
and Why It Happens by Benedict Carey
Mindset: The New Psychology of Success by Carol Dweck
Grit: The Power of Passion and Perseverance by Angela Duckworth
A Mind for Numbers: How to Excel at Math and Science
(Even if You Flunked Algebra) by Barbara Oakey
#What is Mindfulness? By Tamara Russell
Peak: Secrets from the New Science of Expertise by Anders Ericsson and Robert Pool
Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance
by Majid Fotuhi, M.D., Ph.D.
Genius Foods by Max Lugavere.

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2021.09.30-ECE694-Melloch-2.pdf

  • 1. How to Learn II Office EE 318 Email: melloch@purdue.edu Phone: 49-43528 Michael R. Melloch Professor of Electrical and Computer Engineering Purdue University
  • 2. Move three dimes to form a triangle pointing downward
  • 5. Thiss equation contains three errrors.
  • 6. Thiss equation contains three errrors. Error 1: spelling of Thiss Error 2: Spelling of errrors Error 3: There are only two errors, so statement is an error
  • 7. Connect the dots with four continuous straight lines
  • 8. Connect the dots with four continuous straight lines
  • 9. Form four equilateral triangles from six equal-length pencils
  • 10. • Sleep • Mindset • Grit • Exercise • Meditation • Nutrition
  • 11. Human Brain • 2% of the body weight • Uses 20% of the body’s glucose & oxygen 1/3 for cell health maintenance 2/3 for neuron activity • Cut off energy supply and the brain stops functioning in 10 seconds
  • 12. Sleep
  • 13. Factors Determining When You Sleep • Suprachiasmatic Nucleus (Circadian Rhythm) • Adenosine build up
  • 14. • Effects of lack of sleep on functioning when awake • Learning lost from lack of adequate sleep
  • 15. Effects of Lack of Sleep • Memory in-box shut down (hippocampus) • Lack of concentration (microsleeps) • Immune system is impaired • Emotional problems (Amygdala) • Metabolic contaminants build up • Increase in cortisol • Increase risk of type 2 diabetes, cardiovascular disease, stroke, depression, and anxiety.
  • 16. Glymphatic System Jeffrey J. Iliff, et al., “A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β,” Science Translational Medicine Aug 15, 2012, vol. 4, issue 147.
  • 17. Microsleep • Brief period your mind is blind to the outside word • Most of the time you have no awareness
  • 18. Microsleep • Response to hitting a button when a light flashed for 10 minutes. • Eight-hour sleep group maintained stable, near-perfect performance for two weeks • The no-sleep group saw a continuous increase in missed responses indicating microsleeps. • Ten days of six-hour sleep missed responses equivalent to 24 hours of no sleep Julian Lim and David Dinges, “Sleep Deprivation and Vigilant Attention,” Annals of the Hew York Academy of Sciences, 1129, pp 305-322 (2008).
  • 19.
  • 20. Brain Activity Sleep Spindle 8-13 Hz 4-7 Hz < 4 Hz 11-16 Hz
  • 21. Brain Processes Information During Sleep During deep NREM Sleep information transfers from short- to long-term memory
  • 22. Sensory input hippocampus Wake asleep Sleep spindles hippocampus hippocampus Neocortex Neocortex
  • 23. During REM sleep brain works to find hidden relations among memories and to solve problems we were working on while awake.
  • 24. Rats learning a Maze • Implants that monitor brain activity • Could tell where in the maze the rats were from the brain activity • Maze brain activity occurred while rats were sleeping James J. Knierim, “The Matrix in Your Head,” Scientific American Mind, June/ July 2007
  • 25. Scullin, M., McDaniel, M., Howard, D., & Kudelka, C. (2011, June). Sleep and testing promote conceptual learning of classroom materials. Presented at the 25th Anniversary Meeting of the Associated Professional Sleep Societies LLC, Minneapolis, MN. • 102 UG who had never taken an econ course • Split into two groups • Group 1 watched a virtual lecture in the morning and 12 hours later took an exam (wake) • Group 2 watched a virtual lecture in the evening and 12 hours later, after a night’s sleep took an exam (sleep)
  • 27. Another Sleep Example • Subjects taught to solve a mathematical problem using a long tedious method. • Came back 12 hours later to solve more of these problems. • Group 1 stayed awake and group 2 slept • There was a quick simpler method for solving the problem.
  • 28. • 23% of group 1 discovered the simpler quick method • 59% of group 2 discovered the simpler quick method Ulrich Wagner, Steffen Gais, Hide Haider, Rolf Verleger, & Jan Born, “Sleep Inspires Insight, Nature volume 427, 352-355, Jan 22, 2004.
  • 29. Participants learned a novel, artificial grammar to a 90% proficiency • Group 1 slept naturally consuming no alcohol • Group 2 consumed 2-3 shots of vodka the first night, but no other alcohol during the week • Group 3 consumed 2-3 shots of vodka on the third night, but no other alcohol during the week. A week later they were tested on the grammar
  • 30. • Group 1 slept naturally consuming no alcohol Maintained 90% efficiency and showed an enhancement of abstraction • Group 2 consumed 2-3 shots of vodka the first night, but no other alcohol during the week 50% efficiency • Group 3 consumed 2-3 shots of vodka on the third night, but no other alcohol during the week. 60% efficiency
  • 31. People who study in the morning—whether it’s words or pattern recognition games, straight retention or comprehension of deeper structure—do about 30 percent better on an evening test if they’ve had an hour-long nap than if they haven’t. Mednick, Nakayama, and Stickgold, “Sleep-dependent learning: a nap is as good as a night,” Nature Neuroscience, 2003
  • 32. Dreaming • 100 participants studied a virtual maze • Half took a 90-minute nap, half an equivalent period of wake All were prompted three times to report everything that was going through their minds Erin J. Wamsley et al., “Dreaming of a Learning Task is Associated with Enhanced Sleep-Dependent Memory Consolidation, Curr Biol 20, no. 9, 850-855 (2010)
  • 33.
  • 34.
  • 35.
  • 37. Calvin and Hobbes, 1995 Calvin Susie
  • 38. Mindset: The New Psychology of Success by Carol Dweck For effective learning, differences in native ability are dwarfed by habits and methods. Fixed (entity) mindset—effort is a bad thing, means you are not smart or talented Growth (incremental) mindset—effort is what makes you smart or talented Fixed mindset Growth mindset
  • 39. Mindsets • Effort means you don’t have the skill or talent • Concerned with proving • Failure means you are not smart • Self-handicapping to prevent a poor performance from reflecting on their ability (staying up all night partying before a test) Fixed Mindset Growth Mindset • Although people differ in initial talent and aptitude, everyone can grow through application and experience • Concerned with improving • Failure means you are learning • True potential is unknown, it takes time to flower
  • 40. Do you believe your intelligence is fixed or something you could develop?
  • 41. You can increase your intelligence Flynn effect: scores on IQ tests have gone up 15 points over the last 50 years Flynn, James R. “The Mean IQ of Americans: Massive Gains 1932 to 1978,” Psychological Bulletin (1984) 95: 29–51.
  • 42. Brain is remarkably plastic • Brain can grow at any age • Neurons are born in the hippocampus every day (neurogenesis) • Dendrites grow and sprout • Newly born synapses (synaptogenesis) • Newly formed blood vessels (angiogenesis) Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance by Majid Fotuhi, M.D., Ph.D. .
  • 43. J. Altman & G. Das, "Postnatal Neurogenesis in the Guinea-pig,” Nature, 214, 1098–1101 (10 June 1967) Joseph Altman discovered adult neurogenesis, the creation of new neurons in an adult mammalian brain P. Eriksson, E. Perfilieva, T. Bjork-Eriksson, A-M. Alborn, C. Mordborg, D. Peterson, and F. Gage, “Neurogenesis in the Adult Human Hippocampus,” Nature Medicine 4, no. 11 (1998) 1313-1317. G. Kempermann, H.G. Kuhn, and F. Gage, “More Hippocampal Neurons in Adult Mice Living in an Enriched Environment,” Nature 386, no. 6624 (1997), 493-95.
  • 44. Brain is remarkably plastic • Measured IQ of adolescents at the start and end of a four-year period • Performed MRI brain scans at the start and the end of the four-year period • Those who improved their math IQ strengthened the areas of the brain related to math, the same was true with English Ramsden S, Richardson FM, Josse G, et al. Verbal and nonverbal intelligence changes in the teenage brain. Nature. 2011;479(7371):113-116.
  • 45. 1952 Nobel Prize for NMR Edward Mills Purcell (1912–1997)
  • 46. 1952 Nobel Prize for NMR Edward Mills Purcell (1912–1997) Purdue BSEE
  • 47. London Taxi Drivers • Must know an area of 6-mile radius • No grid like other cities, 25,000 streets • Must know most efficient route between any two points • Thames river • Must know location of every landmark • Those who pass the test on “the Knowledge” typically study for 4 years
  • 48. Over the four years of studying “the Knowledge,” MRI studies showed an increase in volume of the posterior hippocampi of those who successfully passed the London Taxi drivers test Maguire, E. A.; Gadian, D. G.; Johnsrude, I. S.; Good, C. D.; Ashburner, J.; Frackowiak, R. S. J.; Frith, C. D., “Navigation-related structural change in the hippocampi of taxi Drivers,” Proceedings of the National Academy of Sciences. 97 (8): 4398–4403 (2000). Katherine Woodlett and Eleanor Maguire, “Acquiring "the Knowledge" of London’s Layout Drives Structural Brain Changes,” Current Biology 21, 2109-2114 (2011).
  • 49. In blind and deaf people the brain rewires to use areas normally dedicated to processing sights or sounds The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity by Norman Doidge
  • 50. Premed Chemistry Determine the mindset by asking questions like, “Do you believe your intelligence is fixed or something you could develop?” • Fixed mindset did poorly reread text and notes, tried to memorize • Growth mindset earned better grades looked for themes and underlying principles studying to learn, not to ace an exam Grant, H. & Dweck, C. S. (2003) “Clarifying achievement goals and their impact,” Journal of Personality and Social Psychology, 85, 541–553
  • 51. Effect of type of Praise • Diverse group of 5th graders given 10 moderately difficult problems from a non-verbal IQ test • One group was praised for their intelligence, one group for their effort, and one group received non-specific praise • They all completed a second test of very difficult problems • They all completed a third test that was similar in difficulty to the first test
  • 52. Mueller, C. M., & Dweck, C. S. (1998). “Intelligence praise can undermine motivation and Performance,” Journal of Personality and Social Psychology, 75, 33–52.
  • 54. Mindset intervention • Entering 7th graders divided into two groups • Control group had six sessions on study skills • Intervention group had six sessions some on study skills and some on growth mindsets— the brain grows new connections and gets smarter when working on challenging tasks
  • 55.
  • 56. • Earned a C- in high school English • SAT verbal score of 475 out of 800 • Needed 5 years to graduate high school • Reads 2 to 3 times slower than average person • Difficulty learning to spell
  • 57. John Irving • Has written 17 novels • The World According to Garp won the National Book Award • He won an Academy Award for his screenplay to his novel The Cider House Rules.
  • 59. Procrastinators report higher stress, worse health, and lower grades Tice, D. M., & Baumeister, R. F. (1997). Longitudinal study of procrastination, performance, stress, and health: The costs and benefits of dawdling. Psychological Science, 8(6), 454-458. “Never put off till tomorrow, what you can do the day after tomorrow,” Mark Twain.
  • 60. Marshmallow test Mischel, W., & Ebbesen, E. B.(1970). Attention in delay of gratification. Journal of Personality and Social Psychology, 16, 329–337
  • 61. Mischel, W., Shoda, Y., & Rodriguez, M. I. (1989) Delay of gratification in children. Science, 244(4907), 933–938 When these students were seniors in high school, it was found there was a direct correlation between their SAT scores and their ability to wait as preschoolers Caveats stability of the home environment could play a role, the participants came from Stanford’s on-campus nursery school and many of the kids were children of Stanford students or professors,
  • 62. Multitasking • 263 students told to study something important for 15 minutes • Researchers noted what they were doing once a minute • On-task behavior began to decline at the 2-minute mark • Spent 65% of the 15 minutes studying Larry D. Rosen, L. Mark Carrier, and Nancy A. Cheever, “Facebook and texting made me do it: Media-induced task-switching while studying,” Computers in Human Behavior, Vol. 29, pages 948-958, May 2013.
  • 63. texting and using Facebook—in class and while doing homework—were negatively correlated with college students’ GPAs Reynol Junco, “Too much face and not enough books: The relationship between multiple Indices of Facebook use and academic performance,” Computers in Human Behavior, Vol 28, pages 187-198, 2012.
  • 64. The new Marshmallow test of self-discipline, the ability to resist a blinking inbox or a buzzing phone
  • 65. Grit Duckworth, Angela & Peterson, Christopher & D Matthews, Michael & R Kelly, Dennis. (2007), “Grit: Perseverance and Passion for Long-Term Goals,” Journal of personality and social psychology. 92. 1087-101. 10.1037/0022-3514.92.6.1087. passion and perseverance for long-term goals https://www.ted.com/talks/angela_lee_duckworth_grit_the_power_ of_passion_and_perseverance#t-178164
  • 66. Self-control is the ability to resist hourly temptations, momentary pleasures that are immediately regretted. Grit is the ability to pursue something challenging for months, years, and sometimes decades. Hereditary Genius: an Inquiry Into Its Laws and Consequences by Francis Galton 1869
  • 67. Grit Math Talent X Effort = Skill Skill X Effort = Achievement
  • 68. Violin Students at the Berlin University of the Arts Anders Ericsson, K & Krampe, Ralf & Tesch-Roemer, Clemens. (1993). “The Role of Deliberate Practice in the Acquisition of Expert Performance,” Psychological Review. 100. 363-406.
  • 69.
  • 70.
  • 71. People with a growth mindset are grittier and more optimistic than fixed mindset people Growth mindset Optimistic Self-talk Perseverance over adversity
  • 72. Grit and self-discipline can be acquired • Culture can instill it, being around gritty people • Thinking of yourself as gritty can lead to being gritty • Engage in an extracurricular activity and stick with it for two years (Steve Faloon was a serious runner) • Make a list of tasks for tomorrow (commitment) • Meditate • Routines • Pomodoro technique Eisenberger, R., “Learned industriousness,” Psychological Review, 99, 248-267 (1992)
  • 73. Six Steps of Original Pomodoro Technique 1. Decide on the task to be done. 2. Set a timer (traditionally to 25 minutes). 3. Work on the task. 4. End work when the timer rings and put a checkmark on a piece of paper. 5. If you have fewer than four checkmarks, take a short break (3–5 minutes), then go to step 2. 6. After four pomodoros, take a longer break (15–30 minutes), reset your checkmark count to zero, then go to step 1.
  • 75. Exercise • Improves Circulation (angiogenesis) • Spurs the production of neurotransmitters • Facilitates synaptic plasticity • Boosts levels of BDNF (brain-derived neurotrophic factor) Hippocampus constantly creates new neurons, BDNF helps them grow. Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance by Majid Fotuhi, M.D., Ph.D.
  • 76. Neurogenesis in Adult Mouse Hippocampus control running Henriette van Praag, Gerd Kempermann, and Fred H. Gage, “Running Increases Cell Proliferation and Neurogenesis in the Adult Mouse Dentate Gyrus,” Nature Neuroscience, Vol 2, no, 3 March 1999.
  • 77. • Sedentary students were recruited at the University of Dublin • For five weeks engaged in strenuous exercise on a stationary bike • MRIs were taken before and after the five weeks looking at the hippocampus
  • 78. Éadaoin W. Griffin, Sinéad Mulally, Carole Foley, Stuart A. Warmington, Shane M. O’Mara, and Áine M. Kelly, “Aerobic Exercise Improves Hippocampal Function and Increases BDNF in the Serum of Young Adult Males,” Physiology and Behavior 104, no. 5 (2011): 934–41. Before After
  • 79. • 59 cognitively health people between ages of 60- 79 years • Split into two groups • One group did aerobic exercises and the other stretching and toning exercises for 6 months • Brain MRI scans taken before and after • Those who did aerobic exercises had more gray and white matter in the frontal and temporal lobes S. J. Colcombe, K. I. Erickson, P. E. Scalf, J. S. Kim, R. Prakash, E. McAuley, S. Elavsky, D. X. Marquez, L. Hu, and A. F. Kramer, “Aerobic Exercise Training Increases Brain Volume in Aging Humans,” Journals of Gerontology, Series A: Biological Sciences and Medicine Sciences 61, no. 11 (2006): 1166–70.
  • 81. Mindfulness Meditation • Strength training for you brain • Many types Some Benefits • Stress relief • Heightened awareness • Enhanced concentration • Ignore the mental chatter that distracts you
  • 82. Mindful Cycle Paying attention to the present moment Becoming distracted Noticing your mind has wondered Deciding to refocus attention Attention Network Salience Network Default Mode Network Wendy Hasenkamp and Lawrence W. Barasou, “Effects of meditation experience on Functional connectivity of distributed brain networks,” Frontiers Human Neuroscience, March 2012
  • 83. Changes the Brain at the Physical Level Harvard Studies — 16 healthy adults who never meditated Weekly classes on meditation Averaged three hours per week meditating for 8 weeks MRI scans before and after increase in gray matter around hippocampus decrease in gray matter around amygdala Britta K. Hölzel, James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar, “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density,” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43.
  • 84. Changes the Brain at the Physical Level UCLA Studies thickens the brain and strengthens the connections between brain cells Slows age-related loss of gray matter larger amounts of gyrification (“folding” of the cortex, which may allow the brain to process information faster) Eileen Luders, Arthur W. Toga, Natasha Lepore, and Christian Gaser, “The Underlying Anatomical Correlates of Long-Term Meditation: Larger Hippocampal and Frontal Volumes of Gray Matter,” NeuroImage 45, no. 3 (2009): 672–78.
  • 85. Study conducted by the University of Pennsylvania Medical Center found that experienced meditators had significantly higher blood flow to the prefrontal cortex, parietal cortex, and other areas of the brain that support attention, regulation of emotion, and autonomic function. Fotuhi, Majid. Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance (Kindle Locations 1865-1868). HarperCollins. Kindle Edition. B. Newberg, N. Wintering, M. R. Waldman, D. Amen, D. S. Khalsa, and A. Alavi, “Cerebral Blood Flow Differences Between Long-Term Meditators and Non-Meditators,” Conscious and Cognition 19, no. 4 (2010): 899–905.
  • 87. Brain • 75% water • 60% of the rest is fat
  • 88.
  • 89.
  • 91. Low Omega-6 to Omega-3 ratio • Wild caught cold water fish • Grass-fed beef • Pasture raised eggs Omega 3 PUFAs found in these foods are EPA and DHA DHA and exercise promote the formation of BDNF
  • 92. High in Omega 6 • Safflower oils • sunflower oils • Canola oils • corn oils • grapeseed (often hidden in salad dressings) • Rapeseed oils • Peanut oils • Vegetable oils • soybean oils Avoid foods fried in any of these oils
  • 93. Monounsaturated Fatty Acids • Extra Virgin Olive Oil* • Avocados • Avocado oil • Macadamia nuts • Wild Salmon • Grass-fed beef Used in the myelin sheath around nerve cells *Aleiz Sala-Vila, et al., “Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial,” JAMA Internal Medicine, 175, no 7, 1094-1103(2015).
  • 94. Refined Sugars • Became available early 1800s • 1900 Americans consumed 26 lbs per year • Today Americans consume 160 lbs per year • Table sugar (50% glucose/50% fructose) • HFCS (45% sugar/55% fructose) • Insulin and glucagon balance the glucose in your blood stream
  • 95. Robert H. Lustig, Laura A. Schmidt, and Claire D. Brindis, “The toxic truth about sugar,” Nature, vol. 482, pages 27-29 (2012).
  • 96.
  • 97. Some Foods that cause inflammation • Sugar and High-Fructose Corn Syrup • Artificial Trans Fats • Vegetable and Seed Oils • Refined Carbohydrates • Excessive Alcohol • Processed Foods
  • 98. Glycation • Attachment of sugar to a protein or lipid • Fructose is 10 times more active glycation • Glycated molecules eventually become Advanced Glycation End Products (AGEs) AGEs are gerontotoxins diabetes, atherosclerosis, chronic kidney disease, and Alzheimer’s
  • 99.
  • 100. Brian Healthy Foods • DHA omega-3 fatty acids (wild-fish, grass-fed beef) • Extra virgin olive oil • Avocados • Almonds • Berries (Blue, black, straw, & rasp) • Red grapes • Dark leafy greens • Cruciferous Vegetables (Broccoli, Brussel sprouts, cabbage) • Pastured raised eggs • Green tea • Dark Chocolate (>85% cacao)
  • 101. Some Key Points • Spaced, instead of blocked • Interleave topics, subjects • Study in different settings • Preparation and incubation • Deliberate practice —study to understand, not just to memorize a procedure or equation —testing, recall • Explain out loud
  • 102. Some Key Points continued • All senses including touch, take handwritten notes • Develop a growth mindset, grit, self-control • Develop a habit of study and reduce your habit of procrastination—Routines, Mindfulness • Make a list of tasks for the next day • Sleep • Exercise • Healthy Diet
  • 103. Make It Stick by Peter Brown, Henry L. Roediger, and Mark A. McDaniel Why We Sleep: Unlocking the Power of Sleep and Dreams, Matthew Walker How We Learn: The Surprising Truth About When, Where, and Why It Happens by Benedict Carey Mindset: The New Psychology of Success by Carol Dweck Grit: The Power of Passion and Perseverance by Angela Duckworth A Mind for Numbers: How to Excel at Math and Science (Even if You Flunked Algebra) by Barbara Oakey #What is Mindfulness? By Tamara Russell Peak: Secrets from the New Science of Expertise by Anders Ericsson and Robert Pool Boost Your Brain: The New Art and Science Behind Enhanced Brain Performance by Majid Fotuhi, M.D., Ph.D. Genius Foods by Max Lugavere.