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A Brief History of Tissue Models For 
Cardiac Electrophysiology 
The last four decades have produced a number of significant advances in the developments 
of computer models to simulate and investigate the electrical activity of cardiac tissue. The 
tissue descriptions that underlie these simulations have been built from a combination of 
clever insight and careful comparison with measured data at multiple scales. Tissue models 
have not only led to greater insights into the mechanisms of life-threatening arrhythmias but 
have been used to engineer new therapies to treat the consequences of cardiac disease. 
This paper is a look back at the early years in the cardiac modeling and the challenges 
facing the field as models move toward the clinic.

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A brief history of tissue models for cardiac electrophysiology

  • 1. A Brief History of Tissue Models For Cardiac Electrophysiology The last four decades have produced a number of significant advances in the developments of computer models to simulate and investigate the electrical activity of cardiac tissue. The tissue descriptions that underlie these simulations have been built from a combination of clever insight and careful comparison with measured data at multiple scales. Tissue models have not only led to greater insights into the mechanisms of life-threatening arrhythmias but have been used to engineer new therapies to treat the consequences of cardiac disease. This paper is a look back at the early years in the cardiac modeling and the challenges facing the field as models move toward the clinic.