Week 1 Introduction
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The content of this presentation was taken from the: MIT Open Course Ware http://ocw.mit.edu ES.S10 Drugs and the Brain This was made on behalf of the final requirements for: CEIT321 Course in Middle East Technical University
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Week 1 Introduction
- 5. RECEPTORS •Excitatory •Sends signals (action potentials) •Inhibitory •Blocks signals
- 6. DRUGS, NEUROTRANSMITTERS, AND OTHER LIGANDS •Agonists •Stimulate receptors, mimic the neurotransmitter •Antagonists •Block receptors
- 7. AGONISTS AND ANTAGONISTS Neurotransmitter Agonist (drug) Antagonist (drug)
- 8. GLUTAMATE • The most common excitatory neurotransmitter • Glutamate is released by 80% of neurons • Learning • Memory
- 9. GABA • The most common inhibitory neurotransmitter in the brain • Sleep • Muscle relaxation • Anxiety relief • Impairs memory
- 10. HOW DRUGS MIMIC NEUROTRANSMITTERS •Drugs look like chemicals normally found in your body
- 11. GABA Neurotransmitter Drug Baclofen GABA Agonist (mimics GABA) Vigabatrin Inhibits GABA breakdown Drug
- 12. NOREPINEPHRINE •Fight or Flight •Increases heart rate •Excitement •Fear
- 13. EPINEPHRINE AND PHENYLEPHRINE Epinephrine Adrenaline Phenylephrine
- 14. DOPAMINE •The Salience Neurotransmitter •Rewards sex, eating •Increases alertness, happiness
- 15. ADDICTION Do more cocaine Damage decision- making and reward-seeking parts of brain Do cocaine
- 16. SEROTONIN (5-HT) •The Satiety Neurotransmitter •Feelings of fullness, contentment •Relieves depression
- 19. SEROTONERGIC DRUGS I Ondansetron Zofran
- 22. SEROTONERGIC DRUGS II Lysergic Acid Diethylamide
- 23. CANNABINOIDS Anandamide 2-AG 2-AGE NADA Marijuana mimics these molecules in the brain.
- 24. OPIOIDS •Morphine mimics these •Relieve pain and worry •Induce sleep •Slow digestive tract
- 25. ACETYLCHOLINE (ACh) •Nicotine mimics this •Alertness •Memory •Moves muscles •Causes secretions (saliva, sweat)
- 26. DOPAMINERGIC AND CHOLINERGIC DRUGS Dopamine Amphetamine MDMA (Ecstasy) Acetylcholine Succinylcholine Edrophonium
- 29. ADENOSINE AND CAFFEINE Adenosine Caffeine
- 30. MIT Open Course Ware http://ocw.mit.edu ES.S10 Drugs and the Brain Spring 2013 Edited by Niña Joy Ubaldo For CEIT321 Project All rights reserved © 2016 Middle East Technical University