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Antitussives drug molecules
1. ANTITUSSIVES
REVIEW I
J COMPONENT
PHARMACEUTICAL BIOTECHNOLOGY
SUBMITTED TO:
Dr VINO S
ASSOCIATE PROFESSOR
SBST
VIT
SUBMITTED BY:
TEJASWINI – 18MSM0074
SANDIP HAZRA – 18MSM0090
TANIA CHATTERJEE – 18MSM0094
MRUNAL PALSOKAR – 18MSM0095
2. Heterogeneous class of compounds that inhibit cough through
either a central or peripheral mechanism; or a mixture of two
Antitussives are thought to work by inhibiting a coordinating
region for coughing located in the brain stem, deterring the
cough reflex arc
Cough is normally produced through the stimulation of
sensory receptors glossopharyngeal and vagus nerves,
innervating the mucous membrane of the lower pharynx,
larynx, trachea and smaller airways of respiratory system
Receptors then transmit the signal to the cough center in the
brain
This then triggers a reflex motor response that results in
contraction of the muscles to close the glottis and contraction
of the muscles of expiration
INTRODUCTION
3. The result is sudden increase in intrathoracic pressure followed
by relaxation of vocal cords, resulting in rapid expulsion of air
Centrally acting agents work by inhibiting the cough center in the
brain, elevating the threshold for coughing (though the exact
mechanism is still poorly understood)
Peripheral acting agents work either by anesthetizing the local
nerve endings or acting as demulcents (agents having soothing
effect on throat)
Examples:
Centrally acting: dextromethorphan, opiates (codeine)
Peripheral acting: camphor, menthol
Antitussives doesn't have any major side-effects but may cause
sleepiness, irritability and dizziness
4. Work plan
RETRIEVIAL OF ANTITUSSIVE
COMPOUND
ACD CHEMSKETCH OF COMPOUNDS
FINDING ADME FEATURES OF
MOLECULES
INTERPRETATION
COMPARETIVE ANALYSIS USING MS
EXCEL
34. INTERPRETATION
From the above compared parameters the Lipinski’s
rule was applicable for most of the drugs.
Among the Lipinski’s rule applicable drugs opium had
high water solubility.
Opium also had the highest bioavailability compared
to other 12 molecules.
And the next best bioavailability molecule was codeine
