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Kuliah biokima hormon

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Santoso Jaeri
TechnologyHealth & Medicine
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Hormone Santoso
Regulation of homeostasis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Hormone ,[object Object],[object Object],[object Object]
Hormone production: “Classic” glands ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hormone production: Less traditional sources ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hormones, cytokines, growth factors ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
Endocrine and nervous systems ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Types of humoral signalization ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chemical characteristics of hormones ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genetic disorders ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Hormone release ,[object Object],[object Object],[object Object],[object Object]
Hormone release ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Regulation of hormone release ,[object Object],[object Object],Gland Target tissue  hormone product inhibition
Regulation of hormone release ,[object Object],[object Object],[object Object],Gland Target tissue  hormone product
Regulation of hormone release ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Combined feedback Stress etc. CRH secretion in hypothalamus ACTH secretion in pituitary  plasma ACTH cortisol secretion in adrenals  plasma cortisol stimulation inhibition
Regulation of hormone release ,[object Object],[object Object],Cortisol (nM) Time of day 09 09 21
Regulation of hormone release ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pulsatility in GnRH & LH release 12:00 16:00 14:00 Time of day
Hormone action ,[object Object],[object Object],[object Object],[object Object]
Hormone action
Receptors ,[object Object],[object Object],[object Object],[object Object]
Membrane receptors ,[object Object],[object Object],[object Object],[object Object],[object Object]
G proteins
G proteins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Intracellular signal transduction (second messengers) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
cAMP
Adenylate cyclase - cAMP - protein kinase A ,[object Object],[object Object],[object Object],[object Object],[object Object]
cGMP
Ca-calmodulin ,[object Object],[object Object],[object Object]
Phospholipase C - IP 3 & DAG ,[object Object],[object Object],[object Object]
Tyrosin kinases ,[object Object],[object Object],[object Object],[object Object],[object Object]
Inhibins, activins & TGF system Hormone
Intracellular receptors ,[object Object],[object Object],[object Object],[object Object],[object Object]
Intracellular receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Function of intracellular receptors ,[object Object],[object Object],[object Object],[object Object]
Magnitude of response ,[object Object],[object Object],[object Object],[object Object],[object Object]
Dose/response max. response ~sensitivity
Decrease in max. response ,[object Object],[object Object],[object Object],[object Object],[object Object]
Drop in sensitivity ,[object Object],[object Object],[object Object],[object Object],[object Object]
Transport of hormones ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Transporter binding lengthens hormone halftime Plasma halftime (days) % bound hormone Thyroxin T3 Testosterone Cortisol
Inactivation of hormones ,[object Object],[object Object],[object Object]
Measuring hormones ,[object Object],[object Object]
KELENJAR APA SAJA YANG DAPAT MENGHASILKAN HORMON ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
KELENJAR HIPOFISA (PITUITARI) ,[object Object],[object Object],[object Object],[object Object]
HIPOFISA ANTERIOR ,[object Object],[object Object],[object Object]
LANJUTAN HIPOFISA ANTERIOR ,[object Object],[object Object],[object Object]
LANJUTAN HIPOFISA ANTERIOR ,[object Object],[object Object],[object Object],[object Object]
HIPOFISA MEDULLA ,[object Object],[object Object],[object Object]
HIPOFISA POSTERIOR = NEUROHIPOFISA ,[object Object],[object Object],[object Object],[object Object]
KELENJAR THYROID ,[object Object],[object Object],[object Object]
KELENJAR PARATHYROID ,[object Object],[object Object],[object Object],[object Object],[object Object]
KELENJAR ADRENAL (ANAK GINJAL) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LANJUTAN KELENJAR ADRENAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
KELENJAR PANKREAS ,[object Object],[object Object],[object Object],[object Object],[object Object]
KELENJAR LAMBUNG (GASTER) ,[object Object],[object Object],[object Object]
KELENJAR DUODENUM ,[object Object],[object Object],[object Object]
KELENJAR THYMUS ,[object Object],[object Object],[object Object],[object Object],[object Object]
KELENJAR OVARIUM ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
KELENJAR TESTIS (TESTES) ,[object Object],[object Object],[object Object],[object Object]
Terima Kasih

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Kuliah biokima hormon

Editor's Notes

  1. endokrinní, parakrinní, autokrinní pusobení
  2. QT movie pohybu dimeru kinesinu po mikrotubulu (a pro srovnání taky myosinu po aktinu) je na http://www.sciencemag.org/feature/data/1049155.shl
  3. Nekolik rodin Ruzné G proteiny prispívají k ruznzm odpovedím po aktivaci téhoy receptoru Heterotrimery:  unikátní,  podobná pro vetsinu rodin Podjednotka  váze receptor, efektor, GDP/GTP
  4. Zpetna vazba z gonad na produkci FSH a LH, patri do rodiny TGF