10. Discussion Figure 1. Arterial plasma concentration–time profiles of oltiprazafter 15 min intravenous (*; n = 5) and intraportal (*; n = 5) infusion (A), and after 15 min intraportalinfusion (&; n = 4) (B) of the drug at a dose of 20 mg/kg to male rats. The inset in Figure 1(B) shows the profiles after intragastric (*; n = 4) and intraduodenal (*; n = 3) administration of the drug at a dose of 20 mg/kg to rats. Each point represents the mean standard deviation. * represents significant difference (p 5 0.001) compared with intravenous data
11. Conclusion The oral bioavailability of Oltipraz at a dose of 20mg/kg was found to be 41.2%