A systematic review summarises the findings of precisely organized healthcare research (controlled trials) and gives a high degree of evidence on the efficacy of healthcare interventions. The evidence may be used to make decisions and guide healthcare recommendations. Reference: https://bit.ly/3morikF For our services: https://pubrica.com/services/research-services/systematic-review/ Why Pubrica: When you order our services, We promise you the following – Plagiarism free | always on Time | 24*7 customer support | Written to international Standard | Unlimited Revisions support | Medical writing Expert | Publication Support | Biostatistical experts | High-quality Subject Matter Experts.   Contact us:      Web: https://pubrica.com/  Blog: https://pubrica.com/academy/  Email: sales@pubrica.com  WhatsApp : +91 9884350006  United Kingdom: +44-1618186353

1. A Research Study
Writing a
Systematic Review
in Clinical Research
An Academic presentation by
Dr. Nancy Agnes, Head, Technical Operations, Pubrica
Group: www.pubrica.com
Email: sales@pubrica.com

2. TODAY'S DISCUSSION
In Brief
Introduction
A systematic review involves a series of distinct steps
About Pubrica

3. A systematic review summarises the findings of
precisely organized healthcare research (controlled
trials) and gives a high degree of evidence on the
efficacy of healthcare interventions.
The evidence may be used to make decisions and
guide healthcare recommendations.
These analyses are complex and rely heavily on the
available clinical trials, how they were conducted
(trial quality), and the assessed health outcomes.
IN BRIEF
Contd...

4. Meta-analyses are a standard method used by review authors to pool numerical data regarding
treatment outcomes.
Next, the authors evaluate the evidence for any advantages or risks associated with such
therapies.
Systematic Review Writing might summarise the existing clinical research on a topic in this way.

5. INTRODUCTION
The most dependable source of evidence to guide
clinical practice is a high-quality systematic review.
A systematic review aims to provide a detailed overview
of all available primary research in answer to a
specific research issue.
A systematic review, often known assecondary
research, uses all available research (research on
research).
Contd...

6. They are commonly used in guideline creation
and are typically needed by research funders to
establish the status of current knowledge.
The results of systematic reviews are frequently
employed in the healthcare field, but they can
also be used elsewhere.
The process used in Conducting a Systematic
Review is detailed and precise to reduce bias and
increase the reliability of the results reached.
A systematic review has the following
characteristics
Contd...

7. explicit objectives with predetermined study eligibility and relevance criteria;
transparent, repeatable methodology; thorough search to find all suitable studies;
a systematic performance and synthesis of the included research,
as well as an assessment of the validity of the conclusions of the included studies

8. A SYSTEMATIC REVIEW INVOLVES A
SERIES OF DISTINCT STEPS
Establish a research question: A well-defined
review question is the backbone of the Clinical
Trial Systematic Review Services systematic
review, similar to a precise specific goal in a
clinical study.
A good review question is clinically relevant, not
too broad but targeted, and usually identifies the
population, the intervention or exposure, and the
desired outcome(s).
Contd...

10. Clearly define the criteria for inclusion and exclusion:
Eligibility requirements are derived mainly from the study
question.
PICO (population, intervention, comparator, outcomes) is
an abbreviation that helps identify which patient population,
treatments or exposures in the treatment and control
groups and outcome(s) research must report being eligible
for inclusion.
Other criteria, such as research design, publication date,
or language, might be used to include or exclude people.
Contd...

11. Conduct a thorough literature search: Bibliographic databases like PubMed,
Web of Knowledge, Scopus, and EMBASE are commonly used to conduct
literature searches.
The study selection criteria must be mapped onto sensible search phrases,
which must then be combined coherently using Boolean operators.
Extra search strategies, such as reviewing reference lists, conference
proceedings, or trial registries, might help you find unpublished research or
additional references.
Contd...

12. Select studies: Titles and abstracts are first
evaluated for inclusion and exclusion criteria.
Full-texts of possibly suitable references are
retrieved to determine which publications to add
further depth.
Two or more researchers should independently
pick studies, extract data, and assess quality, with
the search and selection approach outcomes
shown in a flow diagram.
Contd...

13. Extract data: The kind and amount of data
extracted depends on the review’s goal and scope,
but typically these data include study design
type(s), patient characteristics, and outcome data.
A well-designed data extraction procedure and form
facilitates consistent and thorough data extraction.
Assess the quality of the studies included:
There is a range of quality evaluation techniques for
different research types (e.g., Cochrane risk of bias
tool; Grading of Recommendations Assessment,
Development, and Evaluation [GRADE]; Newcastle-
Ottawa scale).
Contd...

14. The quality evaluation findings are critical for readers to determine if the research provided
trustworthy and generalizable information.
To prevent a “garbage in, garbage out” impact, authors occasionally remove low-quality
papers altogether.
Analyze the data, display it, and analyze it: A meta-analysis is frequently employed to
combine quantitative data, although not always.
However, a meta-analysis should not be undertaken if the included studies are not sufficiently
comparable to allow for significant data synthesis.
For example, here found a lot of clinical and methodological variability (e.g., different chronic
pain conditions, treatment and follow-up durations, and magnesium formulations). Therefore
they did a qualitative analysis and presented the findings descriptively.

15. ABOUT PUBRICA
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Pubrica medical writers help you write and edit the
introduction by introducing the reader to the
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Our experts know the structure that follows the
broad topic, the problem, and background and
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hypothesis.

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