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1. (15 Points) Read the Case Studies on pages 5557 about Ms. Smith in the Study Guide For
Understanding Pathophysiology and answer the following questions: a. Ms. Smith pathology report
staged her tumor as T2, N2, M1 and graded her lung tumor as poorly differentiated (G3). The
terms "anaplastic" and "invasive growth pattern" with "P53 gene methylation evident". How would
you explain the meaning of this report and the grading and staging to M s. Smith? b. What specific
characteristics of cancer cells allowed Ms. Smith's bronchogenic tumor to metastasize to her liver?
c. What is the role of TAM and CAF in cancer tumor survival in Ms. Smith? d. Ms. Smith had a
long history of cigarette smoking. What impact did this have on her lung cancer development? Be
specific. e. What are the most common routes of cancer metastasis with colon cancer as in Mr.
Gillespie's case? f. What are the cues of lung and colon cancer likely seen in Ms. Smith and Mr.
Gillespie?

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1 15 Points Read the Case Studies on pages 5557 about Ms.pdf

  • 1. 1. (15 Points) Read the Case Studies on pages 5557 about Ms. Smith in the Study Guide For Understanding Pathophysiology and answer the following questions: a. Ms. Smith pathology report staged her tumor as T2, N2, M1 and graded her lung tumor as poorly differentiated (G3). The terms "anaplastic" and "invasive growth pattern" with "P53 gene methylation evident". How would you explain the meaning of this report and the grading and staging to M s. Smith? b. What specific characteristics of cancer cells allowed Ms. Smith's bronchogenic tumor to metastasize to her liver? c. What is the role of TAM and CAF in cancer tumor survival in Ms. Smith? d. Ms. Smith had a long history of cigarette smoking. What impact did this have on her lung cancer development? Be specific. e. What are the most common routes of cancer metastasis with colon cancer as in Mr. Gillespie's case? f. What are the cues of lung and colon cancer likely seen in Ms. Smith and Mr. Gillespie?