Koreas has history of 30 years in biopharma sector and started exploring home-grown novel sciences recently. More entrepreneurial activities by KASBP is being encouraged to capitalize on US-based KASBP and Korean growing ecosystem.

1. KASBP 2017 Spring Symposium
Korea, Active Life Science
Hub in Asia
James Jungkue Lee
Bridge Biotherapeutics, Inc

2. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
• Majored Protein X-ray Crystallography
• Researcher, Molecular modeling, LG Life Sciences, 1993~
• R&D Planning, BD, LG Life Sciences, 1995~
• Co-founded CrystalGenomics, 2000~
• Founded Rexbio, 2008~
• Founded Bridge Biotherapeutics, Inc., 2015~
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3. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
• Brief History of BioPharma Industry in Korea (10 mins)
• Current Trends & Bridge Biotherapeutics, Inc (15 mins)
• Recommendation (5 mins)
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4. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
History
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• 1897, Donghwa Pharma
• 1987, GATT Treaty (Composition of matter patent)
• 1991, Lucky licensed 3rd-gen cephalosporin to Glaxo
• 1992, Bioneer(한국생공), the first biotech founded
• 1997, Licensing deals by LG Life Sciences/SK Corp/Yuhan
• 2000, New millennium biotech boom and bubble burst
• 2005, Stem cell scandal
• 2015, Hanmi’s series of blockbuster deals
• 2016, Dong-A ST’s collaboration with Abbvie
GATT: General Agreement on Tariffs and Trade (관세무역 일반협정)

5. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Pioneers
• Dr. Yong-zu Kim
• Former Research Head, LG Life
Sciences (1983~2005)
• 1987
• 1991
• 1997
• Founder & CEO, Legochem
Biosciences (2005~)
• 2005
• 2013
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6. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Asia’s Most Innovative Universities
University Rank In Asia Rank In Global
University of Tokyo 1 44
National University of Singapore 2 50
Peking University 3 53
Tsinghua University 4 57
Nanyang Technological University 5 74
Weizmann Institute of Science 6 101
Kyoto University 7 102
University of Hong Kong 8 106
Seoul National University 9 119
Fudan University 10 121
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US News & World Report, 2017

7. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Asia’s Most Innovative Universities
University In Asia
KAIST 1
Seoul National University 2
University of Tokyo 3
Pohang University of Science & Technology (POSTECH) 4
Sungkyunkwan University 5
Tsinghua University 6
Tohoku University 7
Kyoto University 8
Osaka University 9
Hanyang University 10
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Reuters, 2017

8. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Bravery & Novelties
• Pioneering biosimilar industry
• Celltrion & Samsung Duo (Biologics/Bioepis)
• Venturing novel sciences, backed by VCs
• OliPass Corporation, self-delivering(cell-permeable) oligonucleotide
• Orum Therapeutic, cell-penetrating antibody
• Bridge Biotherapeutics, Pellino-1 biology
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9. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
OliPass Corporation, Self-delivery PNAs
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• Dr. Shin Chung
• Founded in 2007
• Cell-penetrating PNA with modified
nucleic acid
• mRNA splicing modulation
• Ultra-high potency ( < pepto M)
• $2B+ multiple-target discovery deal,
2014
• Ms. Hemmie Chang helped as
transaction lawyer

10. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Orum Therapeutic, Cell-penetrating mAb
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Scientists at Ajou University and
Orum Therapeutic devised a
monoclonal antibody, RT11-i,
which targets the RAS protein in
cells. After it penetrates cells, it
selectively binds to activated RAS,
stopping it from interacting with
effector proteins and setting off a
cascade of tumor-promoting
signaling.

11. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Orum Therapeutic, Cell-penetrating mAb
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Source: BioCentury

12. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Bridge Biotherapeutics, Pellino-1 Biology
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13. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Bridge Biotherapeutics, Pellino-1 Biology
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• Novel function of Smad-6 found by
Professor Seok-Hee Park, Sunkyunkwan
University, in 2006
• Medicinal chemistry by Dr. Kwang-ho
Lee, KRICT, 2015
• Licensed to Bridge Bio, October, 2015
• IND-enabling GLP underway for US
IND filing towards the year-end
• Indications: UC, MS and AMD
• Dr. Christopher Kim serves as board
member

14. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Bridge Biotherapeutics, Autotaxin inhibitor
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15. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Informal New Drug Salon (in Pangyo)
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https://www.facebook.com/groups/newdrugsalon/

16. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Observations & Recommendations
• US-based Korean Scientists’ entry modes into Korea (Returnee)
• Academic position
• Research scientists position at national institutes
• Top 10 local major pharmas
• VC industry started seeking ex-Korean opportunities or bi-
nationally operated biotechs.
• SV Investment, KTB Network, Korea Investment Partners, Mirae-Asset
• Academic research becomes mature, bringing several quality
startups to fruition.
• Orum Therapeutic, Bridge Biotherapeutics, etc.
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17. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Observations & Recommendations
• Time to consider different entry modes
• Launch startups (in US or KR or US/KR)
• Joining established startups
• Seeking positions at VC firms or working as consultants
• Persuading local pharmas to setup US-based R&D center
• Hoping to Launch “Korean Global BioPharma Entrepreneur
Network (KGBPEN)”
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18. KASBP 2017 Spring SymposiumKASBP 2017 Spring Symposium
Thanks for attention !!
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James.lee@bridgebiorx.com
https://www.facebook.com/jamesjungkue.lee?fref=nf