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108 andrew fire - 7538095 - genetic inhibition by double-stranded rnaMello_Patent_Registry
Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello - Genetic Inhibition by Double-Stranded RNA
This patent application describes a method for depositing surface coatings to produce super-hydrophobic and/or super-hydrophilic properties on various substrates. The method uses chemical vapor deposition to apply layers of materials in order to control the wettability of surfaces. The invention relates to applications of these surface properties in electronics and biology. It also incorporates several other patent applications by reference that are relevant to applying thin film coatings.
100 sadanand v. deshpande - 7344983 - clustered surface preparation for sil...Mello_Patent_Registry
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54 przemyslaw szafranski - 6287844 - compositions and methods for controlli...Mello_Patent_Registry
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119 phillip d. zamore - 7893036 - in vivo production of small interfering r...Mello_Patent_Registry
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108 andrew fire - 7538095 - genetic inhibition by double-stranded rnaMello_Patent_Registry
Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello - Genetic Inhibition by Double-Stranded RNA
This patent application describes a method for depositing surface coatings to produce super-hydrophobic and/or super-hydrophilic properties on various substrates. The method uses chemical vapor deposition to apply layers of materials in order to control the wettability of surfaces. The invention relates to applications of these surface properties in electronics and biology. It also incorporates several other patent applications by reference that are relevant to applying thin film coatings.
100 sadanand v. deshpande - 7344983 - clustered surface preparation for sil...Mello_Patent_Registry
Sadanand V. Deshpande, Ying Li, Kevin E. Mello, Renee T. Mo, Wesley C. Natzle, Kirk D. Peterson, Robert J. Purtell - Clustered Surface Preparation for Silicide and Metal Contacts
54 przemyslaw szafranski - 6287844 - compositions and methods for controlli...Mello_Patent_Registry
Przemyslaw Szafranski, Charlene Mello, Takeshi Sano, Cassandra L. Smith, David L. Kaplan, Charles R. Cantor - Compositions and Methods for Controlling Genetically Engineered Organisms
67 charlene mello - 6620917 - method for the purification and aqueous fiber...Mello_Patent_Registry
Charlene Mello, Steven Arcidiacono, Michelle M. Butler - Method for the Purification and Aqueous Fiber Spinning of Spider Silks and Other Structural Proteins
84 parul agrawal - 6935925 - system, method, and apparatus for in-situ acou...Mello_Patent_Registry
Parul Agrawal, Bradley Frederick Baumgartner, Norman Chu, Charles Lee, Tony Mello, Christopher Ramm, Bob Clyde Robinson - System, Method, and Apparatus for In-Situ Acoustic Emission Monitoring of Burnish Heads in Production During Magnetic Media Cleaning or Burnish Process
This patent document describes a floor cleaning machine with a selectively adjustable steering mechanism. The floor cleaning machine includes a chassis supported by wheels, including a steerable wheel connected to a housing. The chassis has multiple movable housing members, including one associated with the steering wheel. The front housing can be rotated or moved away from the other housings without requiring disconnection of the steering wheel, allowing access to internal machine components.
This patent is for a floor treatment apparatus that includes a platform to support an operator. One embodiment of the apparatus is capable of performing 360 degree turns to facilitate treating difficult to access areas of a floor surface. The patent lists 13 inventors and has 27 claims along with 31 drawing sheets. It is a continuation of several earlier patent applications.
110 andrew fire - 7560438 - genetic inhibition by double-stranded rnaMello_Patent_Registry
Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello - Genetic Inhibition by Double-Stranded RNA
Device and method for providing enhanced telephonyTal Lavian Ph.D.
Embodiments of the invention provide an enhanced communication device and a method for providing enhanced telephony. The enhanced communication device comprises a processor. The enhanced communication device further comprises a memory. The memory comprises a database. The database comprises one or more destination phone numbers. Further, the database comprises at least one property associated with the one or more destination phone numbers. Further, the memory comprises instructions executable by the processor for identifying a dialed phone number of a destination. The memory also comprises instructions for determining a location code associated with a current location of the communication device. Further, the memory comprises instructions for comparing the dialed phone number to the one or more destination phone numbers. Furthermore, the method comprises instructions for displaying the at least one property associated with the one or more destination phone numbers based on the comparison.
126 daniel j. nelson - 8180712 - methods and apparatus for determining whet...Mello_Patent_Registry
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Andrew Fire, Stephen Kostas, Mary Montgomery, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello - Genetic Inhibition by Double-Stranded RNA
The patent describes a method for controlled deposition of silicon-containing coatings adhered by an oxide layer using vapor-phase deposition. The method allows for precise control over the amount of reactants added, total pressure in the chamber, partial vapor pressures of components, substrate and surface temperatures. By varying these process parameters, film thickness and roughness can be controlled to produce coatings with desired characteristics.
This patent document describes a method for hiding identification codes or signals within carrier signals, such as electronic data or physical mediums, in a way that allows the identification signal to later be discerned. This allows the carrier signal to be identified or for some machine-responsive action to occur. The technique can be applied to video imagery to control associated video equipment, such as serving as a copy control signal. The document provides background on related prior art and describes the invention over 36 claims and drawings across 21 pages.
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a system for generating an Interactive Voice Response (IVR) database, the system comprising a processor and a memory coupled to the processor. The memory comprising a list of telephone numbers associated with one or more destinations implementing IVR menus, wherein the one or more destinations are grouped based on a plurality of categories of the IVR menus. Further the memory includes instructions executable by said processor for automatically communicating with the one of more destinations, and receiving at least one customization record from said at least one destination to store in the IVR database.
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a system for enhancing user interaction with Interactive Voice Response (IVR) destinations, the system comprising: a processor; and a memory coupled to the processor, the memory comprising: data encoding a database, the database comprising a list of telephone numbers associated with one or more destinations implementing an IVR; instructions executable by the processor for automatically communicating with at least one user; and instructions executable by the processor to pull at least one menu from the database and display the menu to the at least one user, wherein the menu is associated with a telephone number dialed by the at least one user, and wherein the menu comprises at least one icon.
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a communication device. The communication device comprises a database comprising one or more visual IVR menus associated with a plurality of calling devices. Further, the communication device comprises means for receiving a call from a phone number of a calling device, and means for displaying a visual IVR menu associated with the phone number of the calling device.
https://www.google.com/patents/US8548135?dq=US+8548135&hl=en&sa=X&ei=pbVXVO-lD9GIuASg8IKAAg&ved=0CB8Q6AEwAA
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide an enhanced telephone system. The telephone system comprises means for comparing a dialed phone number to a database and displaying a menu comprising menu options based on the comparison. The telephone system also comprises a touch sensitive screen. The touch screen provides activation of the menu options by touch.
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a system for generating an Interactive Voice Response (IVR) database, the system comprising a processor and a memory coupled to the processor. The memory comprising a list of telephone numbers associated with one or more destinations implementing IVR menus, wherein the one or more destinations are grouped based on a plurality of categories of the IVR menus. Further the memory includes instructions executable by said processor for automatically communicating with the one of more destinations, and receiving at least one customization record from said at least one destination to store in the IVR database.
https://www.google.com/patents/US8345835?dq=US+8345835&hl=en&sa=X&ei=e2tSVPHmJInk8gXHx4LQCA&ved=0CB0Q6AEwAA
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide an enhanced telephone system. The telephone system comprises a database that comprises phone numbers and menus corresponding to the phone numbers. Further, the menus comprise options for selection. The telephone system comprises means for comparing a dialed number to the phone numbers in the database, displaying a menu based on a result of the comparison, enabling selection of the options from the displayed menu, and establishing a connection with a destination of the dialed number based on the selection of the options.
https://www.google.com/patents/US8594280?dq=US+8594280&hl=en&sa=X&ei=cLVXVLvLI4zkuQSvqYLgAQ&ved=0CB8Q6AEwAA
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a system for providing advertisements to a caller. The system comprises a database having advertisements associated with a list of telephone numbers. The telephone numbers are associated with destinations implementing Interactive Voice Response (IVR). Further, the system comprises a device configured to display a visual menu for the IVR and the associated advertisements.
https://www.google.com/patents/US8625756?dq=US+8625756&hl=en&sa=X&ei=IrVXVP6ANsSVuAT_wYGQDg&ved=0CB8Q6AEwAA
This patent document provides a summary of an invention related to antithrombogenic hollow fiber membranes and filters for use in extracorporeal blood circuits. The membranes contain 0.005-10% of a surface modifying macromolecule to provide an antithrombogenic surface. The extracorporeal blood circuits can be used for hemofiltration, hemodialysis, hemodiafiltration, and other blood treatments. The document provides background on the invention and cites several other related patents and publications.
Systems and methods for visual presentation and selection of IVR menu US 8406...Tal Lavian Ph.D.
This document is a United States patent that describes systems and methods for visual presentation and selection of interactive voice response (IVR) menus. It lists 57 previous patent references and includes an abstract that describes a system for generating an IVR database. The system includes a processor and memory that stores telephone numbers associated with destinations implementing IVR menus. The memory also includes instructions for automatically communicating with the destinations to receive customization records to store in the IVR database.
Embodiments of the invention provide a portable device comprising at least one processor. The portable device also comprises a memory coupled to the processor comprising data. Further, the portable device comprises a detector configured to detect at least one external device. The at least one external device is configured to connect to the portable device. Further, the portable device comprises an interface to connect to the at least one external device. The interface is configured to transmit or receive one or more control signals excluding the data. Furthermore, the portable device comprises a controller configured to enable controlling of the portable device from the at least one external device; and controlling of the at least one external device from the portable device through the interface.
https://www.google.com/patents/US8572303?dq=US+8572303&hl=en&sa=X&ei=f7VXVLXsJYaJuASAzILwDw&ved=0CB8Q6AEwAA
129 andrew z. fire - 8283329 - genetic inhibition of double-stranded rnaMello_Patent_Registry
Andrew Z. Fire, Stephen A. Kostas, Mary K. Montgomer, Lisa Timmons, SiQun Xu, Hiroaki Tabara, Samuel E. Driver, Craig C. Mello - Genetic Inhibition of Double-Stranded RNA
134 mark s. thompson - 8449349 - elevator load bearing member having a jack...Mello_Patent_Registry
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133 stephanie mello - 8439759 - system and method of facilitating external ...Mello_Patent_Registry
Stephanie Mello, Deepak Polamarasetty, Wendy Yu - System and Method of Facilitating External Notifications for Events that Occur in a Plurality of Different Virtual Spaces
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This patent document describes a floor cleaning machine with a selectively adjustable steering mechanism. The floor cleaning machine includes a chassis supported by wheels, including a steerable wheel connected to a housing. The chassis has multiple movable housing members, including one associated with the steering wheel. The front housing can be rotated or moved away from the other housings without requiring disconnection of the steering wheel, allowing access to internal machine components.
This patent is for a floor treatment apparatus that includes a platform to support an operator. One embodiment of the apparatus is capable of performing 360 degree turns to facilitate treating difficult to access areas of a floor surface. The patent lists 13 inventors and has 27 claims along with 31 drawing sheets. It is a continuation of several earlier patent applications.
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Device and method for providing enhanced telephonyTal Lavian Ph.D.
Embodiments of the invention provide an enhanced communication device and a method for providing enhanced telephony. The enhanced communication device comprises a processor. The enhanced communication device further comprises a memory. The memory comprises a database. The database comprises one or more destination phone numbers. Further, the database comprises at least one property associated with the one or more destination phone numbers. Further, the memory comprises instructions executable by the processor for identifying a dialed phone number of a destination. The memory also comprises instructions for determining a location code associated with a current location of the communication device. Further, the memory comprises instructions for comparing the dialed phone number to the one or more destination phone numbers. Furthermore, the method comprises instructions for displaying the at least one property associated with the one or more destination phone numbers based on the comparison.
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The patent describes a method for controlled deposition of silicon-containing coatings adhered by an oxide layer using vapor-phase deposition. The method allows for precise control over the amount of reactants added, total pressure in the chamber, partial vapor pressures of components, substrate and surface temperatures. By varying these process parameters, film thickness and roughness can be controlled to produce coatings with desired characteristics.
This patent document describes a method for hiding identification codes or signals within carrier signals, such as electronic data or physical mediums, in a way that allows the identification signal to later be discerned. This allows the carrier signal to be identified or for some machine-responsive action to occur. The technique can be applied to video imagery to control associated video equipment, such as serving as a copy control signal. The document provides background on related prior art and describes the invention over 36 claims and drawings across 21 pages.
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a system for generating an Interactive Voice Response (IVR) database, the system comprising a processor and a memory coupled to the processor. The memory comprising a list of telephone numbers associated with one or more destinations implementing IVR menus, wherein the one or more destinations are grouped based on a plurality of categories of the IVR menus. Further the memory includes instructions executable by said processor for automatically communicating with the one of more destinations, and receiving at least one customization record from said at least one destination to store in the IVR database.
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a system for enhancing user interaction with Interactive Voice Response (IVR) destinations, the system comprising: a processor; and a memory coupled to the processor, the memory comprising: data encoding a database, the database comprising a list of telephone numbers associated with one or more destinations implementing an IVR; instructions executable by the processor for automatically communicating with at least one user; and instructions executable by the processor to pull at least one menu from the database and display the menu to the at least one user, wherein the menu is associated with a telephone number dialed by the at least one user, and wherein the menu comprises at least one icon.
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a communication device. The communication device comprises a database comprising one or more visual IVR menus associated with a plurality of calling devices. Further, the communication device comprises means for receiving a call from a phone number of a calling device, and means for displaying a visual IVR menu associated with the phone number of the calling device.
https://www.google.com/patents/US8548135?dq=US+8548135&hl=en&sa=X&ei=pbVXVO-lD9GIuASg8IKAAg&ved=0CB8Q6AEwAA
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Embodiments of the invention provide an enhanced telephone system. The telephone system comprises means for comparing a dialed phone number to a database and displaying a menu comprising menu options based on the comparison. The telephone system also comprises a touch sensitive screen. The touch screen provides activation of the menu options by touch.
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Embodiments of the invention provide a system for generating an Interactive Voice Response (IVR) database, the system comprising a processor and a memory coupled to the processor. The memory comprising a list of telephone numbers associated with one or more destinations implementing IVR menus, wherein the one or more destinations are grouped based on a plurality of categories of the IVR menus. Further the memory includes instructions executable by said processor for automatically communicating with the one of more destinations, and receiving at least one customization record from said at least one destination to store in the IVR database.
https://www.google.com/patents/US8345835?dq=US+8345835&hl=en&sa=X&ei=e2tSVPHmJInk8gXHx4LQCA&ved=0CB0Q6AEwAA
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide an enhanced telephone system. The telephone system comprises a database that comprises phone numbers and menus corresponding to the phone numbers. Further, the menus comprise options for selection. The telephone system comprises means for comparing a dialed number to the phone numbers in the database, displaying a menu based on a result of the comparison, enabling selection of the options from the displayed menu, and establishing a connection with a destination of the dialed number based on the selection of the options.
https://www.google.com/patents/US8594280?dq=US+8594280&hl=en&sa=X&ei=cLVXVLvLI4zkuQSvqYLgAQ&ved=0CB8Q6AEwAA
Systems and methods for visual presentation and selection of IVR menuTal Lavian Ph.D.
Embodiments of the invention provide a system for providing advertisements to a caller. The system comprises a database having advertisements associated with a list of telephone numbers. The telephone numbers are associated with destinations implementing Interactive Voice Response (IVR). Further, the system comprises a device configured to display a visual menu for the IVR and the associated advertisements.
https://www.google.com/patents/US8625756?dq=US+8625756&hl=en&sa=X&ei=IrVXVP6ANsSVuAT_wYGQDg&ved=0CB8Q6AEwAA
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Systems and methods for visual presentation and selection of IVR menu US 8406...Tal Lavian Ph.D.
This document is a United States patent that describes systems and methods for visual presentation and selection of interactive voice response (IVR) menus. It lists 57 previous patent references and includes an abstract that describes a system for generating an IVR database. The system includes a processor and memory that stores telephone numbers associated with destinations implementing IVR menus. The memory also includes instructions for automatically communicating with the destinations to receive customization records to store in the IVR database.
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https://www.google.com/patents/US8572303?dq=US+8572303&hl=en&sa=X&ei=f7VXVLXsJYaJuASAzILwDw&ved=0CB8Q6AEwAA
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The modern software delivery process (or the CI/CD process) includes many tools, distributed teams, open-source code, and cloud platforms. Constant focus on speed to release software to market, along with the traditional slow and manual security checks has caused gaps in continuous security as an important piece in the software supply chain. Today organizations feel more susceptible to external and internal cyber threats due to the vast attack surface in their applications supply chain and the lack of end-to-end governance and risk management.
The software team must secure its software delivery process to avoid vulnerability and security breaches. This needs to be achieved with existing tool chains and without extensive rework of the delivery processes. This talk will present strategies and techniques for providing visibility into the true risk of the existing vulnerabilities, preventing the introduction of security issues in the software, resolving vulnerabilities in production environments quickly, and capturing the deployment bill of materials (DBOM).
Speakers:
Bob Boule
Robert Boule is a technology enthusiast with PASSION for technology and making things work along with a knack for helping others understand how things work. He comes with around 20 years of solution engineering experience in application security, software continuous delivery, and SaaS platforms. He is known for his dynamic presentations in CI/CD and application security integrated in software delivery lifecycle.
Gopinath Rebala
Gopinath Rebala is the CTO of OpsMx, where he has overall responsibility for the machine learning and data processing architectures for Secure Software Delivery. Gopi also has a strong connection with our customers, leading design and architecture for strategic implementations. Gopi is a frequent speaker and well-known leader in continuous delivery and integrating security into software delivery.
Observability Concepts EVERY Developer Should Know -- DeveloperWeek Europe.pdfPaige Cruz
Monitoring and observability aren’t traditionally found in software curriculums and many of us cobble this knowledge together from whatever vendor or ecosystem we were first introduced to and whatever is a part of your current company’s observability stack.
While the dev and ops silo continues to crumble….many organizations still relegate monitoring & observability as the purview of ops, infra and SRE teams. This is a mistake - achieving a highly observable system requires collaboration up and down the stack.
I, a former op, would like to extend an invitation to all application developers to join the observability party will share these foundational concepts to build on:
Unlocking Productivity: Leveraging the Potential of Copilot in Microsoft 365, a presentation by Christoforos Vlachos, Senior Solutions Manager – Modern Workplace, Uni Systems
Enchancing adoption of Open Source Libraries. A case study on Albumentations.AIVladimir Iglovikov, Ph.D.
Presented by Vladimir Iglovikov:
- https://www.linkedin.com/in/iglovikov/
- https://x.com/viglovikov
- https://www.instagram.com/ternaus/
This presentation delves into the journey of Albumentations.ai, a highly successful open-source library for data augmentation.
Created out of a necessity for superior performance in Kaggle competitions, Albumentations has grown to become a widely used tool among data scientists and machine learning practitioners.
This case study covers various aspects, including:
People: The contributors and community that have supported Albumentations.
Metrics: The success indicators such as downloads, daily active users, GitHub stars, and financial contributions.
Challenges: The hurdles in monetizing open-source projects and measuring user engagement.
Development Practices: Best practices for creating, maintaining, and scaling open-source libraries, including code hygiene, CI/CD, and fast iteration.
Community Building: Strategies for making adoption easy, iterating quickly, and fostering a vibrant, engaged community.
Marketing: Both online and offline marketing tactics, focusing on real, impactful interactions and collaborations.
Mental Health: Maintaining balance and not feeling pressured by user demands.
Key insights include the importance of automation, making the adoption process seamless, and leveraging offline interactions for marketing. The presentation also emphasizes the need for continuous small improvements and building a friendly, inclusive community that contributes to the project's growth.
Vladimir Iglovikov brings his extensive experience as a Kaggle Grandmaster, ex-Staff ML Engineer at Lyft, sharing valuable lessons and practical advice for anyone looking to enhance the adoption of their open-source projects.
Explore more about Albumentations and join the community at:
GitHub: https://github.com/albumentations-team/albumentations
Website: https://albumentations.ai/
LinkedIn: https://www.linkedin.com/company/100504475
Twitter: https://x.com/albumentations
Why You Should Replace Windows 11 with Nitrux Linux 3.5.0 for enhanced perfor...SOFTTECHHUB
The choice of an operating system plays a pivotal role in shaping our computing experience. For decades, Microsoft's Windows has dominated the market, offering a familiar and widely adopted platform for personal and professional use. However, as technological advancements continue to push the boundaries of innovation, alternative operating systems have emerged, challenging the status quo and offering users a fresh perspective on computing.
One such alternative that has garnered significant attention and acclaim is Nitrux Linux 3.5.0, a sleek, powerful, and user-friendly Linux distribution that promises to redefine the way we interact with our devices. With its focus on performance, security, and customization, Nitrux Linux presents a compelling case for those seeking to break free from the constraints of proprietary software and embrace the freedom and flexibility of open-source computing.
For the full video of this presentation, please visit: https://www.edge-ai-vision.com/2024/06/building-and-scaling-ai-applications-with-the-nx-ai-manager-a-presentation-from-network-optix/
Robin van Emden, Senior Director of Data Science at Network Optix, presents the “Building and Scaling AI Applications with the Nx AI Manager,” tutorial at the May 2024 Embedded Vision Summit.
In this presentation, van Emden covers the basics of scaling edge AI solutions using the Nx tool kit. He emphasizes the process of developing AI models and deploying them globally. He also showcases the conversion of AI models and the creation of effective edge AI pipelines, with a focus on pre-processing, model conversion, selecting the appropriate inference engine for the target hardware and post-processing.
van Emden shows how Nx can simplify the developer’s life and facilitate a rapid transition from concept to production-ready applications.He provides valuable insights into developing scalable and efficient edge AI solutions, with a strong focus on practical implementation.
Generative AI Deep Dive: Advancing from Proof of Concept to ProductionAggregage
Join Maher Hanafi, VP of Engineering at Betterworks, in this new session where he'll share a practical framework to transform Gen AI prototypes into impactful products! He'll delve into the complexities of data collection and management, model selection and optimization, and ensuring security, scalability, and responsible use.
Goodbye Windows 11: Make Way for Nitrux Linux 3.5.0!SOFTTECHHUB
As the digital landscape continually evolves, operating systems play a critical role in shaping user experiences and productivity. The launch of Nitrux Linux 3.5.0 marks a significant milestone, offering a robust alternative to traditional systems such as Windows 11. This article delves into the essence of Nitrux Linux 3.5.0, exploring its unique features, advantages, and how it stands as a compelling choice for both casual users and tech enthusiasts.
103 roger darios - 7404819 - implantable prosthesis
1. c12) United States Patent
Darios et al.
(54) IMPLANTABLE PROSTHESIS
(75) Inventors: Roger Darios, Foster, RI (US); Ronald
L. Greene, Warwick, RI (US); Dennis
Cherok, Harrisville, RI (US); Thomas J.
Capuzziello, Milford, MA (US); James
D. Mello, N. Dartmouth, MA (US)
(73) Assignee: C.R. Bard, Inc., Murray Hill, NJ (US)
( *) Notice: Subject to any disclaimer, the term ofthis
patent is extended or adjusted under 35
U.S.C. 154(b) by 0 days.
(21) Appl. No.: 09/661,623
(22) Filed: Sep.14,2000
(51) Int. Cl.
A61B 17108 (2006.01)
A61F 2102 (2006.01)
(52) U.S. Cl. .................. 606/151; 623/23.72; 623/23.76
(58) Field of Classification Search .............. 623/14.13,
(56)
623/11.11,7, 8, 23.72, 23.71; 606/151; 600/37
See application file for complete search history.
References Cited
U.S. PATENT DOCUMENTS
2,621,145 A 12/1952 Sano
2,671,444 A 3/1954 Pease, Jr.
3,054,406 A 9/1962 Usher
3,124,136 A 3/1964 Usher
3,272,204 A 9/1966 Artandi et a!.
3,416,524 A 12/1968 Meier
3,625,209 A 12/1971 Clark
3,953,566 A 4/1976 Gore
3,965,703 A 6/1976 Barnhardt
4,051,848 A 10/1977 Levine
4,187,390 A 2/1980 Gore
4,277,429 A 7/1981 Okita
(Continued)
22
24
30
111111 1111111111111111111111111111111111111111111111111111111111111
CA
US007404819Bl
(10) Patent No.:
(45) Date of Patent:
US 7,404,819 Bl
Jul. 29, 2008
FOREIGN PATENT DOCUMENTS
2114282 7/1994
(Continued)
OTHER PUBLICATIONS
Brown, M.D., Gregory L., eta!., "Comparison ofProsthetic Materials
for Abdominal Wall Reconstruction in the Presence of Contamina-
tion and Infections", Annals of Surgery, Jun. 1985, vol. 201, No.6,
pp. 705-711.
(Continued)
Primary Examiner-William H. Matthews
(74) Attorney, Agent, or Firm-Wolf Greenfield & Sacks,
P.C.
(57) ABSTRACT
An implantable prosthesis and a method ofrepairing an ana-
tomical defect, such as a tissue or muscle wall defect, by
promoting tissue growth thereto, while limiting the incidence
ofpostoperative adhesions between a portion ofthe prosthe-
sis and tissue or organs. The prosthesis is formed of a bio-
logically compatible, flexible layer of repair fabric suitable
for reinforcing tissue or muscle and closing anatomical
defects, and a barrier layer for physically isolating at least a
portion of one side of the fabric from areas likely to form
adhesions. A peripheral barrier extends about at least a por-
tion ofthe outer peripheral edge ofthe repair fabric to inhibit
adhesions between the outer peripheral edge and adjacent
tissue and organs. The repair fabric may include an outer
margin that has been melted and resolidified to render the
outer peripheral edge substantially impervious to tissue
ingrowth. The barrier layer may be joined to the repair fabric
with connecting stitches formed from PTFE to inhibit the
formation ofadhesions thereto.
13 Claims, 4 Drawing Sheets
42 28
2. US 7,404,819 Bl
Page 2
U.S. PATENT DOCUMENTS 5,591,234 A 111997 Kirsch
5,593,441 A 111997 Lichtenstein et a!.
4,347,847 A 9/1982 Usher 5,601,579 A 2/1997 Semertzides
4,400,833 A 8/1983 Kurland 5,614,284 A 3/1997 Kranzler et a!.
4,403,604 A 9/1983 Wilkinson et a!. 5,634,931 A 6/1997 Kugel
4,452,245 A 6/1984 Usher 5,634,944 A 6/1997 Magram
4,478,665 A 10/1984 Rubis 5,653,760 A 8/1997 Saffran
4,561,434 A 12/1985 Taylor 5,686,090 A 1111997 Schilder et a!.
4,576,608 A 3/1986 Homsy 5,695,525 A 12/1997 Mulhauser et a!.
4,585,458 A 4/1986 Kurland 5,697,978 A 12/1997 Sgro
4,633,873 A 111987 Dumican et al. 5,716,408 A 2/1998 Eldridge eta!.
4,655,221 A 4/1987 Devereux 5,716,409 A 2/1998 Debbas
4,693,720 A 9/1987 Scharnberg et al. 5,722,992 A 3/1998 Goldman
4,713,075 A 12/1987 Kurland 5,725,577 A 3/1998 Saxon
4,725,279 A 2/1988 Woodroof 5,733,337 A 3/1998 Carr, Jr. et al.
4,760,102 A 7/1988 Moriyama eta!. 5,743,917 A 4/1998 Saxon
4,769,038 A 9/1988 Bendavid et al. 5,759,204 A 6/1998 Seare, Jr.
4,796,603 A 111989 Dahlke eta!. 5,766,246 A 6/1998 Mulhauser et a!.
4,840,626 A 6/1989 Linsky et al. 5,769,864 A 6/1998 Kugel
4,854,316 A 8/1989 Davis 5,795,584 A 8/1998 Totakura et a!.
4,865,026 A 9/1989 Barrett 5,813,975 A 9/1998 Valenti
4,871,365 A 10/1989 Dumican 5,824,082 A 10/1998 Brown
4,882,162 A 1111989 Ikada et al. 5,855,613 A 111999 Antanavich et a!.
4,942,875 A 7/1990 Hlavacek et a!. 5,861,034 A 111999 Taira eta!.
4,955,907 A 9/1990 Ledergerber 5,879,366 A 3/1999 Shaw eta!.
4,994,084 A 2/1991 Brennan 5,916,225 A 6/1999 Kugel
4,997,440 A 3/1991 Dumican 5,919,232 A 7/1999 Chaffringeon et a!.
5,002,551 A 3/1991 Linsky et al. 5,922,026 A 7/1999 Chin
5,007,916 A 4/1991 Linsky et al. 5,948,020 A 9/1999 Yoon eta!.
5,092,884 A 3/1992 Devereux et al. 5,954,767 A 9/1999 Pajotin eta!.
5,100,422 A 3/1992 Bergner et a!. 5,972,007 A 10/1999 Sheffield et al.
5,104,400 A 4/1992 Bergner et a!. 5,990,378 A 1111999 Ellis
5,110,527 A 5/1992 Harada eta!. 5,990,380 A 1111999 Marotta et a!.
5,116,357 A 5/1992 Eberbach 6,004,333 A 12/1999 Sheffield et al.
5,116,360 A 5/1992 Pinchuk et a!. 6,015,844 A 1/2000 Harvey eta!.
5,122,155 A 6/1992 Eberbach 6,031,148 A 212000 Hayes et al.
5,141,515 A 8/1992 Eberbach 6,066,776 A 5/2000 Goodwin et a!.
5,141,522 A 8/1992 Landi 6,066,777 A 5/2000 Benchetrit
5,147,374 A 9/1992 Fernandez 6,075,180 A * 6/2000 Sharber et a!. ................ 606/76
5,147,401 A 9/1992 Bakker eta!. 6,113,623 A 9/2000 Sgro
5,195,542 A 3/1993 Gazielly et a!. 6,120,539 A 9/2000 Eldridge eta!.
5,201,745 A 4/1993 Tayot et al. 6,174,320 B1 1/2001 Kugel eta!.
5,217,494 A 6/1993 Coggins et al. 6,224,616 B1 5/2001 Kugel
5,222,987 A 6/1993 Jones 6,258,124 B1 7/2001 Darois eta!.
5,234,739 A 8/1993 Tanaru eta!. 6,264,702 B1 7/2001 Ory eta!.
5,234,751 A 8/1993 Harada eta!. 6,267,772 B1 7/2001 Mulhauser et a!.
5,254,133 A 10/1993 Seid 6,270,530 B1 8/2001 Eldridge eta!.
5,258,000 A 1111993 Gianturco 6,280,453 B1 8/2001 Kugel eta!.
5,282,851 A 2/1994 Jacob-LaBarre 6,290,708 B1 9/2001 Kugel eta!.
5,290,217 A 3/1994 Campos 6,319,264 B1 1112001 Tormala et al.
5,292,328 A 3/1994 Hain eta!. 6,368,541 B1 * 4/2002 Pajotin eta!. ............... 264/324
5,326,355 A 7/1994 Landi 6,383,201 B1 5/2002 Dong
5,333,624 A 8/1994 Tovey 6,451,032 B1 9/2002 Ory eta!.
5,334,217 A 8/1994 Das 6,497,650 B1 12/2002 Nicolo
5,350,388 A 9/1994 Epstein 6,565,580 B1 5/2003 Beretta
5,356,432 A 10/1994 Rutkow eta!. 6,652,595 B1 1112003 Nicolo
5,366,460 A 1111994 Eberbach 7,156,804 B2 1/2007 Nicolo
5,368,602 A 1111994 de Ia Torre
5,370,650 A 12/1994 Tovey et al. FOREIGN PATENT DOCUMENTS
5,379,754 A 111995 Tovey et al.
5,425,740 A 6/1995 Hutchinson, Jr. DE 298 17 682 Ul 3/1999
5,433,996 A 7/1995 Kranz!er et a!. EP 0 194 192.3 A1 9/1986
5,451,235 A 9/1995 Locket a!. EP 0 334 046 A2 9/1989
5,456,720 A 10/1995 Schultz et al. EP 0 358 819 A1 3/1990
5,461,885 A 10/1995 Yokoyama eta!. EP 0 362 113 A1 4/1990
5,480,436 A 111996 Bakker eta!. EP 0474887 A1 10/1991
5,507,811 A 4/1996 Koike et al. EP 0 560 934 B2 9/1993
5,508,036 A 4/1996 Bakker eta!. EP 0 692 225 A 111996
5,519,004 A 5/1996 Urry EP 0 719 527 A1 7/1996
5,522,896 A 6/1996 Prescott EP 0 827 724 A2 3/1998
5,524,633 A 6/1996 Heaven eta!. EP 0 537 769 4/1998
5,545,178 A 8/1996 Kensey eta!. FR 2145975 2/1973
5,569,273 A 10/1996 Titone FR 2 744 906 A1 8/1997
3. US 7,404,819 Bl
Page 3
FR
GB
GB
su
wo
wo
wo
wo
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2766716
1 352 282
1 406 271
1718857 Al
WO 82/04390 Al
WO 90/14796 Al
WO 92/10218 Al
WO 92/19162 A2
WO 93/17635 Al
WO 94/17747 Al
WO 94/19029 Al
WO 94/27535 Al
WO 96/09795 AI
WO 96/14805 Al
wo 96/40307
WO 97/21461 Al
WO 97/35533 Al
WO 98/14134 A2
WO 98/49967 A
WO 99/06079 AI
W099/51163 Al
WO 00/07520 Al
wo 00/16822
WO 01108594 A
wo 01154589
WO 01143789 Al
WO 01185060 AI
1317 227 Bl
2/1999
5/1974
9/1975
3/1992
12/1982
12/1990
6/1992
1111992
9/1993
8/1994
9/1994
12/1994
4/1996
5/1996
12/1996
6/1997
10/1997
4/1998
1111998
2/1999
10/1999
212000
3/2000
2/2001
2/2001
6/2001
1112001
1112004
OTHER PUBLICATIONS
Cardona, Hernando M.D., "Prosthokeroplasty", Cornea, 1983, vol. 2,
No.3, pp. 179-182.
Interceed(TC7) Adhesion Barrier Study Group (Cohen, Stephen M.,
eta!.), "Prevention ofpostsurgical adhesions by Interceed(TC7),*an
absorbable adhesion barrier: a prospective, randomized multicenter
clinical study", Fertility and Sterility, Jun. 1989, vol. 51, No.6, .pp.
933-938.
Jenkins, Scott D., M.D., eta!., A Comparison ofProsthetic Materials
Used to Repair Abdominal Wall Defects, Surgery, Aug. 1983, vol. 94,
No.2, pp. 392-398.
Uzzo, Robert G. eta!., "The Effects of Mesh Bioprosthesis on the
Spermatic Cord Structures: A Preliminary Report in a Canine
Model", The Journal OfUrology,Apr.l999, vol. 161, pp. 1344-1349.
Walker, Alonzo P., M.D., eta!., "Double-Layer Prostheses for Repair
ofAbdominal Wall Defects in a Rabbit Model.", Jun. 1992, vol. 55,
No. 1, pp. 32-37.
Bard, http://www.davol.com/max.htm, Bard® 3DMax™ Mesh, 2
pages, printed Sep. 10, 2002.
Goldstein, Harold, M.D., F.A.C.S.; atrium Polypropylene Mesh, "An
Atlas of Hernia Repair Using an Inguinal Hernia Repair Preshape
with Keyhole Slit", Atrium Medical Corporation, Jun. 1995, 5 pp.
Groupe Floreane Medical Implants; Reference document 2002-
2003; http://www.actusnews.fr/documents/ACTUS-0-664-
041118_doc_de_ref_2002_2003 .pdf.
Jarsaillon, P., Hernia (2000) 4 [Suppl.]: Sl7-S21; Case Reports:
Laparoscopic treatment ofan umbilical hernia using anew composite
mesh; (c) Springer-Verlag 2000.
Parviz K. Amid eta!., "Experimental evaluation of a new composite
mesh with the selective property of incorporation to the abdominal
wall without adhering to the intestines", Journal ofBiomedical Mate-
rials Research, vol. 28, 373-375 (1994).
Sofradim International, Parietex® Composite, company brochure;
(4) pages.
B.G. Matapurkar eta!., "A New Technique of "Marlex®-Peritoneal
Sandwich" in Repair of Large Incisional Hernias", World Journal of
Surgery 15, 768-770, 1991.
M. L. Baptista, et a!. "Abdominal Adhesions to Prosthetic Mesh
Evaluated by Laparoscopy and Electron Microscopy", Journal ofthe
American College of Surgeons, Mar. 2000.
Woodward eta!., "The Tissue Response to Implants and Its Evalua-
tion by Light Microscopy", Handbook of Biomaterials Evaluation,
MacMillan Publishing Company, 364-378, 1986.
Boyers et a!., "Reduction of postoperative pelvic adhesions in the
rabbit with Gore-Tex surgical membrane", Fertility and Sterility, vol.
49 No.6, 1066-1070, Jun. 1988.
European Search Report for European Application EP 07 11 3064.
* cited by examiner
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1
IMPLANTABLE PROSTHESIS
FIELD OF INVENTION
The present invention relates to an implantable prosthesis
and, more particularly, to a composite prosthesis for use in
soft tissue repair and reconstruction that limits the incidence
of postoperative adhesions.
2
may be melted and resolidified to render an outer peripheral
edge that is substantially impervious to tissue ingrowth.
In another aspect of the invention, the peripheral barrier
may be formed integral with the barrier layer. More particu-
larly, a portion ofthe outer margin ofthe barrier layer may be
wrapped about an outer peripheral edge of the repair fabric.
According to a further aspect of the invention, the periph-
eral barrier may be a separate component that is disposed
along the outer peripheral edge of the repair fabric. In this
DISCUSSION OF RELATED ART 1o regard, adhesion resistant material may be provided about the
outer peripheral edge of the repair fabric. Additionally, or
alternatively, the material may be impregnated into or other-
wise attached to the fabric.
Various prosthetic materials have been proposed to repair
and reinforce anatomical defects, such as tissue and muscle
wall hernias. For example, ventral and inguinal hernias are
commonly repaired using a sheet of biocompatible fabric, 15
such as a knitted polypropylene mesh (BARD MESH). The
fabric is typically sutured, stapled or otherwise provisionally
anchored in place over, under or within the defect. Tissue
integration with the fabric, such as by tissue ingrowth into
and/or along the fabric, eventually completes the repair.
In another embodiment ofthe invention, the layer ofrepair
fabric includes an inner body and an outer margin extending
from the inner body, the outer margin including an outer
peripheral edge. Each ofthe inner body and the outer periph-
eral edge has a thickness with the thickness of the outer
peripheral edge being less than the thickness of the inner
20 body.
It has been suggested that in certain procedures, the pros-
thetic fabric may come into contact with tissue or organs
potentially leading to undesirable postoperative adhesions
between the mesh and the tissue or organs. It had been pro-
posedin U.S. Pat. No. 5,593,441, assigned to C.R. Bard, Inc., 25
also the assignee of the present application, to repair ventral
hernias and/or reconstruct chest walls using a prosthesis that
is coveredwith an adhesionresistant barrier, such as a sheet of
expanded PTFE. In the repair ofventral hernias, the compos-
In a further embodiment ofthe invention, the layer ofrepair
fabric includes an outer margin with an outer peripheral edge
that has been melted and resolidified to render the outer
peripheral edge resistant to the formation of adhesions with
tissue and organs.
In still another embodiment ofthe invention, a plurality of
connecting stitchesjoins the barrier layer to the portion ofthe
repair fabric, the plurality of connecting stitches being
formed from PTFE to inhibit the formation of adhesions
30 thereto.ite is positioned with the barrier facing the region ofpotential
adhesion, such as the abdominal viscera, and in the case of
chest wall reconstruction, the barrier faces the thoracic vis-
cera (i.e., heart and lungs). Other configurations ofcomposite
prostheses can be found in U.S. Pat. Nos. 5,695,525; 5,725,
577 and 5,743,917, each of which is also assigned to C.R 35
Bard, Inc.
International Publication No. WO 97/35533, also assigned
to C.R. Bard, Inc., proposed a universal composite prosthesis
in which one side ofa layer ofmesh material is covered with
a layer of barrier material. The mesh material promotes bio- 40
logical tissue ingrowth while the barrier material retards bio-
logical tissue adherence thereto. The prosthesis may be uti-
lized for various surgical procedures, including ventral hernia
repair and inguinal hernia repair.
It is an object of the present invention to provide an 45
improved method and prosthesis for the repair of tissue and
muscle wall defects.
In still a further embodiment of the invention, the layer of
repair fabric includes an outer margin with an outer peripheral
edge, the outer margin being reinforced to form a bite region
for securing the prosthesis along the outer margin.
Other objects and features of the present invention will
become apparent from the following detailed description
when taken in connection with the accompanying drawings.
It is to be understood that the drawings are designed for the
purpose of illustration only and are not intended as a defini-
tion of the limits of the invention.
BRIEF DESCRIPTION OF THE DRAWINGS
The foregoing and other objects and advantages of the
invention will be appreciated more fully from the following
drawings, wherein like reference characters designate like
features, in which:
SUMMARY OF THE INVENTION
FIG. 1 is a top plan view of an implantable prosthesis in
accordance with one illustrative embodiment of the present
50 invention;
The present invention is an implantable prosthesis and a
method ofrepairing an anatomical defect, such as a tissue or
muscle wall defect, by promoting tissue growth thereto, while
limiting the incidence of postoperative adhesions between a
portion ofthe prosthesis and tissue or organs. The prosthesis
is formed ofa biologically compatible, flexible layerofrepair
fabric suitable for reinforcing tissue or muscle and closing
anatomical defects, and a barrier layerfor physically isolating
at least a portion ofone side ofthe fabric from areas likely to
form adhesions.
In one embodiment of the invention, a peripheral barrier
extends about at least a portion ofan outer peripheral edge of
the repair fabric to inhibit adhesions between the outer
peripheral edge and adjacent tissue and organs.
FIG. 2 is a bottom plan view of the prosthesis of FIG. 1;
FIG. 3 is a cross-sectional view of the outer margin ofthe
prosthesis taken along section line 3-3 of FIG. 1;
FIG. 4 is a top plan view of an implantable prosthesis in
55 accordance with another illustrative embodiment of the
present invention;
60
FIG. 5 is a bottom plan view of the prosthesis of FIG. 4;
FIG. 6 is a cross-sectional view of the outer margin ofthe
prosthesis taken along section line 6-6 of FIG. 4;
FIG. 7 is a fragmented view of the outer margin of the
prosthesis of FIG. 5;
FIG. 8 is a cross-sectional view of the outer margin of a
prosthesis in accordance with another illustrative embodi-
ment of the present invention;
According to one aspect of the invention, the peripheral 65
barrier may be formed integral with the repair fabric. More
particularly, a portion ofthe outer margin ofthe repair fabric
FIG. 9 is a cross-sectional view of the outer margin of a
prosthesis in accordance with a further illustrative embodi-
ment of the present invention; and
9. US 7,404,819 Bl
3
FIG. 10 is a cross-sectional view of the outer margin of a
prosthesis in accordance with still another illustrative
embodiment of the present invention.
DESCRIPTION OF ILLUSTRATIVE
EMBODIMENTS
4
ponent that is attached to or incorporated into the outer
peripheral edge of the implant.
In one illustrative embodiment shown in FIGS. 1-3, the
peripheral barrier 26 is formed from a portion of the repair
fabric 22. In particular, the repair fabric 22 may be altered so
as to substantially eliminate the tissue infiltratable interstices
or openings along its outer margin, thereby creating a periph-
eral barrier 26 which inhibits tissue ingrowth to the outer
peripheral edge 28 of the fabric.
In one embodiment, the outer margin ofthe repair fabric 22
is melted to seal the fabric material and form an outer periph-
eral barrier 26. The barrier layer 24 may be configured, such
as with submicronal sized pores, so that a portion of the
melted fabric material becomes fused to the barrier layer 24.
FIGS. 1-3 illustrate one embodiment of an implantable
prosthesis for repairing soft tissue and wall defects, such as
ventral and inguinal hernias, and/or for chest wall reconstruc- 10
tion by promoting tissue ingrowth thereto while limiting the
incidence of postoperative adhesions to selected portions of
the prosthesis. The prosthesis 20 includes a layer of tissue
infiltratable repair fabric 22, an adhesion resistant barrier
layer 24 overlying at least a portion ofone side of the fabric,
and a peripheral barrier 26 extending about a portion of the
outer peripheral edge 28 of the fabric.
15 In this arrangement, the peripheral barrier 26 may act to
increase the stiffness ofthe outer margin of the barrier layer,
such that the outer edge ofthe barrier layer may become more
resistant to being inadvertently folded back. Additionally, the
outer margin of the barrier layer may tend to soften and
The repair fabric 22 is formed ofa biologically compatible,
flexible material that includes a plurality of interstices or
openings which allow sufficient tissue ingrowth to secure the
prosthesis to host tissue after implantation. The barrier layer
24 and the peripheral barrier 26 are formed of a material
and/or with a structure that does not substantially stimulate
tissue ingrowth and adhesion formation when implanted in
tissue to limit the incidence ofpostoperative tissue adhesions
between the fabric and adjacent tissue and organs.
The prosthesis 20 may be relatively flat and sufficiently
pliable to allow a surgeon to manipulate the shape of the
implant to conform to the anatomical site ofinterest and to be
sutured or stapled thereto. The shape and size ofthe compos-
ite implant, and ofthe respective repair fabric 22, barrier layer
24 and peripheral barrier 26, may vary according to the sur-
gical application as wouldbe apparent to one ofskill inthe art.
In this regard, it is contemplated that the prosthesis may be
preshaped or shaped by the surgeon during the surgical pro-
cedure. It is also contemplated that two or more sheets of
fabric and/or barrier material may be implemented in one or
more layers ofthe prosthesis. The layers may have the same
size and shape, or may have a different size and/or shape. A
separate layer of material may be employed between the
repair fabric and the barrier layer. The prosthesis also may
have a plug or three-dimensional shape, with selected por-
tions, or all of, the edges of the plug covered by barrier
material.
As illustrated, the barrier layer 24 may cover the entire
surface ofa first side 30 ofthe repair fabric 22. This particular
configurationallows tissue ingrowthto a second side 32 ofthe
repair fabric while inhibiting adhesions to tissue and organs
located opposite the anatomical defect site. It is to be appre-
ciated, however, that the barrier layer 24 may be configured to
cover only selected portions ofthe first side ofthe fabric 22 to
enhance tissue ingrowth from both sides ofthe fabric in those
portions free of the barrier layer.
In some instances, it may be desirable to isolate the outer
peripheral edge of the repair fabric from adjacent tissue and
organs. In the illustrative embodiment, the peripheral barrier
20 thereby reduce the brittleness of the peripheral barrier. The
outer peripheral barrier may have a width that is approxi-
mately equal to or greater than the thickness of the fabric
material.
The outer margin ofthe fabric 22 may be melted using any
25 suitable process as would be apparent to one ofskill in the art.
In one embodiment, the outer margin may be melted by heat
sealing the fabric. Other processes may include ultrasonic,
induction, vibration, infrared/laser welding and the like.
As shown in FIG. 3, the peripheral barrier 26 may be
30 configured to decrease in thickness in an outward direction
away from the outer peripheral edge 28 of the repair fabric
and toward the outer edge of the barrier layer 24. In one
embodiment, the peripheral barrier 26 has a tapered shape
resulting in a low profile edge relative to the rest of the
35 prosthesis that may enhance the adhesion resistance of the
peripheral barrier 26. The tapered shape may also provide the
prosthesis with a relatively flexible, adhesion resistant outer
margin. It is to be understood, however, that any suitable
shape may be employed for the peripheral barrier as would be
40 recognized by one ofskill in the art. For example, the periph-
eral barrier 26 may be formed with a stepped configuration,
with a non-uniform taper, or with a constant thickness.
In another illustrative embodiment shown in FIGS. 4-6, the
peripheral barrier 26 is formed from a portion of the barrier
45 layer 24. In particular, the outer margin of the barrier layer
may be extended along a portion ofthe layer ofrepair fabric
22 so that it covers at least a portion of the outer peripheral
edge 28 of the fabric.
In one embodiment, the outer margin ofthe barrier layer 24
50 is wrapped about the repair fabric 22 so that it extends from
the first side 30 ofthe repair fabric and across the thickness of
the outer peripheral edge 28 ofthe fabric. The barrier layer 24
may further extend inwardly across a portion of the second
side 32 ofthe fabric adjacent the outerperipheral edge 28. The
55 barrier material may be hemmed about the repair fabric and
securedwith stitches 34, 36 placed inward ofthe outerperiph-
eral edge of the fabric. This configuration essentially encap-
sulates the outer peripheral edge of the fabric with barrier26 extends completely about the outer peripheral edge 28 of
the fabric to inhibit adhesions thereto. It is to be understood,
however, that the peripheral barrier 26 may be configured to 60
cover only selected portions of the outer peripheral edge of
the fabric that one may wish to protect from the formation of
postoperative adhesions, such as portions ofthe edge that may
material to inhibit adhesions thereto.
The barrier material, however, does not need to wrap
around the peripheral edge and across the second side ofthe
fabric as shown in FIG. 6. In this regard, the barrier material
may extend across and be joined to the outer peripheral edge
ofthe fabric. For example, the barrier material may be bonded
to the outer peripheral edge of the fabric with any suitable
adhesive, such as a silicone, that is compatible with the par-
be exposed to tissue and organs.
The peripheral barrier 26 may be formed integral with 65
eitherthe repair fabric 22 orthe barrierlayer 24. Alternatively,
the peripheral barrier 26 may be formed by a separate com- ticular fabric and barrier materials.
10. US 7,404,819 Bl
5
It may be desirable to configure the hemmed portion ofthe
prosthesis with fluid drainage so as to reduce the potential for
entrapping fluid along its outer margin that could lead to a
seroma and/or an infection. In one illustrative embodiment
shown in FIGS. 5 and 7, the portion of the barrier layer 24 5
overlying the second side 32 ofthe repair fabric 22 includes a
plurality ofapertures 38 adjacent the outer peripheral edge 28
of the fabric. The apertures 38 should have a sufficient size
and be located to permit fluid drainage. In this regard, the
apertures 38 may be spaced inwardly and slightly away from 10
the outer peripheral edge 28 of the fabric, as shown in the
figures.
In one embodiment, the apertures 38 may include slits that
extend inwardly away from the peripheral edge 28 of the
fabric. As shown, the slits may have a generally V-shape that 15
not only allows fluid drainage, but also reduces the likelihood
of developing wrinkles or puckers along the outer margin of
the prosthesis as the barrierlayer is wrapped about the periph-
eral edge of the fabric. This may be of particular concern
when the prosthesis has a curved configuration as shown. In 20
one embodiment, the apex 40 of the apertures 38 may be
spaced inwardly approximately 0.020 to 0.030 inches from
the outer peripheral edge 28 of the fabric. Of course, one of
skill in the art would readily recognize that any suitable
aperture configuration may be employed to provide fluid 25
drainage and/or reduce wrinkle development along the outer
margin of the prosthesis. For example, the apertures 38 may
be configured as a pattern of holes distributed on the portion
ofthe barrier layer overlying the second side ofthe fabric. In
one embodiment, the apertures may have a diameter of 30
approximately 1mm that may be spaced approximately 5 mm
apart.
The repair fabric 22 and barrier layer 24 may be configured
to have any suitable shape that is conducive to facilitating the
repair ofa particular defect. In the embodiments illustrated in 35
FIGS. 1-6, the prosthesis 20 has a generally elliptical or oval
shape. Examples of other shapes include, but are not limited
to, circular, square and rectangular shapes.
In one embodiment, the repair fabric 22 is formed ofa sheet
of knitted polypropylene monofilament mesh fabric such as 40
BARD MESH available from C.R. Bard, Inc. When
implanted, the polypropylene mesh promotes rapid tissue
ingrowth into and around the mesh structure. Alternatively,
other surgical materials which are suitable for tissue rein-
forcement and defect closure may be utilized including 45
PROLENE, SOFT TISSUE PATCH (microporous ePTFE),
SURGIPRO, TRELEX, ATRIUM and MERSELENE.
Absorbable materials, including polyglactin (VICRYL) and
polyglycolic acid (DEXON), may be suitable for applications
involving temporary repair oftissue or wall defects. It also is 50
contemplated that the mesh fabric may be formed from mul-
tifilament yarns and that any suitable method, such as knit-
ting, weaving, braiding, molding and the like, may be
employed to form the prosthetic mesh material.
In one embodiment, the barrier layer 24 is formed from a 55
sheet ofexpanded polytetrafluoroethylene (ePTFE) having a
pore size (submicronal) that discourages tissue ingrowth and
adhesion. Examples of suitable material include FLUORO-
TEX Pericardia! and Peritoneum Surgical Membrane and
FLUORO-TEX Dura Substitute available from C.R. Bard 60
6
and microporous polypropylene sheeting (CELGARD) and
film. Autogenous, heterogenous and xenogeneic tissue also
are contemplated including, for example, pericardium and
small intestine submucosa. Absorbable materials, such as
SEPRAFILM available from Genzyme Corporation and oxi-
dized, regenerated cellulose (Intercede (TC7)) may be
employed for some applications. It is to be appreciated that
any suitable adhesion resistant materials may be used as
would be apparent to one of skill in the art.
In the illustrative embodiments described above, the repair
fabric 22 and the barrier layer 24 are integrally connected
with one or more connecting stitches 42. As shown in FIGS.
1 and 4, multiple series of stitches 42 (including hem stitches
34, 36) may be formed in a concentric pattern that follows the
shape ofthe prosthesis. Stitching may allow total tissue infil-
tration to the fabric while providing a strong connection
between the fabric and the barrier layer. The concentric pat-
tern also maintains composite integrity by preventing the
barrier 24 and underlying fabric 22 from separating should
the prosthesis be trimmedby the surgeon to match a particular
size and shape of the repair site. Any suitable pattern, how-
ever, may be employed so as to minimize separation of the
fabric and the barrier layer.
In one embodiment, the stitches 42 (including hem stitches
34, 36) are formed with a polytetrafluoroethylene (PTFE)
monofilament. PTFE stitches may provide a softer, more
flexible prosthesis that is easier to manipulate as compared to
a prosthesis using other stitch materials, such as polypropy-
lene monofilament. PTFE monofilament also facilitates the
manufacturing process due to the low friction characteristics
of the material. Additionally, PTFE stitches may tend to be
more adhesion resistant than other materials. Nevertheless, it
should be understood that any suitable material, such as
polypropylene monofilament, may be employed for the
stitches.
The barrier layer 24 may be stitched to the repair fabric 22
by positioning the barrier material on the fabric to face the
sewing needle so that the locking portion of each stitch is
formed on the fabric side ofthe composite rather than on the
barrier side to reduce the incidence of localized adhesions
with tissue and organs. The stitches may be formed using a
#10 ball-tipped needle to reduce the potential incidence of
tissue ingrowth through the stitch holes. The sheets offabric
and barrier material may be held by a frame during the sewing
procedure on a computer controlled table that has been pro-
grammed with the desired stitch pattern.
Any other suitable fastening technique and material may be
employed to attach the barrier layer 24 to the repair fabric 22.
For example, the barrier layer 24 may be bonded to the fabric
22 using an adhesive dispensed in a desired pattern, such as a
spiral pattern, a serpentine pattern or a grid-like pattern of
dots or beads, that maintains a sufficient quantity of open or
non-impregnated interstices for tissue infiltration. Alterna-
tively, the barrier layer 24 may be laminated or heat fused to
the fabric 22 by a combination of heat and pressure. This
lamination technique may be enhanced by a second layer of
fabric such as is described in U.S. Pat. No. 6,120,539 which is
also assigned to C.R. Bard, Inc., the assignee of the present
application, and is incorporated herein by reference. The
barrier may also be insert molded to the fabric using any
suitable molding process.and PRECLUDE Pericardia! Membrane, PRECLUDE Peri-
toneal Membrane and PRECLUDE Dura Substitute mem-
brane available from W.L. Gore & Associates, Inc. A repre-
sentative and non-limiting sampling of other suitable non-
porous materials includes silicone elastomer, such as
SILASTIC Rx Medical Grade Sheeting (Platinum Cured)
distributed by Dow Corning Corporation, TEFLON mesh,
It may be desirable to reinforce the outer margin of the
prosthesis 20, particularly when the prosthesis may be
secured using fasteners, such as sutures, staples and the like,
65 along its outer margin. In one illustrative embodiment, a
stitch line 42 (FIG. 3) and 36 (FIG. 6) is provided along the
circumference ofthe prosthesis slightly inward ofthe periph-
11. US 7,404,819 Bl
7
era! barrier 26 to form a bite region away from the outer
peripheral edge 28 ofthe fabric that is configured to receive a
fastener for securing the prosthesis along its circumference.
In this regard, a fastener, such as a suture, may be attached to
the prosthesis inward ofthe stitch line 42 so that the stitch line
may resist tension placed on the suture. In one embodiment,
the stitch line may be located approximately 3 mm inward
from the outer peripheral edge 28 to form a bite region having
a width of approximately 4 mm. Of course, any suitable
reinforcement configuration apparent to one of skill may be 10
employed along the outer margin of the prosthesis.
In an exemplary embodiment, the composite prosthesis 20
includes an approximately 0.027 inch thick sheet 22 of
BARD MESH knitted from polypropylene monofilament
with a diameter of approximately 0.006 inches. An approxi- 15
mately 0.006 to 0.008 inch thick sheet 24 of ePTFE is
attached to the mesh using approximately 3 mm to 4 mm long
stitches 42 formed of a 0.008 inch to 0.012 inch diameter
PTFE monofilament. The prosthesis 20 has a generally ellip-
tical shape that may be configured to have any desired size. 20
The peripheral barrier 26 has a width of approximately 0.10
inches with a tapered shape having a thickness of approxi-
mately 0.005 inches at its tip. It should be understood, how-
ever, that these dimensions are merely exemplary and that any
suitable sizes and shapes may be employed for the prosthesis. 25
In the exemplary embodiment, the peripheral barrier 26 is
formed by melting a ring ofpolypropylene mesh fabric 22 to
the ePTFE barrier layer 24 in a generally elliptical shape that
approximates the desired configuration ofthe prosthesis. This
may be accomplished by overlying oversized sheets of the 30
mesh fabric and ePTFE material in a fixture and heat sealing
the layers using a heated die configured withthe desired shape
ofthe prosthesis. The melted ring may be formed by applying
heat to the fabric at a temperature range of approximately
320° F. to 400° F. for a period ofapproximately 3 to 5 seconds. 35
Once fused, the fabric and barrier layer are stitched, as
described above, and subsequently die cut flush along a por-
tion of the ring to complete the prosthesis with a peripheral
barrier.
Other illustrative embodiments for isolating the outer 40
peripheral edge of the fabric are shown in FIGS. 8-10.
In FIG. 8, the interstices oropenings along the outermargin
8
barrier over portions the repair fabric, including its outer
peripheral edge, with desirable tissue ingrowth to the host
tissue. The composite may be anchored in place by tissue
ingrowth into the fabric interstices and/or may be sutured,
stapled and the like to tissue.
It should be understood that the foregoing description of
the invention is intended merely to be illustrative thereofand
that other embodiments, modifications, and equivalents ofthe
invention are within the scope of the invention recited in the
claims appended hereto.
What is claimed is:
1. An implantable prosthesis for repairing a tissue or
muscle wall defect, the implantable prosthesis comprising:
a layerofrepair fabric that is susceptible to the formation of
adhesions with tissue and organs, the layer of repair
fabric includes a plurality of tissue infiltratable inter-
stices that are constructed and arranged to allow tissue
ingrowth thereto, the layer of repair fabric including a
first surface and an outer margin with an outerperipheral
edge, the outer peripheral edge having a thickness, the
outer margin of the layer of repair fabric having been
melted and resolidified to substantially eliminate the
tissue infiltratable interstices therein and render the
entire thickness ofthe outer peripheral edge ofthe layer
of repair fabric substantially impervious to tissue
ingrowth so that the outer peripheral edge is resistant to
the formation of adhesions with tissue and organs; and
a barrier layer that inhibits tissue ingrowth and the forma-
tion of adhesions with tissue and organs thereto, the
barrier layer being configured to inhibit the formation of
adhesions between at least a portion of the first surface
and adjacent tissue and organs.
2. The implantable prosthesis according to claim 1,
wherein the outer margin has a non-uniform thickness.
3. The implantable prosthesis according to claim 2,
wherein the outer margin has a thickness that decreases in an
outward direction.
4. The implantable prosthesis according to claim 3,
wherein the outer margin has a tapered shape.
5. The implantable prosthesis according to claim 1,
wherein the layer ofrepair fabric includes an outer perimeter,
the outer margin having been melted and resolidified along
the entire outer perimeter.50 may be impregnated orotherwise occluded with a biocom-
patible material, such as silicone, polyethylene, polypropy-
lene, urethane and the like, so as to inhibit tissue ingrowth that
could lead to postoperative adhesions.
6. The implantable prosthesis according to claim 5,
45 wherein the barrier layer covers the entire first surface of the
layer of repair fabric.
In FIG. 9, a body 52 ofadhesion resistant material, such as
a silicone, polyethylene, polypropylene, ePTFE, urethane
and the like, may be deployed about the outer peripheral edge
7. The implantable prosthesis according to claim 1,
wherein the layer of repair fabric and the barrier layer are
connected by at least one series of stitches.
8. The implantable prosthesis according to claim 7,
wherein the series of stitches are formed from an adhesion
resistant material.
28 ofthe repair fabric.Absorbable materials, such as SEPRA- 50
FILM available from Genzyme Corporation and oxidized,
regenerated cellulose (Intercede (TC7)) may be employed for
some applications. It is to be appreciated that any suitable
adhesion resistant materials may be used as would be appar-
ent to one of skill in the art.
9. The implantable prosthesis according to claim 7,
wherein the series of stitches are disposed slightly inward of
55 the outer peripheral edge.
In FIG. 10, a second barrier layer 54 may be placed along
the outer margin of the second side of the repair fabric with
the outer margin 56 of the fabric being melted and sealed
between the first and second barrier layers.
It is to be understood, however, that the above embodi- 60
ments are exemplary and any suitable peripheral barrier con-
figuration may be implemented to isolate the outer peripheral
edge of the fabric from developing adhesions to adjacent
tissue and organs.
The present invention provides a prosthetic repair fabric 65
having certain of the following advantages. The composite
prosthesis combines the low adhesion incidence ofa physical
10. The implantable prosthesis according to claim 1,
wherein the layer of repair fabric is a knitted mesh.
11. The implantable prosthesis according to claim 10,
wherein the knitted mesh is formed of polypropylene
monofilament.
12. The implantable prosthesis according to claim 1,
wherein the barrier layer is formed ofePTFE.
13. The implantable prosthesis according to claim 1,
wherein a portion of the outer margin of the layer of repair
fabric is fused to the barrier layer.
* * * * *