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International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017]
AI Publications ISSN: 2456-8015
www.aipublications.com Page | 1
Maternal & Infant Risks Regarding Extreme
Age of Pregnancy
Naglaa A. El-Sherbiny1
, Mohamed Masoud1
, Alkasseem A. Elgameel2
1
Public Health Dept. Fayoum University, Egypt
2
Pediatric Dept., Fayoum University, Egypt
3
Faculty of Medicine, Fayoum University, Egypt
Abstract— Background: Extremes of maternal age are of
considerable clinical and public health concern as it plays
an important role in infant and maternal health. This study
aims to determine the effect of extreme maternal age at
pregnancy on a mother and infant’s health. Methods: The
study was a cross-sectional analytical observational study,
conducted on a pediatric outpatient clinic at Teaching
Hospital, with a purposive sample of 450 mothers. A
structured questionnaire was designed, which included
socio-demographic data, factors related to pregnancy
care, and factors related to the infant. Results: The main
maternal health problem during pregnancy was anemia
and pregnancy induced hypertension with a statistically
significant association between the mother’s age and
maternal morbidity. The main causes of baby admission
into hospital were diarrhea and acute respiratory diseases,
with a statistical significant. Conclusion: There was an
agonizing correlation between extreme maternal age and
infant health. A serious collaborative effort must be done
between social worker in health facilities and community,
to rise up awareness about the suitable age of marriage
and reproductive health.
Keywords— Extreme maternal age; Infant health;
maternal morbidities.
I. INTRODUCTION
The age of the mother typically plays an integral role in
infant as well as maternal health. Extremes of maternal age
are of considerable clinical and public health concern.
Pregnancies of the teen-age (below 18 years) and advanced
maternal age (above 35 years) are associated with
increased risks of poor outcomes, such as prematurity,
growth retardation and chromosomal abnormalities, with
increased complications during pregnancy and birth [1,2].
Children born to young and old mothers also have worse
health and higher mortality, than those born to mothers
aged 25–34 years [3,4] .
A new-born’s weight at birth is an important indicator of
child health and development. Mothers at the extremes of
maternal age (below 20 years and above 35 years) are
more susceptible to having low birth weight infants, with
increased risk of pre-term delivery [5]. In addition,
gestational age is a determinant of the weight and size of
the baby at birth, with a link of maternal age to foetal
growth restriction [6]. The risk of congenital anomalies,
such as neural tube defects, Down's syndrome and cleft
lip and/or palate, is much more common with older aged
mothers [7]. In contrast to advanced maternal age, it was
documented [8] that children born to mothers below the
age of 18 were at a higher risk of stunting and being
underweight, in comparison to the children of mothers
aged above 18 years.
Regarding the Sustainable Development Goals (SDGs)
No. (3): Ensure healthy lives and promote wellbeing for
all at all ages. Preventing unintended pregnancy and
reducing adolescent childbearing through universal access
to reproductive health-care services seeking of reducing
child and maternal mortality. This requires effective,
affordable interventions, as new-borns caring, breast
feeding and proper nutrition, effective immunization,
prevention and proper treatment of pneumonia and
diarrhoea. These children’s health related strategies are
then complemented by interventions for maternal health;
in particular, skilled care during pregnancy and childbirth
[9]. Globally, the number of deaths of children below five
years of age fell from 12.6 million in 1990, to 6.6 million
in 2012. In developing countries, the percentage of
underweight children below five years old dropped from
28% in 1990, to 17% in 2012. In countries with high
mortality rates, these interventions could reduce the
number of deaths by more than half and improve the child
health status [10].
II. AIM OF WORK
This study aimed to determine the effects of maternal age
at pregnancy, on a mother and infant’s health, whilst
exploring the association between maternal age at
pregnancy with maternal morbidities and pregnancy
outcomes.
Methods: The study was a cross-sectional analytical
observational study, concerned with identifying the
relation of maternal age with maternal morbidities and
pregnancy outcomes. It was conducted on a paediatric out-
patient clinic at the University Teaching Hospital. The
International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017]
AI Publications ISSN: 2456-8015
www.aipublications.com Page | 2
sample was a purposive sample, with inclusion criteria of:
mother’s age above 18 with the babies' age at 2 months or
below, coming for examination for specific diseases or a
routine follow up. A sample size of 450 mothers was
calculated using Epi Info 7, taking into consideration that
the proportion of mothers with maternal complications was
50%, with 95% confidence interval and precision of 5%.
Finally, the sample was increased by 15% to overcome the
problem of no responses and missing data. Participating
mothers were interviewed with a structured coded
questionnaire, formed of the following sections: Firstly,
socio-demographic data related to the mother, that
included age at the beginning of pregnancy, residency,
level of education and occupation. The second section was
related to pregnancy care: gravidity, consanguinity,
morbidity related to pregnancy and mode and place of
delivery. The third section was related to the infant:
determining whether the baby was born full term or pre-
mature, weight at birth, birth order, pattern of feeding,
frequency and causes of hospital admission.
Ethical approval:
This study was reviewed and approved by the Faculty of
Medicine Research Ethical Committee at Fayoum
University with a reference number (5) in October, 2015.
Data entry and statistical analysis:
Data was collected, coded and analysed using SPSS
software (Version 18) under Windows 7; simple
descriptive analysis in the form of percentage distribution,
means and standard deviations were done. Suitable
inferential statistics were done to test the level of
significance, with a confidence level of 0.05.
III. RESULTS
The total number in the study sample was 450 mothers.
Their age range was from 18-40 with a mean age of 25.6
(±5.9) years. 17.1% (N=77) of them were less than 20
years old and 14.2% (N=64) were in the age group of more
than 35 years. Two thirds of them, i.e. 66.4% (N=299)
were living in urban areas. With regards to education level,
59.3% (N=267) were of high educational level and only
38.7% (N=174) of them were working, while housewives
constituted 56.9% (N=256). Only 19.6% (N=88) of the
studied mothers had a positive consanguinity and 47.3%
(N=213) of them were prime-gravida. Regarding the place
and mode of delivery, 56.4% (N=254) delivered in a
hospital and 72.7% (N=327) were delivered by caesarean
section in hospitals and private clinics. There was a
statistically significant association between maternal age
groups with different socio-demographics and delivery
methods. So prime-gravida, housewife with high
education, living in urban areas, and having a positive
consanguinity (P=0.000) delivered through caesarean
section (P=0.004), and delivered in the hospital (P=0.000)
were significantly associated with maternal age. Regarding
relation of maternal age with ANC services, there was a
statistically significant association between maternal age
and time of first ANC visit (P=0.000), while there was no
statistically significant association with number of ANC
visits (Table 1).
Table.1: Socio-demographic, Marriage & Delivery Characteristics related to Maternal age groups
Maternal age groups
Less than 20
years
+20-35 years +35 years Total
P value
N=77 17.1% N=309 68.7% N=64 14.2% N=450 100%
Residency
Urban 32 41.6 230 74.4 37 57.8 299 66.4
0.000*
Rural 45 58.4 79 25.6 27 42.2 151 33.6
Level of Education
Primary 7 9.1 13 4.2 16 25.0 36 8.0
0.000*Secondary 60 77.9 58 18.8 29 45.3 147 32.7
High education 10 13.0 238 77.0 19 29.7 267 59.3
Occupation
House wife 57 74.0 154 49.8 45 70.3 256 56.9
0.000*Student 18 23.4 2 0.6 0 0.0 20 4.4
Working 2 2.6 153 49.5 19 29.7 174 38.7
Consanguinity
Positive 27 35.1 54 17.5 7 10.9 88 19.6
0.000*
Negative 50 64.9 255 82.5 57 89.1 362 80.4
Gravida
Primi 62 80.5 147 47.6 4 6.3 213 47.3 0.000*
International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017]
AI Publications ISSN: 2456-8015
www.aipublications.com Page | 3
2-3 15 19.5 149 48.2 38 59.4 202 44.9
+3 0 0.0 13 4.2 22 34.3 35 7.8
Place of Delivery
Home 4 5.2 4 1.3 10 15.6 18 4.0
0.000*Hospital 39 50.6 176 57.0 39 60.9 254 56.4
Private clinic 34 44.2 129 41.7 15 23.4 178 39.6
Mode of Delivery
Normal vaginal 31 40.3 68 22.0 24 37.5 123 27.3
0.004*
Cesarean section 46 59.7 241 78.0 40 62.5 327 72.7
ANC visit
<5 visits 8 10.4 68 22.0 14 21.9 90 20.0
0.068
≥ 5visits 69 89.6 241 78.0 50 78.1 360 80.0
Time of first visit
During 1st
trimester 56 72.7 184 59.5 29 45.3 269 59.8
0.000*
After 1 st trimester 21 27.3 125 40.5 35 54.7 181 40.2
*P <0.05 is considered significant
In relation to infants, three quarters of them (77.6%, N=349) were born full term; 63.8% (N=287) were normal weight and
58.0% (N=261) were exclusively breast fed during the first 6 months. There was a statistically significant association
between the mother’s age and maturity of the baby (P=0.000), birth weight (P=0.001) and feeding of the baby (P=0.045)
(Table 2).
Table.2: Relation between maternal age, new-borns’ maturity, birth weight and feeding
Maturity
Less than 20 years +20-35 years +35 years
P-value
N=77 17.1% N=309 68.7% N=64 14.2%
Maturity
Full term 45 58.4 252 81.6 52 81.3
0.000*
Pre-mature 32 41.6 57 18.4 12 18.8
Birth weight
Normal 41 53.2 211 68.3 35 54.7
0.001*Underweight 36 46.8 87 28.2 23 35.9
Overweight 0 0 11 3.6 6 9.4
Feeding
Breast 39 50.6 183 59.2 39 60.9
0.045*Bottle 26 33.8 56 18.1 12 18.8
Mixed 12 15.6 70 22.7 13 20.3
*P <0.05 is considered significant
The main maternal morbidity problem during pregnancy
was anaemia, which constituted 42.2% (N=190); then
pregnancy induced hypertension with 11.1% (N=50).
However, 37.6% (N=169) of mothers had a safe
pregnancy devoid of any risk factors.
There was a statistically significant association between
the age of the mother and maternal morbidity during
pregnancy (P=0.000). Anaemia constituted 70.1% (N=54)
and antepartum haemorrhage 9.1% (N=7) was prevalent
in mothers aged below 20 years. The main causes among
mothers > 35 years old was pregnancy induced
hypertension (28.1% N=18), followed by anaemia (18.8%
N=12), then gestational diabetes (6.3% N=4) as shown in
Table 3.
Table.3: Relation of Maternal Age to maternal morbidities and causes of infant admissions
Maturity
Less than 20 years +20-35 years +35 years
P-value
N=77 17.1% N=309 68.7% N=64 14.2%
International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017]
AI Publications ISSN: 2456-8015
www.aipublications.com Page | 4
Maternal morbidities
Gestational Diabetes 0 0.0 14 4.5 4 6.3
0.000*
PIH 2 2.6 30 9.7 18 28.1
Ante-partum hemorrhage 7 9.1 16 5.2 0 0.0
Anemia 54 70.1 124 40.1 12 18.8
No complications 14 18.2 125 40.5 39 46.9
Causes of infant admissions
Diarrhea 23 29.9 43 13.9 9 14.1
0.000*
Respiratory tract infections 22 28.6 44 14.2 6 9.4
Diarrhea & respiratory tract
infections
4 5.2 12 3.9 17 26.6
Congenital anomalies 3 3.9 19 6.1 2 3.1
Others** 5 6.5 14 4.5 12 18.8
No admissions 20 26.0 177 57.3 18 28.1
*P <0.05 is considered significant ** Anemia, surgical adenoidectomy, Neonatal hypoglycemia, Convulsions
The mean number of infant hospital admissions during
the first year of life, among mothers below 20 years old
was 1.1 (±1.6), 20-35 years was 0.6 (±1.2), and more than
35 years was 1.7 (±2.6). There was a statistically
significant difference between mothers aged from 20-35
years, and both, mothers below 20 years (P= 0.006), and
more than 35 years (P= 0.000). Additionally, there was
statistically significant difference between mothers below
20 years, and more than 35 years (P= 0.026).
The main two causes of baby admission into hospital
were diarrhoea and acute respiratory diseases, with a
percentage of 16.7% (N=75) and 16.0% (N=72),
respectively. More than two thirds of mothers with
extremities of age were admitted into hospital with their
babies due to different causes. Diarrhoea and acute
respiratory tract infection were the main causes of baby
hospital admission with mothers aged below 20 years, as
they constituted 29.9% (N=23) and 28.6% (N=22),
respectively, while the main cause in infant’s with
mothers aged above 35 years was congenital disease,
constituting 26.6% (N=17). There was a statistically
significant association between a mother’s age and causes
of baby admissions into hospitals (P=0.000) (Table 3).
Regarding risk factors of maternal morbidities during
ANC, multivariate logistic regression analysis determined
that amongst mothers aged 20-35, there was a three-fold
risk of having maternal morbidities when receiving less
than 5 AVC visits [OR 3.3-95% CI (1.9; 5.8)]. Among
age group ≥ 35 years, below high education [OR 13.5-
95% CI (2.2; 82.6)] and home delivery [OR 41.3-95% CI
(3.2; 526.3)] were associated with increased risk to
maternal morbidities. On the other hand, for infant
admission: among mothers aged less than 20, the risk
increased when the infants had positive consanguinity
[OR 20.5-95% CI (2.4; 176.0)]. While among age group
20- 35 years, positive consanguinity [OR 7.6-95% CI
(3.7; 15.4)], first ANC visit after first trimester [OR 2.3-
95% CI (1.4; 3.93)] and prematurity [OR 3.8-95% CI
(1.9; 7.3)] were associated with increased risk to infant
admission Table 4.
Table.4: Odds ratios (95 % CIs) of significant factors related to maternal morbidities and infant admission in different age
groups of mothers
Factors <20 20-35 >35
Maternal morbidities
ANC less than 5 visits ----- 3.3 (1.9-5.8) ------
Below high Education ----- ----- 13.5 (2.2-82.6)
Home delivery ----- ----- 41.3 (3.2-526.3)
Infant admission
Consanguinity 20.5 (2.4-176.0) 7.6 (3.7-15.4) -----
ANC time after first trimester ----- 2.3 (1.4-3.9) -----
Premature ----- 3.8 (1.9-7.3) -----
IV. DISCUSSION
This study focuses on the relationship between mother
and infant's morbidities within different maternal age
groups, with an emphasis on adolescents and older
mothers, who are deemed a high risk category. Mothers
younger than 18 are known as a group at high
International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017]
AI Publications ISSN: 2456-8015
www.aipublications.com Page | 5
psychosocial, obstetrical and foetal risk; mothers older
than 38 are considered as a group at high maternal and
foetal risk [2,11]. There was a negative association
between advanced maternal age and health, as the
physiological reproductive aging of the mother occurred,
affecting the conception process with a wide array of
negative birth outcomes, foetal development, low-risk
birth, and post-birth development [4]. The World
Health Statistics [12] reported that 11% of all births
worldwide are to girls aged 15 to 19, and the vast
majority is in low and middle income countries, with a
range from 1 to 229 births/1000 girls. The global
adolescent birth rate is 49/1000 girls in this age. Also,
complications linked to pregnancy and childbirth for
mothers are very common place. Early marriage is
associated with a number of poor social and physical
outcomes for young women and their offspring [2,13].
They attain lower schooling, lower social status in their
husbands’ families, have less reproductive control, and
suffer higher rates of maternal mortality and domestic
violence. Our sample consisted of 17.1% of mothers, who
were less than 20 years old, and 14.2% in the age group
over 35 years old; the remainder being between 20 to 35
years old. Two thirds of them (66.4%) were residing in
urban areas; 58.4% of mothers below 20 years of age
were living in rural areas. With regards to educational
level, 59.3% were of high educational level and 56.9% of
them were housewives. The previous figures related to
educational level and being a house-wife, are due to the
culture of this high income level community, where
although it’s preferred that women have a high level of
education, the priority however, is taking care of the
children as income isn’t required. On the flip side, the low
income levels prefer primary or even preparatory
education, with a combination of cultural and religious
arguments backing early marriage. Relieving the family
from her economic burden, or alternatively, working from
a very young age and thereby generating money for
taking financial care of the family, especially in rural
areas [14].
The place and mode of delivery were important elements
in detecting infant health. In our study, 56.4% of the
infants were delivered at hospitals and 72.7% were
delivered by caesarean sections. These figures seemed to
be contradicted as the percent of caesarean section
exceeded the delivery in hospital, but these were related
to living in urban areas with availability of both public
and private health care facilities (hospital and
polyclinics), in which most of the urban population prefer
these polyclinics for higher privacy (than public hospitals)
and for lower prices (than private hospitals).
Our results established that there was a statistically
significant association between maternal health problems
during pregnancy and maternal age (P=0.000); the main
maternal health problem among age groups below 20 was
anaemia, as it constituted 70.1%. This result was in
agreement with [13] who said that young aged girls are
often forced out of school without education; their health
is affected because their bodies are too immature to give
birth. On the other hand, pregnancy induced hypertension
was considered the main cause in ages above 35, with a
level of 28.1%. These findings were similar to the results
of some studies which are known to have reported that the
number of mothers with chronic hypertension increased
with advanced maternal age (starting from the age of 35
years) [3]. However, 37.6% of mothers had a safe
pregnancy without any risk factors; this is due to the
proper ANC check-ups, as for this group, it’s either a
precious pregnancy so they are keen to follow all
instructions of ANC, or they have prior experience with
several pregnancies.
The current work revealed a statistically significant
association between the age of the mother, maturity of the
baby (P=0.000) and birth weight (P=0.001). For the
maternal age group aged below 20, 41.6% and 46.8% of
the babies were preterm and underweight, respectively.
Our results were in agreement with [15] who documented
that young age can be a proxy for “short stature, low body
weight in relation to height, and greater likelihood of
inadequate weight gain during pregnancy, along with
difficulty of delivery”. Amongst mothers above 35 years
old, 18.8% of their babies were premature, while 35.9%
were underweight [16] was inconsistent with our results,
since they reported that advanced maternal age positively
linked with birth weight.
As pertains to the numbers of hospital admissions,
hospitalisation duration of infants born to mothers above
35 years of age (1.7±2.6) and mothers below 20 years old,
(1.1±1.6) was longer than that of mothers aged between
20-35 (0.6±1.2). Similar to our results, [3] calculated that
children born to mothers aged ≥ 40, had a much longer
period of hospital stays than children born to younger
mothers. This current study result disagreed with [17]
who reported that the risk of children being admitted to
hospital declined with increasing maternal age.
In the present work, more than two thirds of the mothers
with extremities of age were admitted to hospitals with
their babies due to different causes, with a statistically
significant association between the age of the mother and
causes of baby admission to the hospital (P=0.000).
Diarrhoea and acute respiratory tract infection were the
main causes of baby hospital admission with mothers
aged below 20 years, as they constituted 29.9% and
28.6%, respectively. The main cause in infants with
mothers aged above 35 years, was congenital disease in
26.6%. Our outcomes were in agreement with [18]
International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017]
AI Publications ISSN: 2456-8015
www.aipublications.com Page | 6
results, which indicated that advanced maternal age
accompanies many negative birth outcomes, such as
malformations and chromosomal abnormalities. However,
[15] documented that children born to mothers aged
below age 27–29 are at a higher risk of poor health
outcomes.
Conclusion: The study concluded that there was an
agonizing correlation between extreme maternal age and
infant health. Anaemia and pregnancy induced
hypertension were the main maternal complications
during pregnancy. Diarrhoea, acute respiratory diseases
and congenital anomalies were the main three causes for
infant hospital admission. There is a growing need for
collaborative efforts between social worker in health
facilities and community, to rise up awareness about the
suitable age of marriage and basic knowledge of
reproductive health.
Ethical approval and consent to participate:
This study was reviewed and approved by the Faculty of
Medicine Research Ethical Committee at Fayoum
University. It was conducted after explaining the study
objectives, and confidentiality was expressed to the
participant mothers.
Consent to publication:
Before distributing the questionnaire a written informed
consent with the data explaining the purpose of the study
was obtained from mothers for their acceptance to be
involved in the study and their agreement for publication
of the results. Each mother had the right not to participate
in the study or withdraw at any time.
Availability of data and materials: please contact
authors for data request
Competing interest:
There is no conflict of interest, as there are no commercial
or financial relationships (no grant or any financial
support, equipment) from any institution or organisation
that could be construed as a potential conflict, and all the
expenses are covered by the authors. There are no
financial competing interests (political, personal,
religious, ideological, academic, intellectual, commercial
or any other) to declare in relation to this manuscript.
Funding:
The authors do not hold any stocks or shares, fees,
funding or salary from any organization that may in any
way gain or lose financially from the publication of this
manuscript, either now or in the future.
Authors’ contributions:
NE: conceived the study, design; carried out the
questionnaire design, participated as interviewer, made
the pilot testing of the questionnaire, performed statistical
analysis and shared in drafting, editing and revision of the
manuscript. MM: calculation of sample size, participated
as interviewer of the questionnaire (data collection),
performed statistical analysis and shared in revision of the
manuscript. AE: shared in questionnaire design,
performed the clinical examination and diagnosis of
children’s diseases, and helped in drafting the manuscript.
All authors read and approved the final manuscript.
ACKNOWLEDGEMENT
The authors would like to thank the mothers who agreed
to participate in this research and honoured their
commitment whilst seeking the long term and enduring
benefits for children.
REFERENCES
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1007.
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Maternal & Infant Risks Regarding Extreme Age of Pregnancy

  • 1. International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017] AI Publications ISSN: 2456-8015 www.aipublications.com Page | 1 Maternal & Infant Risks Regarding Extreme Age of Pregnancy Naglaa A. El-Sherbiny1 , Mohamed Masoud1 , Alkasseem A. Elgameel2 1 Public Health Dept. Fayoum University, Egypt 2 Pediatric Dept., Fayoum University, Egypt 3 Faculty of Medicine, Fayoum University, Egypt Abstract— Background: Extremes of maternal age are of considerable clinical and public health concern as it plays an important role in infant and maternal health. This study aims to determine the effect of extreme maternal age at pregnancy on a mother and infant’s health. Methods: The study was a cross-sectional analytical observational study, conducted on a pediatric outpatient clinic at Teaching Hospital, with a purposive sample of 450 mothers. A structured questionnaire was designed, which included socio-demographic data, factors related to pregnancy care, and factors related to the infant. Results: The main maternal health problem during pregnancy was anemia and pregnancy induced hypertension with a statistically significant association between the mother’s age and maternal morbidity. The main causes of baby admission into hospital were diarrhea and acute respiratory diseases, with a statistical significant. Conclusion: There was an agonizing correlation between extreme maternal age and infant health. A serious collaborative effort must be done between social worker in health facilities and community, to rise up awareness about the suitable age of marriage and reproductive health. Keywords— Extreme maternal age; Infant health; maternal morbidities. I. INTRODUCTION The age of the mother typically plays an integral role in infant as well as maternal health. Extremes of maternal age are of considerable clinical and public health concern. Pregnancies of the teen-age (below 18 years) and advanced maternal age (above 35 years) are associated with increased risks of poor outcomes, such as prematurity, growth retardation and chromosomal abnormalities, with increased complications during pregnancy and birth [1,2]. Children born to young and old mothers also have worse health and higher mortality, than those born to mothers aged 25–34 years [3,4] . A new-born’s weight at birth is an important indicator of child health and development. Mothers at the extremes of maternal age (below 20 years and above 35 years) are more susceptible to having low birth weight infants, with increased risk of pre-term delivery [5]. In addition, gestational age is a determinant of the weight and size of the baby at birth, with a link of maternal age to foetal growth restriction [6]. The risk of congenital anomalies, such as neural tube defects, Down's syndrome and cleft lip and/or palate, is much more common with older aged mothers [7]. In contrast to advanced maternal age, it was documented [8] that children born to mothers below the age of 18 were at a higher risk of stunting and being underweight, in comparison to the children of mothers aged above 18 years. Regarding the Sustainable Development Goals (SDGs) No. (3): Ensure healthy lives and promote wellbeing for all at all ages. Preventing unintended pregnancy and reducing adolescent childbearing through universal access to reproductive health-care services seeking of reducing child and maternal mortality. This requires effective, affordable interventions, as new-borns caring, breast feeding and proper nutrition, effective immunization, prevention and proper treatment of pneumonia and diarrhoea. These children’s health related strategies are then complemented by interventions for maternal health; in particular, skilled care during pregnancy and childbirth [9]. Globally, the number of deaths of children below five years of age fell from 12.6 million in 1990, to 6.6 million in 2012. In developing countries, the percentage of underweight children below five years old dropped from 28% in 1990, to 17% in 2012. In countries with high mortality rates, these interventions could reduce the number of deaths by more than half and improve the child health status [10]. II. AIM OF WORK This study aimed to determine the effects of maternal age at pregnancy, on a mother and infant’s health, whilst exploring the association between maternal age at pregnancy with maternal morbidities and pregnancy outcomes. Methods: The study was a cross-sectional analytical observational study, concerned with identifying the relation of maternal age with maternal morbidities and pregnancy outcomes. It was conducted on a paediatric out- patient clinic at the University Teaching Hospital. The
  • 2. International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017] AI Publications ISSN: 2456-8015 www.aipublications.com Page | 2 sample was a purposive sample, with inclusion criteria of: mother’s age above 18 with the babies' age at 2 months or below, coming for examination for specific diseases or a routine follow up. A sample size of 450 mothers was calculated using Epi Info 7, taking into consideration that the proportion of mothers with maternal complications was 50%, with 95% confidence interval and precision of 5%. Finally, the sample was increased by 15% to overcome the problem of no responses and missing data. Participating mothers were interviewed with a structured coded questionnaire, formed of the following sections: Firstly, socio-demographic data related to the mother, that included age at the beginning of pregnancy, residency, level of education and occupation. The second section was related to pregnancy care: gravidity, consanguinity, morbidity related to pregnancy and mode and place of delivery. The third section was related to the infant: determining whether the baby was born full term or pre- mature, weight at birth, birth order, pattern of feeding, frequency and causes of hospital admission. Ethical approval: This study was reviewed and approved by the Faculty of Medicine Research Ethical Committee at Fayoum University with a reference number (5) in October, 2015. Data entry and statistical analysis: Data was collected, coded and analysed using SPSS software (Version 18) under Windows 7; simple descriptive analysis in the form of percentage distribution, means and standard deviations were done. Suitable inferential statistics were done to test the level of significance, with a confidence level of 0.05. III. RESULTS The total number in the study sample was 450 mothers. Their age range was from 18-40 with a mean age of 25.6 (±5.9) years. 17.1% (N=77) of them were less than 20 years old and 14.2% (N=64) were in the age group of more than 35 years. Two thirds of them, i.e. 66.4% (N=299) were living in urban areas. With regards to education level, 59.3% (N=267) were of high educational level and only 38.7% (N=174) of them were working, while housewives constituted 56.9% (N=256). Only 19.6% (N=88) of the studied mothers had a positive consanguinity and 47.3% (N=213) of them were prime-gravida. Regarding the place and mode of delivery, 56.4% (N=254) delivered in a hospital and 72.7% (N=327) were delivered by caesarean section in hospitals and private clinics. There was a statistically significant association between maternal age groups with different socio-demographics and delivery methods. So prime-gravida, housewife with high education, living in urban areas, and having a positive consanguinity (P=0.000) delivered through caesarean section (P=0.004), and delivered in the hospital (P=0.000) were significantly associated with maternal age. Regarding relation of maternal age with ANC services, there was a statistically significant association between maternal age and time of first ANC visit (P=0.000), while there was no statistically significant association with number of ANC visits (Table 1). Table.1: Socio-demographic, Marriage & Delivery Characteristics related to Maternal age groups Maternal age groups Less than 20 years +20-35 years +35 years Total P value N=77 17.1% N=309 68.7% N=64 14.2% N=450 100% Residency Urban 32 41.6 230 74.4 37 57.8 299 66.4 0.000* Rural 45 58.4 79 25.6 27 42.2 151 33.6 Level of Education Primary 7 9.1 13 4.2 16 25.0 36 8.0 0.000*Secondary 60 77.9 58 18.8 29 45.3 147 32.7 High education 10 13.0 238 77.0 19 29.7 267 59.3 Occupation House wife 57 74.0 154 49.8 45 70.3 256 56.9 0.000*Student 18 23.4 2 0.6 0 0.0 20 4.4 Working 2 2.6 153 49.5 19 29.7 174 38.7 Consanguinity Positive 27 35.1 54 17.5 7 10.9 88 19.6 0.000* Negative 50 64.9 255 82.5 57 89.1 362 80.4 Gravida Primi 62 80.5 147 47.6 4 6.3 213 47.3 0.000*
  • 3. International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017] AI Publications ISSN: 2456-8015 www.aipublications.com Page | 3 2-3 15 19.5 149 48.2 38 59.4 202 44.9 +3 0 0.0 13 4.2 22 34.3 35 7.8 Place of Delivery Home 4 5.2 4 1.3 10 15.6 18 4.0 0.000*Hospital 39 50.6 176 57.0 39 60.9 254 56.4 Private clinic 34 44.2 129 41.7 15 23.4 178 39.6 Mode of Delivery Normal vaginal 31 40.3 68 22.0 24 37.5 123 27.3 0.004* Cesarean section 46 59.7 241 78.0 40 62.5 327 72.7 ANC visit <5 visits 8 10.4 68 22.0 14 21.9 90 20.0 0.068 ≥ 5visits 69 89.6 241 78.0 50 78.1 360 80.0 Time of first visit During 1st trimester 56 72.7 184 59.5 29 45.3 269 59.8 0.000* After 1 st trimester 21 27.3 125 40.5 35 54.7 181 40.2 *P <0.05 is considered significant In relation to infants, three quarters of them (77.6%, N=349) were born full term; 63.8% (N=287) were normal weight and 58.0% (N=261) were exclusively breast fed during the first 6 months. There was a statistically significant association between the mother’s age and maturity of the baby (P=0.000), birth weight (P=0.001) and feeding of the baby (P=0.045) (Table 2). Table.2: Relation between maternal age, new-borns’ maturity, birth weight and feeding Maturity Less than 20 years +20-35 years +35 years P-value N=77 17.1% N=309 68.7% N=64 14.2% Maturity Full term 45 58.4 252 81.6 52 81.3 0.000* Pre-mature 32 41.6 57 18.4 12 18.8 Birth weight Normal 41 53.2 211 68.3 35 54.7 0.001*Underweight 36 46.8 87 28.2 23 35.9 Overweight 0 0 11 3.6 6 9.4 Feeding Breast 39 50.6 183 59.2 39 60.9 0.045*Bottle 26 33.8 56 18.1 12 18.8 Mixed 12 15.6 70 22.7 13 20.3 *P <0.05 is considered significant The main maternal morbidity problem during pregnancy was anaemia, which constituted 42.2% (N=190); then pregnancy induced hypertension with 11.1% (N=50). However, 37.6% (N=169) of mothers had a safe pregnancy devoid of any risk factors. There was a statistically significant association between the age of the mother and maternal morbidity during pregnancy (P=0.000). Anaemia constituted 70.1% (N=54) and antepartum haemorrhage 9.1% (N=7) was prevalent in mothers aged below 20 years. The main causes among mothers > 35 years old was pregnancy induced hypertension (28.1% N=18), followed by anaemia (18.8% N=12), then gestational diabetes (6.3% N=4) as shown in Table 3. Table.3: Relation of Maternal Age to maternal morbidities and causes of infant admissions Maturity Less than 20 years +20-35 years +35 years P-value N=77 17.1% N=309 68.7% N=64 14.2%
  • 4. International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017] AI Publications ISSN: 2456-8015 www.aipublications.com Page | 4 Maternal morbidities Gestational Diabetes 0 0.0 14 4.5 4 6.3 0.000* PIH 2 2.6 30 9.7 18 28.1 Ante-partum hemorrhage 7 9.1 16 5.2 0 0.0 Anemia 54 70.1 124 40.1 12 18.8 No complications 14 18.2 125 40.5 39 46.9 Causes of infant admissions Diarrhea 23 29.9 43 13.9 9 14.1 0.000* Respiratory tract infections 22 28.6 44 14.2 6 9.4 Diarrhea & respiratory tract infections 4 5.2 12 3.9 17 26.6 Congenital anomalies 3 3.9 19 6.1 2 3.1 Others** 5 6.5 14 4.5 12 18.8 No admissions 20 26.0 177 57.3 18 28.1 *P <0.05 is considered significant ** Anemia, surgical adenoidectomy, Neonatal hypoglycemia, Convulsions The mean number of infant hospital admissions during the first year of life, among mothers below 20 years old was 1.1 (±1.6), 20-35 years was 0.6 (±1.2), and more than 35 years was 1.7 (±2.6). There was a statistically significant difference between mothers aged from 20-35 years, and both, mothers below 20 years (P= 0.006), and more than 35 years (P= 0.000). Additionally, there was statistically significant difference between mothers below 20 years, and more than 35 years (P= 0.026). The main two causes of baby admission into hospital were diarrhoea and acute respiratory diseases, with a percentage of 16.7% (N=75) and 16.0% (N=72), respectively. More than two thirds of mothers with extremities of age were admitted into hospital with their babies due to different causes. Diarrhoea and acute respiratory tract infection were the main causes of baby hospital admission with mothers aged below 20 years, as they constituted 29.9% (N=23) and 28.6% (N=22), respectively, while the main cause in infant’s with mothers aged above 35 years was congenital disease, constituting 26.6% (N=17). There was a statistically significant association between a mother’s age and causes of baby admissions into hospitals (P=0.000) (Table 3). Regarding risk factors of maternal morbidities during ANC, multivariate logistic regression analysis determined that amongst mothers aged 20-35, there was a three-fold risk of having maternal morbidities when receiving less than 5 AVC visits [OR 3.3-95% CI (1.9; 5.8)]. Among age group ≥ 35 years, below high education [OR 13.5- 95% CI (2.2; 82.6)] and home delivery [OR 41.3-95% CI (3.2; 526.3)] were associated with increased risk to maternal morbidities. On the other hand, for infant admission: among mothers aged less than 20, the risk increased when the infants had positive consanguinity [OR 20.5-95% CI (2.4; 176.0)]. While among age group 20- 35 years, positive consanguinity [OR 7.6-95% CI (3.7; 15.4)], first ANC visit after first trimester [OR 2.3- 95% CI (1.4; 3.93)] and prematurity [OR 3.8-95% CI (1.9; 7.3)] were associated with increased risk to infant admission Table 4. Table.4: Odds ratios (95 % CIs) of significant factors related to maternal morbidities and infant admission in different age groups of mothers Factors <20 20-35 >35 Maternal morbidities ANC less than 5 visits ----- 3.3 (1.9-5.8) ------ Below high Education ----- ----- 13.5 (2.2-82.6) Home delivery ----- ----- 41.3 (3.2-526.3) Infant admission Consanguinity 20.5 (2.4-176.0) 7.6 (3.7-15.4) ----- ANC time after first trimester ----- 2.3 (1.4-3.9) ----- Premature ----- 3.8 (1.9-7.3) ----- IV. DISCUSSION This study focuses on the relationship between mother and infant's morbidities within different maternal age groups, with an emphasis on adolescents and older mothers, who are deemed a high risk category. Mothers younger than 18 are known as a group at high
  • 5. International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017] AI Publications ISSN: 2456-8015 www.aipublications.com Page | 5 psychosocial, obstetrical and foetal risk; mothers older than 38 are considered as a group at high maternal and foetal risk [2,11]. There was a negative association between advanced maternal age and health, as the physiological reproductive aging of the mother occurred, affecting the conception process with a wide array of negative birth outcomes, foetal development, low-risk birth, and post-birth development [4]. The World Health Statistics [12] reported that 11% of all births worldwide are to girls aged 15 to 19, and the vast majority is in low and middle income countries, with a range from 1 to 229 births/1000 girls. The global adolescent birth rate is 49/1000 girls in this age. Also, complications linked to pregnancy and childbirth for mothers are very common place. Early marriage is associated with a number of poor social and physical outcomes for young women and their offspring [2,13]. They attain lower schooling, lower social status in their husbands’ families, have less reproductive control, and suffer higher rates of maternal mortality and domestic violence. Our sample consisted of 17.1% of mothers, who were less than 20 years old, and 14.2% in the age group over 35 years old; the remainder being between 20 to 35 years old. Two thirds of them (66.4%) were residing in urban areas; 58.4% of mothers below 20 years of age were living in rural areas. With regards to educational level, 59.3% were of high educational level and 56.9% of them were housewives. The previous figures related to educational level and being a house-wife, are due to the culture of this high income level community, where although it’s preferred that women have a high level of education, the priority however, is taking care of the children as income isn’t required. On the flip side, the low income levels prefer primary or even preparatory education, with a combination of cultural and religious arguments backing early marriage. Relieving the family from her economic burden, or alternatively, working from a very young age and thereby generating money for taking financial care of the family, especially in rural areas [14]. The place and mode of delivery were important elements in detecting infant health. In our study, 56.4% of the infants were delivered at hospitals and 72.7% were delivered by caesarean sections. These figures seemed to be contradicted as the percent of caesarean section exceeded the delivery in hospital, but these were related to living in urban areas with availability of both public and private health care facilities (hospital and polyclinics), in which most of the urban population prefer these polyclinics for higher privacy (than public hospitals) and for lower prices (than private hospitals). Our results established that there was a statistically significant association between maternal health problems during pregnancy and maternal age (P=0.000); the main maternal health problem among age groups below 20 was anaemia, as it constituted 70.1%. This result was in agreement with [13] who said that young aged girls are often forced out of school without education; their health is affected because their bodies are too immature to give birth. On the other hand, pregnancy induced hypertension was considered the main cause in ages above 35, with a level of 28.1%. These findings were similar to the results of some studies which are known to have reported that the number of mothers with chronic hypertension increased with advanced maternal age (starting from the age of 35 years) [3]. However, 37.6% of mothers had a safe pregnancy without any risk factors; this is due to the proper ANC check-ups, as for this group, it’s either a precious pregnancy so they are keen to follow all instructions of ANC, or they have prior experience with several pregnancies. The current work revealed a statistically significant association between the age of the mother, maturity of the baby (P=0.000) and birth weight (P=0.001). For the maternal age group aged below 20, 41.6% and 46.8% of the babies were preterm and underweight, respectively. Our results were in agreement with [15] who documented that young age can be a proxy for “short stature, low body weight in relation to height, and greater likelihood of inadequate weight gain during pregnancy, along with difficulty of delivery”. Amongst mothers above 35 years old, 18.8% of their babies were premature, while 35.9% were underweight [16] was inconsistent with our results, since they reported that advanced maternal age positively linked with birth weight. As pertains to the numbers of hospital admissions, hospitalisation duration of infants born to mothers above 35 years of age (1.7±2.6) and mothers below 20 years old, (1.1±1.6) was longer than that of mothers aged between 20-35 (0.6±1.2). Similar to our results, [3] calculated that children born to mothers aged ≥ 40, had a much longer period of hospital stays than children born to younger mothers. This current study result disagreed with [17] who reported that the risk of children being admitted to hospital declined with increasing maternal age. In the present work, more than two thirds of the mothers with extremities of age were admitted to hospitals with their babies due to different causes, with a statistically significant association between the age of the mother and causes of baby admission to the hospital (P=0.000). Diarrhoea and acute respiratory tract infection were the main causes of baby hospital admission with mothers aged below 20 years, as they constituted 29.9% and 28.6%, respectively. The main cause in infants with mothers aged above 35 years, was congenital disease in 26.6%. Our outcomes were in agreement with [18]
  • 6. International Journal of Medical, Pharmacy and Drug Research (IJMPD) [Vol-1, Issue-1, May-Jun, 2017] AI Publications ISSN: 2456-8015 www.aipublications.com Page | 6 results, which indicated that advanced maternal age accompanies many negative birth outcomes, such as malformations and chromosomal abnormalities. However, [15] documented that children born to mothers aged below age 27–29 are at a higher risk of poor health outcomes. Conclusion: The study concluded that there was an agonizing correlation between extreme maternal age and infant health. Anaemia and pregnancy induced hypertension were the main maternal complications during pregnancy. Diarrhoea, acute respiratory diseases and congenital anomalies were the main three causes for infant hospital admission. There is a growing need for collaborative efforts between social worker in health facilities and community, to rise up awareness about the suitable age of marriage and basic knowledge of reproductive health. Ethical approval and consent to participate: This study was reviewed and approved by the Faculty of Medicine Research Ethical Committee at Fayoum University. It was conducted after explaining the study objectives, and confidentiality was expressed to the participant mothers. Consent to publication: Before distributing the questionnaire a written informed consent with the data explaining the purpose of the study was obtained from mothers for their acceptance to be involved in the study and their agreement for publication of the results. Each mother had the right not to participate in the study or withdraw at any time. Availability of data and materials: please contact authors for data request Competing interest: There is no conflict of interest, as there are no commercial or financial relationships (no grant or any financial support, equipment) from any institution or organisation that could be construed as a potential conflict, and all the expenses are covered by the authors. There are no financial competing interests (political, personal, religious, ideological, academic, intellectual, commercial or any other) to declare in relation to this manuscript. Funding: The authors do not hold any stocks or shares, fees, funding or salary from any organization that may in any way gain or lose financially from the publication of this manuscript, either now or in the future. Authors’ contributions: NE: conceived the study, design; carried out the questionnaire design, participated as interviewer, made the pilot testing of the questionnaire, performed statistical analysis and shared in drafting, editing and revision of the manuscript. MM: calculation of sample size, participated as interviewer of the questionnaire (data collection), performed statistical analysis and shared in revision of the manuscript. AE: shared in questionnaire design, performed the clinical examination and diagnosis of children’s diseases, and helped in drafting the manuscript. All authors read and approved the final manuscript. ACKNOWLEDGEMENT The authors would like to thank the mothers who agreed to participate in this research and honoured their commitment whilst seeking the long term and enduring benefits for children. REFERENCES [1] Kyoko YM, Ota E, Ganchimeg T, Kuroda M, Mori R. Cesarean section by maternal age group among singleton deliveries and primiparous Japanese women: a secondary analysis of the WHO Global Survey on Maternal and Perinatal Health. BMC Pregnancy Childbirth.2016; 16:39. [2] Fall HDC, Sachdey SH, Osmond C, Restrepo- Mendez CM, Victora C, Martorell R, Stein DA, Sinha S, Tandon N, Adair L, Bas I, Norris S, Richter ML. Association between maternal age at childbirth and child and adult outcomes in the offspring: a prospective study in five low-income and middle income countries (COHORTS collaboration). The Lancet Global Health; 2015;3:7, e366-e377. [3] Dietl A, Cupisti S, Beckmann MW, Schwab M, Zollner U. Pregnancy and obstetrical outcomes in women over 40 years of Age. Geburtshilfe Frauenheilkd;2015; 75(8):827-832. [4] Myrskyla M, and Fenelon A. Maternal age and offspring adult health: evidence from the health and retirement study. Demography; 2012;49 (4):1000- 1007. [5] Khoshnood B, Bouvier-Colle MH, Leridon H, Blondel B. Impact of advanced maternal age on fecundity and women's and children's health. J Gynecol Obstet Biol Reprod; 2008;37: 733-747. [6] Dewey KG, and Cohen RJ. Does birth spacing affect maternal or child nutritional status? A systematic literature review. Matern Child Nutr; 2007;3: 151-173. [7] Vieira AR, and Taucher CS. Maternal age and neural tube defects: evidence for a greater effect in spina bifida than in anencephaly. Rev Med Chil; 2005;133: 62-67. [8] Raj A, Saggurti N, Winter M. The effect of maternal child marriage on morbidity and mortality of children under 5 in India: cross sectional study of a nationally representative sample. BMJ; 2010;340: (b4) 258.
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