MBBS first year pharma

1. BETA BLOCKERBETA BLOCKER
ININ
THERAPYTHERAPY
PRESENTED BYPRESENTED BY
KAIF QURESHIKAIF QURESHI

2. BETA BLOCKERS DRUGSBETA BLOCKERS DRUGS
• These are the drugs that inhibit adrenergicThese are the drugs that inhibit adrenergic
responses produced by hormonesresponses produced by hormones
AdrenalineAdrenaline andand Nor-adrenaline.Nor-adrenaline.
• DEVELOPED BY ;DEVELOPED BY ;
SIR JAMES BLACKSIR JAMES BLACK

3. ß-receptorsß-receptors
ß-1
●
●
ß-2 ●
ß-3
●Heart ●Bronchi ●Adipose Tissue
●JG Cells in
kidney
●Uterus
●Urinary tract
● Blood Vessel

4. PHARMALOGICAL ACTIONPHARMALOGICAL ACTION
of beta receptorof beta receptor
●
ß1ß1 ●
ß2ß2 ●
ß3ß3
Positive
chronotropic,
dromotropic
and ionotropic
action.
Release of
Renin from
Kidney
●Relaxation of
smooth
muscles
●Endothelium
of B.V
-Vasodilation
●Lipolysis

5. CLASSIFICATIONCLASSIFICATION
●NON-
SELECTIVE
●CARDIO-
SELECTIVE
●ADDITIONAL
α-BLOCKING
PROPERTY
●
PROPANOLOL ●
ATENOLOL ●
LABETALOL
●
TIMOLOL ●
METOPROLOL ●
CARVEDILOL
●
SOTALOL ●
ESMOLOL

6. ACTIONS ON VARIOUSACTIONS ON VARIOUS
ORGANS BYORGANS BY beta blockerSbeta blockerS
1.1. Heart-> Decrease Heart RateHeart-> Decrease Heart Rate
Decreases Myocardial contractilityDecreases Myocardial contractility
Decrease Conduction VelocityDecrease Conduction Velocity
Decreases Cardiac OutputDecreases Cardiac Output
• DUE TO ALL THESE FACTORS WORK LOAD BYDUE TO ALL THESE FACTORS WORK LOAD BY
HEART DECREASES RESULTING INTO FALL INHEART DECREASES RESULTING INTO FALL IN
BLOOD PRESSUREBLOOD PRESSURE

7. 2. BRONCHIAL SMOOTH MUSCLES -> Causes
contraction of muscles
• DUE TO THIS REASON NON-SELECTIVE BETA
BLOCKERS ARE NOT ADVISED TO
ASTHMATIC’S
3. URINARY BLADDER-> Contraction Of Detrusor
Muscle
4. INHIBITS LIPOLYSIS,GLYCOGENOLYSIS

8. ADVANTAGES OF CARDIO-SELECTIVE OVERADVANTAGES OF CARDIO-SELECTIVE OVER
NON-SELECTIVENON-SELECTIVE
• Lower propensity to cause BronchoconstrictionLower propensity to cause Bronchoconstriction
• Less interference with carbohydrate metabolism andLess interference with carbohydrate metabolism and
less inhibition of Glycogenolysis duringless inhibition of Glycogenolysis during
HypoglycaemiaHypoglycaemia
->Safe in Diabetics->Safe in Diabetics
• Lower incidence of cold hands and feet henceLower incidence of cold hands and feet hence
reducing the chances of precipitating Raynaud’sreducing the chances of precipitating Raynaud’s
PhenomenonPhenomenon

9. THERAPEUTIC USESTHERAPEUTIC USES
1.1. HYPERTENSIONHYPERTENSION
2.2. CARDIAC ARRHYTHMIACARDIAC ARRHYTHMIA
3.3. MYOCARDIALMYOCARDIAL
INFARCTIONINFARCTION
4.4. ANGINA PECTORISANGINA PECTORIS
5.5. GLAUCOMAGLAUCOMA
6. ANXIETY6. ANXIETY
7. ESSENTIAL TREMOR7. ESSENTIAL TREMOR
8.8. MIGRAINEMIGRAINE
10.10.CONGESTIVE HEARTCONGESTIVE HEART
FAILUREFAILURE
11.11. SYMPTOMATICSYMPTOMATIC
TREATMENT INTREATMENT IN
THYROTOXICOSIS.THYROTOXICOSIS.

10. ADVERSE EFFECTS
1. WORSENS ASTHMA
2. BRADYCARDIA
3. HYPOGLYCEMIA
4. INCREASES THE RISK OF
CORONARY ARTERY DISEASE
5. ANGINAL ATTACKS AFTER
SUDDEN WITHDRAWAL

11. contra-INDICATORScontra-INDICATORS
1.1. ASTHMAASTHMA
2.2. COPD-BRONCHITISCOPD-BRONCHITIS
3.3. DIABETES MELLITUSDIABETES MELLITUS
4.4. PARTIAL AND COMPLETE HEART BLOCKPARTIAL AND COMPLETE HEART BLOCK