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What is cancer
• Cancer, one of the most deadly in 21st century,
• Officially become the most dangerous killer in the world – World Health
Organization.
• Disease of the body's cells.
• Normally cells grow and multiply in a controlled way, however, if something
causes a mistake to occur in the cells' genetic blueprints, this control can be
lost.
• Cancer is the term used to describe collections of these cells, growing and
potentially spreading within the body.
• As cancerous cells can arise from almost any type of tissue cell, cancer
actually refers to about 100 different diseases affecting nearly every part of
the body
• Cancer cells that do not spread beyond the immediate area in which they
arise are said to be benign ie. they are not dangerous.
• If these cells spread into surrounding areas, or to different parts of
the body, they are known as malignant - commonly referred to as
cancer.
• Malignant, or cancerous tumors crowd out healthy cells, interfere
with body functions, and draw nutrients from body tissues
• Breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer,
and lymphoma are the common types of cancer
• Cancers continue to grow and spread by direct extension or through a
process called metastasis, whereby the malignant cells travel through
the lymphatic or blood vessels -- eventually forming new tumors in
other parts of the body.
Ayurveda and Cancer
• Cancer in Ayurveda – all three doshas (Vata, Pitta and Kapha) are out
of control.
• Tridoshic imbalance (Tridoshaja or Sannipataja) – growth of malignant
tumors.
• Combination of any two of Vataja, Pittaja or Kaphaja is used to signify
a benign neoplasm (abnormal growth of cells in the body)
• Ayurveda, the oldest Indian indigenous medicine system of plant &
metal drugs are known from very early times for preventing or
suppressing various tumors using these natural drugs.
• Nowadays scientists are keener to researches on complementary
and alternative medicine for the management of cancer.
• In Ayurvedic concept, according to ‘Charaka’ and ‘Sushruta
Samhitas’ cancer is described as inflammatory or non-inflammatory
swelling and mentioned either as ‘Granthi’ (minor neoplasm) or
‘Arbuda‘ (major neoplasm).
• The nervous system (Vata or air), the venous system (Pitta or fire)
and the arterial system (Kapha or water) are three basics of
Ayurveda and very important for normal body function.
• In malignant tumors all three systems get out of control (Tridoshas)
and lose mutual coordination that causes tissue damage, resulting
critical condition.
• Tridoshas cause excessive metabolic crisis resulting in proliferation.
Cytocruel
In Vitro Anticancer Activity
In Vivo Chronic Toxicity Study
Acute Toxicity Study of Cytocruel
Cytocruel
• Helps in stopping growth of cancer cells.
• Anti – tumor qualities prevent development of tumors.
• A successful herbal formulation in boosting the immune system.
• Improves the body’s ability to fight cancer.
• Increase the body’s tolerance towards radiotherapy and
chemotherapy.
Cytocruel Capsules
• Cutocruel Caps
• Sarveshvar Parpati – 14.4 mg
• Suvarna Bhasma (Gold oxide) – 3.6 mg
• Ras Kapoor (Mercury sulphide) – 14.4 mg
• Swet Mirch (Piper album) – 42 mg
• Abhrak Bhasma (Mica) – 1.2 mg
• Punarvava Ext. (Boerhavia diffusa) – 25
mg
• Yashtimadhu Ext. (Glycyrrhiza glabra) – 25
mg
• Vasaka Ext. (Adhatoda vasica) – 25 mg
• Hirak Bhasma (Diamond oxide) – 0.3 mg
• Ras Sindur (Ferrous oxide) – 14.4 mg
• Tamra Bhasma (Copper oxide)– 27.6 mg
• Lavang (Syzygium aromaticum) – 21.6 mg
• Panna Bhasma (Emerald oxide) – 0.5 mg
• Saragava (Moringa oleifera) – 25 mg
• Rohitak chhal Ext. (Tecomma undulate) –
25 mg
• Guduchi Ext (Tinospora cordifolia)– 25 mg
Cytocruel AT Tablets
• Cutocruel AT Tablets
• Sarveshvar Parpati – 15 mg
• Suvarna Bhasma (Gold oxide) – 4 mg
• Hirak Bhasma – 1.5 mg
• Abhrak Bhasma 1000 puti (Mica) – 5 mg
• Punarvava Ext. (Boerhavia diffusa) – 30 mg
• Vasaka Ext. (Adhatoda vasica) – 30 mg
• Tamra Bhasma (Copper oxide)– 28 mg
• Panna Bhasma (Emerald oxide) – 1 mg
• Saragava (Moringa oleifera) – 30 mg
• Rohitak chhal Ext. (Tecomma undulate) – 32
mg
• Guduchi Ext (Tinospora cordifolia)– 35 mg
• Kanchnar Guggullu – 40 mg
• Draksha Ext (Vitis vinifera) – 30 mg
• Apple Ext. ( Pyrus malus) – 30 mg
• Green Tea Ext. (Camellia simemsis) – 25 mg
• Aloe Vera Ext. (Aloe barbadensis) – 32 mg
• Ashwagandha (Withania somnifera) – 50 mg
• Haldi Ext. (Curcuma longa) – 20 mg
• Triphala Guggullu – 20 mg
• Mahamanjisthadi Ghan Powder – 30 mg
• Yashtimadhu Ext. (Glycyrrhiza glabra) – 25 mg
• Sunthi (Zingiber officinale) – 30 mg
• Talish Patra (Taxus baccata) – 20 mg
How can Cytocruel AT prevent spreading Cancer
• Fight against tumor (Benign) and primary stage of the cancer
• Act as an adjuvant or a co-therapy along with chemotherapy or radiotherapy
• Post surgery care
• Acts as rasayana. Improving comfort and quality of life.
• Reduce tridoshas
• Side effect of Radio and Chemo therapy
• Antioxidant
• Chemotherapy drugs and some biological therapies can reduce RBC, WBC and
platelets count.
• In Vivo study with Cytocruel the blood cells ration did not affect.
• Serum biochemical parameters as Hb, % Blood cells, Glucose, Triglyceride,
Cholestrol, Urea, Serum Creatinine and HDL were not affected by the treatment
with Cytocruel.
In-Vitro Anticancer activity of CYTOCRUEL
• Herbo-mineral combination
• Anti-cancer activity
• antioxidant,
• anti-inflammatory,
• analgesic,
• antidiarrheal,
• anti-tubercular,
• immune-stimulant,
• hepatoprotective and powerful rejuvenating properties.
• Cytocruel can be used in treatment of various types of cancer.
How Cytocruel stop the growth of tumors?
• Suvarna Bhasma:
• Nano particles of Gold stops the growth of
cancer cells
• Improve immunity to fight off the unwanted
growth of tissues.
• Strong antibacterial against Mycobacterium
tuberculosis.
• Hira Bhasma:
• Advancement of cancer to other part of the
body (Metastasis)
• Immunity
• Reduce tumor size
• 7 different tissues as per Ayurveda: Rasa,
Rakta, Mansa, Meda, Asthi, Majja and Shukr
affected due to cancer can be directly
treated with Hira Bhasma
Combination of these 3 bhasmas is more effective in initial stages of cancer along
with Abhrak Bhasma 1000 puti.
• Tamra Bhasma:
• Tumor formation
• Metastasis
• Energy, relief from fatigue
• Abhrak Bhasma:
• For breathlessness due to Ch Bronchitis,
Asthma, Chest Congestion, Initial stage of TB.
• Nourishes all the 7 dhatus
• Aromatic and stimulates thymus gland to
increase production of T Cell phagocytes.
Increase immunity.
• Anti-viral, Anti-bacterial
• Well known hematinic, Increase RBC and
thereby increasing oxygen capacity.
• Well known for anti-cancer effect as in
leukemia.
• Also beneficial in breast cancer.
How build immunity during chemotherapy and radiotherapy treatment?
• Rasayana drugs
• Guduchi, Punarnava are Tridoshas shaamak.
• Side effect of Alopecia, Nausea, Nail Changes, Constipation, Anorexia and Vomiting. (Study shows)
• Myelo suppression delayed
• Punarnava (Boerhavia diffusa):
• Punarnavine, alkaloid is anticancer agent
• Immune response
• Inhibit the metastatic progression of melanoma cells
• Used whole plant
• Hepatoprotective, Choleretic, anti-cancer and anti-oxidant.
• In breast cancer inhibit drug efflux (flowing out) activity of BRCP (breast cancer resistance protein),
a multidrug transporter responsible for cancer resistance to chemotherapy.
• Guduchi (Tinospora cardifolia):
• Immunoglobulin and leukocytes by stimulation od stem cells.
• Reduce solid tumor volume by 58.8%, comparable to cyclophosphamide.
• Can be used in the prevention of tumors mediated immunosuppression and choice for various
cancer.
• Sargava Ext. (Moringa olifera):
• Vitamins A & C, Minerals (Calcium, Irom, Potassium) and Amino Acids for health & immunity.
• Study shown its anti-tumor capacity.
• Benzyl isothiocyanate in Sargava have anti-cancer and chemoprotective capabilities.
NAME QUANTITY ACTIVITY
SarveshvarParpati(Sulphur&Mercury) 15mg Anti-cancer,Anti-tubercularandImmuno-stimulant
SuvarnaBhasma(Goldoxide) 4mg Immunebooster,Aphrodisiac,CardiacTonic
HirakBhasma(Diamondoxide) 1.5mg Anti-cancer
AbhrakBhasma1000puti(MicaBhasma) 5mg
Immunomodulator,Antacid,Anti-depressant,Anti-inflammatory,Aphrodisiac,Energy
booster,Hematogenic,Hepatoprotective,Nervuinestimulant
PunarvavaExt.(Boerhaviadiffusa) 30mg Anti-cancer,Hepatoprotective,Antioxidant,Analgesic
VasakaExt.(Adhatodavasica) 30mg Anti-cancer,Anti-tubercular,Anti-bacterialandCholagouge
TamraBhasma(Copperoxide) 28mg Anti-tubercular,Anemia,Dyspepsia,andPoisining.
PannaBhasma(Emeraldoxide) 1mg Strengthensnervoussystem
Saragava(Moringaoleifera) 30mg
Anti-cancer(leukemia&Breastcancer),Immunomodulator,Hematinic,Increase
breathingcapacity
RohitakchhalExt.(Tecommaundulate) 32mg Anti-cancer,Anti-bacterial,Analgesic,Hepatoprotective
GuduchiExt(Tinosporacordifolia) 35mg Anti-neoplastic,Hepatoprotective,Antioxidant,Jaundice
NAME QUANTITY ACTIVITY
Kanchnar Guggullu 40mg
Reduces Tumour Tissues by inhibiting abnormal growth of the cancerous cells.
Immunomodulator,
Draksha Ext (Vitis vinifera) 30mg
The JNK protein found in grape seed extracts can neutralize cancer cells by up to 76
percent of the root without any side effects.
Apple Ext. ( Pyrus malus) 30mg
one type of antioxidant, called procyanidins, triggered a series of cell signals that resulted
in cancer cell death.
Green Tea Ext. (Camellia simemsis) 25mg Chemo-protective, Inhibits Tumor genesis. Antioxidant.
Aloe Vera Ext. (Aloe barbadensis) 32mg
Acemannan in aloe vera leaf stimulates immune cells to produce Cytokines (cancer-killing
chemicals), Some chemicals in aloe have effects on immune system and can shrink some
cancers.
Ashwagandha (Withania somnifera) 50mg
Anti-inflammatory, relax the central nervous system. Enhance immune cells and impair or
kill cancer cells.
Haldi Ext. (Curcuma longa) 20mg Chemo-protective, Prevents Angiogenesis & Metastasis,
Triphala Guggullu 20mg Inhibits growth in cancerous cells . Chebulinicacid in Triphala has anti-cancer properties.
Mahamanjisthadi Ghan Powder 30mg Blood purifier. Removes toxicmaterials from blood during Chemo and Radio therapy.
Yashtimadhu Ext. (Glycyrrhiza glabra) 25mg Anti-cancer, Anti-inflammatory, Demulcent, Expectorant, Tonic
Sunthi (Zingiber officinale) 30mg
Indigestion, Flatulence, Abdominal pain, Anorexia, Heart disease, Oedema, Arthritis,
Atonicdyspepsia, Bleeding, Cancer and other conditions.
Talish Patra (Taxus baccata) 20mg Highly effective in Breast and Ovarian cancer. Analgesic, Anti-cancer, Anticonvulsant.
• Indication:
• Primary carcinoma
• Abnormal Tissue Growth
• Immune disorders
• Chronic wounds and gangrene
• PCOD
• Tuberculosis
• Dosages:
• Adult: 1 to 2 Caps/ tabs 2 to 3 times a day or directed by physician

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Cytocruel at

  • 1.
  • 2. What is cancer • Cancer, one of the most deadly in 21st century, • Officially become the most dangerous killer in the world – World Health Organization. • Disease of the body's cells. • Normally cells grow and multiply in a controlled way, however, if something causes a mistake to occur in the cells' genetic blueprints, this control can be lost. • Cancer is the term used to describe collections of these cells, growing and potentially spreading within the body. • As cancerous cells can arise from almost any type of tissue cell, cancer actually refers to about 100 different diseases affecting nearly every part of the body • Cancer cells that do not spread beyond the immediate area in which they arise are said to be benign ie. they are not dangerous.
  • 3. • If these cells spread into surrounding areas, or to different parts of the body, they are known as malignant - commonly referred to as cancer. • Malignant, or cancerous tumors crowd out healthy cells, interfere with body functions, and draw nutrients from body tissues • Breast cancer, skin cancer, lung cancer, colon cancer, prostate cancer, and lymphoma are the common types of cancer • Cancers continue to grow and spread by direct extension or through a process called metastasis, whereby the malignant cells travel through the lymphatic or blood vessels -- eventually forming new tumors in other parts of the body.
  • 4.
  • 5.
  • 6. Ayurveda and Cancer • Cancer in Ayurveda – all three doshas (Vata, Pitta and Kapha) are out of control. • Tridoshic imbalance (Tridoshaja or Sannipataja) – growth of malignant tumors. • Combination of any two of Vataja, Pittaja or Kaphaja is used to signify a benign neoplasm (abnormal growth of cells in the body) • Ayurveda, the oldest Indian indigenous medicine system of plant & metal drugs are known from very early times for preventing or suppressing various tumors using these natural drugs.
  • 7. • Nowadays scientists are keener to researches on complementary and alternative medicine for the management of cancer. • In Ayurvedic concept, according to ‘Charaka’ and ‘Sushruta Samhitas’ cancer is described as inflammatory or non-inflammatory swelling and mentioned either as ‘Granthi’ (minor neoplasm) or ‘Arbuda‘ (major neoplasm). • The nervous system (Vata or air), the venous system (Pitta or fire) and the arterial system (Kapha or water) are three basics of Ayurveda and very important for normal body function. • In malignant tumors all three systems get out of control (Tridoshas) and lose mutual coordination that causes tissue damage, resulting critical condition. • Tridoshas cause excessive metabolic crisis resulting in proliferation.
  • 8.
  • 9. Cytocruel In Vitro Anticancer Activity In Vivo Chronic Toxicity Study Acute Toxicity Study of Cytocruel
  • 10. Cytocruel • Helps in stopping growth of cancer cells. • Anti – tumor qualities prevent development of tumors. • A successful herbal formulation in boosting the immune system. • Improves the body’s ability to fight cancer. • Increase the body’s tolerance towards radiotherapy and chemotherapy.
  • 11. Cytocruel Capsules • Cutocruel Caps • Sarveshvar Parpati – 14.4 mg • Suvarna Bhasma (Gold oxide) – 3.6 mg • Ras Kapoor (Mercury sulphide) – 14.4 mg • Swet Mirch (Piper album) – 42 mg • Abhrak Bhasma (Mica) – 1.2 mg • Punarvava Ext. (Boerhavia diffusa) – 25 mg • Yashtimadhu Ext. (Glycyrrhiza glabra) – 25 mg • Vasaka Ext. (Adhatoda vasica) – 25 mg • Hirak Bhasma (Diamond oxide) – 0.3 mg • Ras Sindur (Ferrous oxide) – 14.4 mg • Tamra Bhasma (Copper oxide)– 27.6 mg • Lavang (Syzygium aromaticum) – 21.6 mg • Panna Bhasma (Emerald oxide) – 0.5 mg • Saragava (Moringa oleifera) – 25 mg • Rohitak chhal Ext. (Tecomma undulate) – 25 mg • Guduchi Ext (Tinospora cordifolia)– 25 mg
  • 12. Cytocruel AT Tablets • Cutocruel AT Tablets • Sarveshvar Parpati – 15 mg • Suvarna Bhasma (Gold oxide) – 4 mg • Hirak Bhasma – 1.5 mg • Abhrak Bhasma 1000 puti (Mica) – 5 mg • Punarvava Ext. (Boerhavia diffusa) – 30 mg • Vasaka Ext. (Adhatoda vasica) – 30 mg • Tamra Bhasma (Copper oxide)– 28 mg • Panna Bhasma (Emerald oxide) – 1 mg • Saragava (Moringa oleifera) – 30 mg • Rohitak chhal Ext. (Tecomma undulate) – 32 mg • Guduchi Ext (Tinospora cordifolia)– 35 mg • Kanchnar Guggullu – 40 mg • Draksha Ext (Vitis vinifera) – 30 mg • Apple Ext. ( Pyrus malus) – 30 mg • Green Tea Ext. (Camellia simemsis) – 25 mg • Aloe Vera Ext. (Aloe barbadensis) – 32 mg • Ashwagandha (Withania somnifera) – 50 mg • Haldi Ext. (Curcuma longa) – 20 mg • Triphala Guggullu – 20 mg • Mahamanjisthadi Ghan Powder – 30 mg • Yashtimadhu Ext. (Glycyrrhiza glabra) – 25 mg • Sunthi (Zingiber officinale) – 30 mg • Talish Patra (Taxus baccata) – 20 mg
  • 13. How can Cytocruel AT prevent spreading Cancer • Fight against tumor (Benign) and primary stage of the cancer • Act as an adjuvant or a co-therapy along with chemotherapy or radiotherapy • Post surgery care • Acts as rasayana. Improving comfort and quality of life. • Reduce tridoshas • Side effect of Radio and Chemo therapy • Antioxidant • Chemotherapy drugs and some biological therapies can reduce RBC, WBC and platelets count. • In Vivo study with Cytocruel the blood cells ration did not affect. • Serum biochemical parameters as Hb, % Blood cells, Glucose, Triglyceride, Cholestrol, Urea, Serum Creatinine and HDL were not affected by the treatment with Cytocruel.
  • 14. In-Vitro Anticancer activity of CYTOCRUEL • Herbo-mineral combination • Anti-cancer activity • antioxidant, • anti-inflammatory, • analgesic, • antidiarrheal, • anti-tubercular, • immune-stimulant, • hepatoprotective and powerful rejuvenating properties. • Cytocruel can be used in treatment of various types of cancer.
  • 15. How Cytocruel stop the growth of tumors? • Suvarna Bhasma: • Nano particles of Gold stops the growth of cancer cells • Improve immunity to fight off the unwanted growth of tissues. • Strong antibacterial against Mycobacterium tuberculosis. • Hira Bhasma: • Advancement of cancer to other part of the body (Metastasis) • Immunity • Reduce tumor size • 7 different tissues as per Ayurveda: Rasa, Rakta, Mansa, Meda, Asthi, Majja and Shukr affected due to cancer can be directly treated with Hira Bhasma Combination of these 3 bhasmas is more effective in initial stages of cancer along with Abhrak Bhasma 1000 puti. • Tamra Bhasma: • Tumor formation • Metastasis • Energy, relief from fatigue • Abhrak Bhasma: • For breathlessness due to Ch Bronchitis, Asthma, Chest Congestion, Initial stage of TB. • Nourishes all the 7 dhatus • Aromatic and stimulates thymus gland to increase production of T Cell phagocytes. Increase immunity. • Anti-viral, Anti-bacterial • Well known hematinic, Increase RBC and thereby increasing oxygen capacity. • Well known for anti-cancer effect as in leukemia. • Also beneficial in breast cancer.
  • 16. How build immunity during chemotherapy and radiotherapy treatment? • Rasayana drugs • Guduchi, Punarnava are Tridoshas shaamak. • Side effect of Alopecia, Nausea, Nail Changes, Constipation, Anorexia and Vomiting. (Study shows) • Myelo suppression delayed • Punarnava (Boerhavia diffusa): • Punarnavine, alkaloid is anticancer agent • Immune response • Inhibit the metastatic progression of melanoma cells • Used whole plant • Hepatoprotective, Choleretic, anti-cancer and anti-oxidant. • In breast cancer inhibit drug efflux (flowing out) activity of BRCP (breast cancer resistance protein), a multidrug transporter responsible for cancer resistance to chemotherapy. • Guduchi (Tinospora cardifolia): • Immunoglobulin and leukocytes by stimulation od stem cells. • Reduce solid tumor volume by 58.8%, comparable to cyclophosphamide. • Can be used in the prevention of tumors mediated immunosuppression and choice for various cancer. • Sargava Ext. (Moringa olifera): • Vitamins A & C, Minerals (Calcium, Irom, Potassium) and Amino Acids for health & immunity. • Study shown its anti-tumor capacity. • Benzyl isothiocyanate in Sargava have anti-cancer and chemoprotective capabilities.
  • 17. NAME QUANTITY ACTIVITY SarveshvarParpati(Sulphur&Mercury) 15mg Anti-cancer,Anti-tubercularandImmuno-stimulant SuvarnaBhasma(Goldoxide) 4mg Immunebooster,Aphrodisiac,CardiacTonic HirakBhasma(Diamondoxide) 1.5mg Anti-cancer AbhrakBhasma1000puti(MicaBhasma) 5mg Immunomodulator,Antacid,Anti-depressant,Anti-inflammatory,Aphrodisiac,Energy booster,Hematogenic,Hepatoprotective,Nervuinestimulant PunarvavaExt.(Boerhaviadiffusa) 30mg Anti-cancer,Hepatoprotective,Antioxidant,Analgesic VasakaExt.(Adhatodavasica) 30mg Anti-cancer,Anti-tubercular,Anti-bacterialandCholagouge TamraBhasma(Copperoxide) 28mg Anti-tubercular,Anemia,Dyspepsia,andPoisining. PannaBhasma(Emeraldoxide) 1mg Strengthensnervoussystem Saragava(Moringaoleifera) 30mg Anti-cancer(leukemia&Breastcancer),Immunomodulator,Hematinic,Increase breathingcapacity RohitakchhalExt.(Tecommaundulate) 32mg Anti-cancer,Anti-bacterial,Analgesic,Hepatoprotective GuduchiExt(Tinosporacordifolia) 35mg Anti-neoplastic,Hepatoprotective,Antioxidant,Jaundice
  • 18. NAME QUANTITY ACTIVITY Kanchnar Guggullu 40mg Reduces Tumour Tissues by inhibiting abnormal growth of the cancerous cells. Immunomodulator, Draksha Ext (Vitis vinifera) 30mg The JNK protein found in grape seed extracts can neutralize cancer cells by up to 76 percent of the root without any side effects. Apple Ext. ( Pyrus malus) 30mg one type of antioxidant, called procyanidins, triggered a series of cell signals that resulted in cancer cell death. Green Tea Ext. (Camellia simemsis) 25mg Chemo-protective, Inhibits Tumor genesis. Antioxidant. Aloe Vera Ext. (Aloe barbadensis) 32mg Acemannan in aloe vera leaf stimulates immune cells to produce Cytokines (cancer-killing chemicals), Some chemicals in aloe have effects on immune system and can shrink some cancers. Ashwagandha (Withania somnifera) 50mg Anti-inflammatory, relax the central nervous system. Enhance immune cells and impair or kill cancer cells. Haldi Ext. (Curcuma longa) 20mg Chemo-protective, Prevents Angiogenesis & Metastasis, Triphala Guggullu 20mg Inhibits growth in cancerous cells . Chebulinicacid in Triphala has anti-cancer properties. Mahamanjisthadi Ghan Powder 30mg Blood purifier. Removes toxicmaterials from blood during Chemo and Radio therapy. Yashtimadhu Ext. (Glycyrrhiza glabra) 25mg Anti-cancer, Anti-inflammatory, Demulcent, Expectorant, Tonic Sunthi (Zingiber officinale) 30mg Indigestion, Flatulence, Abdominal pain, Anorexia, Heart disease, Oedema, Arthritis, Atonicdyspepsia, Bleeding, Cancer and other conditions. Talish Patra (Taxus baccata) 20mg Highly effective in Breast and Ovarian cancer. Analgesic, Anti-cancer, Anticonvulsant.
  • 19. • Indication: • Primary carcinoma • Abnormal Tissue Growth • Immune disorders • Chronic wounds and gangrene • PCOD • Tuberculosis • Dosages: • Adult: 1 to 2 Caps/ tabs 2 to 3 times a day or directed by physician