This regional needs assessment summarizes data on substance use and related factors for Region 8 in Texas. Key findings include that over one-third of the population speaks a language other than English at home, poverty and unemployment rates are higher than national averages in many counties, and high school dropout rates exceed state rates in nearly a third of the region. Substance use of alcohol, tobacco, marijuana and prescription drugs is analyzed alongside consequences like crimes, family violence, and child abuse rates which in many cases exceed state levels. Gaps in services, data and partnerships to address substance misuse in the region are also discussed.