17. Exhibit 3
Change in costs for a thirty-day supply of oral anticancer drugs recently approved by the
FDA, 2007–13
Change after: Change in costs 95% CI P-value
Additional supplemental indication +9.2% 4.3, 14.3 0.001
Additional compendium-
recommended off-label indication
+4.3% 0.0, 8.9 0.061
FDA approval of a competitor drug −1.8% −3.1, −0.4 0.003
One year +4.4% 3.1, 6.0 <0.001
Effect of “competition”??
Competition?
18. Pay for outcomes/performance
• Price of drug/service linked to how well it
works in the ‘real world’
• Involves up-front payment, then post-hoc
true up or reconciliation
• Not a lot of working models in the US, no
data
20. Performance-based pricing schemes
Neumann, Peter J., et al. "Risk-sharing arrangements that link payment for drugs to health
outcomes are proving hard to implement." Health Affairs 30.12 (2011): 2329-2337.
21. Value Based Insurance Design
• Focuses on patient out of pocket costs (co-pay)
– Lower OOP costs for services that are more
beneficial
• Core notion is lower OOP costs increase use
– No OOP for screening tests, for instance
• Does not contemplate the price of the service or
drug
22. Value based drug pricing
• Price should match benefits
• Insurance coverage should follow
– Low copays, no additional discounts
• Puts a ‘third person’ at the negotiating
table with the ‘proper price’
23. Bach, Peter B., and Steven D. Pearson. "Payer and Policy Maker Steps to Support Value-Based Pricing for
How market would respond to value-
based prices
24. Comparison of four solutions
Solution Effect on ‘options’
for doctors
Type of alignment
sought
Relation to overall
budget
Competition Limits About market power Only indirect
Outcomes based pricing None required Benefits to price
(through real world
observation)
Only indirect
Value Based Insurance
Design
None Patient OOP aligned
with benefit
None
Value based pricing None, should lower
OOP costs
Overall price aligned
with benefit
Explicit
26. An example of DrugAbacus pricing: Blincyto
(a drug for leukemia)
The market price for Blincyto is $64,260 a month,
but the suggested DrugAbacus price is just $12,612.
26
30. Figure 1: No change in proportion of cancer doctors in
rural and urban settings from 2012 to 2016 (a time
period that bridges the 2013 sequestration).
Figure 2a: No effect of sequestration on
migration of patients from doctors’ offices to
hospitals
For 12 week-treatment: Paclitaxel Abraxane Difference
Cost to Medicare $201 $16,686
Current Doctor’s Profit: $12 $1,001 $989
Proposed Doctor’s Profit $72 $484 $412
With Sequester:
Current Doctor’s Profit: $ 9 $717 $709
Proposed Doctor’s Profit $68 $216 $148
Figure 3: High variability in cost to Medicare and profits for physicians between
paclitaxel and Abraxane, both indicated for breast cancer, with and without
sequestration.
Figure 2b: No effect of sequestration on percent
of patients receiving care in both doctors’ offices
and HOPD
Figure 2c: No effect of sequestration on percent
of patients where HOPD treatments were more
expensive than treatments in doctors’ offices
31. Copayment central to new models, so
what about copay assistance?
Copay cards have corrosive effect on prices:
Solutions –
Segregate coupons from cash payment
Central registry so all patients can find
Include for life cycle of prescription (don’t just end when OOP
max is reached)
Incorporate into Medicaid Best Price determination