Leptospira

1. LEPTOSPIRA
Mahsa jalili
MSC.medical microbiology

2. INTRODUCTION
 Leptospira
 wide range of host
 distinct ecological adaptation

3.  The most frequent hosts are rodents, especially the common
rat.
 Other animals can include, but are not limited to:
 Cattle
 Horses
 Dogs
 Wild animals

4.  Leptospires can enter their human through intact skin or mucous
membranes, but entry is facilitated by cut.
 spirochaete can survive in water for months.
 Drinking contaminated water can also cause infection

5. THE ROLE OF THE COMPLEMENT SYSTEM IN THE HOST’S DEFENSE
AGAINST PATHOGENS
 first lines of defense against invading microorganism.
 classical, alternative, and lectin pathways(CP, AP, and LP,
respectively)

6. COMPLEMENT EVASION STRATEGIES BY LEPTOSPIRA
 recruitment of host complement regulators
 acquisition of host proteases that cleave complement proteins on the
bacterial surface
 secretion of proteases that inactivate complement in the Leptospira
surroundings

9. CONCLUDING REMARKS
 Complement is a precisely regulated system
 Leptospira is a highly invasive spirochete
 new target for treatments

10. thank you