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Meningococal Septicaemia

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Meningococal Septicaemia is an infectious disease caused by Neisseria meningitidis. I created this presentation for my final year case study. I'd like to share this information with world.

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Meningococal Septicaemia

  1. 1. Mifrah Ziyard AHS/ MLS/ 05/ 53 Faculty of Allied Health Sciences University of Peradeniya.
  2. 2. <ul><li>A 35 years old man presented to the emergency room from an outside hospital with general malaise, low-grade fever, and purplish discoloration on his hands. He also had headache and hypotension. 10 days prior, he had return from a trip to sub Saharan Africa. Blood cultures were drawn and he was admitted to the intensive care unit. Blood culture bottles were sent to the microbiology laboratory along with a proper request form for culture and ABST. </li></ul>
  3. 3. <ul><li>Appearance </li></ul><ul><ul><li>Fair man with Generalized purpura </li></ul></ul><ul><ul><li>Edematous eye lids </li></ul></ul><ul><ul><li>Entire hands are purpuric </li></ul></ul><ul><ul><li>Malaise </li></ul></ul><ul><li>Temperature 38 o C </li></ul><ul><li>Lungs </li></ul><ul><ul><li>Clear and equal breath sounds </li></ul></ul><ul><li>Cardiac </li></ul><ul><ul><li>Tachycardia </li></ul></ul><ul><li>Blood Pressure </li></ul><ul><ul><li>70/50 mmHg </li></ul></ul>
  4. 4. <ul><li>FBC </li></ul><ul><ul><li>RBC 3.63 X 10 12 /L </li></ul></ul><ul><ul><li>WBC 14.3 X 10 9 /L </li></ul></ul><ul><ul><li>Differential count </li></ul></ul><ul><ul><ul><li>Neutrophils 35 % </li></ul></ul></ul><ul><ul><ul><li>Immature forms 52% </li></ul></ul></ul><ul><ul><ul><li>Lymphocytes 10% </li></ul></ul></ul><ul><ul><li>Hb 10.8 g/dL </li></ul></ul><ul><ul><li>HCV 30.6 % </li></ul></ul><ul><ul><li>PLT 20 X 10 9 /L </li></ul></ul>
  5. 5. <ul><li>Sodium 134 mmol/ L </li></ul><ul><li>Potassium 4.8 mmol/ L </li></ul><ul><li>Creatinine 1.5 mg/ dL </li></ul><ul><li>Glucose 51 mg/dL </li></ul><ul><li>Amylase 117 U/L </li></ul>
  6. 6. <ul><li>Specimen </li></ul><ul><ul><li>Blood </li></ul></ul><ul><li>Gram stain </li></ul><ul><li>Culture Media </li></ul><ul><ul><li>Blood Agar </li></ul></ul><ul><ul><ul><li>Convex, Grey, Translucent, non pigmented </li></ul></ul></ul><ul><ul><ul><li>and non Hemolytic colonies </li></ul></ul></ul><ul><ul><li>Chocolate Agar </li></ul></ul><ul><ul><li>Selective Media </li></ul></ul><ul><ul><ul><li>Thayer Martin Medium </li></ul></ul></ul>
  7. 7. <ul><li>Oxidase Positive </li></ul><ul><li>Catalase Positive </li></ul><ul><li>DNAse Test Negative </li></ul><ul><li>Acid Production </li></ul><ul><ul><li>Glucose: Ferment </li></ul></ul><ul><ul><li>Maltose: Ferment </li></ul></ul><ul><ul><li>Fructose: not Ferment </li></ul></ul><ul><ul><li>Sucrose: not Ferment </li></ul></ul>
  8. 8. <ul><li>Modified Thayer Martin Agar </li></ul><ul><ul><li>Convex, glistening, elevated colonies </li></ul></ul><ul><ul><li>mucoid colonies </li></ul></ul><ul><li>Gram stain smear from aspirate of petechiae </li></ul>
  9. 9. <ul><li>Ampicillin/Penicillin </li></ul><ul><li>Ceftriaxone </li></ul><ul><li>Chloramohenicol </li></ul><ul><li>Rifampicin </li></ul><ul><li>Ciprofloxacin </li></ul><ul><li>Meropenem </li></ul>
  10. 10. <ul><li>Clinical Medicine; kumar P and Clark M; Elsevier Saunders; 6 th edition; Page 75 – 76. </li></ul><ul><li>Laboratory Exercise in Microbiology; Prescott H; The MacGraw – Hill; 5 th edition; Page 355 -357. </li></ul><ul><li>http://path.upmc.edu/cases.html </li></ul>

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