This document discusses 10 common myths about multiple sclerosis (MS) and provides facts to clarify each myth. Some of the key myths addressed include: that all MS treatments are the same; that strong treatments are hard to tolerate; and that there are MS therapies without side effects. The document emphasizes that MS is unpredictable and individualized, so it's important to choose a treatment tailored to each person's needs and lifestyle. It promotes the treatment BETASERON as being well-tolerated with mild side effects that decrease over time, and having the most extensive support program.

1. RETIN-A MICRO Page 1 of 1
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3116/2007
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2. LEVITRA ED medication at LEVITRA Page 1 of2
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Patient Information Important Sa ely Info Health Care
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Important Safety and Dosing Information
LEVITRA is a prescription medicine that is used to treat erectile dysfunction (ED). Men taking
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Such combinations could cause blood pressure to drop to an unsafe level.
AS with all ED drugs, there is a rare risk of an erection lasting longer than four hours. To avoid
long-term injury, seek immediate medical attention. LEVITRA does not protect against sexually
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med icine, includi ng LEVITRA) reported a sudden decrease or loss of vision in one or both eyes. It
is not possible to determine whether these events are related directly to these medicines or to
other factors. If you experience sudden decrease or loss of vision, stop taking PDES inhibitors,
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DiscuSS your medical conditions, including heart problems, and medications, including alpha
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LEVITRA is right for you and that you are healthy enough for sexual activity.
The starting dose of LEVITRA is 10 mg taken no more than once per day. Your doctor will decide
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3116/2007
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3. Myths and Facts of MS: Betaseron.com Page 1 of 4
B
Myths and Facts of MS
Real People, Real Stories
Heal from Brad
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Don't believe everythi.ng you he,ll about MS
There are a lot of fOlsCOnCeptions aboul multiple sclerosis (MS). Take a look at this list of 10 myths about MS and see if you've heard any of them
before-then take u lillie tIme 10 get the real quot;tory in the fact scellon included below each myth.
MYTH # I: All MS treatments are the same
The fact is, although MS therapies Illay secm similar. thcre arc some important differencequot; you should be aware of.
The most common treatment options are the beta interferons (BETASERON, Rebi(quot;;, and Avonex®) and glatiramer acetale (Copawne@). Of these,
the interferon beta therapies are the most frequently prescnbed. There are imponalll distinctions among them, sueh as:
How oftenlhey are injected l -4
•
How e()lIlfl r1abk they are to injeelS.6
•
• Th 'Ike of the needle used to inject 1-4
• The need for refrigeralion 1·4
• The support available
BETASERON )S also the only high-dose, high-freqnency interferon beta FDA-approved for use 'lIthe carlie.st tug.: of relapquot;ing MS and is ,hnwn
to delay the progression of clinically definLle MS (CDMS) when used frOin the fllst even sugge.stil·e of MS 2 A
MYTH # 2: Strong, elfective therapies are hard to tolerate
The faci is. strong Iherapies like BETASERON can be welilolerated. Ovel the years. we've learned thaI there are stcps you can lake L help reduce
common side effects. For example, gradually increasing the dose (called titration) can help you adjust to Iherapy2 And many people lind 0Ier-tI1e­
counter pain relievers often lessen nu-Iike symptoms 2 Your heallhcare leam and BETA Nurse can give you olher ways to help manage L1l1y side
effects you may have.
BETASERON is well tolerated by people living With MS. In the BENEFIT Study. 93% ofpcople living with MS receiving BETASE1{ON
completed the ~tudy, a rail' similar Lo thaL of people nOltaking anYlhing. And 96% of all people who completed the study chose LO ontinue wllh
BETASERON as pan of a 3D-year follow up analysis 7
It helps thai all people taking BETASERON have access 10 BETA Nurses-any tIme, day or night. The.'c MS-trained nurses even prOVIde one-on­
one Injeclion training in your home'quot; or In your healthcare team's office.
MYTH # 3: A few relapses per year is a normal part of MS
ThefaC/ is. if you're having several relapses a year. your current treatmenl might noL be working for you. And if that's the case, you should consider
doing something about it. Talk to your healtheare team. Many people living with MS have sucn:quot;fully switched therapies quot;,ilb positi lJ resulh.
MYTH # 4: I'm already on treatment-J should just stay with it
The fau is. we learn more about MS Iherapies every day. The Ireatment you began with may not be Ihe right choice for you now. [f you are haVIng
frequent relapses, Or if you're flnding thaL your normal aCLivities are becoming more difficult. you should talk to your healtheare professional about
finding a better. more effecli ve MS Ireatment Lhal's right for you.
BETASERON, lhc most extensively quot;udied MS medication available. is constantly being researched. SClenllst> are also lesling new MS therapies
4/1412009
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4. Myths and Facts of MS: Betaseron.com Page 3 of 4
Page 2 of 4
Myths and Facts of MS: Betaseron.com
with promiSing resulls.
MYTH # 5: I feel fine, so there's no reason to starl MS treatment
~crimh
la ok hy many expclb-bulllOW quot;'e know tlial
The./i/cr is. MS can be deceiving. Not long ago. delaying therapy was consider d 'LCC'I
damage can happen very early. MS doesn'l wait, and neilher should you.
A rcecnt study showed that MS can eause over 3 times more d'i111agc in the first year than in years 5 to 10 8 In another study, 8Y,} of pc ric who
II ad one episoLle sugge.live ofMS dewlopcd L'linically definite MS (CDMS) withIn 2 ye;lr.> when the.. fJ left UllI 3l~ 7 So wlul(' ynll rnay nOl
feel symptoms, Ihis early damage can affecl memory and infol111ation processing-even wor:.c, It may b~ irrecrsibJe. Remember, bcing Ir,-~ ,'1
sy,nptoms doesn't mean you're free of MS. F.l:ry mUIl1ent you delay effective treatment is a nomen[ you RIllY never get back.
A reeenl sludy of people who have experIenced a firsl MS eenl has shown Ihat when used early, BETASERON can signifieanlly delay
progression to a second MS tlare-up 7.9
MYTH # 6: MS aITects everyone the same way so you should treat it the same way, too
Thefacr is, MS is unprediclable. After you've had a firsl MS event, there is no way to tell when relapses mighl occur or how severe the <;:ff.:cts
might be,
While scientists continue to e:'k answers. there are f~Cls you can bc sure of-like the importance of starling treatment as soon as rossible.. ' Thi,
way you ean start slowing down MS before it begins interfering wilh your life.
Not every person hying with MS is the same and there are ilnportalll differences bel ween MS Lrealmenls (see Myth # I). Some treatments Will tit
i.nto your life beller than others. and It'S worth taKing some time [0 look elosely at all of [hem.
MYTH # 7: I should deal with MS alone
heallh~are
ThefaCI is, a goud support syslem can Inake a real differenee whcn you're dealing with MS. People like your team. family, and fr,it'nds
arc your importanl fir~! line of sUppOJ1..
Another valuable source of support is Ihe BETA PLUS Peer MenlOI' Program. Thi;: Pt;cr MentOJ.'s are people who are eurrenlly lukinquot; 8 :r SERON
and can share witb you tll.:ir own experiences wllh MS and how tbey manage. pe-aking wilh someone el c who truly under.';[ands Vhat you arc
gl iug through can really help. Peer Mentors are available to you by visiling ~ quot;quot; '_lJetll!,er '1lquot;.j,rn/lTh!nl -r or call1llg 1-800-788- I·Hi7.
MYTH # 8: All injectable MS therapies are painful
ThefaC/ is, some people report pain while olbers do nol. Some therapic, may cause less injeetion discomfort tban others. Only BETASERON has
the thinnest needle In MS. And in a study. people laking BETASERON reportcd that alnlost 86'/0 of their injections were pam-free an hour after
jnjection 9
In another study, people laking BETASERON reponed 4 times more pain-free injections [han those laking Rebif ilnnlcdrately after mJection 5
MYTH # 9: All MS support programs are the same
The facl is, support programs differ in the level of services they offer. The BrTAI'LUS 'quot; program. brought to you by BF.TASERON, is the only
suppon program thaI a. signs an MS-traincd BETA Nursc to every person. So you'll have access to an MS-lrained nursc any tllne, day or night.
From one-on-one injection training i]1 your homequot; or healthc<lfe team's office, ,t phone calls Ju;;t to check in, your BETA Nurse WIll ;Iways be
there for you, ThaI's part of the Bayer MS pledge 10 every person taking i3ETASERON, and a big reason why people liVing wilh MS rated
BETAPLUS the # I support progra1111n MS. t
BETAPLUS also offers you a personal Peer Mentor for gllid;lm:e and support. Access Specialist. to help with insurancc issues, as well as
educational webcasts.
MYTH # to: There are MS therapies without side ellects
Thefaci is, every injectable lherapy has ,ome side effects and MS therapy is no different. Knowing more aboutlhe pOSSible side effects of each
MS therapy can help you choose the therapy thaI's rlght for you
[n one study, people taking BETASERON had 20% fewer injecIJon-site reactions than those taking Copaxone. In the sanle study, more people
taking Bf.TASERON completcd the study than those taking Copaxone 9
'vlild injectlon-sile rcactions. such as redness or quot;,,,,,,elling, usually improve over time, while others require inunediale allenlJon. Talk to your
healthcare team before you ,Ian therapy so you can discuss your options.
Ru-like symptoms are another lype of side effect assOCiated with MS Iherapy. With BETASERON, these symploms are typlcaily mIld and there's
evidenoe t'hey decrease over time 2 In the study clIed above, there was a higher incidence of nu-like symptoms with BETASERON; however these
4/1412009
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5. Myths and Facts of MS: Betaseron.com Page 3 of 4
symptoms decreased markedly ufter J year for those laking BETASFRON. In another recenL 2-year study, tile maJotil or people takIng
BETASERON reported no flu-like symptoms throughout the sludy7 During t e first year, 42~quot; of people taking B'TASERON reported flll-like
symptollls, but that nllmher was down 10 just 13'1c by the s 'cond year.? That':, impOrlanl becausquot; with MS, you need an Jkclive therapy 111:11'5 .:asy
to stan wilh and easy to stay with over Ihe long term.
quot;Where state Jaws and your insurance allow.
tIn iln independent study. I3ETAPLUS (formerly MS Pathways) wus raled sii!lIitieamly higher on h w va.luable it IS people' 'Iiillg with MS
to
compured with other MS support programs
® pad'..'1gc insert]. Cambndge, MA: Biogen [dec Inc; 2006.
I. Avone
BETA. ERO ® lpackage in crtJ, M .ntviJlc. NJ: Bayer HcalthCare Pharmaccutic<lls Ine; 2008.
2.
3. Copaxon(.'1 lrackage inSCrI]. nsas City. MO: Tcva Neuroscience, Inc; 2007.
Rebif® [pac a~e insel'l]. Rockland. MA: Serono. [nl': 2005.
4.
Ballm K. O'Leary C, Coret Ferrer F, Klimova E, Prochazkova L. Bugge J, and lor the Bright Study Group. Comparison of injcction sitc pain
5.
and injection SilC reactions in n:bpsing-remining multiple sclerosis patients trc<lled with interferon beta-I a or lb. Muh Scler. 2007; 13: I] 53.
hllp:/Iin;;.p:agepub.com/cgi/contentJah,tTH,·tJ] 3/9/ I J53. Ace -,quot;sed Octoher 29, 2007.
O'Leary C, Baum K. Ferrer FC. Kllmova E. Proehazkova L. The BRIGHT Study: evalu~ling injection tolerability dLu'ing lnterf~mJl beta
6.
treatment. Poster presenled ut: 9th European FcderU!lon of Neurological Societies (81 '. ); September 17·20.2005; AtJlens. G ceee.
Kappos L. Polman CH, Freedman MS, et al. Trcatmcnt wilh interreron hda-Ib delays' n·cr. Ion Lo clini lAlly definite 111ld Md)onitld MS In
7.
pallents wllh clinIcally isolated syndromes. lquot;eurologlquot; 2006:67:J 242-9.
Kuhlmann T, Lingfeld G, Bitsch A. Schuchardt J, BJ'A',~ck, W. Acute axonal damage in multiple sclerosis is Inosl extensive in carly discilse
8.
stages and dOCrCii. es over lime. Brain. 2002; 125:1202-12l2.
9. Durelli L, Verdull E, Barbero Pet al. Every-other-day interferon beta-I b versus once-w elJy interferon beta-I a for multiple sclerosis: results
of <I 2-year prospecti ve randomized mulLi centre study (INCOM[N) Lancet, 2002, 359: lAS 3-60
Thinnest Needle MS
Jll
Peer Mentor Program
Sign up now Lo connect with a real person wllo is liVing well with MS.
BETAPLUS'M
MS Support Program
MS.~·
The MS Supp0rl program rated #1 by people !tving with Acccss a BETA Nurse 2417,365 days a year.
Call 1-800-788-1467
or
Join BETAPLUS Now.
• Iquot;i 1..... ~lfd 10.1 'ric n I
,inl Page
INDICATIONS
BETASERON® (interferon beta-lb) is .indicated for the treatment of relapsing forms of multiple sclerosis 10 reduce the frequency of clinical
exacerbations. Patients with mulilple sclerosis in whom efticacy has been demonstrated include patients who have experiene~d.1 first clinical
episode and have MRl feutures consistent with multiple Tlerosis.
IMPORTANT ._AF'ETV INFORMATION
The most commonly reporled adverse reactions are lymphopenia. injecllon-site [eaClion. a5lt'lenia, flu-like symptom cOllplex, headache, lIf1d pain.
Gradual dose titration and use of analg.esics during lrcatm.:nl initialion may help reduce flu-like synlpLoms. BETASERON 'he uld b u.ccl wilh
C,llllion in p<lllents with depreSSion. lnjectioA-site necrosis has been reported in 4'1f of patients in controlled tria.ls. Palicnts should be advi. ed ot' Ibe
importance of rotating injection sites. Female palients should be warned aboul the potential nsk to pregnancy. Cases of anaphylaxis ha ....: ~.t.:n
repol1ed rarely. See quot;Warning.s.quot; quot;Precautions,quot; and quot;Adverse Reactionsquot; scctions of fuJI Presenbing lnform;lIion.
You are encouraged to report negative side effecls of prescription drugs to tile FDA. Visit www.fda.gov/medwalch, or call 1-800-FDA-I08S.
For imporLant risk and us' information, please s'e the fulllquot;e rill II I'III Tffillllon,
BETASERON is a r>gis!ered trademark and BETAPLUS is a tradelnark of Bayer Heal.tbCare Pllannaceutkals Inc.
© 2009 Bayer HealthCare PharmaceuLicals [ne. All righls reserved.
4/14/2009
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