Chemistry in industry - A Guidance to BSc, MSc graduates in Chemistry
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This presentation is about various opportunities that exists for Science graduates in Chemistry in India/ Mumbai.
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Chemistry in industry - A Guidance to BSc, MSc graduates in Chemistry
- 1. CHEMISTRY IN INDUSTRY A GUIDANCE TO BSC MSC GRADUATES IN CHEMISTRY Sudhir Sawant PhD (Chemistry) DGM – Synthesis & Process Development Enalteclabs Pharma, Ambernath
- 2. WHY MAKE IN INDIA? Increasing overhead costs in Europe due to various economic reasons and Less availability of trained manpower. European companies looking at India as an opportunity towards establishing manufacturing sites in India….Why India? well educated and trained man power, youngest average age about 30 years Good english speaking population, good communication skills – verbal & written Flexible, systematic approach, talent pool. Professional integrity and reliable professional Government is encouraging direct foreign investments in SEZs in all over India
- 3. PHARMACEUTICALS Organic Chemistry Named reactions: Enantioselective synthesis [Chiral synthesis] Corey-Itsuno - Dapoxetine.HCl Wittig Reaction : Rosuvastatin
- 4. HOW WE DO WHAT WE DO? – GENERICS APIS Project allotment Literature survey Laboratory experiments Optimisation experiments Scale up – Kilo lab, Pilot plant, Manufacturing plant Validation campaign Filing for USFDA approval Commercialisation
- 6. ENANTIOSELECTIVE SYNTHESIS Corey−Itsuno Reduction of Ketones
- 7. MECHANISM – CHIRAL SYNTHESIS Reference: Corey−Itsuno Reduction of Ketones: A Development of Safe and Inexpensive Process for Synthesis of Some API Intermediates Rajendra D. Mahale,* Sudhir P. Chaskar, Kiran E. Patil, Golak C. Maikap,* and Mukund K. Gurjar, Organic Process Research & Development., 2012, 16, 710−713
- 8. DAPOXETINE SYNTHESIS – NAMED REACTIONS Knoevenagel condensation Reductive alkylation Fischer Esterficati Michael Addition Reduction
- 9. ROSUVASTATIN – WITTIG REACTION TEMPO OXIDATION WITTIG REACTION
- 11. TEMPO OXIDATION MECHANISM Proposed mechanism for the oxidation of primary alcohols under basic conditions M. Angelin, M. Hermansson, H. Dong, O. Ramström, Eur. J. Org. Chem., 2006, 4323-4326
- 12. ANALYTICAL CHEMISTRY Wet chemistry HPLC method development HPLC/MS analysis GC, GC/MS Ion chromatography Spectroscopic instrumental analysis: NMR, IR, MS, PXRD, Single Crystal, DSC, TGA, Reaction Calorimetry
- 13. OPPORTUNITIES Synthesis development Analytical development* Intellectual property management* Quality assurance Regulatory affairs* Manufacturing: “Make in India” initiative Industrial Safety & environment: Fire safety* * post graduate courses offered
- 14. Consumer Health care : FMCG : Colgate Palmolive, HLL, Godrej,Femicare Forensic Science Laboratory Foods and Beverages industry : Cadbury, Nestle. Speciality chemicals Industry : Ciba Vision, Flavours and fragnances industry : IFF Inorganic Chemicals industry : Tata Chemicals, Agrochemical industry : Gharda Chemicals, Veterinary medicines : Pfizer, Petrochemical Industry: Reliance, Construction / Ceramic chemicals : Effluent treatment chemicals / Water treatment /softening chemicals Textile industry: OPPORTUNITIES
- 15. AN ADVICE Prepare well for your final Exams! All the best! Do not forget your teachers after exams are over. Keep in touch with them for guidance and career opportunities.