Sle What Lies Beneath
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Dr Eric Jason Amante lectures about the complex pathophysiology of SLE
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Sle What Lies Beneath
- 1. Systemic Lupus Erythematosus: What lies beneath
- 3. TNF -‐ ALPHA That’s All I Knew!!
- 4. YOU CAN UNDERSTAND IT! JUST OPEN YOUR MIND!
- 5. Impaired immune system in SLE Guerra et al. Arthri+s Research & Therapy 2012 14:211
- 6. The pathogenesis of Systemic Lupus Erythematosus (SLE) involves: • B cells • T Cells • Complement • All of the above
- 7. SLE Pathogenesis: The Panoramic View Reumatologica Clinica 2012
- 8. DefecKve clearance in this process leads to increased release of auto-‐anKgens: • Tolerance • Cellular ProliferaKon • Apoptosis • TransformaKon
- 9. Apoptosis: Programmed Cell Death
- 10. Some;mes things don’t go as Programmed…..
- 11. Complement in the pathogenesis of SLE Sturfelt, G. & Truedsson, L. (2012) Complement in the immunopathogenesis of rheumaKc disease Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2012.75
- 12. The complement pathway most involved in SLE is: • AlternaKve Pathway • Classical Pathway • Neoclassical Pathway • Straight Pathway
- 13. CYTOKINES IN SLE
- 14. Cytokines in SLE • decreased expression of interleukin (IL)-‐2 • increased produc;on of IL-‐17 and related cytokines • B-‐cell ac;va;ng factor, which promotes B-‐ cell survival and autoan;body produc;on • interferon-‐α, which acts as an immune adjuvant • tumor necrosis factor, which contributes to organ inflamma;on Nature Reviews Rheumatology 6, 317-‐325 (June 2010)
- 15. Figure 1 Soluble BAFF and APRIL signalling Vincent, F. B. et al. (2014) The BAFF/APRIL system in SLE pathogenesis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2014.33
- 16. Figure 3 Role of BAFF in the pathogenesis of SLE Vincent, F. B. et al. (2014) The BAFF/APRIL system in SLE pathogenesis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2014.33
- 17. BAFF is a member of which cytokine superfamily? • Interferons • IL-‐10 • TNF-‐Alpha • Chemokines
- 18. Toll – Like Receptors : Lead to IFN-‐Alpha producKon in SLE Liu et al Nature Medicine 2012
- 19. Interferon in SLE IFN-‐α produced promotes a. DC1 development b. T cell acKvaKon c. autoanKbody producKon by B cells
- 20. The Toll Like Receptors primarily involved in SLE Pathogenesis are : • 23, 6, 24 • 10, 11, 12 • 7, 8, 9 • 21, 17, 10
- 21. End Organ Damage in SLE: What Gives? Nature , 2012
- 22. Pathophysiology understanding drives treatment advances! Dema, DiscoveryMedicine, May 2014
- 24. In Disability Lies Opportunity!
- 25. JOIN THE FIGHT AGAINST LUPUS TODAY!