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THE PRODUCT
Alchemist PVC (Parameterized & Virtual Connect) is an
online consultation platform where the doctors can give
medications based on the patients vital body parameters
instead of asking for symptoms from the patient.
This is a low cost device is used by the patients
and it enables doctor to view the patient’s
Systolic & Diastolic blood pressure, ECG, Heart
Beat, Temperature, Blood Oxygen Level.
Fig.1 Website
Fig.2 Hardware
WHAT’S SO UNIQUE ??
• MORA => Measure Once Retrieve Anywhere.
The data being measured can be retrieved(viewed) from anywhere around the
world. This not only comes as an aid during this COVID-19 pandemic but also improves the reach of
doctors in rural India where medication is still a dream.
#medication_Is_A _Right
• NON-INVASIVE => The device is non-invasive ie. there is no creation of skin breaks. Thus can be
used even by an unskilled and an uneducated person.
• PORTABLE => The device is almost the size of a watch thus making it a highly portable.
• AFFORDABLE => The device measures 6 vital body parameters but still comes at an affordable
price of $35 USD .
SECRETE OF OUR COST EFFECTIVENESS
DEVICES AVERAGE COST
Thermometer $10
Blood Pressure
Monitor
$100
ECG Monitor $100
Total Cost === $210
Fig.3 Cost Of the devices when purchased separately
Reduced the number of sensors : The sensors were so chosen such that the parameters to be
extracted had either complete dependency or had a correlation factor greater than 80%.
Sensors Used === ECG Sensor + SpO2 Clip
PHOTOPLETHYSMOGRAPHY
BEER–LAMBERT LAW
ELECTROCARDIOGRAPHY
MOENS-KORTWEG EQUATION.
PULSE TRANSIT TIME
COMPONENTS IN PRINCIPLE
ABSORBANCE OF LIGHT CONCENTRATION OF THE SAMPLE
BEER–LAMBERT LAW
PPG – Photo Plethysmo Graph
• When the heart beats, capillaries expand and contract based on blood
volume changes.
• Since light is more strongly absorbed by blood, the changes in
blood flow can be detected by PPG sensors as changes in the
intensity of light .
• Voltage signal from PPG Quantity of blood flowing.
SPO2 clip:
Photodiode and IR led of 940nm wavelength. Uses of low-intensity
Infrared green (IR) light.
Optical Technique with motion-tolerant technology which is
proved to be more faster and accurate than any tecchniques.
Photoplethysmography is used to measure the blood volume changes in
micro vascular bed tissues providing high precision .
Photoplethysmograph:
Photoplethysmograph:
Systolic
peak
Diastolic
peak
A
Dicrotic
Notch
Rise Time
PAP
TIME
PPT
SITE OF MEASUREMENT
The places where photoplethysmograph could be taken are
1. right and left ear lobes ,
2. index fingers(method we use) ,
3. great toes
WHY FINGER??
• Noises can be reduced when compared to other sources.
• Signal processing becomes easy when compared to signals from other
places and Area of exposure is less.
ELECTROCARDIOGRAPHY
An SMD soldered
chip along with
electrodes to
measure ECG.
The electrodes are
placed using the
Einthoven’s triangle
3 Lead ECG is
used in this
process.
Using ECG for each
heart beat a pulse is
produced which
causes the blood to
squeeze through the
veins.
It records the electrical activity of the heart using electrodes
placed on the skin.
EINTHOVEN'S TRIANGLE
• Einthoven's triangle is an imaginary
formation of three limb leads in a triangle
used in electrocardiography .
• The shape forms an inverted equilateral
triangle with the heart at the center
• The right leg electrode acts to reduce
interference .
• Each lead measures the electric field
created by the heart during
the depolarization and repolarization of
myocytes
PULSE TRANSIT TIME
PTT
SYSTOLIC PEAK
PULSE TRANSIT TIME
• Pulse transit time refers to the time it takes a pulse wave to travel
between two arterial sites.
• Speed of the arterial pressure wave Blood pressure.
• Technology have allowed accurate estimation of the arrival of the pulse
wave at a peripheral site such as the finger using photoplethysmography
WHY PTT??
• Shows a strong correlation with blood pressure (measured by ABPM).
• Provides continuous, non-invasive, cuff-less blood pressure .
• The pulse pressure waveform is known to contain vital information - acts
as an indicator of cardiovascular diseases.​
• PTT is not well correlated with absolute blood pressure values at a
given point in time, but it is capable of predicting changes in blood
pressure over a short period of time.
PROPOSED SOLUTION
● The time difference between the generation of pressure at heart and the
increase in blood volume at the peripheral site is denoted by Pulse Transit
Time(PTT), and the velocity of the propagation of this pressure is pulse
wave velocity (PWV).
● PTT is estimated from the measured ECG and photoplethysmogram
(PPG), this method has been used to develop wearable devices to
measure BP continuously and conveniently.
● Proposed solution = SpO2 sensor + Calibrating ECG module .BLOOD PRESSURE= SpO2 sensor + Calibrating ECG module .
COMPONENTS USED
Processor
• 32 Bit Processing
SPO2 CLIP
• PPG SENSOR
OP-AMP
• 4 channel OP-AMP
• Notch Filter
• Low Pass Filter
• Inverting Amplifier
RECHARGEABLE
BATTERY
• Type-B charger
• 3.7V, 2.1A
• Lithium-ion battery
PCB
ECG ELECTRODES
• For obtaining ecg .
• To form
Einthoven's triangle.
INSTRUMENTATION
AMPLIER
COMPONENTS USED
Multilayer PCB
Dimensions == 3.6cm*3.5cm
For ECG
Measurement
● The device modeling and development is under the guidelines of
MEDICAL STANDARDS.
● The OP-amp is also a medically approved .
● The device is built-in in with no moving parts and an operating
voltage of 3.3V.
● The SpO2 is a clinically approved blood saturation sensor with
940nm operation.
DESIGN STANDARDS
IT’S JUST A PROTOTYPE
Fig.3 Product Circuitry Fig.4 Product Casing
CUSTOMIZED DESIGN OF PCB
Fig.5 3D Design of the PCB 3.6cm*3.5cm Fig.6 Back view of the PCB
PCBBOARD
(DESIGN)
WORKING
PHASE 1 : PPG EXTRACTION
SpO2 Clip
Notch filter
+
Low Pass Filter
+
Inverting
Amplifier
PPG Waveform
Parameters
Extraction
WORKING
PHASE 2 : ECG EXTRACTION
ECG
Electrodes
Instrumentation
Amplifier
ECG Waveform
Parameters Extracted
WORKING
ECG AND PPG
WAVEFORM
SIGNAL
PROCESSING
SYSTOLIC PEAK + R-R TIME + PTT +
QRS COMPLEX PEAK+ SYSTOLIC-TO-SYSTOLIC TIME
+ PULSE WAVE VELOCITY
PHASE 3 : PARAMETER EXTRACTION + SIGNAL PROCESSING
Multiple
Linear
Regression
Parameters
PPG WAVEFORM:
ECG WAVEFORM:
PARAMETERS EXTRACTED:
WEBSITE
MORA- Measure Once Retrieve Anywhere
DEVICE FireBase
WEBSITE
HTML, CSS,
JavaScript, React,
Chart.js
WEBSITE
Step-1: Sign up
WEBSITE
Step-2: Log in
WEBSITE
Step-3: BOOK AN
ONLINE CONSULTATION
WEBSITE
Step-4: CHOOSE A DOCTOR
WEBSITE
Step-5: CLICK THE GENERATE BUTTON
1. MULTIPLE LINEAR REGRESSION :
To determine Diastolic BP, Systolic BP,
Heart Beat and Temperature from the
Extracted Parameters.
MACHINE LEARNING
MODEL
BUILDING BLOCKS OF A BUSINESS MODEL :
TARGETED
CONSUMER
DIETICIANS
PSYCHIATRISTS
BIO-MEDICAL SCIENTIST
FITNESS TRAINERS
Used by military fitness trainers to continuously
monitor blood pressure during experimental
exercise regiments.
The effect of different drugs on blood pressure can be
analyzed .
To study the relationship between the emotions and
blood pressure .
The effect of different food habits on blood pressure
can be found .
HOSPITALS (ICU)
Used in ICUs and operation theaters to continuously
monitor blood pressure .
VALUE PROPOSITIONS
MORA
Inbuilt WiFi
Reserve Battery
Predicts your future blood
pressure values
Increased life time*
Inbuilt Bluetooth
Portable
Rechargeable battery
No external field is used(risk
reduction)
Better User Interface
32-Bit Processor
Lower cost*
CHANNELS
CUSTOMER RELATIONSHIP :
Channels are established by,
Advertising through partner owned websites
Ie. through YOUTUBE channel (cpc –Rs 7 to Rs 21)
GOOGLE (cpc-Rs 70 to Rs140)
Types of customer relationship Types of customers
Dedicated personal assistance High net worth clients
(Eg Apollo Hospitals)
Automated services Rest of the clients
REVENUE STREAMS
KEY RESOURCES
• Device Cost
• Advertisements
Physical Workspace .
Intellectual None
Human Human resources for producing ,
marketing and customer care .
Financial Stock option pool for the purchase of
work-area .
KEY PARTNERSHIP
Establishing relationship with third party clients for
• Delivering
• Post purchase assistance and
COST STRUCTURE :
COMPONENTS COST (INR)
SPO2 CLIP 1000
BATTERY 400
PCB FABRICATION 200
HARDWARE COMPLIANCES(ECG) 300
3D CASING 500
DESIGN AND TESTING 100
TOTAL 2500/-
FUTURISTIC SCOPE :
Providing better UI for the website.
The device can be made more accurate and region independent by
taking more datasets.
Improving the security of the website.
Providing an App facility.
Increase the scalability of the website .
• COMPONENTS USED
FUTURISTIC SCOPE
Patience is required in order to create a
disruptive technology.
But it takes greater patience to review it !!!
Thanks for your patience.
~Team Alchemist

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Hcl hh20

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  • 5. THE PRODUCT Alchemist PVC (Parameterized & Virtual Connect) is an online consultation platform where the doctors can give medications based on the patients vital body parameters instead of asking for symptoms from the patient. This is a low cost device is used by the patients and it enables doctor to view the patient’s Systolic & Diastolic blood pressure, ECG, Heart Beat, Temperature, Blood Oxygen Level. Fig.1 Website Fig.2 Hardware
  • 6. WHAT’S SO UNIQUE ?? • MORA => Measure Once Retrieve Anywhere. The data being measured can be retrieved(viewed) from anywhere around the world. This not only comes as an aid during this COVID-19 pandemic but also improves the reach of doctors in rural India where medication is still a dream. #medication_Is_A _Right • NON-INVASIVE => The device is non-invasive ie. there is no creation of skin breaks. Thus can be used even by an unskilled and an uneducated person. • PORTABLE => The device is almost the size of a watch thus making it a highly portable. • AFFORDABLE => The device measures 6 vital body parameters but still comes at an affordable price of $35 USD .
  • 7. SECRETE OF OUR COST EFFECTIVENESS DEVICES AVERAGE COST Thermometer $10 Blood Pressure Monitor $100 ECG Monitor $100 Total Cost === $210 Fig.3 Cost Of the devices when purchased separately Reduced the number of sensors : The sensors were so chosen such that the parameters to be extracted had either complete dependency or had a correlation factor greater than 80%. Sensors Used === ECG Sensor + SpO2 Clip
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  • 10. ABSORBANCE OF LIGHT CONCENTRATION OF THE SAMPLE BEER–LAMBERT LAW
  • 11. PPG – Photo Plethysmo Graph • When the heart beats, capillaries expand and contract based on blood volume changes. • Since light is more strongly absorbed by blood, the changes in blood flow can be detected by PPG sensors as changes in the intensity of light . • Voltage signal from PPG Quantity of blood flowing.
  • 12. SPO2 clip: Photodiode and IR led of 940nm wavelength. Uses of low-intensity Infrared green (IR) light. Optical Technique with motion-tolerant technology which is proved to be more faster and accurate than any tecchniques. Photoplethysmography is used to measure the blood volume changes in micro vascular bed tissues providing high precision . Photoplethysmograph:
  • 14. SITE OF MEASUREMENT The places where photoplethysmograph could be taken are 1. right and left ear lobes , 2. index fingers(method we use) , 3. great toes WHY FINGER?? • Noises can be reduced when compared to other sources. • Signal processing becomes easy when compared to signals from other places and Area of exposure is less.
  • 15. ELECTROCARDIOGRAPHY An SMD soldered chip along with electrodes to measure ECG. The electrodes are placed using the Einthoven’s triangle 3 Lead ECG is used in this process. Using ECG for each heart beat a pulse is produced which causes the blood to squeeze through the veins. It records the electrical activity of the heart using electrodes placed on the skin.
  • 16. EINTHOVEN'S TRIANGLE • Einthoven's triangle is an imaginary formation of three limb leads in a triangle used in electrocardiography . • The shape forms an inverted equilateral triangle with the heart at the center • The right leg electrode acts to reduce interference . • Each lead measures the electric field created by the heart during the depolarization and repolarization of myocytes
  • 18. PULSE TRANSIT TIME • Pulse transit time refers to the time it takes a pulse wave to travel between two arterial sites. • Speed of the arterial pressure wave Blood pressure. • Technology have allowed accurate estimation of the arrival of the pulse wave at a peripheral site such as the finger using photoplethysmography
  • 19. WHY PTT?? • Shows a strong correlation with blood pressure (measured by ABPM). • Provides continuous, non-invasive, cuff-less blood pressure . • The pulse pressure waveform is known to contain vital information - acts as an indicator of cardiovascular diseases.​ • PTT is not well correlated with absolute blood pressure values at a given point in time, but it is capable of predicting changes in blood pressure over a short period of time.
  • 20. PROPOSED SOLUTION ● The time difference between the generation of pressure at heart and the increase in blood volume at the peripheral site is denoted by Pulse Transit Time(PTT), and the velocity of the propagation of this pressure is pulse wave velocity (PWV). ● PTT is estimated from the measured ECG and photoplethysmogram (PPG), this method has been used to develop wearable devices to measure BP continuously and conveniently. ● Proposed solution = SpO2 sensor + Calibrating ECG module .BLOOD PRESSURE= SpO2 sensor + Calibrating ECG module .
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  • 22. COMPONENTS USED Processor • 32 Bit Processing SPO2 CLIP • PPG SENSOR OP-AMP • 4 channel OP-AMP • Notch Filter • Low Pass Filter • Inverting Amplifier RECHARGEABLE BATTERY • Type-B charger • 3.7V, 2.1A • Lithium-ion battery PCB ECG ELECTRODES • For obtaining ecg . • To form Einthoven's triangle. INSTRUMENTATION AMPLIER COMPONENTS USED Multilayer PCB Dimensions == 3.6cm*3.5cm For ECG Measurement
  • 23. ● The device modeling and development is under the guidelines of MEDICAL STANDARDS. ● The OP-amp is also a medically approved . ● The device is built-in in with no moving parts and an operating voltage of 3.3V. ● The SpO2 is a clinically approved blood saturation sensor with 940nm operation. DESIGN STANDARDS
  • 24. IT’S JUST A PROTOTYPE Fig.3 Product Circuitry Fig.4 Product Casing
  • 25. CUSTOMIZED DESIGN OF PCB Fig.5 3D Design of the PCB 3.6cm*3.5cm Fig.6 Back view of the PCB
  • 27. WORKING PHASE 1 : PPG EXTRACTION SpO2 Clip Notch filter + Low Pass Filter + Inverting Amplifier PPG Waveform Parameters Extraction
  • 28. WORKING PHASE 2 : ECG EXTRACTION ECG Electrodes Instrumentation Amplifier ECG Waveform Parameters Extracted
  • 29. WORKING ECG AND PPG WAVEFORM SIGNAL PROCESSING SYSTOLIC PEAK + R-R TIME + PTT + QRS COMPLEX PEAK+ SYSTOLIC-TO-SYSTOLIC TIME + PULSE WAVE VELOCITY PHASE 3 : PARAMETER EXTRACTION + SIGNAL PROCESSING Multiple Linear Regression Parameters
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  • 34. WEBSITE MORA- Measure Once Retrieve Anywhere DEVICE FireBase WEBSITE HTML, CSS, JavaScript, React, Chart.js
  • 39. WEBSITE Step-5: CLICK THE GENERATE BUTTON
  • 40. 1. MULTIPLE LINEAR REGRESSION : To determine Diastolic BP, Systolic BP, Heart Beat and Temperature from the Extracted Parameters. MACHINE LEARNING MODEL
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  • 42. BUILDING BLOCKS OF A BUSINESS MODEL :
  • 43. TARGETED CONSUMER DIETICIANS PSYCHIATRISTS BIO-MEDICAL SCIENTIST FITNESS TRAINERS Used by military fitness trainers to continuously monitor blood pressure during experimental exercise regiments. The effect of different drugs on blood pressure can be analyzed . To study the relationship between the emotions and blood pressure . The effect of different food habits on blood pressure can be found . HOSPITALS (ICU) Used in ICUs and operation theaters to continuously monitor blood pressure .
  • 44. VALUE PROPOSITIONS MORA Inbuilt WiFi Reserve Battery Predicts your future blood pressure values Increased life time* Inbuilt Bluetooth Portable Rechargeable battery No external field is used(risk reduction) Better User Interface 32-Bit Processor Lower cost*
  • 45. CHANNELS CUSTOMER RELATIONSHIP : Channels are established by, Advertising through partner owned websites Ie. through YOUTUBE channel (cpc –Rs 7 to Rs 21) GOOGLE (cpc-Rs 70 to Rs140) Types of customer relationship Types of customers Dedicated personal assistance High net worth clients (Eg Apollo Hospitals) Automated services Rest of the clients
  • 46. REVENUE STREAMS KEY RESOURCES • Device Cost • Advertisements Physical Workspace . Intellectual None Human Human resources for producing , marketing and customer care . Financial Stock option pool for the purchase of work-area .
  • 47. KEY PARTNERSHIP Establishing relationship with third party clients for • Delivering • Post purchase assistance and COST STRUCTURE : COMPONENTS COST (INR) SPO2 CLIP 1000 BATTERY 400 PCB FABRICATION 200 HARDWARE COMPLIANCES(ECG) 300 3D CASING 500 DESIGN AND TESTING 100 TOTAL 2500/-
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  • 49. FUTURISTIC SCOPE : Providing better UI for the website. The device can be made more accurate and region independent by taking more datasets. Improving the security of the website. Providing an App facility. Increase the scalability of the website . • COMPONENTS USED FUTURISTIC SCOPE
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  • 51. Patience is required in order to create a disruptive technology. But it takes greater patience to review it !!! Thanks for your patience. ~Team Alchemist