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Ā
Bad brain
1.
2.
3. Dorothea Lynde Dix (1802 ā1887)
ā¢ Dorothea Dix ā American
activist - Superintendent of
Army Nurses.
ā¢ Opened first Lunatic Asylum
for the mentally ill
ā¢ Trenton, New Jersey, 1848
ā¢ She suffered debilitating
mental breakdowns
ā¢ Eventually admitted to the
same Hospital
WORLD MENTAL HEALTH DAY - 10 October
4. Therapy for Mental Illness
ā¢ Jules Wagner-Jauregg (University of Vienna)
ā¢ Observation - Mental symptoms disappeared
in mental patients ill with Fever
ā¢ He injected malarial blood into mentally ill
patients to induce fever
ā¢ Fever - therapy was dangerous
ā¢ No effective Malaria Rx
ā¢ Killing about 15% of patients
ā¢ So it was abandoned
ā¢ Received the Nobel Prize in 1927
5. Phineas Gage 1823 - 1860
ā¢ American railroad construction foreman - Blaster
ā¢ 1848 - Rock blasting accident with a large iron rod
3 feet 7 inches long and 3.2cm diameter, 6kg
ā¢ Pierced through his head, destroying his brain
ā¢ He was conscious and able to walk within minutes
of the accident. Taken to Hospital
6. Phineas Gage 1823 - 1860
ā¢ Operated for removal of bone pieces and
part of the brain
ā¢ Comatose for 14 days
ā¢ Miraculously recovered
ā¢ Personality changed after brain injury
7. The Transformation
ā¢ Before ā Hard working responsible
ā¢ He was favorite, efficient, capable
ā¢ After ā Mind changed, vulgar, indecent
ā¢ Psychopath ā Aggressive and violent,
drinking, lying, brawling, Unacceptable
ā¢ Died due to Status Epilepticus
ā¢ 12 yrs after his injury
ā¢ This case gave newer approaches for
treatment of Mental Illnesses
8. Antonio Egas Moniz 1874 ā 1955
ā¢ Portuguese Neurologist
ā¢ First Cerebral angiography - 1927
ā¢ 1935 ā First lobotomy of Frontal Lobe
ā¢ To change the mindset of violent patients
ā¢ 20 patients who had suffered from anxiety,
depression, schizophrenia.
ā¢ Used crude hammer and chisel
9. Antonio Egas Moniz 1874 ā 1955
ā¢ Drilled holes in the skull on both sides
ā¢ Injected alcohol to destroy nerve fibers
ā¢ Leucotome ā Extend a metal loop inside to cut
the brain parts
ā¢ Tried on Murder Convicts of the prison
ā¢ Shot by one of his patients in spine
ā¢ He became paraplegic - on wheelchair
11. Dr. Walter J Freeman 1895 - 1972
ā¢ American Physician, Neurologist
ā¢ Yale university (Not a Surgeon)
ā¢ Lobotomy to disconnect Thalamus
(Emotional Brain) from the Frontal
lobe ā (Thinking brain)
ā¢ To calm patients emotions and
stabilize their personalities without
changing their intelligence and
motor functions.
ā¢ Trans-orbital approach
12. The Trans-orbital approach
ā¢ Ice Pick Lobotomy ā Transorbital
ā¢ Electro-convulsive shock before surgery
ā¢ To reach the frontal lobe through the tear ducts.
ā¢ The Ice-pick would then be scrambled from side
to side in order to damage the frontal lobe
13. Transorbital lobotomy
ā¢ Blind dissection of the brain
ā¢ Lobotomobile ā Operation Van
ā¢ High Mortality and Morbidity
ā¢ Done in 10 minutes, anywhere, without
anaesthesia, without asepsis and without the
assistance of a surgeon.
ā¢ Despite a 14 per cent fatality
rate, Freeman performed 3,439
lobotomies.
ā¢ Total 40000 done in US.
14. Rosemary Kennedy
ā¢ Sister of President John F Kennedy, 23 yrs
ā¢ Violent Mood swings and rebellious.
ā¢ Erratic behavior in convent school
ā¢ Considered psychologically unstable by her family
ā¢ 1941 - Lobotomy done by Dr. Freeman to calm her
ā¢ She was conscious during the procedure
ā¢ They asked her to recite National anthem
ā¢ Continued till she stopped responding
ā¢ There was a big mistakeā¦.
15. Fate of Rosemary Kennedy
ā¢ She Became vegetative
ā¢ Poor Brain functions like an infant
ā¢ Unable to speak or walk
ā¢ Lived in Psychiatric hospital
ā¢ Died at 86 yrs in same status
ā¢ Eunice Kennedy became an activist
in the field of mental retardation.
ā¢ She founded the Special Olympics
for mentally disabled athletes
Lobotomies were banned after the death of a patient of
Dr. Freeman due to brain Haemorrhage - 1967
16. Charles Whitman 1941 -1966
ā¢ Charles Whitman, 25yrs, US Marine
corps and Engineering student
ā¢ Stayed away from his father (Rude)
ā¢ Loved his mother and wife
ā¢ Good Student of Marine services
ā¢ Noticed Sudden change in his behavior,
consulted five Psychiatrists
ā¢ āI have been a victim of many unusual
and irrational thoughtsā
ā¢ He was consuming large doses of
Dexdrine ā Amphetamine
17. The Unexpected fateā¦
ā¢ 1st Aug 1966 - Killed his mother
and wife in sleep by stabbing them
ā¢ He wrote letters beside his mother
and wife after killing them.
ā¢ He mentioned ā āHe loved them,
and wanted them to be safe in
heavenā
ā¢ Then he went to the Texas
University
18. Texas University Shootout Case
ā¢ Went to top of Texas University
ā¢ Killed 3 people on the way
ā¢ Fired at innocent people for 96min, killing 14
people and injuring 32.
ā¢ He was shot dead by the police
19. Brain ib6aD
ā¢ He had requested for autopsy
after his death to find out reason
of his headaches and moods.
ā¢ There was a Frontal lobe tumor,
Astrocytoma pressing on the
amagdala
ā¢ It could have contributed to his
inability to control his emotions
and actions.
ā¢ Excess of Dexdrine
21. SPLIT ā BRAIN
ā¢ Roger W. Sperry, Neuropsychologist
ā¢ Nobel Prize in 1981
ā¢ āSplit-Brainā studies on cats
ā¢ Different functions of Left and Right Brain
ā¢ Both sides are involved in each function
differently
ā¢ One side may dominate other
ā¢ Personality change with Rt or Lt ?