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Gene Therapy Resala

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قالوا سبحانك لا علم لنا إلا ما علمتنا إنك أنت العليم الحكيم قالوا سبحانك لا علم لنا إلا ما علمتنا إنك أنت العليم الحكيم
 
Alaa Ibrahim Essa Demonstrator of pharmacology
Gene Therapy A promising Approach in Prevention and Treatment of the Diseases
Under supervision of Nabila Hassan El-Barody Prof. Dr. Ass. Prof Ibrahim Aly Awwad Ass. Prof Ahmed Abd El Azim Mobasher .Dr. .Dr.
Prof. Dr . Naamat Ahmed zakaria Prof. Dr. Moneer Nageeb Ibrahim Ass. Prof Ibrahim Aly Awwad .Dr. .Dr.
 
[object Object],[object Object]
[object Object],[object Object],[object Object]
Aim of the work ,[object Object],[object Object]
History of Gene Therapy
[object Object]
[object Object],[object Object]
[object Object]
[object Object],[object Object]
Genomes ,[object Object]
DNA-modifying enzymes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RNA versus DNA ,[object Object],[object Object],[object Object]
[object Object]
An ideal gene delivery method has three major criteria: ,[object Object],[object Object],[object Object]
[object Object]
Gene therapy In vivo Ex vivo
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Some of viruses used in gene therapy:- ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adenoviruses Vectors: ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nonviral delivery methods :- ,[object Object],[object Object],[object Object]
Gene Transfer by Physical Methods:- ,[object Object]
2-Gene Transfer by Electroporation:- ,[object Object]
The advantages of using of electroporation:- ,[object Object],[object Object],[object Object],[object Object],[object Object]
3-Ultrasound-Facilitated Gene Transfer ,[object Object],[object Object]
4-Hydrodynamic Gene Delivery ,[object Object],[object Object],[object Object]
Gene Delivery by Chemical Methods:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cancer gene therapy
Cancer Gene therapy strategies:- ,[object Object],[object Object],[object Object],[object Object],[object Object]
Immunotherapy The induction of cytokine Genetic modification of lymphocytes Tumor antigen vaccines
A) Induction of cytokine or co-stimulatory molecule expression :- ,[object Object],[object Object]
B) Genetic modification of lymphocytes:- ,[object Object],[object Object],[object Object]
C) Tumour antigen vaccines:- ,[object Object],[object Object],[object Object]
II- Introduction of tumor suppressor genes & induction of apoptosis:- ,[object Object],[object Object],[object Object]
III- Virus-directed enzymerodrug therapy:- ,[object Object],[object Object],[object Object]
 
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Gene therapy strategies in neurological insult:- ,[object Object]
[object Object],[object Object],[object Object],A) The first approach
B) A second approach ,[object Object],[object Object],[object Object]
C) The third approach ,[object Object],[object Object],[object Object],[object Object],[object Object]
Gene therapy for Parkinson's disease: - ,[object Object],[object Object],[object Object]
Gene therapy for Alzheimer: ,[object Object],[object Object]
Gene therapy in epilepsy:- ,[object Object]
Gene therapy in stroke :- ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object]
 

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Gene Therapy Resala

  • 1. قالوا سبحانك لا علم لنا إلا ما علمتنا إنك أنت العليم الحكيم قالوا سبحانك لا علم لنا إلا ما علمتنا إنك أنت العليم الحكيم
  • 2.  
  • 3. Alaa Ibrahim Essa Demonstrator of pharmacology
  • 4. Gene Therapy A promising Approach in Prevention and Treatment of the Diseases
  • 5. Under supervision of Nabila Hassan El-Barody Prof. Dr. Ass. Prof Ibrahim Aly Awwad Ass. Prof Ahmed Abd El Azim Mobasher .Dr. .Dr.
  • 6. Prof. Dr . Naamat Ahmed zakaria Prof. Dr. Moneer Nageeb Ibrahim Ass. Prof Ibrahim Aly Awwad .Dr. .Dr.
  • 7.  
  • 8.
  • 9.
  • 10.
  • 11. History of Gene Therapy
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22. Gene therapy In vivo Ex vivo
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.
  • 30.
  • 31.
  • 32.
  • 33.
  • 34.
  • 36.
  • 37. Immunotherapy The induction of cytokine Genetic modification of lymphocytes Tumor antigen vaccines
  • 38.
  • 39.
  • 40.
  • 41.
  • 42.
  • 43.  
  • 44.
  • 45.
  • 46.
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  • 55.