The duodenum has four parts with different anatomical relationships and blood supply. The first part is anterior to the liver and posterior to major blood vessels. The second part is anterior to the gallbladder and colon and posterior to renal vessels. The third part is anterior to major abdominal vessels and posterior to the inferior vena cava. The fourth part is anterior to the transverse colon and posterior to left abdominal structures. It receives its blood supply from branches of the celiac trunk and superior mesenteric artery, and drains into the splenic, superior mesenteric, and portal veins. Its nerve supply comes from the celiac plexus.