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Population Genetics
• Red hair will eventually die out because
it’s recessive...
• Brown eyes are dominant so they will
take over...
• Little toes will go away because we don’t
use them...
• Humans will get bigger brains because
we need them...
You may have heard that...
But is that how it works?
Genetics & Populations
• Evolution = Change in the gene
frequencies of a population across
generations.
• Red hair and blue eyes are inherited
traits. If red hair or blue eyes are to “die
out,” what would cause this kind of
change in the genetics of a population?
Hardy & Weinberg
• Hardy & Weinberg asked the opposite
question: Under what conditions would
there be NO change in the genetics of a
population?
• Conditions of NO change: large
population, random mating, no migration,
no mutations, no selection.
(a) Population size = 10,000 (b) Population size = 4
generation generation
frequency
of
allele
A
frequency
of
allele
A In the small population,
one allele may become
extinct in a few
generations.
In the large population,
allele frequencies remain
relatively constant.
Population size
Random events have a larger effect on smaller populations.
The gene pool of a
population contains
equal numbers of
red, blue, yellow, and
green alleles.
After the population
grows and returns to
its original size, blue
alleles predominate;
red and green
alleles
have disappeared.
By chance, the gene
pool of the reduced
population contains
mostly blue and a
few yellow alleles.
A bottleneck event
drastically reduces the
size of the population.
A drastic change in population size decreases genetic
diversity in later generations.
Non-random mating
Many living species have
ways to compete for mates.
In some populations, only a
few individuals can mate.
Mate preference is non-
random. Even in the same
species, many animals will
prefer mates that resemble
themselves.
Sexual selection, the result of non-random mating,
selects for traits that secure mates — though some
attractive traits are drawbacks in other ways.
Migration
Migration can remove genes from populations, add genes
to a population, or create a small population with different
gene ratios than the population it derives from.
“Founder effect” and
polydactyly in the Amish.
Mutations
Small mutations creep into populations over time. Some
are helpful, some harmful, and many are neutral but may
be beneficial or harmful later. Mutations increase genetic
variation in a population.
original DNA sequence
nucleotide pair changed from A–T to T–A
substitution
Selection
Selection occurs when a trait or set of traits gives a
survival advantage or a disadvantage.
Selection in favor = trait helps individuals survive and have
offspring.
Selection against = trait interferes with survival and
reproduction.
Traits increase in a population if they cause individuals
to have more offspring. Traits decrease in a population
if they kill off individuals before they can reproduce.
Average phenotype does
not change; phenotypic
variability declines.
BEFORE
SELECTION
AFTER
SELECTION
(c) DISRUPTIVE
SELECTION
(a) DIRECTIONAL
SELECTION
(b) STABILIZING
SELECTION
percent
of
population Larger-than-average
sizes favored.
Average sizes
favored.
Smaller-than-average
and larger than-
average sizes favored.
range of a particular characteristic (size, color, etc.)
Average phenotype
shifts to larger size
over time.
Population divides into
two phenotypic groups
over time.
• Is there any population on the planet
where all Hardy-Weinberg conditions
(large population, random mating, no
migration, no mutations, no selection)
holds true?
• What must be true of all populations of
living things?
• Red hair will eventually die out because
it’s recessive.
• Brown eyes are dominant so they will
take over.
• Little toes will go away because we don’t
use them.
• Humans will get bigger brains because
we need them.
Using what you know about population genetics,
reassess these claims:

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Extra-Pop_Gen.ppt

  • 2. • Red hair will eventually die out because it’s recessive... • Brown eyes are dominant so they will take over... • Little toes will go away because we don’t use them... • Humans will get bigger brains because we need them... You may have heard that...
  • 3. But is that how it works?
  • 4. Genetics & Populations • Evolution = Change in the gene frequencies of a population across generations. • Red hair and blue eyes are inherited traits. If red hair or blue eyes are to “die out,” what would cause this kind of change in the genetics of a population?
  • 5. Hardy & Weinberg • Hardy & Weinberg asked the opposite question: Under what conditions would there be NO change in the genetics of a population? • Conditions of NO change: large population, random mating, no migration, no mutations, no selection.
  • 6. (a) Population size = 10,000 (b) Population size = 4 generation generation frequency of allele A frequency of allele A In the small population, one allele may become extinct in a few generations. In the large population, allele frequencies remain relatively constant. Population size Random events have a larger effect on smaller populations.
  • 7. The gene pool of a population contains equal numbers of red, blue, yellow, and green alleles. After the population grows and returns to its original size, blue alleles predominate; red and green alleles have disappeared. By chance, the gene pool of the reduced population contains mostly blue and a few yellow alleles. A bottleneck event drastically reduces the size of the population. A drastic change in population size decreases genetic diversity in later generations.
  • 8. Non-random mating Many living species have ways to compete for mates. In some populations, only a few individuals can mate. Mate preference is non- random. Even in the same species, many animals will prefer mates that resemble themselves.
  • 9. Sexual selection, the result of non-random mating, selects for traits that secure mates — though some attractive traits are drawbacks in other ways.
  • 10. Migration Migration can remove genes from populations, add genes to a population, or create a small population with different gene ratios than the population it derives from. “Founder effect” and polydactyly in the Amish.
  • 11. Mutations Small mutations creep into populations over time. Some are helpful, some harmful, and many are neutral but may be beneficial or harmful later. Mutations increase genetic variation in a population. original DNA sequence nucleotide pair changed from A–T to T–A substitution
  • 12. Selection Selection occurs when a trait or set of traits gives a survival advantage or a disadvantage. Selection in favor = trait helps individuals survive and have offspring. Selection against = trait interferes with survival and reproduction. Traits increase in a population if they cause individuals to have more offspring. Traits decrease in a population if they kill off individuals before they can reproduce.
  • 13. Average phenotype does not change; phenotypic variability declines. BEFORE SELECTION AFTER SELECTION (c) DISRUPTIVE SELECTION (a) DIRECTIONAL SELECTION (b) STABILIZING SELECTION percent of population Larger-than-average sizes favored. Average sizes favored. Smaller-than-average and larger than- average sizes favored. range of a particular characteristic (size, color, etc.) Average phenotype shifts to larger size over time. Population divides into two phenotypic groups over time.
  • 14. • Is there any population on the planet where all Hardy-Weinberg conditions (large population, random mating, no migration, no mutations, no selection) holds true? • What must be true of all populations of living things?
  • 15. • Red hair will eventually die out because it’s recessive. • Brown eyes are dominant so they will take over. • Little toes will go away because we don’t use them. • Humans will get bigger brains because we need them. Using what you know about population genetics, reassess these claims: