International Conference "Reconnecting economy and society through innovation - A new bioeconomy infrastructure for the regeneration of local areas" 30th September 2016

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CHRISTOPHE SCHILLING, Ph.D.
TAGLIO DI PO, ROVIGO, ITALY
SEPTEMBER 30TH, 2016
THE VALUE OF
A STRATEGIC PARTNERSHIP
TO BUILD TECHNOLOGICAL
LEADERSHIP

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4. 4Strategic Partnership for the Bioeconomy…starting with BDO
Collaboration grounded in shared principles that drive successful commercialization of high impact technologies
pioneering innovation mindset
belief in the power of biotechnology
passion for sustainable development

5. Genomatica Innovation Center
San Diego, California
About Genomatica
• Bioengineering Technologies for the chemical industry
• Privately-held, founded in 2000
• San Diego, California a US biotechnology hub
• ~ 80 employees
• > 50% advanced technical/business degrees

6. 6Bioengineering innovations disrupting traditional value chains
Complete platform to “industrialize” biotechnology; combining synthetic biology and bioprocess engineering

7. 7Driving Technologies from Concept to Commercial Realization
Core competencies across computation, experimentation, and bioprocessing, all tightly integrated
optimizing
cell factories
integrating process
design & engineering
engineering
enzyme components
high fidelity scaling
to commercial
Enabling Science
& Discoveries
Commercial
Realization
in silico design &
prototyping pathways
guiding with
techno-economics
Innovation Engine
systems
bioengineering
optimal
pathway
bank
Lab Pilot Demo Commercial
$/ton
Scalable
Engineering
Idea Conception &
Modeling Analysis

8. 8Global Symbol for the Bioeconomy
Novamont’s Mater-Biotech BDO Plant harnesses the power of biotechnology with the Genomatica GENO BDO Process

9. 9Ideation and design of the optimal BDO Organism - 2007
Metabolic Engineering designs for the first organism to produce 1,4-Butanediol from sugars
Carbohydrates
1,4-Butanediol
O
HO OH
OH
OH
HO
six-carbon sugars
(ex. dextrose)
five-carbon sugars
(e.x. xylose)
disaccharides
(ex. sucrose)

10. 10The First BDO Producting Organisms - 2008
Genetically engineering E. Coli bacteria converting sugar into 1,4-butanediol

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O
HO
OH
OH
OH
OPO3
O
OH
OH
HO
HO
OPO3
“Single Step Biocatalyst” converting Sugar into Butanediol
Sequence of biochemical reactions convert sugar into BDO inside the organism
O
HO
OH
OH
OH
HO
O
OPO3
OH
HO
HO
OPO3
OH
O
OPO3
O
OH
OPO3
OPO3
OH
OPO3
O
OPO3
OH
OPO3
O
OH
OH
OPO3
O
OH
OH
OPO3
O
OH
OPO3
OH
O
OH
OPO3
OH
O
OH
OPO3
O
OH
OPO3
O
Dextrose Sugar 1,4-Butanediol

12. 12Purified 1,4-Butanediol - 2009
Designed and tested full process to produce on-spec BDO from sugars

13. 13Scaling-up the GENO BDO Process – 2010 to 2013
Move from Lab-Scale to Commercial-Scale validation with partners facilities and cooperation
3,000 Liter piloting
2010
Integrated Demonstration Plant
2011
Shipping Tons of Product
2012
Commercial Scale Campaigns
2013

14. 14The Journey toward the Mater-Biotech BDO Plant
Setting new standards, 5 years concept to commercial scale, and now the world’s first dedicated bio-BDO plant
Mater-Biotech
BDO Plant
family of biodegradable
& compostable bioplastics
• enabling strategic partnership
• world’s 1st bio-based plant for
a major intermediate chemical
• differentiated BDO applications
3,000L
13,000L
2013…
Commercial scale
2012 campaigns
Shipping tons
2011
Integrated demo plant
2010
Piloting
2009
Purified BDO
2008
BDO producing organisms
GENO BDOTM
Process Technology

15. 15Potential to serve existing BDO market applications
$4B global market producing 2 Million tons – exact same chemical made a better way
1,4-Butanediol
(BDO)
THF
Tetrahydrofuran
PBT
Polybutylene Terephthalate
Spandex /
Elastane
Polyurethane
Polyester
GBL
Gamma-Butyrolactone
Direct use
Derivatives
Downstream
Exact same chemical
…now made a better way

16. 16Driving a Broader Transformation toward Green Chemicals
Technologies targeting Large Existing Markets in Basic, Intermediate, and Specialty Chemicals
Applications for Renewables
 packaging
 apparel
 automotive
 carpeting
 cosmetics
 personal care
 nutraceuticals
Volume
$/ton
* Not to scale
Pharma, Flavor
Fragrance
Intermediate Chemicals
 ~30 products
 Ave. $9Bn each
Butadiene
$20Bn+
BDO
$4Bn
CPL
$10Bn
ADA
$6Bn
HMD
$3Bn
Basic Chemicals
 7 products
 Ave. $37Bn each
Specialty Chemicals
 100’s of products
 $100M-1Bn each
$1-2Tn Core of the
Chemical Industry
Genomatica Process Technologies

17. 17Accelerating the Pace of Bioprocess Technology Development
New Strategic Alliance between Genomatica and Ginkgo Bioworks, a leader in organism engineering
• New alliance announced September 29 between technology leaders with highly complementary platforms
• Brings more capabilities to rapidly engineer organisms leveraging automation and ‘semi-conductor like’ foundries
• Advances in biotechnology continue to reduce the cost of R&D, and accelerate the potential for new technologies

18. 18Bright Future for the Bioeconomy
Combined Team of Talented Passionate People have made this Achievement Possible
Team Novamont – leadership, vision, courage, drive, and determination
Investors – financiers supporting Novamont, Genomatica, and the Mater-Biotech project
National & Regional Support – openness to local revitalization and a bioeconomy vision
Mater-Biotech Team – dedication in construction, commissioning, start-up, and operations
On behalf of everyone at Genomatica we wish to acknowledge and provide our deepest thanks to:

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CHRISTOPHE SCHILLING, Ph.D.
TAGLIO DI PO, ROVIGO, ITALY
SEPTEMBER 30TH, 2016
THE VALUE OF
A STRATEGIC PARTNERSHIP
TO BUILD TECHNOLOGICAL
LEADERSHIP

20. 20Bio-based Butadiene together with Versalis
Joint Venture developing combined technology for renewable butadiene with a annual volumes 10x larger than BDO
100% bio-based poly-butadiene synthetic rubber – February 2016
most advanced program for
renewable & on-purpose butadiene