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Cytopathology ofOsteolytic Lesions in Bone   Dr Genevieve Warner Learmonth    Cytopathologist / Histopathologist,    Cyto...
Lytic lesions in Bone Lytic lesions are easily aspirated using a  Jam Shedi needle. Most lytic lesions in bone are metas...
Bony lesion: A shepherdess aged 60 yearshas difficulty in walking.X Ray: knee joint destroyed.Clinical Diagnosis: ?Aneurys...
Clear Fluid with scanty translucenthooklets and laminated membrane
Clinical Impression:                          Note extensive involvement                           of tibia, fibula, knee...
Lytic lesion in Clavicle. Scolices and Rostellum of hooklets
Histology of lytic lesion in clavicle, cross sectionof scolex, and laminated membrane
Life cycle of Echinococcusgranulosus in South Africa
A wolf in sheep’s clothing
TUBERCULOSIS in BONE35 year old woman presents withpain in lumbar area for months, thensudden paraplegiaX-rays show lytic...
Collapse of spine with Kyphosis
Necrotising Inflammation, noevidence of granulomata
Rare Langhan’s cell
Ragged fragments of bone
TB bacilli, ZN stain andautofluorescence withPapanicolaou stain using LED
Histology ---Necrotising inflammation.No granulomata.
   Drug-susceptible TB and MDR-TB are    spread the same way. TB germs are put    into the air when a person with TB    d...
TB and HIV ---the terrible twins
When screening a slide, note carefully what youobserve, no matter how odd it may seem
   Difficult to reach with health services
Cytopathology of lesions in bone
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Cytopathology of lesions in bone

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Cytopathology of lytic lesions in bone can be helpful to diagnose infectious processes as well as neoplastic lesions. Tuberculosis, hydatid disease of bone are illustrated. Haemosiderosis of bone is also discussed,

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Cytopathology of lesions in bone

  1. 1. Cytopathology ofOsteolytic Lesions in Bone Dr Genevieve Warner Learmonth Cytopathologist / Histopathologist, Cytopathology Laboratory, Groote Schuur Hospital University of Cape Town
  2. 2. Lytic lesions in Bone Lytic lesions are easily aspirated using a Jam Shedi needle. Most lytic lesions in bone are metastatic tumours. However infectious lesions of bone due to Tuberculosis and opportunistic infections due to HIV/AIDS are becoming more common in South Africa. Metabolic diseases can also present as lytic lesions in bone
  3. 3. Bony lesion: A shepherdess aged 60 yearshas difficulty in walking.X Ray: knee joint destroyed.Clinical Diagnosis: ?Aneurysmal Bone Cyst.Jam Shedi needle aspiratedclear fluid for Cytology.
  4. 4. Clear Fluid with scanty translucenthooklets and laminated membrane
  5. 5. Clinical Impression:  Note extensive involvement of tibia, fibula, knee joint space, patella and soft tissues.  No clinical signs of inflammation  No sinus formation  No pain  No clinical evidence of parathyroid dysfunction.  No renal disease
  6. 6. Lytic lesion in Clavicle. Scolices and Rostellum of hooklets
  7. 7. Histology of lytic lesion in clavicle, cross sectionof scolex, and laminated membrane
  8. 8. Life cycle of Echinococcusgranulosus in South Africa
  9. 9. A wolf in sheep’s clothing
  10. 10. TUBERCULOSIS in BONE35 year old woman presents withpain in lumbar area for months, thensudden paraplegiaX-rays show lytic lesions in lumbar vertebraeJam Shedi needle aspirate yields necroticmaterial.Cytology: Papanicolaou stain
  11. 11. Collapse of spine with Kyphosis
  12. 12. Necrotising Inflammation, noevidence of granulomata
  13. 13. Rare Langhan’s cell
  14. 14. Ragged fragments of bone
  15. 15. TB bacilli, ZN stain andautofluorescence withPapanicolaou stain using LED
  16. 16. Histology ---Necrotising inflammation.No granulomata.
  17. 17.  Drug-susceptible TB and MDR-TB are spread the same way. TB germs are put into the air when a person with TB disease of the lungs or throat coughs, sneezes, speaks, or sings. These germs can float in the air for several hours, depending on the environment. Persons who breathe in the air containing these TB germs can become infected.
  18. 18. TB and HIV ---the terrible twins
  19. 19. When screening a slide, note carefully what youobserve, no matter how odd it may seem
  20. 20.  Difficult to reach with health services

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