3. Bone Cement
In reality, “Bone Cement” is a misnomer .Word cement is used to
describe a substance that bonds two things together, But bone
cement acts as a space-filler that creates a tight space which holds the
implant against the bone.
Originally developed for Dental applications.
Using in orthopaedics for more than 40 years.
Gold standard in the field of joint replacement surgery.
Neither Osteoinductive, nor Osteoconductive and does no remodeling
of bone.
4. History trace back to…..
Themistokles Gluck ,a German surgeon, 1870
Fixed a total knee prosthesis made of ivory using
cement made of plaster and colophony
“...for a better fixation, I mixed plaster with
colophony, which cures up to the hardness ofglass.”
5. History trace back to…..
1958 – Sir John Charnley used self
curing PMMA to anchor femoral head
prosthesis to femur
First cement - Nulife
6. What is bone cement?
Self curing organic or inorganic formulations which may or
may not contain antibiotics used to fill up a cavity or to create
a mechanical fixation of prosthesis to living bone.
Chemical name - PMMA
7. Interest in orthopaedics
Joint Replacement Surgery
Spinal Compression Fractures
Chronic Osteomyelitis
Tumours
9. Why separate components?
Polymerisation of MMA is too slow ( hrs to days)
Pure MMA is of low viscosity can easily diffuse in blood
Much easier to shape
Heat polymerisation can boil monomer
Pure MMA volumetric shrinkage
11. 1.Mixing
Viscosity starts to increase
Chemical reaction :
1. Wetting - Surface area of Polymer beads
dissolved by MMA
2. Polymerization
Phase ends – formation of Homogenous mass
(tooth paste like consistency)
which is transferred to cement gun
12. What is polymerisation?
Free radical polymerisation.
Carbon-to-carbondouble bonds broken
and newcarbonsingle bonds form
Exothermic reaction.
Temperature reach up to 70-120 C.
May cause thermal bone damage.
Viscosity increases.
13. How to mix?
Hand mixing :
Open bowl using spatula
1 to 2 Hz, period of 2min
Disadvantages :
- Introduction of Voids
- Porosity 7% and higher
- Excessive mixing
increases porosity
14. Centrifugation
Liquid & powder hand mixed then
centrifuged
2300 – 4000 rpm for 0.5 – 3 min
Adv : Dramatic decrease in porosity by
1%
Disadv : Sedimentation of radiopacifiers
It works only in low viscosity and its
achieved by chilling MMA monomer
15. Vacuum mix
Contents placed in bowl –
mixed after vacuum conditions
Adv : Low Porosity
Low exposure of
vapours
Distribution of
Radiopacifiers
17. 3.Working phase
Cement is no longer sticky but of sufficiently low viscosity to
enable surgeon to easily apply cement
Chemical reaction :
Exothermic reaction
Polymerisation continues
Viscosity increases
19. Functions of Bone cement
Allows secure fixation of implant and bone
Mechanical interlock and space filling
Load transferring
Maintenance/restoration of bone stock
Release of antibiotics
20. How to deliver cement?
1st Generation
Hand / Finger packing
Femoral component used – stainless steel & co
– cr alloy
Failed due to geometry of implants
narrow medial margins
sharp corners
21. 2nd Generation
Cement gun
Placement of bone cement - retrograde fashion
Plastic plug – cement pressurisation
Pulsatile lavage – cleanse femoral canal of loose
cancellous bone, blood, fat, marrow contents & dried
prior to cementing
it increases the shear strength at bone cement
interface
improved survival rate of implant
25. Antibiotics Loaded Bone cement
Ideal antibiotic properties :
Preparation must be thermally stable
Antibiotic properties not affected by heat
Must be water soluble for diffusion into tissues
Bactericidal
Gradual elution over an appropriate time period
Minimal local inflammatory response
26. Contd..
Have action against common pathogens like S.aureus, S.
epidermidis ,coliforms and anaerobes.
Must not significantly compromise mechanical integrity
Must be available as a powder.
Must have a low incidence of allergy.
27. Which antibiotics to use?
Gentamycin (most common) andtobramycin are commonly
used
Vancomycin (ultrafine powder) is used as lyophilised
vancomycin. It greatly reduces fatigue strength.
Ciprofloxacin may inhibit soft tissuehealing
Penicillins and cephalosporins exhibits stability and good
elution properties. But are avoideddue to their potential
allerginicity.
29. How to asses radiologically?
Barrack’s Cement mantle grading
Gruen zones
30. Barrack’s femoral component
cementation Quality grading
Grade Radiographic charcterstics
A Complete filling of medullary canal, without radiolucent line between
cement & bone ( White-Out)
B Radiolucent line covering upto 50% of cement-bone interface
C Radiolucent line covering between 50 -99% of cement – bone
interface or incomplete cement mantle
D Complete Radiolucent line (100%) at cement-bone interface and/or
absence of cement distally to end of stem
31. Gruen zones
7 zones in AP / lateral
Radiographs
What is measured?
Radiolucent lines at bone
cement and prosthesis cement
interface
Progression of no. of Zones -
Loosening
32. Mechanism of loosening
Debris produced because of
mechanical factors
Biological response by formation of
FIBROUS MEMBRANE b/w cement &
bone interface
Results in loosening
33. Bone cement in Tumours
Benificial role
Cytotoxic effect
Direct
toxicity of
monomer
By mixing
with MTX
Mechanical
Decreases
blood
supply
Thermal
Structural
support
35. Bone Cement Implantation
Syndrome – (BCIS)
HYPOXIA, HYPOTENSION or both and/or unexpected LOSS
OF CONSCIOUSNESS
occurring around the time of cementation, prosthesis
insertion, reduction of the joint or, occasionally, tourniquet
deflation in a patient undergoing cemented bone surgery.