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Job Description and Analysis
Jeremy Taylor
Week Three Assignment
HR Management Fundamentals
22 October 2022
Job Description and Analysis
Company's Overview, Mission, Vision, and Organizational
Strategy
Coca-Cola is an Atlanta, Georgia-based American
international beverage corporation. Since its founding in 1892,
this company has specialized in the production and distribution
of various syrups and refreshments (Robert et al., 2020). Cola-
cola refreshments are carbonated, sugary non-alcoholic
beverages. In addition to its original beverage, the company
produces and markets more than 500 other brands of soft drinks
in more than 200 countries worldwide. Since it sells over 1.7
billion servings per day, its goods are widely used and known
all over the world.
The mission of the corporation is to restore the planet. The
brand inspires hopeful and joyful moments, with the goals of
creating value and making a difference. In addition, the
company's mission is to provide alternative beverages and
goods that people love and that refresh them physically and
mentally. This is done to develop a longer-lasting organization
and a more promising common future for people everywhere.
There is an emphasis on leadership, collaboration, honesty,
respect, tolerance, diversity, enthusiasm, responsibility, and
product excellence. The company's vision is to become an
endless beverage provider, therefore its organizational approach
is to increase the number of drinks it sells. They need to
accommodate low- and no-sugar choices in a wide variety of
product types, as well as in a number of different packaging
options and retail settings.
Job Position – Business Co-ordinator
Qualifications, Skills and Experience
1. The minimum education required is a Bachelor of Science or
Bachelor of Technology degree in a relevant field of science or
technology.
2. A minimum of five years' experience working in a Food
Processing Plant, with at least two of those years spent
coordinating management systems.
3. Should have a solid understanding of the process, particularly
with experience working in a bottling environment.
4. FSSC V5 Awareness or Internal Audit QMS OSH EMS
training Certificate in Lead Auditor.
5. Should be at least 18 years old to participate.
How Position's Duties and Responsibilities Reflect the
Company's Mission, Vision, and Strategic Goals
The business system director will be crucial in
understanding and carrying out the organization's strategic
business objectives. This will be essential to achieving the
company's strategic objectives and achieving its mission and
ambitions of making a difference, renewing the world, and
producing value (Belyh, 2019). In addition, they will make sure
that quality goods are produced by guaranteeing that Coca-
Cola's goods meet the relevant health and quality requirements.
Consequently, its clients can enjoy the beverages without
worrying about health concerns like contamination. Due to its
excellent reputation for safe and high-quality products, the
Coca-Cola Corporation (TTCC) will offer more of its drinks to
more consumers across the globe.
The business system coordinator is also responsible for
ensuring that both the organization as well as its products
adhere to the regulations that have been established. Due to the
fact that Coca-Cola must comply with the rules of each state in
which it operates, this will play an essential role in the
company's expansion strategy. Hence, if it conforms to all of
the requirements, the corporation will make a big difference and
bring about a revitalization of the world. Workers will also have
plenty of time to respect their legal wants and requirements and
abide by them.
Purpose of the Position in the Company
When hired, a business systems coordinator will be
responsible for a wide range of tasks. The worker will learn the
company's strategic priorities and put them into action. For this
reason, they will make sure that their quality targets and goals
are in line with the company's strategic business aims, and they
will work with its internal customers to build collaborations and
capabilities in the areas of safety, health, environmental, and
quality (SHEQ). In addition, he or she will oversee the quality
assurance, incorporated management system, as well as food
safety initiatives at the manufacturing facility.
The successful applicant for this position will also be
responsible for ensuring that the quality of the products and
their packaging satisfies all applicable laws, company
standards, and TCCC guidelines. Responsibility for
coordinating with other groups and driving the execution of
TCCC product specs while maintaining quality control falls
under this division's purview. All facilities adhere to FSSC
22000 and GMP (Good Manufacturing Practice) guidelines. In
addition, it is necessary to regularly examine artwork and
packaging for accuracy and conformity, conduct necessary
training, and update procedures and policies in accordance with
any changes made to the relevant specifications and guidelines.
Additionally, the employee must document and monitor
records. He must maintain the SHEQ policies and
documentation needed by the standard, guarantee the most
recent versions of papers are readily available at the time of
use, and execute regular changes to the master-list of records
and documentation. The person will also conduct both internal
and external audits by preserving a certification and
surveillance audit calendar, organizing the internal audit actions
strategy, audit execution, as well as reporting, as well as
identifying trends, tracking audited vehicles, and submitting
monthly audit reports.
The business systems director will also support problem-
solving and continual improvement programs within the
organization by leading root-cause examination of system non-
conformances and evaluating continuous improvement efforts
for patterns to prompt corrective action where necessary.
Among these tasks are the performance of actual performance
indicators, internal audits, assessments, lack of compliance and
remedial action processes. The employee will also organize the
execution of standards for quality, security, health, as well as
the environment. This position is accountable for directing
certification audit operations related to “FSSC integrated
control systems and managing performance appraisal and
internal audits for FSSC 22000 and Information management
systems (IMS) standards.” A part of the responsibilities include
the planning, carrying out, monitoring, and reporting of the
SHEQ tasks that are defined in the SHEQ activity calendar. In
addition, this involves tasks like identifying problematic
tendencies that need fixing or escalating and carrying out
relevant safety, health, and environmental quality (SHEQ)
training.
The reporting tasks, which include reporting customer
complaints and ecological performance measures on a monthly
basis as specified, will also be completed by the professionals.
In addition to this, the business will call for a weekly update on
key performance metrics (KPIs) on a monthly basis. A monthly
report will be provided by a business system planner detailing
the status of all FSSC version 5 and IMS audit appropriate
measures, information governance inspection audit disciplinary
proceedings, internal audit cars, and performance management
activities, as well as reporting on the status of quality
management activities.
Determination of Duties and Qualifications of the Job
There were a few different approaches that were taken
while determining the qualifications and responsibilities
associated with the employment post. First, each employee was
required to fill out a job evaluation questionnaire. I also
conducted interviews with the staff members of the
organization, asking them specific questions pertaining to their
jobs and responsibilities. In addition to conducting a desk audit,
during which I observed employees as they went about their
workday, I obtained log sheets detailing employees' weekly time
spent on each duty. Furthermore, I spoke with managers,
supervisors, co-workers, customers, and clients that the
employee would normally interact with in the course of their
employment. In the end, I determined the position's salary range
by comparing it to similar positions within the same department
and within the same job category.
Employment Laws in the Creation of the Job Descriptions
Business coordinator duties and responsibilities were
drafted with reference to significant employment legislation like
the “Equal Pay Act (EPA) and the Fair Labour Standards Act
(FLSA)” (Dau-Schmidt et al., 2019) The FLSA governs the
rights of both public and private sector workers, including the
minimum wage, work hours, documentation, as well as child
labour requirements. When drafting the job requirements, the
firm's human resources department made sure that the business
system director role qualified for overtime pay in accordance
with federal law.
The Human Resources Department of the corporation has
complied with the law by including overtime pay for the
business system coordinator role in the job requirements. The
job falls underneath the executive and managerial employee’s
bracket as per Section 13(a) of the FLSA, making the holder
eligible for exemption from minimum income, as well as
overtime pay as long as the responsibilities and income of the
role explained meet all standards of the Department of Labor's
restrictions (Gold, 2018). In accordance with the Equal Pay Act,
the worker will receive the same salary regardless of her or his
gender.
References
Belyh, A. (2019, September 23).
What are job requirements and how to define them.
Retrieved October 18, 2022, from
https://www.cleverism.com/job-requirements/
Dau-Schmidt, K. G., Malin, M. H., Corrada, R. L., Cameron, C.
D. R., & Fisk, C. L. (2019).
Labor law in the contemporary workplace. West
Academic.
Golovina, S. Y. (2020).
The influence of the technological and organizational
factors on the ... Retrieved October 18, 2022, from
https://iopscience.iop.org/article/10.1088/1757-
899X/913/4/042019
Gold, M. E. (2018).
Introduction to the Law of Employment Discrimination.
Cornell University Press.
Robert, L., & Crawford, B. (2020, December 8).
Decoding Coca-Cola: A biography of a global brand:
Robert Crawford. Retrieved October 18, 2022, from
https://doi.org/10.4324/9781351024020
5
Cancer
Student Name
University
Professor
Course
Date
Cancer
Cancer is a major cause of morbidity and mortality globally,
accounting for 9.5 million deaths as of 2018. Thyroid Cancer is
one of the most frequent endocrine malignancies, contributing
to 3.4 percent of all cancers in the United States each year
Indini et al.(2022). While there has been significant progress in
the development of new cancer treatments and the increase in
the use of anticancer drugs over the past few years, the side
effects of these drugs can be severe and sometimes life-
threatening. However, there is still a lack of evidence regarding
their efficacy and safety. As a result, it is critical to assess the
benefits and risks of these medications before hospitals use
them to treat cancer patients. This literature review aims to
assess the benefits and risks of anticancer medicines in patients
with advanced cancer. This literature study will aid in a deeper
understanding of these medications and their prospective usage
in cancer care.
Similarities
Methodology
Silaghi et al. (2022) and Bachelard et al. (2021) conducted
systematic reviews and meta-analyses to investigate the risks
and advantages of anticancer medications in patients with
advanced cancer, as well as potential causes of resistance to
such treatments. Both investigations looked for clinical trials in
English written between the years 2000 through 2021 and
followed the PRISMA criteria. Indini et al. (2022) employed a
different technique conducting a systematic review of the
function of the mTOR and NAD pathways in malignancy
treatment, progression, and resistance. This study searched
Google Scholar, Scopus, PubMed, and Embase for English
language papers published between 2000 through 2021.
Findings
Anticancer medication usage was related to a considerable risk
of death in advanced cancer patients, according to Silaghi et al.
(2022) and Bachelard et al. (2021). However, the authors
discovered that these medications were linked to a considerable
increase in the likelihood of surviving for at least a year.
Furthermore, the researchers discovered that using these
medications was related to a considerable increase in the
likelihood of living for more than five years. Their findings
differed significantly from those of Indini et al. (2022), who
discovered that the mTOR and NAD paths are responsible for
drug resistance in malignant cells. Furthermore, the authors
discovered that these pathways might be possible targets for
future treatment methods.
Recommendations
Targeted therapy is recommended by Bachelard et al. (2021),
Indini et al. (2022), and Silaghi et al. (2022) as potential
therapeutic choices for individuals with advanced cancer who
have completed standard-of-care treatment. They also
emphasize the necessity of knowing medication resistance
mechanisms to design more effective targeted therapeutics.
Furthermore, they underline the need for trustworthy biomarkers
in guiding treatment decisions. Finally, they examine the
prospects of immunotherapeutic and combinatorial treatment as
resistance-busting techniques for targeted therapeutics.
Differences
Methodology
There are major discrepancies in technique between studies by
Bachelard et al.(2021) and Indini et al. (2022). Bachelard et
al.(2021) assessed the benefits and dangers of anticancer
medicines in advanced cancer patients using a meta-analysis and
systematic review. Indini et al.(2022) conducted a literature
review to find the most recent guidelines, clinical and
preclinical research, and novel perspectives in treating
advanced, malignant RAIR-DTC. Both Bachelard (2021) and
Indini et al. (2022) employed various databases and search
phrases. Such databases included PubMed, Google Scholar, and
Embase. Bachelard et al. (2021) explored clinical trials testing
Anti-cancer medications in adult patients with metastatic
tumors, whereas Indini et al. (2022) looked for publications
about DTC therapy and innovative therapeutic approaches. It is
also worth mentioning that Bachelard et al. (2021) included a
data meta-analysis, but Indini et al. (2022) did not; this is the
most likely because Bachelard (2021) was concerned with
assessing the effectiveness of anticancer medications. In
contrast, Indini et al. (2022) were concerned with locating the
most recent recommendations and research on the therapy of
DTC.
Results
Indini et al. (2022) had different results than Silaghi et al.
(2022). While Indini et al. (2022) discovered that the mTOR and
NAD paths play a role in drug resistance development in
malignant cells, Silaghi et al. (2022) discovered that targeted
therapy is a viable therapeutic option for thyroid cancer.
Recommendations
When discussing therapy choices with advanced cancer
patients, Bachelard et al. (2021) propose that adverse effects
documented in clinical trials should be considered.
As prospective options for overcoming resistance, Indini et al.
(2022) propose combinatorial treatment, redifferentiation
therapy, targeting alternative pathways and immunotherapy.
Silaghi et al. (2022) propose targeted therapy for patients with
distinguishable thyroid carcinoma who have developed
resistanceto radioiodine treatment. They advocate salvage
treatment for patients who fail to respond to first-line Tyrosine
kinase inhibitors therapy.
References
Indini, A., Fiorilla, I., Ponzone, L., Calautti, E., & Audrito, V.
(2022). NAD/NAMPT and mTOR pathways in melanoma:
Drivers of drug resistance and prospective therapeutic targets.
International Journal of Molecular Sciences, 23(17), 9985.
https://doi.org/10.3390/ijms23179985
Moreau Bachelard, C., Coquan, E., du Rusquec, P., Paoletti, X.,
& Le Tourneau, C. (2021). Risks and benefits of anticancer
drugs in advanced cancer patients: A systematic review and
meta-analysis. EClinicalMedicine, 40, 101130.
https://doi.org/10.1016/j.eclinm.2021.101130
Silaghi, H., Lozovanu, V., Georgescu, C. E., Pop, C., Nasui, B.
A., Cătoi, A. F., & Silaghi, C. A. (2022). State of the art in the
current management and future directions of targeted therapy
for differentiated thyroid cancer. International Journal of
Molecular Sciences, 23(7), 3470.
https://doi.org/10.3390/ijms23073470
References
Activity: Develop Your Recommendation with Evidence
Replicate the orange columns in your notebook.
Steps
Name of Steps
Description of Steps
Guidance to Success
Citations
3
Form your recommendation
Use your selected company/organization/
program/policy as a basis for your recommendation.
Connect this recommendation to the research problem.
· Identify what is the same and different between your research
population and the ‘solution’s’ population:
Same:
Different:
· Explain how you envision the “specific parts of the ‘solution’”
helping to mitigate your research problem:
· What must be changed/altered to work for YOUR problem?:
Activity: Find a Company/Organization/Policy Working to
Mitigate the Problem
Steps
Name of Steps
Description of Steps
Guidance to Success
Citations
2
Find and summarize an existing evidence-based solution to use
as a foundation to YOUR recommendation.
Conduct further research to find a company/organization/
program/policy that is doing a good job trying to mitigate this
problem (this could be from another state or even another
country where populations are comparable).
· Include the name of company/organization/
program/policy:
· Include detailed evidence that this ‘solution’ is working (do
not forget to include dates/years, and statistics as support):
· Identify specific parts of the solution that you think will be
useful and define/summarize them:
Replicate the orange columns in your notebook.
Activity: Summarize Your News Article to Identify the
Problem and Populations Affected
Fill in the orange
columns:
Steps
Name of Steps
Description of Steps
Guidance to Success
Citations
1
Summarize, making sure to identify:
·
the problem
·
populations affected by the problem
·
location of the problem, if applicable
Summarize the proof that the problem exists today by providing
an ‘example’ of your research problem happening in the world.
For KG-604, for your ‘example’, you will use your news article
or your research articles
(I
n other courses you might use a case study
from your textbook, a summary of the problem provided by your
professors, or you may need to find a relevant ‘case’ on your
own.)
1. Identify the problem and show it actually exists:
2. Identify populations affected:
3. Identify the location:

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1 7Job Description and Analysis Jeremy .docx

  • 1. 1 7 Job Description and Analysis Jeremy Taylor Week Three Assignment HR Management Fundamentals 22 October 2022 Job Description and Analysis Company's Overview, Mission, Vision, and Organizational Strategy Coca-Cola is an Atlanta, Georgia-based American international beverage corporation. Since its founding in 1892, this company has specialized in the production and distribution of various syrups and refreshments (Robert et al., 2020). Cola- cola refreshments are carbonated, sugary non-alcoholic beverages. In addition to its original beverage, the company produces and markets more than 500 other brands of soft drinks in more than 200 countries worldwide. Since it sells over 1.7 billion servings per day, its goods are widely used and known
  • 2. all over the world. The mission of the corporation is to restore the planet. The brand inspires hopeful and joyful moments, with the goals of creating value and making a difference. In addition, the company's mission is to provide alternative beverages and goods that people love and that refresh them physically and mentally. This is done to develop a longer-lasting organization and a more promising common future for people everywhere. There is an emphasis on leadership, collaboration, honesty, respect, tolerance, diversity, enthusiasm, responsibility, and product excellence. The company's vision is to become an endless beverage provider, therefore its organizational approach is to increase the number of drinks it sells. They need to accommodate low- and no-sugar choices in a wide variety of product types, as well as in a number of different packaging options and retail settings. Job Position – Business Co-ordinator Qualifications, Skills and Experience 1. The minimum education required is a Bachelor of Science or Bachelor of Technology degree in a relevant field of science or technology. 2. A minimum of five years' experience working in a Food Processing Plant, with at least two of those years spent coordinating management systems. 3. Should have a solid understanding of the process, particularly with experience working in a bottling environment. 4. FSSC V5 Awareness or Internal Audit QMS OSH EMS training Certificate in Lead Auditor. 5. Should be at least 18 years old to participate. How Position's Duties and Responsibilities Reflect the Company's Mission, Vision, and Strategic Goals The business system director will be crucial in understanding and carrying out the organization's strategic business objectives. This will be essential to achieving the company's strategic objectives and achieving its mission and ambitions of making a difference, renewing the world, and
  • 3. producing value (Belyh, 2019). In addition, they will make sure that quality goods are produced by guaranteeing that Coca- Cola's goods meet the relevant health and quality requirements. Consequently, its clients can enjoy the beverages without worrying about health concerns like contamination. Due to its excellent reputation for safe and high-quality products, the Coca-Cola Corporation (TTCC) will offer more of its drinks to more consumers across the globe. The business system coordinator is also responsible for ensuring that both the organization as well as its products adhere to the regulations that have been established. Due to the fact that Coca-Cola must comply with the rules of each state in which it operates, this will play an essential role in the company's expansion strategy. Hence, if it conforms to all of the requirements, the corporation will make a big difference and bring about a revitalization of the world. Workers will also have plenty of time to respect their legal wants and requirements and abide by them. Purpose of the Position in the Company When hired, a business systems coordinator will be responsible for a wide range of tasks. The worker will learn the company's strategic priorities and put them into action. For this reason, they will make sure that their quality targets and goals are in line with the company's strategic business aims, and they will work with its internal customers to build collaborations and capabilities in the areas of safety, health, environmental, and quality (SHEQ). In addition, he or she will oversee the quality assurance, incorporated management system, as well as food safety initiatives at the manufacturing facility. The successful applicant for this position will also be responsible for ensuring that the quality of the products and their packaging satisfies all applicable laws, company standards, and TCCC guidelines. Responsibility for coordinating with other groups and driving the execution of
  • 4. TCCC product specs while maintaining quality control falls under this division's purview. All facilities adhere to FSSC 22000 and GMP (Good Manufacturing Practice) guidelines. In addition, it is necessary to regularly examine artwork and packaging for accuracy and conformity, conduct necessary training, and update procedures and policies in accordance with any changes made to the relevant specifications and guidelines. Additionally, the employee must document and monitor records. He must maintain the SHEQ policies and documentation needed by the standard, guarantee the most recent versions of papers are readily available at the time of use, and execute regular changes to the master-list of records and documentation. The person will also conduct both internal and external audits by preserving a certification and surveillance audit calendar, organizing the internal audit actions strategy, audit execution, as well as reporting, as well as identifying trends, tracking audited vehicles, and submitting monthly audit reports. The business systems director will also support problem- solving and continual improvement programs within the organization by leading root-cause examination of system non- conformances and evaluating continuous improvement efforts for patterns to prompt corrective action where necessary. Among these tasks are the performance of actual performance indicators, internal audits, assessments, lack of compliance and remedial action processes. The employee will also organize the execution of standards for quality, security, health, as well as the environment. This position is accountable for directing certification audit operations related to “FSSC integrated control systems and managing performance appraisal and internal audits for FSSC 22000 and Information management systems (IMS) standards.” A part of the responsibilities include the planning, carrying out, monitoring, and reporting of the SHEQ tasks that are defined in the SHEQ activity calendar. In addition, this involves tasks like identifying problematic tendencies that need fixing or escalating and carrying out
  • 5. relevant safety, health, and environmental quality (SHEQ) training. The reporting tasks, which include reporting customer complaints and ecological performance measures on a monthly basis as specified, will also be completed by the professionals. In addition to this, the business will call for a weekly update on key performance metrics (KPIs) on a monthly basis. A monthly report will be provided by a business system planner detailing the status of all FSSC version 5 and IMS audit appropriate measures, information governance inspection audit disciplinary proceedings, internal audit cars, and performance management activities, as well as reporting on the status of quality management activities. Determination of Duties and Qualifications of the Job There were a few different approaches that were taken while determining the qualifications and responsibilities associated with the employment post. First, each employee was required to fill out a job evaluation questionnaire. I also conducted interviews with the staff members of the organization, asking them specific questions pertaining to their jobs and responsibilities. In addition to conducting a desk audit, during which I observed employees as they went about their workday, I obtained log sheets detailing employees' weekly time spent on each duty. Furthermore, I spoke with managers, supervisors, co-workers, customers, and clients that the employee would normally interact with in the course of their employment. In the end, I determined the position's salary range by comparing it to similar positions within the same department and within the same job category. Employment Laws in the Creation of the Job Descriptions Business coordinator duties and responsibilities were drafted with reference to significant employment legislation like the “Equal Pay Act (EPA) and the Fair Labour Standards Act (FLSA)” (Dau-Schmidt et al., 2019) The FLSA governs the rights of both public and private sector workers, including the minimum wage, work hours, documentation, as well as child
  • 6. labour requirements. When drafting the job requirements, the firm's human resources department made sure that the business system director role qualified for overtime pay in accordance with federal law. The Human Resources Department of the corporation has complied with the law by including overtime pay for the business system coordinator role in the job requirements. The job falls underneath the executive and managerial employee’s bracket as per Section 13(a) of the FLSA, making the holder eligible for exemption from minimum income, as well as overtime pay as long as the responsibilities and income of the role explained meet all standards of the Department of Labor's restrictions (Gold, 2018). In accordance with the Equal Pay Act, the worker will receive the same salary regardless of her or his gender. References Belyh, A. (2019, September 23). What are job requirements and how to define them. Retrieved October 18, 2022, from https://www.cleverism.com/job-requirements/ Dau-Schmidt, K. G., Malin, M. H., Corrada, R. L., Cameron, C. D. R., & Fisk, C. L. (2019). Labor law in the contemporary workplace. West Academic. Golovina, S. Y. (2020). The influence of the technological and organizational factors on the ... Retrieved October 18, 2022, from https://iopscience.iop.org/article/10.1088/1757- 899X/913/4/042019 Gold, M. E. (2018). Introduction to the Law of Employment Discrimination. Cornell University Press. Robert, L., & Crawford, B. (2020, December 8).
  • 7. Decoding Coca-Cola: A biography of a global brand: Robert Crawford. Retrieved October 18, 2022, from https://doi.org/10.4324/9781351024020 5 Cancer Student Name University Professor Course Date Cancer Cancer is a major cause of morbidity and mortality globally,
  • 8. accounting for 9.5 million deaths as of 2018. Thyroid Cancer is one of the most frequent endocrine malignancies, contributing to 3.4 percent of all cancers in the United States each year Indini et al.(2022). While there has been significant progress in the development of new cancer treatments and the increase in the use of anticancer drugs over the past few years, the side effects of these drugs can be severe and sometimes life- threatening. However, there is still a lack of evidence regarding their efficacy and safety. As a result, it is critical to assess the benefits and risks of these medications before hospitals use them to treat cancer patients. This literature review aims to assess the benefits and risks of anticancer medicines in patients with advanced cancer. This literature study will aid in a deeper understanding of these medications and their prospective usage in cancer care. Similarities Methodology Silaghi et al. (2022) and Bachelard et al. (2021) conducted systematic reviews and meta-analyses to investigate the risks and advantages of anticancer medications in patients with advanced cancer, as well as potential causes of resistance to such treatments. Both investigations looked for clinical trials in English written between the years 2000 through 2021 and followed the PRISMA criteria. Indini et al. (2022) employed a different technique conducting a systematic review of the function of the mTOR and NAD pathways in malignancy treatment, progression, and resistance. This study searched Google Scholar, Scopus, PubMed, and Embase for English language papers published between 2000 through 2021. Findings Anticancer medication usage was related to a considerable risk of death in advanced cancer patients, according to Silaghi et al. (2022) and Bachelard et al. (2021). However, the authors discovered that these medications were linked to a considerable increase in the likelihood of surviving for at least a year. Furthermore, the researchers discovered that using these
  • 9. medications was related to a considerable increase in the likelihood of living for more than five years. Their findings differed significantly from those of Indini et al. (2022), who discovered that the mTOR and NAD paths are responsible for drug resistance in malignant cells. Furthermore, the authors discovered that these pathways might be possible targets for future treatment methods. Recommendations Targeted therapy is recommended by Bachelard et al. (2021), Indini et al. (2022), and Silaghi et al. (2022) as potential therapeutic choices for individuals with advanced cancer who have completed standard-of-care treatment. They also emphasize the necessity of knowing medication resistance mechanisms to design more effective targeted therapeutics. Furthermore, they underline the need for trustworthy biomarkers in guiding treatment decisions. Finally, they examine the prospects of immunotherapeutic and combinatorial treatment as resistance-busting techniques for targeted therapeutics. Differences Methodology There are major discrepancies in technique between studies by Bachelard et al.(2021) and Indini et al. (2022). Bachelard et al.(2021) assessed the benefits and dangers of anticancer medicines in advanced cancer patients using a meta-analysis and systematic review. Indini et al.(2022) conducted a literature review to find the most recent guidelines, clinical and preclinical research, and novel perspectives in treating advanced, malignant RAIR-DTC. Both Bachelard (2021) and Indini et al. (2022) employed various databases and search phrases. Such databases included PubMed, Google Scholar, and Embase. Bachelard et al. (2021) explored clinical trials testing Anti-cancer medications in adult patients with metastatic tumors, whereas Indini et al. (2022) looked for publications about DTC therapy and innovative therapeutic approaches. It is also worth mentioning that Bachelard et al. (2021) included a data meta-analysis, but Indini et al. (2022) did not; this is the
  • 10. most likely because Bachelard (2021) was concerned with assessing the effectiveness of anticancer medications. In contrast, Indini et al. (2022) were concerned with locating the most recent recommendations and research on the therapy of DTC. Results Indini et al. (2022) had different results than Silaghi et al. (2022). While Indini et al. (2022) discovered that the mTOR and NAD paths play a role in drug resistance development in malignant cells, Silaghi et al. (2022) discovered that targeted therapy is a viable therapeutic option for thyroid cancer. Recommendations When discussing therapy choices with advanced cancer patients, Bachelard et al. (2021) propose that adverse effects documented in clinical trials should be considered. As prospective options for overcoming resistance, Indini et al. (2022) propose combinatorial treatment, redifferentiation therapy, targeting alternative pathways and immunotherapy. Silaghi et al. (2022) propose targeted therapy for patients with distinguishable thyroid carcinoma who have developed resistanceto radioiodine treatment. They advocate salvage treatment for patients who fail to respond to first-line Tyrosine kinase inhibitors therapy. References Indini, A., Fiorilla, I., Ponzone, L., Calautti, E., & Audrito, V. (2022). NAD/NAMPT and mTOR pathways in melanoma: Drivers of drug resistance and prospective therapeutic targets. International Journal of Molecular Sciences, 23(17), 9985. https://doi.org/10.3390/ijms23179985 Moreau Bachelard, C., Coquan, E., du Rusquec, P., Paoletti, X., & Le Tourneau, C. (2021). Risks and benefits of anticancer drugs in advanced cancer patients: A systematic review and meta-analysis. EClinicalMedicine, 40, 101130. https://doi.org/10.1016/j.eclinm.2021.101130 Silaghi, H., Lozovanu, V., Georgescu, C. E., Pop, C., Nasui, B.
  • 11. A., Cătoi, A. F., & Silaghi, C. A. (2022). State of the art in the current management and future directions of targeted therapy for differentiated thyroid cancer. International Journal of Molecular Sciences, 23(7), 3470. https://doi.org/10.3390/ijms23073470 References Activity: Develop Your Recommendation with Evidence Replicate the orange columns in your notebook. Steps Name of Steps Description of Steps Guidance to Success Citations 3 Form your recommendation Use your selected company/organization/ program/policy as a basis for your recommendation.
  • 12. Connect this recommendation to the research problem. · Identify what is the same and different between your research population and the ‘solution’s’ population: Same: Different: · Explain how you envision the “specific parts of the ‘solution’” helping to mitigate your research problem: · What must be changed/altered to work for YOUR problem?:
  • 13. Activity: Find a Company/Organization/Policy Working to Mitigate the Problem Steps Name of Steps Description of Steps Guidance to Success Citations 2 Find and summarize an existing evidence-based solution to use as a foundation to YOUR recommendation. Conduct further research to find a company/organization/ program/policy that is doing a good job trying to mitigate this problem (this could be from another state or even another country where populations are comparable). · Include the name of company/organization/ program/policy: · Include detailed evidence that this ‘solution’ is working (do not forget to include dates/years, and statistics as support):
  • 14. · Identify specific parts of the solution that you think will be useful and define/summarize them: Replicate the orange columns in your notebook. Activity: Summarize Your News Article to Identify the Problem and Populations Affected Fill in the orange columns: Steps Name of Steps Description of Steps Guidance to Success Citations 1 Summarize, making sure to identify:
  • 15. · the problem · populations affected by the problem · location of the problem, if applicable Summarize the proof that the problem exists today by providing an ‘example’ of your research problem happening in the world. For KG-604, for your ‘example’, you will use your news article or your research articles (I n other courses you might use a case study from your textbook, a summary of the problem provided by your professors, or you may need to find a relevant ‘case’ on your own.) 1. Identify the problem and show it actually exists: 2. Identify populations affected:
  • 16. 3. Identify the location: