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_________________________________
* Corresponding author:
Bayew Tsega,
College of Medicine and Health Sciences,
University of Gondar, PO Box – 196, Gondar, Ethiopia.
E-mail address: bayewtsega14@gmail.com
Available Online at: www.ijrpp.com Print ISSN: 2278 - 2648
Online ISSN: 2278 - 2656
(Research article)
Analysis of patient care and facility indicators in public and private health
institutions of wolkite town, south west Ethiopia
*1
Bayew Tsega, 2
Zeryawkal Ergetie, 1
Alemayehu Berhane
1
Clinical Pharmacy Unit, School of Pharmacy, University of Gondar, PO Box – 196, Gondar,
Ethiopia.
2
Pharmaceutical Chemistry Unit, School of Pharmacy, University of Gondar, Gondar,
Ethiopia.
_________________________________________________________________________
ABSTRACT
The main aim of this study was to evaluate the drug use pattern in private and public health sectors in Wolkite
town, South West Ethiopia. Drug use pattern study is a means of assessing the drug use situation in a health
facility or groups of facilities; it is a way to identify irrational drug use in health facilities. Six hundred patients
were interviewed prospectively in the private and public drug retail outlets in February and March, 2012. World
health organization patient care and facility indicators were used to evaluate the drug use status. The average
consultation and dispensing times were 7.8+2.1 minutes and 14.3+12.3 seconds, respectively. One thousand
ninety five (92.7%) drugs were dispensed, out of which 731 (61.9%) were adequately labeled. Five hundred
seventy (95.0%) patients had adequate knowledge of the drug instructions they were given. Two (11.1%) health
facilities had at least one copy of essential drug list or formulary, whereas three (15.8 %) health facilities had
clinical guideline. An average of 9.5 (86.4%) key drugs was available in the health facilities. Shortage of
essential drugs, copy of essential drug list/formulary and standard treatment guideline still occurred in the health
facilities studied. Short dispensing time and labeling of drugs in dispensaries were shown.
Key words: Patient care indicators, Facility indicators, Health institutions, South West Ethiopia
INTRODUCTION
According to World Health Organization (WHO),
rational drug use requires that patients receive
medications appropriate to their clinical needs, in
doses that meet their individual requirements for an
adequate period of time, at an affordable cost 1, 2, 3
.
Unfortunately,inappropriate use of medicines conti
nues to be a widespread problem in developing and
transitional countries; nearly half of the world’s
patients receive their drug inappropriately.
Such inappropriate use endangers lives and wastes
money. Ethiopia cannot be an exception as
availability of essential medicines, trained health
care providers and literacy level of patients is low
which is in coherent with the countries low
economic status 4, 5, 6, 7
.
The share of out-of-pocket expenditure on drugs is
very high in Ethiopia (47%). Unavailability of
drugs is the number one reason for the patients not
to take drugs from the public retail outlets. This
implies that a large segment of the population
purchase their drugs from private drug retail outlets
where prices of drugs are quite high. This results in
low economic access to drugs, particularly by the
poor, and creates equity problem 5, 8, 9
.
To ensure consistent, valid and reliable
identification of drug use problems, WHO
developed and tested a set of standardized
International Journal of
Research in Pharmacology and
Pharmacotherapeutics
173
Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177]
www.ijrpp.com
indicators of general out patients care 3, 10, 11
.
Among the uses of these indicators are to describe
current treatment practices, compare health
facilities and prescribers and allow for
identification of potential drug use problems that
may affect patient care 10, 11
.
The Patient care indicators include Average
consultation time, Average dispensing time,
Percentage of medicines actually dispensed,
Percentage of medicines adequately labeled and
Percentage of patients with knowledge of correct
dose; while facility indicators include availability
of essential drug list or formulary to practitioners,
availability of clinical guidelines and Percentage of
key medicines available in a facility 10
.
There is no drug use study done in the private
health sector despite the fact that following the
privatization policy in Ethiopia a lot of private
health facilities have been established and
significant section of the population is getting
health service in these facilities. Even the drug use
study in the primary public health sector in
Ethiopia, which covers 43% of the Ethiopian
population 12
, is very rare and outdated. Wolkite
town, the second largest town in South West
Ethiopia in terms of population, health facilities
were attended by more than 60, 000 patients in one
year, from September 2010 to August 2011 13, 14
.
No drug use study had been done in that town. So
there was no evidence that shows the drug use
situation in the town.
Therefore, the findings of the study may be used as
a baseline data. It in general help the health
management, in particular those looking after the
health institutions in the town understand the extent
of the problem in the private and public health
facilities and drug retail outlets and it trigor further
studies.
METHODS
The study was conducted in public and private
primary health care facilities and drug retail outlets
of Wolkite town, South West Ethiopia from
February 21 to March 12, 2012. Wolkite town was
founded in the 1940s and now it is the second
largest town, next to Jimma, in Southwest Ethiopia
13, 14
.
In the town there were one health center, two
clinics, one health post and two pharmacies.
Whereas the private health sector had six medium
clinics, two lower clinics, and six drug shops 14
. All
health sectors in the town, prescriptions, and
patients who attended them in the study period
were the source population for the study. The study
was a cross-sectional prospective in both public
and private primary health care facilities and drug
retail outlets of Wolkite town, South West
Ethiopia. In order to produce representative and
comparable statistics of appropriate dispensing,
indicators defined by WHO (patient care and
facility indicators) was employed in health
facilities10
. Prospective data consisting of
prescriptions, consulting and dispensing times were
collected from health facilities and drug retail
outlets in order to assess the patient care and
facility indicators as indicated.
Based on WHO recommendation to collect
prospective data 4, 10
, 50 patients per retail outlet in
the private sector were interviewed and observed
for adequate knowledge, dispensing time, adequacy
of labeling and prescribed drugs actually dispensed.
Stop watch was used to record the dispensing and
counseling times. The total patients that were
included in the 6 private drug retail outlets were
300. In the public pharmacy, 300 patients were
interviewed, observed and checked for their drugs.
Data were checked for its completeness every day.
The data outcome from those evaluations by the
aforementioned professionals was entered into
Statistical Package for Social Sciences (SPSS)
version-16.0 software to be edited, cleaned and
analyzed. The data were summarized and described
using cross tabulation and bivariate analysis with
95% confidence interval to infer associations and
predictions. The patient care and facility indicators
were calculated using the WHO formula to
calculate core drug use indicators.
Simple bivariate logistic regression analysis was
employed to see the association between patients
(age, sex, drug, and education.) and health sectors
characteristics versus WHO patient care and
facility indicators (crude odds ratio was obtained).
Then, to control the effect of confounding factors,
each variable was entered in to multiple logistic
regression models as the independent variable with
each medication use indicators being a dependent
variable in order to identify independent predictors
of process criteria and medication use indicators.
RESULTS
Patient care indicators
The socio-demographic characteristics of
respondents, who visited the drug retail outlets,
Wolkite town, South West Ethiopia, are shown in
174
Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177]
www.ijrpp.com
table 1. Male to female ratio was 0.9 which shows
comparable number of the two genders. The
average age of respondents attended the drug retail
outlets was 33.6+3.8. Responders in the age range
of 31-44 years comprised of 242 (40.3%). One
hundred seventy (28.3%) and 155 (25.8%)
responders were in the age range of 15-30 and 45-
64 years, respectively. Elderly comprised of 33
(5.5%).
Two hundred twenty five (37.5%) responders were
unable to write or read (illiterate), 152 (25.3%)
attended primary school, 147(24.5%) of responders
were in high school or above educational levels,
and 76 (12.7%) responders were able to read and
write.
Table 1: Socio-demographic characteristics of respondents (N=600) who attended the drug retail outlets,
Wolkite town, South West Ethiopia, February to March, 2012.
Characteristics Frequency (%)
Sex Male 282 (47.0)
Female 318 (53.0)
Age Ranges 15-30 170 (28.3)
31-44 242 (40.3)
45-64 155 (25.8)
>64 33 (5.5)
Education Illiterate 225 (37.5)
Read and write only 76 (12.7)
Primary school 152 (25.3)
Secondary school or above 147 (24.5)
The WHO patient care indicators are presented in
table 2. The average consultation times were 9.0
and 5.5 minutes in private and public health
facilities, respectively. The average dispensing
times were 17.5 seconds in the private and 11.1
seconds in public drug retail outlets. The likelihood
of getting consultations in private was 1.5 (95% CI
2.9- 8.1 and P value 0.001) times that in public
health facilities.
Table 2: Patient care indicators for patient encounters attending to private (N=300) and public (N=300)
drug retail outlets, Wolkite town, South West Ethiopia, February, 2012.
Patient care indicators Frequency (%) OR (95%CI) P value
Mean (+SD) Consultation time (Min)
Private health facilities
Public health facilities 9.0
5. 5
1.5 (2.9- 8.1)
1.0
0.001
Mean (+SD) dispensing time (Sec)
Private health facilities
public health facilities
17.5
11.1
1.34 (0.4- 3.2)
1.0
0.09
Medicines actually dispensed
Private health facilities
Public health facilities
450 (87.2)
645 (97.3)
1.0
1.8 (2.5-11.6)
0.04
Medicines adequately labeled
Private health facilities
Public health facilities
274 (53.1)
457 (69.0)
1.0
2.3 (3.6-18.7)
0.00
Patients adequate knowledge of
drug dosage regimen
Private health facilities
Public health facilities
278 (92.7)
292 (97.3)
1.0
1.6 (.14-9.5)
0.07
175
Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177]
www.ijrpp.com
Four hundred fifty (87.2%) and 645 (97.3 %) drugs
were dispensed in the private and public drug retail
outlets, respectively. Two hundred seventy four
(53.1%) dispensed drugs were adequately labeled
in private drug retail outlets where as 457 (69%)
drugs were adequately labeled in the public
pharmacy. Two hundred seventy eight (54%)
patients in the private and 292 (44%) patients in
public drug retail outlets had adequate knowledge
of drug instructions. The likelihood of getting
medicines adequately labeled and medicines
actually dispensed in public were 2.3 (95%CI 3.6-
18.7 and P value 0.00) and 1.8(95%CI 2.5- 11.6
and P value 0.04) times that in private health
facilities.
Facility indicators
World health organization health facility indicators
for the health facilities and drug retail outlets are
shown in table 3. One (7.1%) private and one (25.0
%) public facilities had at least one copy of
essential medicine list or formulary whereas one
(7.1 %) private and two (50.0%) public health
sectors had clinical guideline. An average of 9
(85.7%) and 10 (88%) key drugs were available in
private and public health facilities, respectively.
Table 3: Facility indicators for private (n=14) and public (n=4) health institutions, Wolkite town, South
West Ethiopia, February, 2012.
Health
facilities
Facility indicators
Availability of essential drug list or
formulary to practitioners
Availability of
clinical guidelines
Percentage of key medicines
available in a facility
Private N
(%)
1 (7.1) 1 (7.1) 9 (85.7)
Public N
(%)
1 (25.0) 2 (50.0) 10 (88.0)
DISCUSSION
The need and potential for counseling the patients
regarding their drug therapy has been an important
part of the pharmacy practice and pharmaceutical
care. It has been the responsibility of the
pharmacist to counsel the patients before
dispensing the medication although the prescriber
gives some information about drugs prescribed in
primary care. Counseling not only enhances
compliance (by enhancing knowledge), but also
reduces complications due to non-compliance to
treatments 15
. The quality of labeling applied by
dispensers, the time spent informing the patients,
and the communication skills of the dispenser can
therefore affect compliance rates 10
.
This study showed that average consultation time
was better than the previous studies done in
developing countries, including Ethiopia. But the
average dispensing time was short 16-18
. Adequacy
of patient knowledge on drug instructions was
found to be far better than those of previous studies
done in developing countries 7, 19, 14
. Percentage of
labeling was shown to be high when compared to
previous studies from Ethiopia and Sudan but
lower than finding from Tanzania 16, 17, 19
.
Prescriptions containing 1181 drugs were brought
to the private and public drug retail outlets by 600
patient encounters. Percent of drugs actually
dispensed was comparable to global study done by
WHO but higher than previous Ethiopian studies 18,
19, 20
.
To be able to prescribe rationally and cost-
effectively, prescribers require up-to-date,
contextual and readily accessible information on
medicines. It is, however, reported that, especially
in resource-poor settings, prescribers have
difficulties in accessing relevant information 21, 22
,
which may have severe consequences as the quality
of prescribing has been found to be associated with
accessible information on medicines 23
. In this
study only one private out of fourteen and one
public health out of four health sectors had at least
one copy of essential drug list or formulary. The
availability of essential drug list/ formulary was
lower compared to study finding from Tanzania 24
.
In modern medicine, there may be more than one
treatment modality available for many medical
conditions. This leads to confusion and in many
cases incorrect treatment. In this regard, standard
treatment guidelines provide a health professional a
system for controlling cost by using funds more
efficiently the most effective therapy in terms of
176
Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177]
www.ijrpp.com
quality and provide a basis for evaluating quality of
care provided by the health care professionals, and
can be a vehicle for integrating special programs
(diarrhea disease control, acute respiratory
infection, tuberculosis control, malaria) at the
primary health care facilities 25
. In this study only
one of the private and two public health sectors had
at least one copy of clinical guideline. Standard
treatment guidelines availability in those health
facilities was shown to be comparable to study
findings done nation-wide in Ethiopia but very low
as compared to that of the Tanzanian finding 16, 19
.
While most of the prescribers (12 out of 19) were
untrained nurses in the health facilities,
unavailability of essential drug list and standard
treatment guidelines would lead to irrational
prescribing in terms of economic cost and quality
of health care.
Eleven key medicines that should be available at all
time in the health facilities were selected based on
disease prevalence and drug utilization profile
assessment just during one month before data
collection. In this regard 84.5% key medicines
were available in the health sectors. Artemether +
Lumefanthrine tablet was available in 20% of
health sectors where as procaine penicillin powder
for injection in 70% of the sectors. Study from
Ethiopia (nation-wide) showed comparable result
but lower than what was seen in Tanzania 16, 19
.
While malaria and upper respiratory tract infections
were the most frequent diagnosis, Artemether +
Lumefanthrine and procaine penicillin shortage
would pose a great problem in the provision of care
in health facilities.
The average number of causes of morbidity per
encounter in Wolkite private and public health
facilities was 1.23 + 1.4. Malaria, upper respiratory
tract infections and intestinal parasite caused 36.2%
of total morbidity. Seventy eight percent of
prescribed drugs in Wolkite private and public
health facilities were antibiotics, analgesics or
antiprotozoals. This was incoherent with the
morbidity profiles found in the health facilities.
Diclofenac, paracetamol, amoxicillin, chloroquine
and ciprofloxacin alone comprised 47.1% of the
total drugs prescribed. Studies done in North West
Ethiopia and Mexico showed comparable profile of
antibiotics and analgesics use 18, 26
.
LIMITATION OF THE STUDY
Any drug utilization study based on the WHO core
drug use indicators has limitations. The patient care
indicators do not capture many fundamental issues
related to the quality of examination and treatment
10
. However, the present study provides important
useful baseline data which will be useful for
comparison when in future any patient care and
facility indicator study is carried out.
CONCLUSION
The present study showed that there was shortage
of drug information sources like essential drug
list/formulary and standard treatment guidelines.
Availability of drugs in dispensaries was high but
labeling of them was seen in low number of drugs
relative to other studies and dispensed at shorter
duration. Some health sectors were short of supply
of the key drugs like Artemether + Lumefanthrine
and procaine penicillin.
ACKNOWLEDGMENT
The researchers would like to thank the Gurage
Zonal health bureau, Wolkite Town health
administration office, the Wolkite town health
institutions administrations and professionals for
their keen cooperation during the study.
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Analysis of patient care and facility indicators ijrpp

  • 1. 172 _________________________________ * Corresponding author: Bayew Tsega, College of Medicine and Health Sciences, University of Gondar, PO Box – 196, Gondar, Ethiopia. E-mail address: bayewtsega14@gmail.com Available Online at: www.ijrpp.com Print ISSN: 2278 - 2648 Online ISSN: 2278 - 2656 (Research article) Analysis of patient care and facility indicators in public and private health institutions of wolkite town, south west Ethiopia *1 Bayew Tsega, 2 Zeryawkal Ergetie, 1 Alemayehu Berhane 1 Clinical Pharmacy Unit, School of Pharmacy, University of Gondar, PO Box – 196, Gondar, Ethiopia. 2 Pharmaceutical Chemistry Unit, School of Pharmacy, University of Gondar, Gondar, Ethiopia. _________________________________________________________________________ ABSTRACT The main aim of this study was to evaluate the drug use pattern in private and public health sectors in Wolkite town, South West Ethiopia. Drug use pattern study is a means of assessing the drug use situation in a health facility or groups of facilities; it is a way to identify irrational drug use in health facilities. Six hundred patients were interviewed prospectively in the private and public drug retail outlets in February and March, 2012. World health organization patient care and facility indicators were used to evaluate the drug use status. The average consultation and dispensing times were 7.8+2.1 minutes and 14.3+12.3 seconds, respectively. One thousand ninety five (92.7%) drugs were dispensed, out of which 731 (61.9%) were adequately labeled. Five hundred seventy (95.0%) patients had adequate knowledge of the drug instructions they were given. Two (11.1%) health facilities had at least one copy of essential drug list or formulary, whereas three (15.8 %) health facilities had clinical guideline. An average of 9.5 (86.4%) key drugs was available in the health facilities. Shortage of essential drugs, copy of essential drug list/formulary and standard treatment guideline still occurred in the health facilities studied. Short dispensing time and labeling of drugs in dispensaries were shown. Key words: Patient care indicators, Facility indicators, Health institutions, South West Ethiopia INTRODUCTION According to World Health Organization (WHO), rational drug use requires that patients receive medications appropriate to their clinical needs, in doses that meet their individual requirements for an adequate period of time, at an affordable cost 1, 2, 3 . Unfortunately,inappropriate use of medicines conti nues to be a widespread problem in developing and transitional countries; nearly half of the world’s patients receive their drug inappropriately. Such inappropriate use endangers lives and wastes money. Ethiopia cannot be an exception as availability of essential medicines, trained health care providers and literacy level of patients is low which is in coherent with the countries low economic status 4, 5, 6, 7 . The share of out-of-pocket expenditure on drugs is very high in Ethiopia (47%). Unavailability of drugs is the number one reason for the patients not to take drugs from the public retail outlets. This implies that a large segment of the population purchase their drugs from private drug retail outlets where prices of drugs are quite high. This results in low economic access to drugs, particularly by the poor, and creates equity problem 5, 8, 9 . To ensure consistent, valid and reliable identification of drug use problems, WHO developed and tested a set of standardized International Journal of Research in Pharmacology and Pharmacotherapeutics
  • 2. 173 Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177] www.ijrpp.com indicators of general out patients care 3, 10, 11 . Among the uses of these indicators are to describe current treatment practices, compare health facilities and prescribers and allow for identification of potential drug use problems that may affect patient care 10, 11 . The Patient care indicators include Average consultation time, Average dispensing time, Percentage of medicines actually dispensed, Percentage of medicines adequately labeled and Percentage of patients with knowledge of correct dose; while facility indicators include availability of essential drug list or formulary to practitioners, availability of clinical guidelines and Percentage of key medicines available in a facility 10 . There is no drug use study done in the private health sector despite the fact that following the privatization policy in Ethiopia a lot of private health facilities have been established and significant section of the population is getting health service in these facilities. Even the drug use study in the primary public health sector in Ethiopia, which covers 43% of the Ethiopian population 12 , is very rare and outdated. Wolkite town, the second largest town in South West Ethiopia in terms of population, health facilities were attended by more than 60, 000 patients in one year, from September 2010 to August 2011 13, 14 . No drug use study had been done in that town. So there was no evidence that shows the drug use situation in the town. Therefore, the findings of the study may be used as a baseline data. It in general help the health management, in particular those looking after the health institutions in the town understand the extent of the problem in the private and public health facilities and drug retail outlets and it trigor further studies. METHODS The study was conducted in public and private primary health care facilities and drug retail outlets of Wolkite town, South West Ethiopia from February 21 to March 12, 2012. Wolkite town was founded in the 1940s and now it is the second largest town, next to Jimma, in Southwest Ethiopia 13, 14 . In the town there were one health center, two clinics, one health post and two pharmacies. Whereas the private health sector had six medium clinics, two lower clinics, and six drug shops 14 . All health sectors in the town, prescriptions, and patients who attended them in the study period were the source population for the study. The study was a cross-sectional prospective in both public and private primary health care facilities and drug retail outlets of Wolkite town, South West Ethiopia. In order to produce representative and comparable statistics of appropriate dispensing, indicators defined by WHO (patient care and facility indicators) was employed in health facilities10 . Prospective data consisting of prescriptions, consulting and dispensing times were collected from health facilities and drug retail outlets in order to assess the patient care and facility indicators as indicated. Based on WHO recommendation to collect prospective data 4, 10 , 50 patients per retail outlet in the private sector were interviewed and observed for adequate knowledge, dispensing time, adequacy of labeling and prescribed drugs actually dispensed. Stop watch was used to record the dispensing and counseling times. The total patients that were included in the 6 private drug retail outlets were 300. In the public pharmacy, 300 patients were interviewed, observed and checked for their drugs. Data were checked for its completeness every day. The data outcome from those evaluations by the aforementioned professionals was entered into Statistical Package for Social Sciences (SPSS) version-16.0 software to be edited, cleaned and analyzed. The data were summarized and described using cross tabulation and bivariate analysis with 95% confidence interval to infer associations and predictions. The patient care and facility indicators were calculated using the WHO formula to calculate core drug use indicators. Simple bivariate logistic regression analysis was employed to see the association between patients (age, sex, drug, and education.) and health sectors characteristics versus WHO patient care and facility indicators (crude odds ratio was obtained). Then, to control the effect of confounding factors, each variable was entered in to multiple logistic regression models as the independent variable with each medication use indicators being a dependent variable in order to identify independent predictors of process criteria and medication use indicators. RESULTS Patient care indicators The socio-demographic characteristics of respondents, who visited the drug retail outlets, Wolkite town, South West Ethiopia, are shown in
  • 3. 174 Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177] www.ijrpp.com table 1. Male to female ratio was 0.9 which shows comparable number of the two genders. The average age of respondents attended the drug retail outlets was 33.6+3.8. Responders in the age range of 31-44 years comprised of 242 (40.3%). One hundred seventy (28.3%) and 155 (25.8%) responders were in the age range of 15-30 and 45- 64 years, respectively. Elderly comprised of 33 (5.5%). Two hundred twenty five (37.5%) responders were unable to write or read (illiterate), 152 (25.3%) attended primary school, 147(24.5%) of responders were in high school or above educational levels, and 76 (12.7%) responders were able to read and write. Table 1: Socio-demographic characteristics of respondents (N=600) who attended the drug retail outlets, Wolkite town, South West Ethiopia, February to March, 2012. Characteristics Frequency (%) Sex Male 282 (47.0) Female 318 (53.0) Age Ranges 15-30 170 (28.3) 31-44 242 (40.3) 45-64 155 (25.8) >64 33 (5.5) Education Illiterate 225 (37.5) Read and write only 76 (12.7) Primary school 152 (25.3) Secondary school or above 147 (24.5) The WHO patient care indicators are presented in table 2. The average consultation times were 9.0 and 5.5 minutes in private and public health facilities, respectively. The average dispensing times were 17.5 seconds in the private and 11.1 seconds in public drug retail outlets. The likelihood of getting consultations in private was 1.5 (95% CI 2.9- 8.1 and P value 0.001) times that in public health facilities. Table 2: Patient care indicators for patient encounters attending to private (N=300) and public (N=300) drug retail outlets, Wolkite town, South West Ethiopia, February, 2012. Patient care indicators Frequency (%) OR (95%CI) P value Mean (+SD) Consultation time (Min) Private health facilities Public health facilities 9.0 5. 5 1.5 (2.9- 8.1) 1.0 0.001 Mean (+SD) dispensing time (Sec) Private health facilities public health facilities 17.5 11.1 1.34 (0.4- 3.2) 1.0 0.09 Medicines actually dispensed Private health facilities Public health facilities 450 (87.2) 645 (97.3) 1.0 1.8 (2.5-11.6) 0.04 Medicines adequately labeled Private health facilities Public health facilities 274 (53.1) 457 (69.0) 1.0 2.3 (3.6-18.7) 0.00 Patients adequate knowledge of drug dosage regimen Private health facilities Public health facilities 278 (92.7) 292 (97.3) 1.0 1.6 (.14-9.5) 0.07
  • 4. 175 Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177] www.ijrpp.com Four hundred fifty (87.2%) and 645 (97.3 %) drugs were dispensed in the private and public drug retail outlets, respectively. Two hundred seventy four (53.1%) dispensed drugs were adequately labeled in private drug retail outlets where as 457 (69%) drugs were adequately labeled in the public pharmacy. Two hundred seventy eight (54%) patients in the private and 292 (44%) patients in public drug retail outlets had adequate knowledge of drug instructions. The likelihood of getting medicines adequately labeled and medicines actually dispensed in public were 2.3 (95%CI 3.6- 18.7 and P value 0.00) and 1.8(95%CI 2.5- 11.6 and P value 0.04) times that in private health facilities. Facility indicators World health organization health facility indicators for the health facilities and drug retail outlets are shown in table 3. One (7.1%) private and one (25.0 %) public facilities had at least one copy of essential medicine list or formulary whereas one (7.1 %) private and two (50.0%) public health sectors had clinical guideline. An average of 9 (85.7%) and 10 (88%) key drugs were available in private and public health facilities, respectively. Table 3: Facility indicators for private (n=14) and public (n=4) health institutions, Wolkite town, South West Ethiopia, February, 2012. Health facilities Facility indicators Availability of essential drug list or formulary to practitioners Availability of clinical guidelines Percentage of key medicines available in a facility Private N (%) 1 (7.1) 1 (7.1) 9 (85.7) Public N (%) 1 (25.0) 2 (50.0) 10 (88.0) DISCUSSION The need and potential for counseling the patients regarding their drug therapy has been an important part of the pharmacy practice and pharmaceutical care. It has been the responsibility of the pharmacist to counsel the patients before dispensing the medication although the prescriber gives some information about drugs prescribed in primary care. Counseling not only enhances compliance (by enhancing knowledge), but also reduces complications due to non-compliance to treatments 15 . The quality of labeling applied by dispensers, the time spent informing the patients, and the communication skills of the dispenser can therefore affect compliance rates 10 . This study showed that average consultation time was better than the previous studies done in developing countries, including Ethiopia. But the average dispensing time was short 16-18 . Adequacy of patient knowledge on drug instructions was found to be far better than those of previous studies done in developing countries 7, 19, 14 . Percentage of labeling was shown to be high when compared to previous studies from Ethiopia and Sudan but lower than finding from Tanzania 16, 17, 19 . Prescriptions containing 1181 drugs were brought to the private and public drug retail outlets by 600 patient encounters. Percent of drugs actually dispensed was comparable to global study done by WHO but higher than previous Ethiopian studies 18, 19, 20 . To be able to prescribe rationally and cost- effectively, prescribers require up-to-date, contextual and readily accessible information on medicines. It is, however, reported that, especially in resource-poor settings, prescribers have difficulties in accessing relevant information 21, 22 , which may have severe consequences as the quality of prescribing has been found to be associated with accessible information on medicines 23 . In this study only one private out of fourteen and one public health out of four health sectors had at least one copy of essential drug list or formulary. The availability of essential drug list/ formulary was lower compared to study finding from Tanzania 24 . In modern medicine, there may be more than one treatment modality available for many medical conditions. This leads to confusion and in many cases incorrect treatment. In this regard, standard treatment guidelines provide a health professional a system for controlling cost by using funds more efficiently the most effective therapy in terms of
  • 5. 176 Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177] www.ijrpp.com quality and provide a basis for evaluating quality of care provided by the health care professionals, and can be a vehicle for integrating special programs (diarrhea disease control, acute respiratory infection, tuberculosis control, malaria) at the primary health care facilities 25 . In this study only one of the private and two public health sectors had at least one copy of clinical guideline. Standard treatment guidelines availability in those health facilities was shown to be comparable to study findings done nation-wide in Ethiopia but very low as compared to that of the Tanzanian finding 16, 19 . While most of the prescribers (12 out of 19) were untrained nurses in the health facilities, unavailability of essential drug list and standard treatment guidelines would lead to irrational prescribing in terms of economic cost and quality of health care. Eleven key medicines that should be available at all time in the health facilities were selected based on disease prevalence and drug utilization profile assessment just during one month before data collection. In this regard 84.5% key medicines were available in the health sectors. Artemether + Lumefanthrine tablet was available in 20% of health sectors where as procaine penicillin powder for injection in 70% of the sectors. Study from Ethiopia (nation-wide) showed comparable result but lower than what was seen in Tanzania 16, 19 . While malaria and upper respiratory tract infections were the most frequent diagnosis, Artemether + Lumefanthrine and procaine penicillin shortage would pose a great problem in the provision of care in health facilities. The average number of causes of morbidity per encounter in Wolkite private and public health facilities was 1.23 + 1.4. Malaria, upper respiratory tract infections and intestinal parasite caused 36.2% of total morbidity. Seventy eight percent of prescribed drugs in Wolkite private and public health facilities were antibiotics, analgesics or antiprotozoals. This was incoherent with the morbidity profiles found in the health facilities. Diclofenac, paracetamol, amoxicillin, chloroquine and ciprofloxacin alone comprised 47.1% of the total drugs prescribed. Studies done in North West Ethiopia and Mexico showed comparable profile of antibiotics and analgesics use 18, 26 . LIMITATION OF THE STUDY Any drug utilization study based on the WHO core drug use indicators has limitations. The patient care indicators do not capture many fundamental issues related to the quality of examination and treatment 10 . However, the present study provides important useful baseline data which will be useful for comparison when in future any patient care and facility indicator study is carried out. CONCLUSION The present study showed that there was shortage of drug information sources like essential drug list/formulary and standard treatment guidelines. Availability of drugs in dispensaries was high but labeling of them was seen in low number of drugs relative to other studies and dispensed at shorter duration. Some health sectors were short of supply of the key drugs like Artemether + Lumefanthrine and procaine penicillin. ACKNOWLEDGMENT The researchers would like to thank the Gurage Zonal health bureau, Wolkite Town health administration office, the Wolkite town health institutions administrations and professionals for their keen cooperation during the study. REFERENCES 1. R. Holland, J. Desborough, L. Goodyer, S. Hall, D. Wright & Y. Loke. Does pharmacist- led medication review help to reduce hospital admissions and deaths in older people? A systematic review and meta-analysis. BJCP. 2007; 65(3): 303-316. 2. World Health Organization. Report of the conference of experts. The rational use of drugs, Kenya, Nairobi. November 1985; pp: 17-25. 3. Federal Ministry of Health, Nigeria National Primary Health Care Development Agency (NPHCDA). Moving on: The Bamako Initiative in Nigeria. 1994. 4. World Health Organization. Medicines use in primary care in developing and transitional countries Fact Book summarizing results from studies reported between 1990 and 2006, Geneva, Switzerland. 2009. 5. International Monetary Fund. World Economic and Financial Surveys, Regional Economic Outlook, Sub-Saharan Africa: Resilience and Risks, Washington D.C. 2010. 6. World Health Organization. The rational use of drugs World Health Assembly Resolution WHA39.27, Geneva. 1985.
  • 6. 177 Bayew Tsega et al / Int. J. of Res. in Pharmacology and Pharmacotherapeutics Vol-1(2) 2012 [172-177] www.ijrpp.com 7. Hutin YJ, Chen RT. Injection safety: a global challenge. Bulletin of WHO, 1999; 77:787- 788. 8. http://www.Dsprud.org/train.htm. Delhi society for the promotion of rational drug use. Rational drug use: Concepts and perspectives. [accessed on 2011 Oct 20]. 9. Drug Administration and Control Authority of Ethiopia, Management sciences for Health. Antimicrobials use, resistance and containment baseline survey syntheses of findings, Addis Ababa, Ethiopia. August 2009. 10. World Health Organization. Action Programme on Essential Drugs. How to investigate drug use in health facilities, Geneva. 1993; pp: 9-31 11. Hogerzeil HV, Ross-Degnan D, Laing RO, Ofori-Adjei D, Santoso B, et al. Field tests for rational drug use in twelve developing countries. Lancet. 1993; 4: 1408-1410. 12. Daniel Zewde, Yohannes Jorge, Tsige Gebre- Mariam. A preliminary assessment of outpatient councelling in four referral hospitals of Addis Ababa. Ethiop. Pharm. J. 1999; 17: 44-51. 13. Gurage zone health bureau, Wolkite town health office. Module on private and public health facilities and drug retail outlets. Wolkite town, September, 2010. 14. Federal Democratic Republic of Ethiopia Population Census Commission. Summary and Statistical Report of the 2007 Population and Housing Census Results, Addis Ababa, Ethiopia, 2007. 15. Poudel A,Khanal S, Alam K,Palaian S. Perception of Nepalese community pharmacists towards patient counseling and continuing pharmacy education program: a multicentric study. Journal of Clinical and Diagnostic Research 2009; 3: 1408-1413. 16. Lewis PJ, Dornan T, Taylor D, Tully MP, Wass V, Ashcroft DM. Prevalence, incidence and nature of prescribing errors in hospital inpatients: a systematic review. Drug Saf. 2009; 32(5):379-89. 17. A.Y. Massele, S.E.D. Nsimba and G. Rimoy. Prescribing habits in church owned primary health care facilities in Dar es Salaam and other Tanzanian coast regions. East Afr Med J. 2001; l, 78, 10. 18. Desta Z., Abula T., Beyene L. Assessment of rational drug use and prescribing in primary health care facilities in North West Ethiopia. East Afr Med J. 1997; 74(12):758-63. 19. Federal Ministry of Health of Ethiopia. Assessment of the Pharmaceutical Sector in Ethiopia, Addis Ababa, Ethiopia. October 2003. 20. Joint Commission on the Accreditation of Healthcare Organizations. Comprehensive accreditation manual for hospitals. Oakbrook Terrace (IL): Joint Commission on the Accreditation of Healthcare Organizations; 1994. 21. Kale R. Health Information needs for the developing world. BMJ 1994; 309: 939-942. 22. Katikireddi SV. HINARI: bridging the global information divide. BMJ 2004; 328: 1190- 1193. 23. Gandhi TK, Weingart SN, Borus J, et al. Adverse drug events in ambulatory care. New Engl J Med. 2003; 348:1556–64. 24. Figueiras A, Caamano F, Gestal-Otero JJ., 2000; Influence of physician’s education, drug information and medical care settings on quality of drugs prescribed. Eur J Clin Pharmacol 2000; 56: 747-753. 25. Rational Pharmaceutical Management Plus Program. Standard Treatment Guidelines— DRAFT Drug and Therapeutics Committee. Revised Draft: May 2001. 26. Miriam Zavaleta-Bustos, Lucila Isabel Castro- Pastrana, Ivette Reyes-Hernández, Maria Argelia López-Luna, Isis Beatriz Bermúdez- Camps. Prescription errors in a primary care university unit: urgency of pharmaceutical care in Mexico. RBCF 2008; 44(1): 115-125.