Global Human Growth Hormone Market Report is researched by Koncept Analytics. For more mail: vikas@konceptanalytics.com

1. Global Human Growth Hormone Market Report
-----------------------------------------
2015
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2. Executive Summary
 Pituitary - the master gland of human body is responsible for controlling crucial hormonal secretion, which, in turn, regulates other key
aspects of the body such as temperature, growth, thyroid functioning, urination, and production of other hormones. It is a pea sized
gland situated at the base of brain and is a major component of human body as it expedites the response towards the surrounding
environment and settings.
 Any deformity or damage to the pituitary gland can adversely impact the production and activity level of the above mentioned hormones,
thereby affecting the body work process and stunting the outcomes especially in the case of growth hormone. Marred pituitary function
leads to either over or under secretion of the somatropin that is the growth hormone. Its over secretion causes disfiguration in the body
parts like hands, face, feet, etc. whereas, its deficiency impedes the growth of body parts/whole body, thus leading to disease states like
dwarfism or gigantism.
 It is observed that the growth hormone related problems usually affect children and teenagers, but it is seen to grip adults as well though
to a lesser extent. The major factors which vitiate the pituitary operations thus impairing the GH role include kidney malfunction,
tumors/cancer especially associated with brain. There are some other unknown causes as well which are termed as idiopathic. Earlier,
to deal with these predicaments, growth hormone used to be extracted from the human cadavers but, as time passed and evolution of
technology/tools/techniques/R&D took place, the extraction of GH also got altered and many novel innovations and discoveries were
made in the respective field.
 Nowadays, many leading companies are heavily involved in the R&D process for devising longer acting and sustained release versions
of the somatropin which are produced using the recombinant technology. The competition prevalent in the respective industry is heating
up day by day. The human growth hormone market is monopolized by a few players viz. Pfizer, NovoNordisk, Eli Lilly, Sandoz and
Roche.
 The global HGH report discusses the key ongoing trends like global agreement for Long-Acting Human Growth Hormone (HGH-CTP),
increasing use of biosimilar version of drugs and continuous growth of recombinant growth hormones market. On the industry
development front, the current inclination is towards developing better treatments for Alzheimer’s disease and advancements in needle
free injections technology. Furthermore, the major factors driving the HGH market include rising cancer and CKD/ESRD cases and
increasing healthcare expenditure on worldwide basis. In addition, a few factors posing challenges in front of the HGH industry are the
problems in diagnosis of growth hormone deficiency, risks associated with use of recombinant growth hormone therapies and off-label
HGH use which, to an extent, are hindering the growth and development of the same.
 By combining SPSS Inc.’s data integration and analysis capabilities with our relevant findings, we have predicted the future growth of
the industry. We employed various significant variables that have an impact on this industry and created regression models with SPSS
Base to determine the future direction of the industry. Before deploying the regression model, the relationship between several
independent or predictor variables and the dependent variable was analyzed using standard SPSS output, including charts, tables and
tests.
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3. The Growth Hormone market is expected to grow on account of long acting therapies and the growth is
also coming from approval of new agents…
 In 2014, the global market for human growth hormone
reached US$... billion based on key drug sales, a decline of
…% compared to US$... billion in 2013 registering a CAGR
of …% from 2010-2014.
 The HGH market reached … Kg in terms of volume from …
Kg in the previous fiscal registering an annual growth rate
of …%. During 2010-2014, the market registered a CAGR
of …%.
 The key products representing global HGH market included
NovoNordisk’s Norditropin, which constituted around ..%
of the global market share, Pfizer’s Genotropin with ..%,
followed by Eli Lilly’s Humatrope with ..% and Sandoz’s
Omnitrope with ..% share in 2014.
 The human growth hormone market grew rigorously in the
developed geographies like the US, Canada, Europe, and
Japan.
Global Human Growth Hormones Market by Volume (2010-2015*)
Global Human Growth Hormones Market by Value (2010-2015*)
Global HGH Market Share (2014)
-15%
-10%
-5%
0%
5%
10%
15%
20%
25%
0
0.5
1
1.5
2
2.5
3
3.5
US$Billion
Sales Value Annual Growth
-2%
0%
2%
4%
6%
8%
10%
12%
14%
16%
0
10
20
30
40
50
60
70
80
Kilograms(Kg)
Salesa Volume Annual Growth
Novo Nordisk Pfizer Lilly Sandoz Merck Kgaa Roche Others

4. In 2014, the global market for human growth hormone reached US$... billion based on key drug sales….
 The primary indications in children are pediatric GHD which is
estimated to have a maximum contribution of …% followed by idiopathic
short stature (ISS) with a contribution of …% of the total revenue. The
third highest contributor is Turner syndrome with …% share.
 The global market is estimated to be split roughly by ..-..% use in
pediatrics and ..-..% use in adults.
 The worldwide pediatric growth hormone deficiency market is estimated
to grow to US$... million by 2020 from US$... million in 2014. The
estimated annual growth rate was ..% for 2014.
 The US pediatric GHD market is estimated to reach US$... million in
2020 from US$... million in 2014. The annual growth rate for 2014 stood
at …% and is estimated to reach …% by 2020.
Worldwide Pediatric GHD Market Opportunity (2014-20120E)
Global HGH Sales by Growth Disorder Indication ( 2015E)
The U.S. Pediatric GHD Market (2014-2020E)
Pediatric GHD Idiopathic Short Stature Turner Syndrome
Adult GHD Prader-Willi Short for Gestational Age
Others
0%
1%
2%
3%
4%
5%
6%
7%
8%
0
500
1000
1500
2000
2500
US$Million
Sales Value Annual Growth
0%
2%
4%
6%
8%
10%
12%
14%
0
100
200
300
400
500
600
700
800
US$Million
Sales Annual Growth

5. Given the multiple diseases that can be treated with rGH and concordant increasing use of treatment, the
market has been growing continuously…
 The European pediatric GHD market is estimated to reach US$...
million by 2020 from US$... million in 2014. The market is
estimated to experience modest growth along with estimated
penetration of ..% within 7 years from 2014.
 Japan’s market for GHD is estimated to reach US$... million by
2020 from US$... million in 2014. The annual growth rate for 2014
stood at …%.
 After the anticipated launch, the global opportunity for VRS-317 is
estimated to be US$... million for the year 2018, and is further
expected to be worth US$... million by 2024, at a CAGR of …%.
 The global HGH market is forecasted to reach US$... billion in
2018 as compared to US$... billion in 2015.The same is expected
to record a CAGR of about …% for the period spanning 2012 to
2018.
Japan’s Pediatric GHD Market (2014- 2020E)
European Pediatric GHD Market (2014- 2020E)
Global Human Growth Hormones Market Forecast (2012-2018E)
0%
1%
2%
3%
4%
5%
6%
0
100
200
300
400
500
600
700
800
900
US$Million
Sales Annual Growth
0%
2%
4%
6%
8%
0
200
400
600
800
US$Million
Sales Annual Growth
0
0.5
1
1.5
2
2.5
3
3.5
4
US$Billion

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