27. Pem Chemo Vs Extreme
Total Population
HR = 1.34 (1.13 – 1.59)
28.
29. Overall Response Rate
Pembro alone Pembro + chemo EXTREME
CPS > 20 26% 43% 36%
CPS > 1 19% 36% 35%
Total population 17% 36% 36%
Median Duration Of Response
Pembro alone Pembro + chemo EXTREME
CPS > 20 22.6 mo 7.1 mo 4.2 mo
CPS > 1 23.4 mo 6.7 mo 4.5 mo
Total population 22.6 mo 6.7 mo 4.5 mo
30.
31.
32.
33. Conclusion of the Authors
Pembrolizumab combined with platinum and 5-
fluorouracil is an appropriate first-line
treatment for recurrent or metastatic HNSCC
and pembrolizumab monotherapy is an
appropriate first line treatment for PD-L1-
positive recurrent or metastatic HNSCC.