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CNS Malignancies Michael Guiou, M.D.
Outline ,[object Object],[object Object],[object Object]
Annual Incidence of Brain Tumors (USA) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Primary Brain Tumors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],40 - 50% 15 - 20% 10% 6 - 10% 5% 5% Brain Tumors: Prevelance
Benign tumors ,[object Object],[object Object],[object Object],[object Object]
Meningioma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Histopathology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Meningioma ,[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Meningioma: RT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Meningioma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vestibular schwannoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vestibular schwannoma: Imaging ,[object Object]
Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Craniopharyngioma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Craniopharyngioma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Craniopharyngioma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],CT MRI
Glioma ,[object Object],[object Object],[object Object],[object Object],[object Object]
Low Grade Glioma (LGG) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LGG: Treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LGG: Radiotherapy  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Glioblastoma ,[object Object],[object Object],[object Object]
Role of RT in GBM ,[object Object],[object Object],[object Object]
RTOG Target Delineation
[object Object]
RTOG Boost Volume Delineation
[object Object]
 
Anaplastic astrocytoma ,[object Object]
Poor KPS, Elderly GBM ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Ependymomas
Ependymoma Kun, Tarbell ASTRO 2003 Refresher Course
RT for ependymoma ,[object Object],[object Object],[object Object],[object Object],[object Object]
Posterior Fossa Delineation
Adult medulloblastoma ,[object Object],[object Object],[object Object]
Technical pitfalls- Cribiform plate recurrences ,[object Object]
Technical pitfalls- Cribiform plate recurrences ,[object Object]
Cranial field design ,[object Object],[object Object],[object Object]
Spinal field design ,[object Object],[object Object],[object Object]
Conventional PF field design ,[object Object],[object Object],[object Object]
Junctioning fields ,[object Object],[object Object],[object Object]
Exact match ,[object Object]
Divergent match ,[object Object],[object Object]
Divergence into lens ,[object Object],[object Object]
Geometric match ,[object Object],[object Object]
Various junction techniques ,[object Object],[object Object],[object Object],[object Object]
Brain Metastases -Epidemiology -WBRT + SRS
Histology and Frequency ,[object Object],[object Object],[object Object],[object Object]
Histology & Frequency ,[object Object],[object Object],[object Object]
Histology and Frequency ,[object Object],[object Object],[object Object]
Other histologies ,[object Object],[object Object],[object Object]
Role of RT ,[object Object],[object Object],[object Object],[object Object]
Prognostic factors -RPA Class ,[object Object],[object Object],[object Object],[object Object],[object Object]
RTOG Dose-fractionation schemes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RTOG dose fractionation schemes ,[object Object],[object Object],[object Object]
RTOG altered fractionation ,[object Object],[object Object]
Postoperative WBRT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Stereotactic Radiosurgery ,[object Object],[object Object]
Radiosurgery data ,[object Object],[object Object]
Patient selection for surgery verus radiosurgery ,[object Object],[object Object],[object Object],[object Object]
Complications of WBRT ,[object Object],[object Object],[object Object],[object Object]
WBRT +/-SRS for KPS  > 70 and controlled primary or Surgery (if highly symptomatic, or mass effect) + WBRT or WBRT for KPS <70 or uncontrolled primary Primary Therapy for Metastatic Brain Disease Lesion number Diagnostic uncertainty and asymptomatic  Observation If grows, surgery or SRS+/-WBRT Surgery 1 <1cm >1cm Convincing Metastasis Single Solitary 2-3 >3 KPS  >  70 and controlled primary KPS  < 70 or uncontrolled primary Surgery +/- WBRT  or SRS (<3cm) +/- WBRT  for non-surgical candidate (if >3cm, WBRT only) WBRT (surgery to lesions causing mass effect) WBRT (Surgery if tumor causes mass effect) *Surgery or SRS (<3cm) +/- WBRT or
RTOG 90-05 ,[object Object],[object Object],[object Object],[object Object],Shaw E, et al Int J Radiat Oncol Biol Phys. 2000 May 1;47(2):291-8.

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CNS tumors_MG

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  • 63. WBRT +/-SRS for KPS > 70 and controlled primary or Surgery (if highly symptomatic, or mass effect) + WBRT or WBRT for KPS <70 or uncontrolled primary Primary Therapy for Metastatic Brain Disease Lesion number Diagnostic uncertainty and asymptomatic Observation If grows, surgery or SRS+/-WBRT Surgery 1 <1cm >1cm Convincing Metastasis Single Solitary 2-3 >3 KPS > 70 and controlled primary KPS < 70 or uncontrolled primary Surgery +/- WBRT or SRS (<3cm) +/- WBRT for non-surgical candidate (if >3cm, WBRT only) WBRT (surgery to lesions causing mass effect) WBRT (Surgery if tumor causes mass effect) *Surgery or SRS (<3cm) +/- WBRT or
  • 64.