1. Phenotypic Drug Discovery of Anticancer Compounds
Dr. José M. Padrón, Head
jmpadron@ull.es
http://jmpadron.webs.ull.es/
Natural products Synthetic compounds
State-of-the-art: The identification of drug targets represents a major challenge in drug discovery
Strategy: An in-house PDD approach for the discovery of anticancer compounds
Aim: Unravel the cell target(s) and the mechanism of antiproliferative action of small-molecules
Human solid tumor
cell lines
2. DB of >3000 natural & synthetic compounds
• Chemical structure
• GI50 values against human solid tumor cell lines
Looking for new targets using
computational methods
LICENSED IN 2014 TO
Structure-Activity DB for Virtual Screening
SAR-DB