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P450 Inhibitors
Don't join this group it will make your spirit go down...
SICKFACES.COM Group
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol..binge drinking
Chloramphenicol
Erythromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole
Grapefruit juice
P450 Inducers
CRAP GPS induce me to madness!!
Carbemazepines
Rifampicin
Alcohol (chronic)
Phenytoin
Griseofulvin
Phenobarbitone
Sulphonylureas
Cyp 3a4
M.C. ENZYME METABOLISM
Cyp 2D6
NERUROLEPTIC (TYPICALANTIPSY)
TCA
SSRI
ABC ---ANTIARRHYTHIC ,,,,,,BBLOCKER,,,,,,,,,CODEIN
Cyp 2C8/9
PHENYTOIN
WARFARIN
Cyp 2C19
CLOPIDOGREL (ACTIVATION)
PPI (INHIBITION )
ACETYLATION –SHIPP C
SULFONAMIDE
HYDRALAZINE
ISONIAZIDE
PROCAINAMIDE
PAS
CONAZPAM
STOMACH Absorption
SULFONAMIDE
ALCOHOL
BARBITURATES
NSAIDS
HISTAMINE RELEASE –PADMAVATI S
POLYMIXIN
AMPHETAMINE
D TUBOCURARINE (CURIUMS ) ( CURONIUMS NO BASIC –NO HISTAMINE)
MORPHINE
VANCOMYCIN
ACTIVE – INACTIVE
MOST COMMON
ACTIVE –ACTIVE
FLUOXETINE – NOR FLEUOXETINE
CODEIN – MORPHINE
DIAZEPAM– DES METHYL DIAZEPAM, OXAZEPAM
INACTIVE -- ACTIVE
ACYCLOVIR
VALCYCLOVIR
CYCLOPHOSPHAMIDE
ACE I ( ESCEPT CAPTOPRIL/LISINOPRIL)
ZERO ORDER KINETIC
ALCOHOL
PHENYTOIN
THEOPHYLINE
TOLBUTAMIDE
WARFARIN
CETUXIMAB
NARROW THERAPEUTIC INTEX –
DAT LAAT MC
DIGITALIS
ANTIARRHYTHMICS
LETHIUM ‘
AMINOGLYCOSIDE
ANTIPSYCHOTIC
TCA
METHOTREXATE
CALCENEURIUMINHIBITORS

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Enzyme

  • 1. P450 Inhibitors Don't join this group it will make your spirit go down... SICKFACES.COM Group Sodium valproate Isoniazid Cimetidine Ketoconazole Fluconazole Alcohol..binge drinking Chloramphenicol Erythromycin Sulfonamides Ciprofloxacin Omeprazole Metronidazole Grapefruit juice P450 Inducers CRAP GPS induce me to madness!! Carbemazepines Rifampicin Alcohol (chronic) Phenytoin Griseofulvin Phenobarbitone Sulphonylureas
  • 2. Cyp 3a4 M.C. ENZYME METABOLISM Cyp 2D6 NERUROLEPTIC (TYPICALANTIPSY) TCA SSRI ABC ---ANTIARRHYTHIC ,,,,,,BBLOCKER,,,,,,,,,CODEIN Cyp 2C8/9 PHENYTOIN WARFARIN Cyp 2C19 CLOPIDOGREL (ACTIVATION) PPI (INHIBITION )
  • 3. ACETYLATION –SHIPP C SULFONAMIDE HYDRALAZINE ISONIAZIDE PROCAINAMIDE PAS CONAZPAM STOMACH Absorption SULFONAMIDE ALCOHOL BARBITURATES NSAIDS HISTAMINE RELEASE –PADMAVATI S POLYMIXIN AMPHETAMINE D TUBOCURARINE (CURIUMS ) ( CURONIUMS NO BASIC –NO HISTAMINE) MORPHINE VANCOMYCIN
  • 4. ACTIVE – INACTIVE MOST COMMON ACTIVE –ACTIVE FLUOXETINE – NOR FLEUOXETINE CODEIN – MORPHINE DIAZEPAM– DES METHYL DIAZEPAM, OXAZEPAM INACTIVE -- ACTIVE ACYCLOVIR VALCYCLOVIR CYCLOPHOSPHAMIDE ACE I ( ESCEPT CAPTOPRIL/LISINOPRIL)
  • 5. ZERO ORDER KINETIC ALCOHOL PHENYTOIN THEOPHYLINE TOLBUTAMIDE WARFARIN CETUXIMAB NARROW THERAPEUTIC INTEX – DAT LAAT MC DIGITALIS ANTIARRHYTHMICS LETHIUM ‘ AMINOGLYCOSIDE ANTIPSYCHOTIC TCA METHOTREXATE CALCENEURIUMINHIBITORS