Prof. Sima Lev: Lipid transfer proteins in cancer biology & metastasis
•Download as PPTX, PDF•
0 likes•311 views
Prof. Sima Lev, Molecular Cell Biology Department. Weizmann Institute of Science, Rehovot, Israel
Recommended
More Related Content
What's hot
What's hot (17)
Similar to Prof. Sima Lev: Lipid transfer proteins in cancer biology & metastasis
Similar to Prof. Sima Lev: Lipid transfer proteins in cancer biology & metastasis (20)
More from Sima Lev
More from Sima Lev (14)
Recently uploaded
Recently uploaded (20)
Prof. Sima Lev: Lipid transfer proteins in cancer biology & metastasis
- 1. Prof. Sima Lev, Molecular Cell Biology Department Weizmann Institute of Science, Rehovot, Israel Lipid dynamics and membrane contact sites FEBS 2018, 31 August- 7 September, Spetses, Greece Lipid transfer proteins in cancer biology & metastasis
- 2. PIns signaling & Cancer Nir2 in EMT and cancer Metastasis Other LTPs and cancer progression & metastasis Lipid transfer proteins in cancer biology & metastasis Nir2 regulates PIns-associated signaling pathways MAPK, PI3K/AKT LTPs in breast cancer; bioinformatic analysis Open questions & further approaches
- 3. PDK1-mTORC2-SGK axis Rac AKT PIns signaling & Cancer
- 4. Nir2 regulates GF-mediated signaling pathways
- 5. Nir2 regulates GF-mediated signaling pathways
- 8. Wild type Nir2, but not its mutants, restores PI(4,5)P2 levels at the PM of Nir2-depleted cells Kim. et al, EMBO Reports 2013 Nir2 is an upstream regulator of key phosphoinositide pathways in mammalian cells: the PI3K/AKT and MAPK pathways
Editor's Notes
- only a small subset of PH domains in the human genome are thought to bind PIP3 with high affinity and specificity (10–20% out of 290 PH domains have been shown to robustly bind phosphoi-nositides, with some of these robustly binding PI-3,4-P2 or PI-4,5-P2 but not PIP3) [9,10]. Of the PH domain-containing proteins that do bind PIP3, the serine/threo-nine AGC-family protein kinase AKT has received the greatest attention, especially for its multi-faceted roles in promoting glucose metabolism and cancer