2. Introduction
It is an abnormal condition of the placenta where they are
partly degenerative and partly proliferative changes in the
young chorionic villi.
These result in the formation of the clusters of the small
cysts of varying size.
3. Introduction contd……
Because of its superficial resemblance to hydratid cyst, it is
named as hydratidiform mole.
It is best regardes as a benign neoplasia of the chorion with
malignant potential.
4. Incidence
There is a wide range of geographical and ethnic variation
of the prevalence of the condition . It is more common in
China, Indonesia ,Japan.
Highest in philippines-1 in 100 pregnancy
Lowest in European countries(USA)-1in 2000
Incidence in India –1 in 400
6. Classification
Partial mole
• Some fetal tissue ,blood vessels and villi present
Complete mole
• No fetal tissue , blood vessels and villi formation
7. Etiology
The cause is not definitely known ,but it appears to be
related to the ovular defect as it sometimes affects one ovum
of a twin pregnancy .however, the following faactors and
hypothesis have been forwarded:
8. Etiology contd..
Its prevalence is higher in teenagers and in women aged
beyond 35 years.
The prevalence appears to vary with race and ethnic group
Inadequate intake of protein , carotene and high intake of
animal fat specially in oriental countries.
Imbalance immune mechanism eg in hepatic disease rise in
gamaglobuline ,AB blood group.
9. Etiology contd.....
Cytogenetic abnormalities
The higher the ratio of paternal :maternal chromosomes,
the greater is the molar change . Complete mole show 2:1
ratio
History of prior hydratidiform mole increases the chance of
recurrence(1 to 4%).
11. Pathophysiology contd…..
Death of the ovum or failure of the embryo to grow is
essential to develop complete hydratidiform mole
The secretion from hyperplastic cells and transferred
substances from the maternal blood accumulate in the
stroma of the villi
Results in the distension of the villi to form vessicles
14. b. vomitting become excessive
c.breathlessness due to pulmonary embolism of trophoblastic
cell
Expulsion of grapes like vesicles per vagina is diagnose of
vesicle mole
History of quickening is absent
15. Sign
Feature suggestive of early months of pregnancy are
evident
The patient look more ill than can be accounted for.
Pallor is usually prominent ,out of the proportion of the
visible blood loss
16. Feature of preeclampsia due to the hyperactivity of the
trophoblastic cells
Per abdomen :
The size of the uterus : larger
The feel of the uterus : firm elastic
Fetal parts: not palpable
Absence of fetal heart sound
17. Vaginal examination
Internal ballottement can not be elicited
Finding of the vesicles in the vaginal discharge
If cervical os is open, instead of membranes,blood clot or
the vesicles may be felt.
18. Investigations
Full blood count ,ABO and Rh typing
Hepatic ,renal and thyroid function are carried out
Sonography:
Qualitative estimation of chorionic gonadotrophin
Straight X- ray abdomen
CT and MRI
Beta –hCG estimation
20. Complication
Haemorrhage and shock due to vaginal bleeding over a
time
Sepsis – inccrease the chances of ascending infection due
to blood clot ,vaginal bleeding and absence of fetal
membrane
Uterine perforation – due to invasive mole or surgical
procedure
21. Complication contd…..
Gestational trophoblastic disease – it may develop
persistently elevated beta –hCG and may lead to
choriiocarcinoma
Recurrence – there are chances of recurrence of the mole in
subsequent pregnancies.
22. Management
The principle of management are :
Supportive therapy to restore the blood pressure and
infection
Evacuation of the uterus as soon as diagnosis is made
Counselling for regular follow up to detect the persistent
trophoblastic disease
23. Management Contd…
1.supportive management
Group A – the patient usually presents with various amount
of bleeding :
to starts a ringers solution I.V. infusion
Arrangement is made for blood transfusion
25. Management contd…...
2. Definitive management :
Suction evacuation (it is the treatment of choice
irrespective of the uterine size)
suctioning with manual vacuum aspiration is safe, which
should be done rapidly. The risk of perforation is high in
using metal curettage.
26. Management contd…
digital exploration and removal of the mole by ovum
forceps may helpful to evacuate the content of the uterus.
Infuse oxytocin 20 unit in 1 liter IV fluids (NS or RL) at 60
drops per minute to prevent hemorrhage once evacuation is
under way.
Administration of Rh ( D) immunoglobulin to women who
are Rh negative to prevent isoimmunization
27. Management contd……
Hysterotomy : the procedure are rarely done. The
indications are;
Profuse vaginal bleeding
Cervix unfavourable for immediate vaginal evacuation
28. Management contd…
Hysterectomy :this is indicated in;
Patient with age over 35
High risk patient with development of future malignancy
Female has completed her family irrespective of age
Perforating mole
Placental site trophoblastic tumor
29. Management contd….
2. Follow up management:
Routine follow up is mandatory for all cases for at least 6
months following molar pregnancy.
first B- hCG level is obtained 48 hours after evacuation
Then monitor serum hCG levels every weekly till they
become normal for three consecutive weeks.
30. Management contd….
Once the hCG levels falls to a normal level for 3 weeks,
test the patient monthly for 6 months; then follow- up is
discontinued and pregnancy allowed.
During the 6 month surveillance period, patient is advised
not to become pregnant.
31. Contraceptive advice
Contractive of choice being combined oral pills
IUD is contraindicated, because of its frequence
association of the irregular bleeding
Inj. DMPA can be used safely
surgical sterilization is another alternative when family
size is complete