1. Least Action Parametric
Quantification of AD NaKATPase in E-E Compensation
For background information
see Gibbs Molar Action

2. Gibbs Molar Action
As derived from Transition
State Theory, Ralph Sherman,
IDTech ca. 2011

3. Concerning the roll of
“Action” in Enzyme Kinetics
How much energy, for how long

4. k = A / e ^ G / RT
GMA = G / k
= joule second / mol^2

5. See the work of:
Arthur Iberall, H. Soodak, Homeokinetics
F. Eugene Yates, Homeodynamics, 2008
On Varieties of information 2012

6. Thanks to Bradley Droessler for critical
review and technical support.
My public profile on LinkedIn is:
http://www.linkedin.com/pub/ralph-sherman/19/571/2a

7. 8) Kairane C, et al. Tartu University, Estonia
Regulation of the frontocortical sodium pump by
Na+ in Alzheimer's disease: difference from the agematched control but similarity to the rat model.
FEBS Lett. 2002 Nov 6;531(2):241-4. PubMed
PMID: 12417319.
9) Salum T, et al Tartu University, Estonia.
tiit.salum@kliinikum.ee
Temperature dependence of the sodium pump is
altered in the cerebral cortex of CCK2 receptordeficient mice
Neurochem Res. 2010 May;35(5):688-92. Epub
2010 Jan 8.

8. Fig. 5. Temperature (Arrhenius) dependence of
the Na,K-ATPase activity in the membranes from
AD and Co frontal cortex (v0 : velocity of the
enzyme reaction). Values represent means =+/S.E.M., n=3 per group.
NOTE that here Kairane does not use the
traditional inverted temperature scale. The 25
degree spread is short enough to represent minor
curvature. The primary datum in this graph is the
two Critical Temperatures (both are in error).

10. Here I have inverted the graph to
mimic the traditional Arrhenius style.

11. Here I have erased the black data line but retained
the data points. In my view the red lines do a better
job of representing the data.
The blue lines indicate parallels lines, that is,
having Equal Activation Energy.
Note, there is only one critical temperature (Tc)
between 24 and 25 degrees.
Note, the activation energy for the AD is the same
above and below the Tc.
Note, above Tc AD and CO have the same
Activation Energy
Note, for AD there is an Activation Entropy
increase at Tc.