63. WBRT +/-SRS for KPS > 70 and controlled primary or Surgery (if highly symptomatic, or mass effect) + WBRT or WBRT for KPS <70 or uncontrolled primary Primary Therapy for Metastatic Brain Disease Lesion number Diagnostic uncertainty and asymptomatic Observation If grows, surgery or SRS+/-WBRT Surgery 1 <1cm >1cm Convincing Metastasis Single Solitary 2-3 >3 KPS > 70 and controlled primary KPS < 70 or uncontrolled primary Surgery +/- WBRT or SRS (<3cm) +/- WBRT for non-surgical candidate (if >3cm, WBRT only) WBRT (surgery to lesions causing mass effect) WBRT (Surgery if tumor causes mass effect) *Surgery or SRS (<3cm) +/- WBRT or