Pediatrics HIV/AIDS, DIAGNOSIS, LINKAGE , CARE AND TREATMENT, ADHERENCE STRATERGIES AND RETENTION IN CARE.

1. PEDIATRIC HTS ,CLINICAL STAGING AND ART REGIMEN
DR EKWELIBE E.O

2. Pediatric testing
cascade!
DNA/RNA PCR tests
(EID 0 -18 MONTHS OF LIFE)
Antibody tests for diagnosing
HIV(>18MONTHS) include:
• Rapid tests
• Enzyme Linked Immunosorbent Assay (ELISA)
• Western Blot (confirmatory test if available)
• Indirect Immunofluorescent Antibody Assay (IFA)
EMPLOY HIV TESTING ALGORITHM

3. Determine HIV
UniGold
First Test
Reactive:
Report as POS
Non –Reactive:
Report as NEG
Second Test
Reactive
Report as: POS
Non –Reactive:
Report as INDETERMINATE)
HIV TESTING ALGORITHM

4. SELF TEST KITS
https://www.youtube.com/watch?v
=dlldduI79ic

7. Options for PrEp REGIMEN
PrEp for discordant couples (Daily dosing)
CHILDREN >30KG
TDF/FTC or TDF/3TC (1 daily)
PrEp for MSM, (Event driven (ED-PrEP)>30KG  The first dose of 2 pills (TDF/FTC or TDF/3TC) loading dose should be
taken between 2 and 24 hours prior to exposure
 The second dose (after sex) is a single pill taken 24 hours after the first
dose.
 The third dose is a single pill taken 24 hours after the second dose.
 If more sex acts take place over the following days, a single PrEP pill can
be continued daily for as long as sex continues, with a single daily pill
taken for the next two days after the last sex act.
PRE EXPOSURE PROPHYLAXIS

9. Recommended ART Regimen for Adults, Adolescents and Children
Based on 2020 National ART guideline.
First-line ART regimens for adults and adolescents (2020 Guideline)
First-line ART for children
First-line ART Preferred first-line Alternative firstline regimens Special Circumstances
Adults and Adolescents TDF + 3TC (or FTC) + DTG TDF + 3TC (or FTC) + EFV 400 TAF + 3TC (or FTC) + DTG ABC
+ 3TC + DTG AZT + 3TC + EFV
400
Weight (Kg) Age (years) Preferred First Line
Regimen
Alternative First Line
Regimen
Special
Circumstances
Neonates
< 3kg < 1 month AZT + 3TC + DTG* or
RAL
AZT + 3TC + LPV/r** AZT+3TC+NVP
Infants & Children
< 20kg < 6years ABC +3TC + DTG ABC+3TC +LPV/r AZT
+ 3TC +LPV/r ABC (or
AZT) +3TC+ RAL**+
ABC + 3TC +EFV* +
(or NVP) AZT + 3TC +
EFV (or NVP) AZT +
3TC + LPV/r (or RAL)
20 – 30kg 6-10years ABC+3TC+DTG Or
TDF***(TAF)**** +
3TC +DTG
ABC+3TC +LPV/r ABC
+3TC + RAL

11. THANK YOU!