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MBS-6
How did it come about?
• Charlotte’s virus
• Jisel, Chula, and
  Cl ostridium botulinum
• Transmission of virus
• Specialized transduction to
  Mo’s cleavage plate           Specialized Transduction. Digital image. Microbiol - MCB 201 0.
                                                                                  ogy
                                Teresa G. Fischer, 2010. Web. 24 Apr. 2012. <http://faculty.irsc.edu/
                                FACULTY/TFischer/micro%20resources.htm>.
The story of Patient 0
The New Gene
• Keyboard habitat
• Easily contracted
• New gene: blocks release
  of Acetylcholine at
  neuromuscular junctions
• Paralysis-victims often
  found using Facebook
                             Acetylcholine. Digital image. Pharmacology. 9 Mar. 2012. Web. 24
                             Apr. 2012. <http://pharmacology-notes-free.blogspot.com/2012/03/
                             acetylcholine.html>.
Signs and Symptoms
• Upper respiratory complications
  – Congestion
  – Coughing
  – Sneezing
• Muscle and joint aches
  – Focused around the neck and shoulder area
• Fever
• Carpal tunnel
• Fatigue
Public Health Risk/Prevention
• Shorten social network site exposure
• Only add/accept people you know
  – Stranger danger
• Wash hands frequently
• Take walks outdoors
  – At least 20mins
Morbidity versus Mortality
                     32,122 Infections
                         97 Deaths
  0.3% of those infected are expected to die from MBS-6
99.7% of those infected are expected to make a full recovery
At Risk Populations
       College Educated Women in California
                       Number of Deaths by Education Level

70



60                                                    58



50



40                                                           no response
                                                             some high school
                                                             high school grad
                                                             some college
30                                                           college grad
Number of Deaths                                 24

20



10                 9

                          4
                                     2
 0
                                 # of deaths
                               Education Level
At Risk Populations
                                  number of deaths by sex



                           male
Women were almost 3        23%




times more likely to die                                    female
                                                            male




    from MBS-6!!
                                              female
                                               77%
At Risk Populations
                                                 Number of Deaths


                                            2%
                                  1%
80% of Those                     1%
                                        1%
                                       3%
                             1%
                            2%
                        1%
Who Died from           3%

                       2%
                                                                          California
                  1%                                                      Colorado`
MBS-6 Lived       2%                                                      England
                                                                          Florida
                                                                          Hawaii
                                                                          Maryland
in                                                                        Mexico
                                                                          Michigan
                                                                          New Jersey
                                                                          Pakistan

California !!!!                                                           Texas
                                                                          Washington
                                                                          Unreported




                                                                    80%
MBS-6
         A global disease
         A global disease


Countries affected:
United States, UK, Pakistan, Mexico,
New Zealand, Australia
MBS-6
Deaths per Day
Deaths per Day
MBS-6 R0
•R   0   = Basic reproduction number
•R   0   = (βΝ)/Υ
 •   R0 = (Contact rate x Total Population) / Average infection period


• Initial estimate: R < 3      0


• Actual: R > 5  0


• R > 1 is considered an epidemic
     0
Possible cures and vaccines?
• Vaccination
 – Herd immunity
• Inactivation of toxic producing cells
 – Blocking hemmaglutinin and neuraminadase
Immediate response
• Anticholinergenic agent
• Reversible agents
 – Nicotine
 – caffeine

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Mbs6

  • 2. How did it come about? • Charlotte’s virus • Jisel, Chula, and Cl ostridium botulinum • Transmission of virus • Specialized transduction to Mo’s cleavage plate Specialized Transduction. Digital image. Microbiol - MCB 201 0. ogy Teresa G. Fischer, 2010. Web. 24 Apr. 2012. <http://faculty.irsc.edu/ FACULTY/TFischer/micro%20resources.htm>.
  • 3. The story of Patient 0
  • 4. The New Gene • Keyboard habitat • Easily contracted • New gene: blocks release of Acetylcholine at neuromuscular junctions • Paralysis-victims often found using Facebook Acetylcholine. Digital image. Pharmacology. 9 Mar. 2012. Web. 24 Apr. 2012. <http://pharmacology-notes-free.blogspot.com/2012/03/ acetylcholine.html>.
  • 5. Signs and Symptoms • Upper respiratory complications – Congestion – Coughing – Sneezing • Muscle and joint aches – Focused around the neck and shoulder area • Fever • Carpal tunnel • Fatigue
  • 6. Public Health Risk/Prevention • Shorten social network site exposure • Only add/accept people you know – Stranger danger • Wash hands frequently • Take walks outdoors – At least 20mins
  • 7. Morbidity versus Mortality 32,122 Infections 97 Deaths 0.3% of those infected are expected to die from MBS-6 99.7% of those infected are expected to make a full recovery
  • 8. At Risk Populations College Educated Women in California Number of Deaths by Education Level 70 60 58 50 40 no response some high school high school grad some college 30 college grad Number of Deaths 24 20 10 9 4 2 0 # of deaths Education Level
  • 9. At Risk Populations number of deaths by sex male Women were almost 3 23% times more likely to die female male from MBS-6!! female 77%
  • 10. At Risk Populations Number of Deaths 2% 1% 80% of Those 1% 1% 3% 1% 2% 1% Who Died from 3% 2% California 1% Colorado` MBS-6 Lived 2% England Florida Hawaii Maryland in Mexico Michigan New Jersey Pakistan California !!!! Texas Washington Unreported 80%
  • 11. MBS-6 A global disease A global disease Countries affected: United States, UK, Pakistan, Mexico, New Zealand, Australia
  • 13. MBS-6 R0 •R 0 = Basic reproduction number •R 0 = (βΝ)/Υ • R0 = (Contact rate x Total Population) / Average infection period • Initial estimate: R < 3 0 • Actual: R > 5 0 • R > 1 is considered an epidemic 0
  • 14. Possible cures and vaccines? • Vaccination – Herd immunity • Inactivation of toxic producing cells – Blocking hemmaglutinin and neuraminadase
  • 15. Immediate response • Anticholinergenic agent • Reversible agents – Nicotine – caffeine