albn10
2015-02-22 17:31
can you answer this question?
In this discussion, we will investigate confidence intervals and t tests for continuous data. To do this, we will revisit the TAA data that you studied in the Week Three assignment.
You may recall from the Week Three assignment that you have available data on 12 tumor-associated antigens (TAAs), from 90 normal individuals (controls) and 160 hepatocellular carcinoma patients (cases). These data are in the Excel file
MHA610_Week 3_Assignment_Data.xls
; the levels of the 12 TAAs are given in the columns with headings Ab14, HCC1, IMP1, KOC, MDM2, NPM1, P16, P53, P90, RaIA, and Survivin.
First, randomly select three of the 12 TAAs for further study.
Next, Perform two sample t-tests for comparing the levels of each of your three TAAs between the cases and the controls.
Then, Use the t-tests to order the TAAs in terms of relative ability to discriminate between the cases and controls, from best to worst discriminator. Is this ordering helpful if you want to select a subset of TAAs to discriminate between cases and controls? Assume for now that you can judge the relative merits of your three TAAs by the magnitudes of their respective two-sided p-values from the two sample t-tests, so that your best discriminator is the TAA with the smallest p-value.
Lastly, Construct and report 95% confidence intervals for the mean level of your best TAA discriminator in the controls, the mean level of your best TAA discriminator in the cases, and the difference in mean levels (cases - controls). Discuss whether your confidence intervals are concordant with the t-tests.
source
group
groupid
Ab14
HCC1
IMP1
KOC
MDM2
NPM1
P16
P53
P62
P90
SD
control
0
0.102
0.068
0.083
0.023
0.117
0.12
0.102
0.098
0.177
0.097
SD
control
0
0.02
0.06
0.035
0.016
0.005
0.004
0.017
0.014
0.049
0.011
SD
control
0
0.064
0.13
0.111
0.058
0.092
0.046
0.258
0.057
0.28
0.05
SD
control
0
0.068
0.041
0.056
0.019
0.077
0.05
0.067
0.055
0.104
0.049
SD
control
0
0.036
0.07
0.067
0.04
0.026
0.019
0.057
0.027
0.107
0.019
SD
control
0
0.049
0.188
0.079
0.063
0.073
0.018
0.107
0.053
0.128
0.027
SD
control
0
0.053
0.231
0.214
0.105
0.05
0.009
0.277
0.061
0.253
0.06
SD
control
0
0.071
0.045
0.133
0.19
0.086
0
0.098
0.055
0.161
0.058
SD
control
0
0.066
0.139
0.105
0.065
0.095
0.041
0.193
0.075
0.188
0.037
SD
control
0
0.071
0.077
0.095
0.039
0.132
0.058
0.22
0.077
0.108
0.064
SD
control
0
0.033
0.091
0.064
0.059
0.012
0.01
0.039
0.034
0.087
0.025
SD
control
0
0.053
0.024
0.06
0.026
0.147
0.102
0.114
0.064
0.108
0.05
SD
control
0
0.045
0.014
0.05
0.02
0.045
0.144
0.051
0.039
0.049
0.029
SD
control
0
0.153
0.08
0.071
0.034
0.021
0.118
0.063
0.041
0.071
0.029
SD
control
0
0.033
0.023
0.047
0.019
0.048
0.219
0.056
0.043
0.071
0.039
SD
control
0
0.111
0.047
0.104
0.049
0.103
0.064
0.285
0.09
0.185
0.452
SD
control
0
0.082
0.023
0.071
0.258
0.091
0.129
0.116
0.055
0.165
0.11
SD
control
0
0.115
0.01
0.383
0.162
0.113
0.229
0.298
0.075.
After studying the assigned reading The Handbook of Communication .docx
albn102015-02-22 1731can you answer this questionIn this dis.docx
1. albn10
2015-02-22 17:31
can you answer this question?
In this discussion, we will investigate confidence intervals and t
tests for continuous data. To do this, we will revisit the TAA
data that you studied in the Week Three assignment.
You may recall from the Week Three assignment that you have
available data on 12 tumor-associated antigens (TAAs), from 90
normal individuals (controls) and 160 hepatocellular carcinoma
patients (cases). These data are in the Excel file
MHA610_Week 3_Assignment_Data.xls
; the levels of the 12 TAAs are given in the columns with
headings Ab14, HCC1, IMP1, KOC, MDM2, NPM1, P16, P53,
P90, RaIA, and Survivin.
First, randomly select three of the 12 TAAs for further study.
Next, Perform two sample t-tests for comparing the levels of
each of your three TAAs between the cases and the controls.
Then, Use the t-tests to order the TAAs in terms of relative
ability to discriminate between the cases and controls, from best
to worst discriminator. Is this ordering helpful if you want to
select a subset of TAAs to discriminate between cases and
controls? Assume for now that you can judge the relative
merits of your three TAAs by the magnitudes of their respective
two-sided p-values from the two sample t-tests, so that your
best discriminator is the TAA with the smallest p-value.
Lastly, Construct and report 95% confidence intervals for the
mean level of your best TAA discriminator in the controls, the
mean level of your best TAA discriminator in the cases, and the
difference in mean levels (cases - controls). Discuss whether
your confidence intervals are concordant with the t-tests.
source
group