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Natural history of select agents
The world is awash in microorganisms ,[object Object],[object Object],[object Object],[object Object]
Some of these bad guys we’ve known for thousands of years ,[object Object],[object Object],[object Object]
We love to categorize  ,[object Object],[object Object],[object Object],[object Object]
Some researched for bioweapons ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Some other nasty guys out there ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
USDA lists agents with tremendous potential economic impact ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Natural history of select agents ,[object Object],[object Object],[object Object],[object Object],[object Object]
Bacillus anthracis
Traits for success in nature make BA dangerous to us ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cholera-one of the most feared diseases on earth .  ,[object Object]
The natural habitat of  Vibrio , isn’t our insides, but estuaries
Monsoons bring changes in salinity and temperature in estuaries
Leading to increased encounters between  Vibrio  and copepods
Filter feeders come in next
Understanding  Vibrio  ecology has broader implications
How did Vibrio acquire enterobacteriaciae-like toxin?
The ocean is teeming with phages (1-10 million/ml)
Acanthamoeba are everywhere ,[object Object],[object Object],[object Object],[object Object]
Trophozoite feeds on bacteria, algae, yeasts, fungi.
Franciscella tularensis  (Ft) is the causative agent of Tularemia.
Several select agents are obligate or facultative intracellular bacteria. ,[object Object],[object Object],[object Object]
Emerging Infectious Diseases
Global emergence of a zoonotic pathogen needs 3 steps.  ,[object Object],[object Object],[object Object],Many agents move between animal and humans but fail steps 2 and 3
Environmental changes aid emergence of new diseases ,[object Object],[object Object],[object Object],[object Object],[object Object]
Known and emerging agents challenge our response capability  ,[object Object],[object Object],[object Object]
Detection is built on timescales ,[object Object],[object Object],[object Object]
Three methods of detection ,[object Object],[object Object],[object Object]
White powder HazMat response ,[object Object],[object Object]
Epidemiological surveillance ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
An EPI monitoring system
Early detection is critical
Faster and faster widgets ,[object Object],[object Object],[object Object],[object Object],[object Object]
Challenges for widgets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Threats to water systems ,[object Object]
The path ahead

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Natural History of Select Agents

Editor's Notes

  1. I am going to talk about microbes You deal with them everyday; I am going to ask you to think about them differently How are faster, more connected world is bringing new threats and challenges from these guys