2. WHAT IS ANTIBIOTIC PROPHYLAXIS
Administration Of An Antibiotics Prior To Contamination
Of Previously Sterile Tissues .
The Use Of Antibiotics For Dirty And Contaminated
Procedure Is Not Prophylaxis...
3. GOALS OF ANTIBIOTICS PROPHYLAXIS ??
1ā¦ā¦ā¦Reduce the incidence of surgical site infection.
2ā¦ā¦. Minimize the effect on the patients normal bacterial
flora
3ā¦ā¦.Minimize adverse side effect of antibiotics.
4ā¦ā¦..Minimize the emergence of antibiotics resistance.
5ā¦ā¦ā¦Cost effectiveness.
6. CONSIDERATION TO CONTINUE AS
THERAPEUTIC.
ļBreach of sterility during surgery
ļExtensive contamination during surgery.
7. Use of prophylactic
antibiotics is not a
replacement for optimal
patient preparation, good
surgical technique and
theatre environment.
But keep in mind:
8. IMPORTANCE OF ANTIBIOTICS IN
DIF.TYPES OF
OPERATIONS
CLASS OF OPERATION SSI,WITH PROPHYLAXIS WITHOUT PROPHYLAXIS
1:-CLEAN SURGERY 1-2% SAME (1-2%)
2:-CLEAN CONTAMINATED 3% 6-9%
3:-contaminated 6% 13-20%
4:-dirty 7% 40%
9. TIMING OF PROPHYLXAXIS
ā¢ The risk begin s at the time of incision so effective
tissue concentration must be reached at that time ..
ā¢ Who ā¦ā¦ā¦within 60 mints prior to incision .
ā¢ Cdcā¦..Also recommends 60 mints
10. BUT
ā¢ The duration of antibiotics prophylaxis should not be
routinely exceed 24 hrs
ā¢ 1 dose preop and 2 doses post op ie total 3 doses ..
11. MICRO-ORGANISMS IN DIFFERENT SYSTEMS
ā¢ Git-colon ā¦.Ecoli , klebsiella ,enterobacter ,clostridia and
bacteriods
ā¢ Billiary tract ā¦ecloi , klebsiella and clostridia
ā¢ Skin ā¦.Staph.Aureus ,staph.Epidermidis
ā¢ Nose ā¦staph.Aureus ,pneumoccocus ,ecoli
ā¢ Mouth and pharynxā¦streptoccocus and pneumoccocus
ā¢ Urinary tractā¦.Ecoli , proteus ,
13. SURGICAL PROPHYLAXIS IN BILLIARY TRACT
PROCEDURE
ā¢ Antimicrobial prophylaxis is not necessary in low risk
patients undergoing elective laparoscopic
cholecystectomy..
ā¢ But its recommended in pts undergoing lap. Chole who
have an increased risk of infectious complications.
14. WHAT ARE SUCH RISKS
ā¢ EMERGENCY SURGERY ,DIABETIC PT , PROLONG PROCEDURE DURATION
EXCEEDING 120 MINTS ,INTRAOPERATIVE GALL BLADDER RUPTURE ,OPEN CHOLE
, ANTICIPATED BILE SPILLAGE , NON FUNCTIONING GALLBLADDER , ACUTE
CHOLECYSTITIS.
ā¢ BECAUSE SOME OF THESE FACTORS CANNOT BE DETERMIND BEFORE SURGERY
SO ITS REASONABLE TO GIVE ONE SINGLE DOSE OF PROPHYLAXIS
15. SMALL INTESTINE PROCEDURE
ā¢ For small intestine procedure with no evidence of
obstruction , first generation cephalosporine ie
cefazoline is recommended.
ā¢ For pt
ā¢ with obstructions a first generation cephalosporine with
flagyle or second generation cephalosporine with
anaerobic activity like cefoxitin or cefotetan is the
recommended agent.
16. APPENDECTOMY PROCEDURE
ā¢ Anaerobic and aerobic gram negative enteric organisms
ā¦
ā¢ Bacteroides fragilis is the most commonly cultured
anaerobe and ecoli ie the most frequent aerobe.
ā¢ So for uncomplicated appendicitis , the recommend
regimen is a single dose of a cephalosporine with
anaerobic activity like cefoxitin or first generation
cephalo. Plus flagyle.
17. COLORECTAL PROCEDURES
ā¢ B.Fragilis and other obligate anaerobe are the most
frequently
ā¢ Ecoli most common aerobe
ā¢ A single dose of second generation cephalosporine with
both aerobic and anaerobic activities or cefazoline plus
flagyle is recommended for colon procedures.
ā¢ In instituition where increasing resistance to fist and
second generation then can use ceftriaxone and flagyle.
18.
19.
20.
21. CONCLUSION OF PROPHYLAXIS
ā¢ Prophylactic antibiotics should be given in clean surgery
with prosthetic implant
ā¢ In clean contaminated.
ā¢ Should be given within 1 hour prior to surgery.
ā¢ Minimize unnecessary use of antibiotics to avoid
resistance
ā¢ Try to use right antibiotics for right choice .