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Doctor, I know that you have been
                                                                                                 anxious to have a new product in your
                                                                                                 treatment arsenal. Today, I am excited to
                                                                                                 share with you new IQUIX® (Ievofloxacin
                                                                                                 ophthalmic solution) 1.5%, a newer­
                                                                                                 generation fluoroquinolone that
                                                                                                 delivers powerful sustained levels of
                                                                                                 concentration, both above and below
                                                                                                 the ocular surface. New IQUIX® 1.5%
                                                                                                 takes concentrat,ion to a new level.




                 For   ,                                        h wfth pllyskJilIJs.
                           re~t4l11ve   <Be only. MJ'. til be




                                                                                                                   ®
                                                                                                     I
                                                                                       (Ievofloxacin aphtha mic
FORTRAIN G ,pu POSES ONLY.
 or fOR DETAIUNG. DO NOT
                                                                                       so utquot;on) 1.5%
DUPLICATE OR DISTRIBUTE.


                                                                                                                  a ew
                                                                                       Ta             tion
                                                                                            Concan                            Ll::=iVe=
Doctor, you should feel confident that
                                                                                                                                                       IQUIX® delivers sustained levels of
                                                                                                                                                       concentration above and below the
                                                                                                                                                       ocular surface.


                                                                                                                                                       New IQUIX 1.5% is the only newer
                                                                                                                                                       fluoroquinolone approved for treatment
                                                                                                                                                       of corneal ulcers, and deli,vers high
                                                                ApPIIquot;ll)led 0
                                                                                                                                                       sustained concentrations where your
                         High           Btnined, Concentratio
                                                                                                                                                       patients may need it most. It provides
                                             'a~13l;'           ~llS1alns                                    i~
                                                                            111 /'1 concenlli ions
                           R3p:aly ac                                                                             tearsquot;
                                                                                                                                                       rapid penetration in tears that is
                           Penelrates human co.-neal Issue ood llq1.:eous 11U1nor to con:enlrations thai exceed MIG.
                                                                                                                                                       sustained over time. IQUIX® also achieves
                           valll~s of commo ocular pathogens'
                                                                                                                                                       high concentrations in human corneal
                         High Concentr;                           • n and ODv                         89
                                                                                                                                                       tissue and aqueous humor that exceed
                           Broad c(werage of gram-l1l3g3tlve and gram-poo; i~e pathogens, Including P aerlJgillosB,
                                                                                                                                                       the MIC90 values of common ocullar
                           S. marcescens. S. awe ,S, epiderm/dis, and S. pr.-elJm(lniae'
                                                                                                                                                       pathogens. IQUIXc:; has broad coverage of
                           Qc;ular TRU.s . s~etll                           data documents h/g susceptibility of key
                           (2QOO.2007}'                                                                                                                gram-negative pathogens, including
                           Dual mechanism of action $imilar 0 galifloxacin and moxifioxac nt                                                           Pseudomonas aeruginosa and Serratia
                                                                                                                                                       marcescens, as well as gram-positive
                                                                                 B.tion
                               II-·Yoltel'l!l't:ad 'Co
                                                                                                                                                       pathogens, including Staph epidermidis.
                                                                                             do heiJal ce!ls

                           Low cylotoXJly to bolh human comool
                           and keratocyles'
                                                                                                           The high susceptibility of key ocular
                           Pw.~ervative--free.                                  form~iatlo~l
                                                        near neutral pH                                                                                pathogens is further documented by the
                                                                                                                                                       Ocular TR.U.S.T surveillance data. But
                                                                                                                                                       equally important, IQUIX® is well
                                                                                                                                                       tolerated. It is preservative-free with a
                                                                                                                                                       near neutra I pH, and is less cytotoxic tha n
                                                                                                                                                       other newer FQs.




                                                                                                                                                       Pro e: Now that you know how new
                                                                                                                                                       IQUIXill 1.5% measures up to the other
                                                                                                                                                       new r fQ . at you use r., your practice,
                                                                                                                    ..........-.......,..--­
          will yo u pr scri e IQUI XQI wne n you nBed
                                                                                                                             ,.,
                                                                                                                                                       a potent nuoroquinolon with sustained
                                                                                                                                                       con centrations ov r ti m@?




FORTiRAJNI G PURPOSES 0 LV: OT FOR DETAtlING.                                                                                                                                 ®

DO, 0 DUPLICATE OR D STRIBU

                                                                                                      o
        II • 1l.C.. II~ t~lIar'a ':'~ I)s:cro .s';mhQ Co lid, Tokyc. J,mol1 ..,. _.

                                                                                                                                                (Ievofloxacin ophthalmquot;c
                            Ov~ 1.:trrlpeJe. t '11. nj §mtlll1·

     Urllltnil«:l Lv $.:I
                                                                                            .2. ­ 

(I..'Lio1J1ttTl,;:::! t·yVrST/ooJ(.{JN ~m-=f1uU               LLC. J~k~onville. -/orjl'lquot;
                                                        :So
                         rttilW!:i!W lrad~      .. oIVI~rJ.KOr-.:
VISTAKO        14                                                       f'llarmacl!u cals, LLof

                    OJ


                                                                                                                                                SO utio ) .5%,
               r,·quot;'ar acllllicals, LLC 200i'                                                                              2707)0-014
                                                                     Allllq quot;IS reserved                   10107
 1/ S AKU'-




                                                                                                                                                Ta e -one nation              a Ne          evel

                                                                                                                                                                          0
In-fused with
~sed              with, R'E MOD U 1 I N~'
                                      (treprostin11 50dium) Injectio
.
                                                                                  When initial therapy loses momentum, think REMODULlN@

'5t a           nlv Prostacyclin for Bo                          nfusio
JLlNf/ll delivers the power of continuously infused prostacyclin with:
                                                                          a:::.
packs necessary
    half-life
                                                                                                                                •
                                                                                                             ODU
    rized pump options
                                                                                              (treprostinil sodium) Injection
)L1N delivers results
led hemodynamics
;hed symptoms associated with exercise in NYHA Class II-IV patients                          Joanne
                                                                                              REMODULIN patient
ted deterioration In those requiring transition from Flolan®


JLlN has flexible dosing
to titrate to effect
t8 hours (IV) or 72 hours (SC) between reservoir changes


nt Safety Information: Chronic intravenous infusions of
JLlN are delivered using an Indwelling central venous catheter.
e is associated with the risk of blood stream infections (BSI)
IS, which may be fatal.




Iportant Safety Information on page 17.
II prescribing informiltio~ in pocket.


liled
erapeutics
J    •

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Dtp Iquix And Remodulin Sales Aid Covers

  • 1. Doctor, I know that you have been anxious to have a new product in your treatment arsenal. Today, I am excited to share with you new IQUIX® (Ievofloxacin ophthalmic solution) 1.5%, a newer­ generation fluoroquinolone that delivers powerful sustained levels of concentration, both above and below the ocular surface. New IQUIX® 1.5% takes concentrat,ion to a new level. For , h wfth pllyskJilIJs. re~t4l11ve <Be only. MJ'. til be ® I (Ievofloxacin aphtha mic FORTRAIN G ,pu POSES ONLY. or fOR DETAIUNG. DO NOT so utquot;on) 1.5% DUPLICATE OR DISTRIBUTE. a ew Ta tion Concan Ll::=iVe=
  • 2. Doctor, you should feel confident that IQUIX® delivers sustained levels of concentration above and below the ocular surface. New IQUIX 1.5% is the only newer fluoroquinolone approved for treatment of corneal ulcers, and deli,vers high ApPIIquot;ll)led 0 sustained concentrations where your High Btnined, Concentratio patients may need it most. It provides 'a~13l;' ~llS1alns i~ 111 /'1 concenlli ions R3p:aly ac tearsquot; rapid penetration in tears that is Penelrates human co.-neal Issue ood llq1.:eous 11U1nor to con:enlrations thai exceed MIG. sustained over time. IQUIX® also achieves valll~s of commo ocular pathogens' high concentrations in human corneal High Concentr; • n and ODv 89 tissue and aqueous humor that exceed Broad c(werage of gram-l1l3g3tlve and gram-poo; i~e pathogens, Including P aerlJgillosB, the MIC90 values of common ocullar S. marcescens. S. awe ,S, epiderm/dis, and S. pr.-elJm(lniae' pathogens. IQUIXc:; has broad coverage of Qc;ular TRU.s . s~etll data documents h/g susceptibility of key (2QOO.2007}' gram-negative pathogens, including Dual mechanism of action $imilar 0 galifloxacin and moxifioxac nt Pseudomonas aeruginosa and Serratia marcescens, as well as gram-positive B.tion II-·Yoltel'l!l't:ad 'Co pathogens, including Staph epidermidis. do heiJal ce!ls Low cylotoXJly to bolh human comool and keratocyles' The high susceptibility of key ocular Pw.~ervative--free. form~iatlo~l near neutral pH pathogens is further documented by the Ocular TR.U.S.T surveillance data. But equally important, IQUIX® is well tolerated. It is preservative-free with a near neutra I pH, and is less cytotoxic tha n other newer FQs. Pro e: Now that you know how new IQUIXill 1.5% measures up to the other new r fQ . at you use r., your practice, ..........-.......,..--­ will yo u pr scri e IQUI XQI wne n you nBed ,., a potent nuoroquinolon with sustained con centrations ov r ti m@? FORTiRAJNI G PURPOSES 0 LV: OT FOR DETAtlING. ® DO, 0 DUPLICATE OR D STRIBU o II • 1l.C.. II~ t~lIar'a ':'~ I)s:cro .s';mhQ Co lid, Tokyc. J,mol1 ..,. _. (Ievofloxacin ophthalmquot;c Ov~ 1.:trrlpeJe. t '11. nj §mtlll1· Urllltnil«:l Lv $.:I .2. ­ (I..'Lio1J1ttTl,;:::! t·yVrST/ooJ(.{JN ~m-=f1uU LLC. J~k~onville. -/orjl'lquot; :So rttilW!:i!W lrad~ .. oIVI~rJ.KOr-.: VISTAKO 14 f'llarmacl!u cals, LLof OJ SO utio ) .5%, r,·quot;'ar acllllicals, LLC 200i' 2707)0-014 Allllq quot;IS reserved 10107 1/ S AKU'- Ta e -one nation a Ne evel 0
  • 3. In-fused with ~sed with, R'E MOD U 1 I N~' (treprostin11 50dium) Injectio . When initial therapy loses momentum, think REMODULlN@ '5t a nlv Prostacyclin for Bo nfusio JLlNf/ll delivers the power of continuously infused prostacyclin with: a:::. packs necessary half-life • ODU rized pump options (treprostinil sodium) Injection )L1N delivers results led hemodynamics ;hed symptoms associated with exercise in NYHA Class II-IV patients Joanne REMODULIN patient ted deterioration In those requiring transition from Flolan® JLlN has flexible dosing to titrate to effect t8 hours (IV) or 72 hours (SC) between reservoir changes nt Safety Information: Chronic intravenous infusions of JLlN are delivered using an Indwelling central venous catheter. e is associated with the risk of blood stream infections (BSI) IS, which may be fatal. Iportant Safety Information on page 17. II prescribing informiltio~ in pocket. liled erapeutics J •