GOOD LUCK

1. The Influence of Periodontal
Infection on Systemic
Health
By
Prof. Hakem Hussein ElSayed

2. Periodontal disease can theoretically
affects systemic health by one or more
of several mechanisms
1) Direct extension of periodontium infection from to deeper
adjacent tissues ( facial plane, sinus or brain infections).
2) Passage of inflammatory mediators from the
periodontium into the circulation (e.g. atherosclerosis).
3) Penetration of oral bacteria into the systemic circulation to
(endocarditis, thrombosis/atherosclerosis).
4) Inhalation or ingestion of oral bacteria(gram-ve), their products
(pulmonary or gastrointestinal tract infection- lung abscess).

3. Periodontal disease has been found to play
a role in the pathogenesis of important
systemic diseases
infective endocarditis,
atherosclerosis
pulmonary infections,
diabetes mellitus
preterm low birth weight child.

4. infective endocarditis
Periodontal /
Dental procedure
in patients with
rheumatic or
congenital heart
disease.
Circulation with various
organisms particularly the
streptococcus group
vegetation of (bacteria /
platelet / fibrin)

5. Atherosclerosis
injury to the endothelium
Platelet aggregation +blood
coagulation
Endotoxins (LPS)
produced by
periodontal
pathogens
Streptococcus sangius
if enters the circulation,
( it contains a bacterial
protein“mimics” platelet
receptor ) initiates
thrombus formation.
Periodontal infection
prostaglandins,
Interleukin
Proliferation of
vascular smooth muscle
increased B.V wall
thickness
Endothelium injury -Thrombosis - Wall thickness

6. Periodontal infection as a possible risk
factor for pregnancy complications
Throughout
gestation ( in
normal healthy
condition )
the amniotic level of
prostaglandins, especially
PGE2, rises steadily
until a sufficient level is
achieved in the amnion
to induce labor and
delivery

7. Periodontal infection as a possible risk
factor for pregnancy complications
So additional inflammatory PGE2 and TNF-α +steadily rise of
gestational PGE2 may pose a potential threat for pregnancy
outcome (uterine contraction before the normal date of birth)
Periodontal
infection,
Acts as a reservoir for
gram-ve anaerobic
organisms, LPS (endotoxin)
and inflammatory mediators
as PGE2 and TNF-α
leading to onset of
preterm labor.

8. Periodontal infection & Diabetes
gram-negative
Chronic periodontal
infection,
+++ Stress Hormons
result in increased
insulin resistance
After periodontal treatment and reduced inflammation
might restore insulin sensitivity over time& improve
glycemic control

9. Respiratory infections
Inhalation of
( anaerobic bacteria )
subgingival flora
anaerobic respiratory
infection
suppurative
respiratory diseases
such as pulmonary
abscess infection

10. Thank you