Question 48 (2 points) Which statement regarding chronic venous insufficiency is INCORRECT? Poor circulation makes tissues vulnerable to trauma and infection resulting in the formation of varicose veins. Chronic venous insufficiency (CVI) is inadequate venous return over a long period. Symptoms include edema of the lower extremities and hyperpigmentation of the skin of the feet and ankles. Venous hypertension, circulatory stasis, and tissue hypoxia cause an inflammatory reaction in vessels and tissue leading to fibrosclerotic remodeling of the skin and then to ulceration..