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NECST Lab @ Politecnico di Milano

Hackathon on Rare Disease

Healthcare

HACKATHON
pBook
A rare diseases smart management platform
Guido W. Di Donato, Jacopo Fidanza, Marco Arnaboldi, Lorenzo Di Tucci
{guidowalter.didonato,marco1.arnaboldi}@mail.polimi.it
lorenzo.ditucci@polimi.it
jacopo.ﬁdanza92@gmail.com

HACKATHON
2
Problem deﬁni-on
Two way  
communication
Late 
diagnosis
Everyday 
management

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Problem deﬁni-on
Two way  
communication
Late 
diagnosis
Everyday 
management

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Proposed solu-on
Patient
Specialists medical equipe

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Patient Specialists medical equipe
Proposed solu-on

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Proposed solu-on
Patient Specialists medical equipe

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Proposed solu-on
Patient Specialists medical equipe

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Proposed solu-on
Patient Specialists medical equipe

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Proposed solu-on
Patient Specialists medical equipe
Hospitals & Clinics

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Proposed solu-on
Patient Specialists medical equipe
Hospitals & Clinics

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Proposed solu-on
Patient Specialists medical equipeCommunity
Hospitals & Clinics

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Proposed solu-on
Patient Specialists medical equipeCommunity
Hospitals & Clinics
Distance
Learning

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Proposed solu-on
Patient Specialists medical equipeCommunity
Hospitals & Clinics
NotiﬁcationSchedule
Distance
Learning

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Proposed solu-on
Patient Specialists medical equipeCommunity
Hospitals & Clinics
NotiﬁcationSchedule
Distance
Learning

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Patient Specialists medical equipe
Proposed solu-on
Community
Hospitals & Clinics
Alarm NotiﬁcationSchedule
Distance
Learning

HACKATHON
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data transfer
notification calendar
silicone intercambiabile
allarm
CUSTOMIZABLE
DESIGN FOR ALL
VISUAL INPUT: LED
SENSOR IMPUT: VIBRATION
WIRELES RECHARGE
DIGITAL SIM
SENSORS: CARDIAC RITM - HUMIDITY - EXTERNAL TEM-
PERATURE - BODY TEMPERATURE

HACKATHON
17
Thanks :)
by
Guido W. Di Donato guidowalter.didonato@mail.polimi.it
Jacopo Fidanza jacopoﬁdanza92@gmail.com
Marco Arnaboldi marco1.arnaboldi@mail.polimi.it
Lorenzo Di Tucci lorenzo.ditucci@polimi.it
jacopo.ﬁdanza92@gmail.com

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- Filippo Carloni, M.Sc. student in Computer Science and Engineering Expressions (REs) are widely used to find patterns among data, like in genomic markers research for DNA analysis, signature-based detection for network intrusion detection systems, or search engines. TiReX is a novel and efficient RE matching architecture for FPGAs, based on the concept of matching core. RE passes into the compilation and optimization phase to be efficiently translated into sequences of basic matching instructions that a matching core runs on input data, and can be replaced to change the RE to be matched.

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- Daniele Valentino de Vincenti, B.Sc. graduate in Biomedical Engineering @Politecnico di Milano - Lorenzo Farinelli, B.Sc. graduate in Computer Science and Engineering @Politecnico di Milano Plaster is a multi-layered infrastructure (based on C++) aimed at supporting the development of multi-FPGA systems and the management of large data flows between the nodes. In particular, the goal of the project is to provide the end-user with a set of tools (by the means of a Python library and a C++ service) to easily assign bitstreams to nodes and route data between them, in the context of a PYNQ-based cluster suitable for distributed acceleration of computation-intensive tasks. Using this platform, an abandoned objects detection tool is implemented, designed as a Multi-FPGA distributed system exploiting an hardware accelerated version of the YOLO neural network for image detection.

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BlastFunction: How to combine Serverless and FPGAs

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- Sofia Breschi, B.Sc. student in Biomedical Engineering - Beatrice Branchini, B.Sc. student in Biomedical Engineering In the last few years, the use of Next Generation Sequencing technology in medicine has become more and more common, in particular for the diagnosis of genetic diseases and the production of personalized drugs. In this context, the identification of characteristic patterns in the human genome plays an important role. Exact pattern matching algorithms are an efficient way to identify those sequences. However, this process represents a bottleneck in the genomic field as it is very computationally intensive and time-consuming. Moreover, general-purpose architectures are not optimized to handle the huge amount of data and operations used in a genomics context. Due to these considerations, we propose an implementation of the Knuth-Morris-Pratt (KMP) algorithm on FPGA, a particular family of integrated circuits capable of reconfiguration for an infinite number of times. The KMP algorithm results in being very fast and efficient, by reducing unnecessary comparisons of characters that have already been matched. Furthermore, to achieve an overall speedup of the alignment process, the implementation on FPGA will bring on an even faster and more efficient solution, thus providing the patient with a quick response.

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Disinfection of medical instruments is important for preventing the spread of disease. Cleaning and disinfecting reusable equipment after it comes into contact with patients can be expensive, both in the cost of the disinfection procedure, but also in terms of time away from the patients themselves. Not all medical instruments can be fully sterilized after each use. Thankfully, not all reusable instruments need the highest level of disinfection. But how to determine the minimum level of disinfection in a given situation? Earle H. Spaulding devised a rational approach to disinfection and sterilization of patient-care items and equipment Spaulding believed the nature of disinfection could be understood readily if instruments and items for patient care were categorized as critical, semi-critical, and non-critical according to the degree of risk for infection involved in use of the items. Spaulding recognized that the need for disinfection of equipment in medical settings ranged from non-critical to semi-critical to critical, depending on the likelihood of spreading disease. For example, sterilization is necessary for equipment that comes into contact with a patient’s bloodstream or sterile tissue. This category of equipment, such as surgical knives, is designated “critical” because it presents a high risk of disease transmission from patient to patient. Equipment that only touches healthy, unbroken skin presents a low risk of contamination because intact skin acts as an effective barrier to most microorganisms. Examples in this “non-critical” category include bedpans, blood-pressure cuffs, and bedrails. In between those two scenarios, a “semi-critical” level of disinfection presents a medium risk of contamination. This would include equipment such as endoscopes used on mucous membranes or areas of broken skin.

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Today’s healthcare leaders are seeking technology solutions to optimize efficiencies and improve patient care. However, without effective change management and strategies in place, healthcare leaders struggle to strategically improve patient flow, space, to strategically improve patient flow, space, and schedule management, and implement daily huddles. The role of technology in supporting operational efficiency and change management initiatives is inevitable. During this webinar, attendees will learn how to optimize Ambulatory Operational Efficiencies and Change Management. Attendees will also learn about the importance of visual management boards in enhancing clinic performance and insights into effective change management approaches.

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Oppenheimer & Co. Inc, co-Head of Healthcare Investment Banking, Michael Margolis, provides H1 Healthcare Financing, Funding and M&A Overview. Table of Contents 1. Broader Market Overview 2. Biotech M&A Market Overview 3. Private Biotech Financing Market Update 4. Key Advice For Healthcare Companies Current State of Play; Healthcare has Underperformed the Broader Market Over the Last Twelve Months; Signal-to-Noise is Getting Worse; Healthcare IPO Activity has Decreased Significantly Since 20–21 Pandemic Levels; Biotech Financing Activity Has Remained Robust in 2024; Biotech M&A Market Remains Incredibly Active; Biotech M&A Market Remains Incredibly Active; Big Pharma Upcoming Patent Expirations; Since November 2023 Oncology has accounted for over half of all M&A; Oncology, Autoimmune / I&I, and CV & Metabolic Remain the Top Areas in M&A; Small Molecule Beats Out All Other Modalities in M&A Despite IRA Concerns; Value of Big Pharma Acquisitions by Therapeutic Area in Q1 2024; Private Financing Market Update; 2024 Private Placement Activity On Track to Approach, If Not Exceed, 2020 Levels; Oncology, Particularly Solid Tumor, Continues to Attract VC Investors; Despite the IRA, Small Molecules Continue to Attract VC Dollars; Preclinical-Stage Companies Make Up Almost Half of Private Placements in 2023; Valuations by Development Stage – 2023; Typical Biotech Investors Remained Active in Q1 2024; 23 $100M+ Deals were Raised in Q1 2024; Biotech Fundraising Momentum Continued into 2024; Key Advice For Israeli Healthcare Companies; Although Israel has Strong Presence on US Public Markets, There is Room to Grow; Telling Your Story Effectively; Interacting with Investors to Build Long-term Credibility; Seven Simple Rules for Pitch Decks;

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