Green chemistry nikhil

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Green chemistry nikhil

  1. 1. WELCOME
  2. 2. GREEN CHEMISTRY INPHARMACEUTICALS
  3. 3. PRESENTED BY,NIKHIL MOHAN.P.MAYISHAMUBEENA.ASREELAKSHMI.KSAREENANASRIN.K.PAKHILAATHIRA HARIDAS
  4. 4. WHAT IS GREEN CHEMISTRY?
  5. 5. Green chemistry is a pro-activeapproach to pollution preventionIt targets pollution at the designstage, before it even begins.It is designing chemical produtsand processes that reduce oreliminate the use and thegeneration of hazardoussubstances.
  6. 6. PRINCIPLES OF GREEN CHEMISTRY Waste reduction in chemical synthesis Using rawmaterials and feedstocks from renewable sources Employing catalysts. Avoiding chemical derivatives. Maximising atom economy
  7. 7. Replacing or reducing solvents.Increasing energy efficiency ofchemical reactionsUsing in-process or real timemonitoring.Other process safety andenvironmental consideration.
  8. 8. GREEN CHEMISTRY IN PHARMACEUTICAL Currently,the pharma industry is trying to curb spending in the industry. Green chemistry offers significant cost advantages. Compared with other sectors in its green practices,the pharma ranks low The E-factor
  9. 9. AMERICAN CHEMICAL SOCIETY GREEN CHEMISTRY INSTITUTE [ACSGCI] In 2005,several firms along with ACSGCI established the GCI Phrmaceutical Round table [ACSGCIPR]. The major companies included in this are Pfizer,Johnson&Johnson, Astrazeneca, GalaxoSmithKline etc. They reviewed work in 14 areas.
  10. 10. THE AREAS REVIEWED BY ACSGCIPRSolvent reduction or replacement.OxidationAmide formationAssymetric hydrogenationsFlourinationCarbon-hydrogen activationBio catalysisChemistry in waterAlcohol activation for nucleophilic displacem’tFriedel-crafts chemistryContinous processing intensificationSupercritical fluid chromatography separation
  11. 11. GSK’S ECO-DESIGN TOOL KIT A Green chemistry &technological guide A material guide to solvents & bases with related environmental health &safety data A fast lifecycle assesment for synthetic chemistry that streamlines evaluations of environmental lifecycle & measures green metrics A green packaging guide A guide that identifies legislation phasing out hazardous substances
  12. 12. SOME HIGH PROFILE SUCCESSES IN PHARMACEUTICAL INDUSTRY Rochebetters route for Pyridinylimadazole – based drug. Merck’s green process for Raltegravir Pfizer’s green synthesis of Pregabalin Eli Lilly optimizes production of neurokinin-1 antagonist

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