1. 1
Executive Management: Research and Process Development for APIs, Drug intermediates and
Specialty chemicals
 Accomplished professional with over 21 years of distinguished experience in:
Research & Development; Cost Reduction Analysis; Product Development for APIs;
Custom Synthesis; Technology Development and Strategic Planning
 Demonstrated competence in executing a wide gamut of functions viz. process management,
process scale up studies, process documentation and co-ordination with QA/RA in
generating DMF (for API’s) etc.
 Expert in identifying, collecting, processing, analysing and cataloguing data according to
established protocol, procedures & standards, as appropriate to specific objectives of the
research study
 Recognized for having managed 11 Research Publications and filed 2 Indian Patents for
granting patent rights
 Demonstrated acumen in developing various Active Pharmaceutical Ingredients (API’s),
drug intermediates, custom synthesis products, specialty chemicals and few natural products
 Skilled in steering R&D Team encompassing design of lab experiments, process
development, process optimization, process validation at different stages, transfer of
technologies for commercial scale productions, process costing, process improvement and
troubleshooting
SHIVA PRAKASH.S
No.127, 16th
Main Road, B.S.K 1st
Stage,
2nd
Block, Srinagar, Bangalore 560050
: +91 - 9620372600 / 9448226830
: shivarc127@yahoo.com

2. 2
 Proficient in managing:
o A variety of chemical reactions like Grignard Reaction, Mannich Reaction,
Sandmeyer’s, Friedel-crafts Acylation, Wittig Reaction, Hofmann Rearrangement,
Darzen’s Reactions, Strecker Synthesis, etc.
o Sulfonation, Nitration, Halogenation, Hydrogenation, Chloromethylation, Cyanide
Reactions etc.
 Sound in-depth theoretical and practical knowledge in synthestic organic chemistry which
could help me to develop new products and processes
 Conversant with:
o Searching literature by both manual and online methods using SCIFINDER for
designing synthetic schemes for quick development
o Interpretation of research results to identify and characterize the synthesized compounds
using various analytical techniques like GCMS, NMR, IR, HPLC, GC, etc.
Accomplishments:
 Played a vital role in synthesizing more than 50 organic compounds, which include API’s,
drug intermediates, specialty chemicals and few natural products for various applications
o Majority of the products are commercialized
 Instrumental in planning and developing several custom products, commercialized and
supplied as per the customer requirement
 Executed time bound projects
 Bestowed with the Excellence Performance Award for the year 1996-97 from the
management of Recon Ltd., Bangalore, India for outstanding contribution
 Formulated cis-cinnarizine, cis-flunarizine and cis-clocinizine for the first time (Ph.D work).
These are counterparts of well-known antihistamine drugs viz., Cinnarizine, Flunarizine and
Clocinizine that possess trans-geometry.

3. 3
ORGANIZATIONAL EXPERIENCE
Since Oct’08 – Nov 14 with Vittal Mallya Scientific Research Foundation, Bangalore,
Karnataka as Project Leader - Chemical Sciences
Role:
Natural Product Chemistry:
 Worked on Neem Products – Extraction, Isolation of active component of neem and
preparation of its water soluble formulations
 New water-soluble powder formulation of neem extract was developed and applied for
patent rights (Indian Patent filed on 2010)
 Extraction and isolation of Hydroxycitric acid (HCA) from Garcinia combogia rind and
preparation of Hydroxycitric acid lactone at 200g scale
 Testicular toxicity study of HCA-Lactones conducted in animal model and published in the
reputed Indian journal
 Extraction of cashew nut shell liquid (CNSL) – Experiments conducted at 1.0 Kg batch size.
The active compound ‘anacardic acid’ was isolated. Using this as a starting material, various
new synthetic derivatives were prepared and studied their antibacterial activity (for research
purpose)
Synthetic Chemistry: (Doctoral Degree Work)
 Stereoselective synthetic method for producing cis-isomers of Cinnarizine, Flunarizine and
Clocinizine was developed for the first time via Wittig reaction and studied their biological
importance
 Seven new cis-anologs of cinnarizine were prepared and studied their anticancer potential
 Synthesized 2, 4, 5-timethoxy stilbene derivatives by Wittig method and studied their
phytopathogenic effect
 Prepared several new stilbenes having pyridine moiety and studied their biological
importance
 Attempted a new synthetic method for the preparation of trans-Resveratrol- a naturally
available antioxidant

4. 4
Mar’06 – Sep’08 with Sanmar Specialty Chemicals Ltd., Hosur, Tamil Nadu as Executive
Manager - R&D
Role:
 Headed four-memberd team; Reporting to VP -R &D
 Ensured preparation of process costing at different stages and updated fortnight / monthly
reports
 Resolved findings of review meeting; liaised with inter departments for timely completion
of projects and overall technical support to production team when ever needed
 Developed following products from Kilogram level to bulk quantities based on customer
requirement
Drug Intermediates:
 S-2-Aminobutanamide HCl (Levitiracetam intermediate) -1 Kg
 5, 6, 7, 8-Tetrahydro quinoline-8-one -2Kg
 CD675 – Scale up study of customer process (Under phase-3 trial), supplied -200kg
 3, 4 Dichlorobenzyl cyanohydrine o-THP
 2-Fluoro acetophenone -1Kg
 Methyl-alpha-Bromo-2- chloro phenyl acetate (Clopidogrel intermediate)
 N-Methyl 2- nitro aniline- Commercialized (> 50 MT)
 Mebeverine intermediates; Commercialized (>50 MT)
 Indole-3-carboxylic acid,
 2-Allyloxy phenol
 3-methoxy tyramine (AE phenol) – worked for Syngenta; Set up a new plant for regular
production
 Tri hydroxyl phenyl ethane (THPE)
 Tris-(2-aminoethyl) amine
 4-n-Propylcyclohexanone, etc.
Jul’04 – Mar’06 with Hikal Ltd., Jigani, Bangalore as Scientist-I - Process Development Lab
Role:
 Headed process development lab of team comprising of 4 members
 Provided technical support to production teams for ongoing plant batches

5. 5
 Carried out troubleshooting analysis and new products development in accordance to
business interest
 Worked API’s and intermediate:
o Gabapentin
o AcebutalolHCI
o Gemfibrozil
o Cinnarazine
o Theo Bromine
o 1-Cyclo-2-hexenone
Jan’04 – Jun’04 with Syngene International Pvt. Ltd., Bangalore as Executive Scientist
Role:
 4-Piperidine-2-ethanol – Process developed, prepared and supplied 2 kg of this material to
Aldrich chemicals.
Jun’01 – Dec’03 with Hikal Ltd., Bangalore as Group Leader- R&D Centre
Role:
Steered team comprising of 3 members and developed synthetic procedures for the following
API’s, drug intermediates and custom products from lab scale to commercial productions
 API’s
o Bupropion HCI, an “antidepressant” drug and its impurities as per USP – Regular
production
o Risedronate Sodium – drug used for bone related problems, 100kgs
o Suramine Sodium-Intermediate – 5kgs
o Intermediates / Custom synthesis
o 5, 7-Dimethyl Isatin -10kg
o 4-Benzyloxyaniline HCl - 300kgs
o Cyclohexylbenzene- 2MT

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o Benzonitrile-3-Acetyl -5Kgs
o 3-Nitro-2.2.2-Trifluoroacetophenone - 100kgs
o 5-Bromo-2-Chloroanisole(CBA)-2MT
o Diethyloxomalonate-10Kgs
o 4-Chloromethyl-3.5-dimethylisoxazole-10kgs
o 2.4-Dinitroimidazole- 200gms
o 4-Amino-1.3.5-trimethyl pyrazole – 2kgs and
o 4-Nitro 2-trifluoromethyl benzonitrile -2kgs
o 2-Amino-3-methyl-5-chlorobenzoicacid – Process developed, scaled up to plant batches,
200kg material supplied to ‘Dupont’ along with tech pack details.
PREVIOUS EXPERIENCE
Apr’00 – May’01 with Rallis (India) Ltd., Bangalore as Research Officer-Pharma R&D
o 6-Methyl-3, 4-Methylene dioxy benzyl chloride - Supplied 300 Kgs
o 5-chloro-2-methyl Indol - Supplied 5Kgs
Mar’95 – Mar’00 with Recon Ltd, Bangalore as Assistant Manager- R&D Centre
o Api’s: Ondonsteron HCl; Nabumetone; Ambroxal; Pentoxyfyline; Sertraline HCl;
Sulfadiazine Sodium and Meloxicam
o Custom’s products: 4-Phenyl-2-oxazolidinone; 4-Benzyl-2-oxazolidinone; 5-amino-2-
methyl Indol; 4R, 5S-1, 5-dimethyl-4-Phenyl-2-Imidazolidinone and its (N-Propenoyl)
derivatives
Jul’93 – Jan’95 with ASTRA-IDL Ltd., Bangalore as Research Associate
o Worked on Prostaglandin intermediates (Carboprost) (15-Me-PGF2α).

7. 7
PUBLICATIONS
1. ‘Issue of testicular toxicity of hydroxycitric acid lactone’, D. Ranjith, S. ShivaPrakash, A.
C. Karunakara, Latha Diwakar and G. Chandrasekara Reddy. Current Science 2011, 100(1),
24-27
2. ‘Synthesis of Mitoxantrone Analogues and in-vitro Cytotoxity’, P. Hareesh Kumar, S. Shiva
Prakash, S. Krishna Kumar, Latha Diwakar and G. Chandrasekara Reddy. International
Journal of Chem.Tech. Research 2011, 3(2), 690-694
3. ‘Stereoselective synthesis of (Z)-1-benzhydryl-4- cinnamylpiperazines via the Wittig
reaction’, Shivaprakash. S, Reddy G. C. Syn.Comm. 2014, 44, 600-609
4. ‘(Z)-1-Diphenylmethyl-4-(3-phenylprop-2-enyl) piperazine’, S. Shivaprakash, G.
Chandrasekara Reddy and Jerry P. Jasinski. Acta Cryst. Section E 2014, E70, o576
5. ‘1-[Bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine-1,4-dium
dichloride hemihydrate’, S. Shivaprakash, G. Chandrasekara Reddy and Jerry P. Jasinski.
Acta Cryst. Section E 2014, E70, o694-o695
6. ‘In vivo studies of (Z)-1-benzhydryl-4- cinnamylpiperazines as anti-inflammatory and
analgesics’ S. Shivaprakash, Anaxee Burman, Latha Diwakar and G. Chandrasekara
Reddy. Int. J. Pharmacy 2014, 4(3), 154-157
7. ‘Synthesis of (E) Stilbenes from 2, 4, 5-Trimethoxybenzyltriphenyl phosphonium Ylide and
their Fungicidal Activity’ S. Shivaprakash, Rajendra Hegde and G. Chandrasekara Reddy.
Am. J. Pharmtech. Res. 2014, 4(5), 146-157
8. ‘Acute Toxicity study of (Z)-1-benzhydryl-4-cinnamylpiperazines in Swiss albino mice’
Anaxee Barman, S. Shivaprakash, Latha Diwakar and G. C. Reddy. Asian J Pharm Clin
Res. 2015, 8(1), 223-224
9. ‘Synthesis and in-vitro study of novel (Z)-1-benzhydryl-4-cinnamylpiperazine derivatives as
potential anticancer agents’ S. Shivaprakash, K. R. Kiran, Latha Diwakar, G.
Chandrasekara Reddy. Int J Pharm Pharm Sci. 2015, 7(1), 416-420
10. ‘Stilbene heterocycles: Synthesis, antimicrobial, antioxidant and anticancer activities’ S.
Shivaprakash, Latha Diwakar and G.Chandrasekara Reddy. The Pharma Innovation
Journal 2015, 3(12), 24-30.
11. ‘A sterically congested cis-stilbene and its phosphonium salt precursor’ Shivanna
Shivaprakash, G. Chandrasekara Reddy, Jerry P. Jasinski, Sean P. Millikan, Courtney E.
Duff and Christopher Glidewell* Acta Crystallographica Section C 2015, C71, 479-484.

8. 8
PATENTS
o Water soluble powder formulation of enriched Azadirachtin and its process thereof -
Shivanna Shivaprakash, Pasupulati Anilkumar, Anilkumar Kush, Goukanapalli
Chandrasekara Reddy; Indian patent filed on July 2010
o Process for isolation of Azadirachtin from neem seed - Shivanna Shivaprakash,
Karunakara, Anil Kumar Kush, Goukanapalli Chandrasekara Reddy; Indian patent filed on
July 2014
EDUCATION
 Ph.D (Synthetic Organic Chemistry with Medicinal values)
Thesis titled ‘Synthesis and Biological Evaluation of 1, 4-Disubstituted Piperazine and
Stilbene Compounds’. June 2015, University of Mysore, Mysore, India.
 M.Sc. Organic Chemistry – Got master’s degree in the year 1993(1st class), Studied Organic
Chemistry as a major subject, Central College, Bangalore University, Bangalore, India
 M.Sc. Mathematics – Central College, Bangalore University, Bangalore, India. (1990-91 but
discontinued in the 2nd year)
 B.Sc. Physics, Chemistry and Mathematics – Got bachelor’s degree in the year 1990(1st
class), Bangalore University, Bangalore, India.
 Additional course: One year full time certificate course on ‘Post graduation Diploma in
Computer Applications’ completed and received course certificate in the year 1986
REFERENCES
Provided on request
.